Testicular toxicity of rinbacin in ratsOrish Ebere Orisakwe
Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Anambra State, Nigeria
Biol Pharm Bull 25:206-8. 2002
..Rinbacin decreases the ESN and causes degenerative lesions, especially at the high dose, in prepubertal rats...
- Investigation into the nephrotoxicity of Nigerian bonny light crude oil in albino rats
O E Orisakwe
Toxiocology Unit, Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Anambra State, Nigeria
Int J Environ Res Public Health 1:106-10. 2004
..05) in creatinine in the high dose group (800mg/kg), and a significant decrease (p ? 0.05) in urea concentration. Histological examination indicates that crude oil induced severe pathologic changes in the forms of necrosis and oedema...
- Heavy metal hazards of sachet water in Nigeria
Orish Ebere Orisakwe
Toxicology Unit in the Department of Pharmacology, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria
Arch Environ Occup Health 61:209-13. 2006
..003 to 0.050 mg/l. The biological oxygen demand of the samples ranged from 3.20 to 36.80 mg/L. Other parameters were normal. The authors found that some of the sachet waters contain heavy metals, and consumers may be exposed to hazards...
Heavy metals health risk assessment for population via consumption of food crops and fruits in Owerri, South Eastern, NigeriaOrish Ebere Orisakwe
Toxicology Unit, Clinical Pharmacy Faculty of Pharmacy University of PortHacourt Rivers State Nigeria, PortHacourt, Nigeria
Chem Cent J 6:77. 2012
..abstract:..
- Spermatoxic effects of operation sweep herbal supplement in male albino rats
O E Orisakwe
Toxicology Unit, Department of Clinical Pharmacy and Management, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Rivers State, Nigeria
J Basic Clin Physiol Pharmacol 21:147-56. 2010
..5 and 2.25 g/kg. This study suggests that the aqueous extract of the OPS powder may cause epididymal toxicity as shown in the adverse effect on sperm quality...
Lead and cadmium levels of commonly administered pediatric syrups in Nigeria: a public health concern?Orish Ebere Orisakwe
Toxicology Unit, Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Anambra State, Nigeria
Sci Total Environ 407:5993-6. 2009
....
- Environmental pollution and blood lead levels in Nigeria: who is unexposed?
Orish Ebere Orisakwe
Pharmacology Department, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria
Int J Occup Environ Health 15:315-7. 2009
..Continued high BLLs in Nigeria cast doubt on researchers' ability to find real "unexposed control subjects" in future studies, and point to the importance of controlling environmental lead exposures...
- Liver and kidney function tests amongst paint factory workers in Nkpor, Nigeria
O E Orisakwe
College of Health Sciences, Nnamdi Azikiwe University, P M B 5001, Nnewi, Anambra State, Nigeria
Toxicol Ind Health 23:161-5. 2007
..In conclusion, it should be noted that occupational exposure to cadmium or lead among PFW, may compromise the liver and renal functions in man...
- Some plasma and saliva pharmacokinetics parameters of rifampicin in the presence of pefloxacin
Orish E Orisakwe
Biokinetics Research Group, Toxicology Unit, Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Anambra State, Nigeria
Am J Ther 11:283-7. 2004
....
- Urinary excretion of rifampicin in the presence of ciprofloxacin
Orish E Orisakwe
Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Anambra State, Nigeria
Am J Ther 11:171-4. 2004
..The study indicates that rifampicin may be coadministered with ciprofloxacin to check the development of drug resistance to single-drug therapy by susceptible organisms...
- Testicular toxicity of Nigerian bonny light crude oil in male albino rats
Orish Ebere Orisakwe
Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, PMB 5001, Nnewi, Anambra State, Nigeria
Reprod Toxicol 18:439-42. 2004
..This study suggests that the Nigerian bonny light crude oil is a testicular toxicant and its use as a folklore medicine may cause infertility...
- Testicular effects of sub-chronic administration of Hibiscus sabdariffa calyx aqueous extract in rats
Orish Ebere Orisakwe
Toxicology Unit, Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Anambra State, Nigeria
Reprod Toxicol 18:295-8. 2004
..The 4.6 g/kg dose group, on the other hand, showed disintegration of sperm cells. The results indicate that aqueous HS calyx extract induces testicular toxicity in rats...
- Effect of pefloxacin on the urinary excretion of rifampicin
Orish E Orisakwe
Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, PMB 5001, Anambra State, Nigeria
Am J Ther 11:13-6. 2004
..Pefloxacin increases the absorption and urinary excretion of rifampicin by decreasing the gastrointestinal motility through chelation mechanisms...
- Heavy metal contamination of foods by refuse dump sites in Awka, southeastern Nigeria
John K C Nduka
Pure and Industrial Chemistry Department, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria
ScientificWorldJournal 8:941-8. 2008
..Taken together, we may conclude that the consumption of leafy vegetables and crops produced on contaminated soils may pose a health risk to those that reside around the refuse dumps...
- Toxicological study of the Anam River in Otuocha, Anambra State, Nigeria
Innocent O Igwilo
Department of Applied Biochemistry, Nnamdi Azikiwe University, Awka, Nigeria
Arch Environ Occup Health 61:205-8. 2006
..00 +/- 1.73 mg/L, 14.44 +/- 3.13 mg/L, 19.33 +/- 0.67 ps cm-L, and 7.09 +/- 0.05, respectively. The World Health Organization guidelines for the parameters in soil were exceeded...
- Impact of effluents from a car battery manufacturing plant in Nigeria on water, soil, and food qualities
Orish Ebere Orisakwe
Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nigeria
Arch Environ Health 59:31-6. 2004
....
- Effects of rinbacin extract on rat kidney
Onyenmechi Johnson Afonne
Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University Nnewi, Anambra State, Nigeria
Biol Pharm Bull 25:1022-5. 2002
..The effects were less marked in the low dose than the high dose group. Chronic administration of rinbacin extract induces nephrotoxicity in young rats...
- Assessment of environmental distribution of lead in some municipalities of South-Eastern Nigeria
John Kanayochukwu Nduka
Environmental Chemistry and Toxicology Research Unit, Pure and Industrial Chemistry Department, Nnamdi Azikiwe University, Awka Anambra State, Nigeria
Int J Environ Res Public Health 7:2501-13. 2010
..13-0.49 mg/kg and 0.15-0.47 mg/kg for 2007 and 2008, respectively. Rain samples had the least Pb concentration, ranging from 0.103 +/- 0.000 to 0.163 +/- 0.046 mg/L. We may conclude that Nigerians are exposed to environmental Pb...
- Nitrate and nitrite levels of potable water supply in Warri, Nigeria: a public health concern
John Kanayochukwu Nduka
Nnamdi Azikwe University, Department of Pharmacology, College of Health Sciences, Anambra State, Nigeria
J Environ Health 72:28-31. 2010
..This study suggests that indiscriminate disposal of waste and poor sanitation may be additional contributing factors in the nitrate pollution of the water supply in the Niger Delta area of Nigeria...
- Precipitation chemistry and occurrence of acid rain over the oil-producing Niger Delta region of Nigeria
John K C Nduka
Pure and Industrial Chemistry Department, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria
ScientificWorldJournal 10:528-34. 2010
..Crude oil exploration and gas flaring in the Niger Delta, and multiplicity of cottage industries in Awka, impacted on the inorganic ion pollution of the rainwater. This may have public health implications in the region...
- Water-quality issues in the Niger Delta of Nigeria: a look at heavy metal levels and some physicochemical properties
John Kanayochukwu Nduka
Environmental Chemistry and Toxicology Research Unit, Pure and Industrial Chemistry Department, Nnamdi Azikiwe University, P M B 5025, Nnewi, Awka Anambra State, Nigeria
Environ Sci Pollut Res Int 18:237-46. 2011
..The present work is an improved attempt at a scientific discourse of water-quality issues in the Niger Delta of Nigeria with respect to heavy metal levels in surface water in view of the hitherto dearth of scientific data...
- Heavy metal hazards of pediatric syrup administration in Nigeria: a look at chromium, nickel and manganese
John Kanayochukwu Nduka
Environmental Chemistry and Toxicology Research Unit, Pure and Industrial Chemistry Department, Nnamdi Azikiwe University, P M B 5025, Awka Anambra State, Nigeria
Int J Environ Res Public Health 6:1972-9. 2009
..The public health hazards from ingestion of these syrups should be identified and disclosed by in-depth risk assessment studies...
- Safety warnings and first aid instructions on consumer and pharmaceutical products in Nigeria: has there been an improvement?
Stanley Catherine Nonyelum
Faculty of Pharmaceutical Sciences, University of Port Harcourt, Choba Port Harcourt, Rivers State Nigeria
J Pak Med Assoc 60:801-4. 2010
..To investigate the adequacy of safety warnings and first aid instructions on the labels of pharmaceutical and consumer products in Nigeria...
- Nephrotoxic actions of low-dose mercury in mice: protection by zinc
Onyenmechi J Afonne
Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nwewi Campus, Nigeria
Arch Environ Health 57:98-102. 2002
..The results indicate that low-dose mercury exposure in mice kidney induces some degenerative effects, which are prevented by zinc...
