- Perspectives of CD44 targeting therapies
Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Postfach 3640, 76021, Karlsruhe, Germany
Arch Toxicol 89:3-14. 2015
..We are convinced that the success of these therapies will depend on an increased understanding of the molecular functions of specific CD44 isoforms in particular in cancer stem cells. ..
- CD44 is a multidomain signaling platform that integrates extracellular matrix cues with growth factor and cytokine signals
Karlsruhe Institute of Technology, Institute of Toxicology and Genetics, Karlsruhe, Germany Electronic address
Adv Cancer Res 123:231-54. 2014
- Opposing effects of high- and low-molecular weight hyaluronan on CXCL12-induced CXCR4 signaling depend on CD44
Karlsruhe Institute of Technology, Institute of Toxicology and Genetics, Karlsruhe, Campus North, Postfach 3640, Karlsruhe, Germany
Cell Death Dis 4:e819. 2013
..These findings provide novel insights into how microenvironmental components interact with cell surface receptors in multi-component complexes to regulate key aspects of tumor growth and progression. ..
- CD44, a therapeutic target for metastasising tumours
Karlsruhe Institute of Technology, Institute for Toxicology and Genetics, Hermann von Helmholtzplatz 1, 76344 Eggenstein Leopoldshafen, Germany
Eur J Cancer 46:1271-7. 2010
..Other peptides block RTK activation and thereby inhibit tumour angiogenesis and metastatic spread...
- c-Met recruits ICAM-1 as a coreceptor to compensate for the loss of CD44 in Cd44 null mice
Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, 76344 Eggenstein Leopoldshafen, Germany
Mol Biol Cell 22:2777-86. 2011
..Our experiments demonstrate the functional substitution of a protein by a heterologous one in a knockout mouse...
- Hepatocyte growth factor-induced Ras activation requires ERM proteins linked to both CD44v6 and F-actin
Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, 76021 Karlsruhe, Germany
Mol Biol Cell 18:76-83. 2007
..So far the cytoskeleton has mainly been identified as a "responder" to signal transduction. Here, we show now that F-actin acts as an "inducer" that actively organizes the signaling cascade...
- CD44 is required for two consecutive steps in HGF/c-Met signaling
Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, D 76021 Karlsruhe, Germany
Genes Dev 16:3074-86. 2002
..This suggests a role for ERM proteins and possibly their link to the cortical actin cytoskeleton in signal transfer...
- Internalization of Met requires the co-receptor CD44v6 and its link to ERM proteins
Karlsruhe Institute of Toxicology, Institute for Toxicology and Genetics, Karlsruhe, Germany
PLoS ONE 8:e62357. 2013
..Both CD44v6 and Met are co-internalized upon Hepatocyte Growth Factor induction suggesting that Met-induced signaling from the endosomes relies on its collaboration with CD44v6 and the link to the cytoskeleton provided by ERM proteins...
- Genes upregulated in a metastasizing human colon carcinoma cell line
Forschungszentrum Karlsruhe, Institute of Toxicologie and Genetics, Karlsruhe, Germany
Int J Cancer 113:699-705. 2005
..Cancer profiling arrays as well as in situ hybridization study revealed that at least some of the genes obtained in the SSH screen are also differentially expressed in human tumors...
- A CD44v6 peptide reveals a role of CD44 in VEGFR-2 signaling and angiogenesis
Forschungszentrum Karlsruhe, Institute for Toxicology and Genetics, Karlsruhe, Germany
Blood 114:5236-44. 2009
- A five-amino-acid peptide blocks Met- and Ron-dependent cell migration
Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, Karlsruhe, Germany
Cancer Res 65:6105-10. 2005
..Peptides comprising these three amino acids (the smallest containing only five amino acids) efficiently act as competitors and block ligand-dependent activation of Met or Ron and subsequent cell migration...
- Adhesion proteins meet receptors: a common theme?
Institute for Toxicology and Genetics, Forschungszentrum Karlsruhe, Karlsruhe, Germany
Adv Cancer Res 101:63-92. 2008
..Furthermore, the functions of the CAMs can be controlled by the cellular environment and the binding to their ligands...
- Haploinsufficiency of c-Met in cd44-/- mice identifies a collaboration of CD44 and c-Met in vivo
Forschungszentrum Karlsruhe, Institute for Toxicology and Genetics, Postfach 3640, 76021 Karlsruhe, Germany
Mol Cell Biol 27:8797-806. 2007
..These results are the first genetic data showing that CD44 and c-Met collaborate in vivo and that they are involved in synaptogenesis and axon myelination in the central and peripheral nervous systems...
- Endocytosis of Fgf8 is a double-stage process and regulates spreading and signaling
Karlsruhe Institute of Technology KIT, Institute of Toxicology and Genetic ITG, Karlsruhe, Germany
PLoS ONE 9:e86373. 2014
..Therefore, we hypothesize that Fgf8 receiving cells control both, the propagation width and the signal strength of the morphogen. ..