Hilmi Orhan

Summary

Publications

  1. doi request reprint Urinary lipid and protein oxidation products upon halothane, isoflurane, or sevoflurane anesthesia in humans: potential biomarkers for a subclinical nephrotoxicity
    Hilmi Orhan
    Department of Toxicology, Faculty of Pharmacy, Ege University, Bornova Izmir, Turkey
    Biomarkers 18:73-81. 2013
  2. ncbi request reprint Conventional and novel approaches in generating and characterization of reactive intermediates from drugs/drug candidates
    Hilmi Orhan
    Department of Toxicology, Faculty of Pharmacy, Ege University, 35100 Bornova Izmir, Turkey
    Curr Drug Metab 12:383-94. 2011
  3. ncbi request reprint Erythrocyte antioxidant defense response against cigarette smoking in humans--the glutathione S-transferase vulnerability
    Hilmi Orhan
    Department of Toxicology, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey
    J Biochem Mol Toxicol 19:226-33. 2005
  4. ncbi request reprint Synthesis and evaluation of in vitro antioxidant capacities of some benzimidazole derivatives
    Hande Gurer-Orhan
    Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Hacettepe University, Sihhiye 06100, Ankara, Turkey
    J Enzyme Inhib Med Chem 21:241-7. 2006
  5. pmc Misincorporation of free m-tyrosine into cellular proteins: a potential cytotoxic mechanism for oxidized amino acids
    Hande Gurer-Orhan
    Department of Toxicology, University of Hacettepe, Faculty of Pharmacy, 06100, Ankara, Turkey
    Biochem J 395:277-84. 2006
  6. ncbi request reprint Quantification of urinary o,o'-dityrosine, a biomarker for oxidative damage to proteins, by high performance liquid chromatography with triple quadrupole tandem mass spectrometry. A comparison with ion-trap tandem mass spectrometry
    Hilmi Orhan
    Toxicology Department, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey
    J Chromatogr B Analyt Technol Biomed Life Sci 827:104-8. 2005
  7. ncbi request reprint Circulating biomarkers of oxidative stress in complicated pregnancies
    Hilmi Orhan
    Department of Toxicology, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey
    Arch Gynecol Obstet 267:189-95. 2003
  8. ncbi request reprint Analyses of representative biomarkers of exposure and effect by chromatographic, mass spectrometric, and nuclear magnetic resonance techniques: method development and application in life sciences
    Hilmi Orhan
    Department of Toxicology, Faculty of Pharmacy, Ege University, 35100 Bornova Izmir, Turkey
    J Sep Sci 30:149-74. 2007

Collaborators

Detail Information

Publications8

  1. doi request reprint Urinary lipid and protein oxidation products upon halothane, isoflurane, or sevoflurane anesthesia in humans: potential biomarkers for a subclinical nephrotoxicity
    Hilmi Orhan
    Department of Toxicology, Faculty of Pharmacy, Ege University, Bornova Izmir, Turkey
    Biomarkers 18:73-81. 2013
    ..To investigate whether lipid and protein oxidation products are elevated and correlated with routine clinical markers of hepatic and renal function in patients anesthetized with halothane, isoflurane, or sevoflurane...
  2. ncbi request reprint Conventional and novel approaches in generating and characterization of reactive intermediates from drugs/drug candidates
    Hilmi Orhan
    Department of Toxicology, Faculty of Pharmacy, Ege University, 35100 Bornova Izmir, Turkey
    Curr Drug Metab 12:383-94. 2011
    ..This review is aimed at briefly summarizing the state of the art and compiling the highlighted studies in characterization of the reactive metabolites from drug molecules...
  3. ncbi request reprint Erythrocyte antioxidant defense response against cigarette smoking in humans--the glutathione S-transferase vulnerability
    Hilmi Orhan
    Department of Toxicology, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey
    J Biochem Mol Toxicol 19:226-33. 2005
    ....
  4. ncbi request reprint Synthesis and evaluation of in vitro antioxidant capacities of some benzimidazole derivatives
    Hande Gurer-Orhan
    Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Hacettepe University, Sihhiye 06100, Ankara, Turkey
    J Enzyme Inhib Med Chem 21:241-7. 2006
    ..Furthermore their effects on various antioxidant enzymes are discussed and evaluated from the perspective of structure- activity relationships...
  5. pmc Misincorporation of free m-tyrosine into cellular proteins: a potential cytotoxic mechanism for oxidized amino acids
    Hande Gurer-Orhan
    Department of Toxicology, University of Hacettepe, Faculty of Pharmacy, 06100, Ankara, Turkey
    Biochem J 395:277-84. 2006
    ..Thus misincorporation of free oxidized amino acids during protein synthesis may represent an alternative mechanism for oxidative stress and tissue injury during aging and disease...
  6. ncbi request reprint Quantification of urinary o,o'-dityrosine, a biomarker for oxidative damage to proteins, by high performance liquid chromatography with triple quadrupole tandem mass spectrometry. A comparison with ion-trap tandem mass spectrometry
    Hilmi Orhan
    Toxicology Department, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey
    J Chromatogr B Analyt Technol Biomed Life Sci 827:104-8. 2005
    ..This is comparable to the previously reported values of 5.8+/-0.3 micromol/mol creatinine in non-smokers night-time urines, and 12.3+/-5 micromol/mol creatinine in day-time urines measured by the ion-trap instrument...
  7. ncbi request reprint Circulating biomarkers of oxidative stress in complicated pregnancies
    Hilmi Orhan
    Department of Toxicology, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey
    Arch Gynecol Obstet 267:189-95. 2003
    ..These multiparameter biomarkers can also be used in monitoring the efficiency of antioxidant supplementation in complicated pregnant women, as has recently been suggested for diabetic and preeclamptic pregnancies...
  8. ncbi request reprint Analyses of representative biomarkers of exposure and effect by chromatographic, mass spectrometric, and nuclear magnetic resonance techniques: method development and application in life sciences
    Hilmi Orhan
    Department of Toxicology, Faculty of Pharmacy, Ege University, 35100 Bornova Izmir, Turkey
    J Sep Sci 30:149-74. 2007
    ..In Section 4, method development for protein and DNA oxidation products by LC-tandem MS and its application in mammalian cells and in humans are summarized. Possibilities, limitations, and future perspectives are discussed in Section 5...