Joseph P R O Orgel

Summary

Publications

  1. pmc Microfibrillar structure of type I collagen in situ
    Joseph P R O Orgel
    Center for Synchrotron Radiation Research and Instrumentation, Department of Biological, Chemical, and Physical Sciences, Illinois Institute of Technology, 3101 South Dearborn Street, Chicago, IL 60616, USA
    Proc Natl Acad Sci U S A 103:9001-5. 2006
  2. pmc Non-enzymatic decomposition of collagen fibers by a biglycan antibody and a plausible mechanism for rheumatoid arthritis
    Olga Antipova
    Pritzker Institute of Biomedical Science and Engineering, Illinois Institute of Technology, Chicago, Illinois, United States of America
    PLoS ONE 7:e32241. 2012
  3. pmc Decorin core protein (decoron) shape complements collagen fibril surface structure and mediates its binding
    Joseph P R O Orgel
    BioCAT and microCoSM Centres Pritzker Institute of Biomedical Science and Engineering, Illinois Institute of Technology, Chicago, Illinois, USA
    PLoS ONE 4:e7028. 2009
  4. pmc In situ D-periodic molecular structure of type II collagen
    Olga Antipova
    Center for Molecular Study of Condensed Soft Matter Centers microCoSM, Pritzker Institute of Biomedical Science and Engineering, Chicago, Illinois 60616, USA
    J Biol Chem 285:7087-96. 2010
  5. ncbi request reprint Flanking polyproline sequences inhibit beta-sheet structure in polyglutamine segments by inducing PPII-like helix structure
    Gregory Darnell
    Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA
    J Mol Biol 374:688-704. 2007
  6. pmc Collagen fibril architecture, domain organization, and triple-helical conformation govern its proteolysis
    Shiamalee Perumal
    Center for Synchrotron Radiation Research and Instrumentation, Department of Biological, Chemical, and Physical Sciences, Illinois Institute of Technology, 3101 South Dearborn Street, Chicago, IL 60616, USA
    Proc Natl Acad Sci U S A 105:2824-9. 2008
  7. ncbi request reprint Sequence context and modified hydrophobic moment plots help identify 'horizontal' surface helices in transmembrane protein structure prediction
    Joseph P R O Orgel
    Rosalind Franklin Structural Biology Laboratories, Department of Biochemistry, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, 3333 Green Bay Road, IL 60064, USA
    J Struct Biol 148:51-65. 2004

Collaborators

  • John E Scott
  • Olga Antipova
  • Shiamalee Perumal
  • Gregory Darnell
  • Stephen C Meredith
  • Reinhard Pahl

Detail Information

Publications7

  1. pmc Microfibrillar structure of type I collagen in situ
    Joseph P R O Orgel
    Center for Synchrotron Radiation Research and Instrumentation, Department of Biological, Chemical, and Physical Sciences, Illinois Institute of Technology, 3101 South Dearborn Street, Chicago, IL 60616, USA
    Proc Natl Acad Sci U S A 103:9001-5. 2006
    ....
  2. pmc Non-enzymatic decomposition of collagen fibers by a biglycan antibody and a plausible mechanism for rheumatoid arthritis
    Olga Antipova
    Pritzker Institute of Biomedical Science and Engineering, Illinois Institute of Technology, Chicago, Illinois, United States of America
    PLoS ONE 7:e32241. 2012
    ..We speculate that the initiation of RA associated tissue destruction in vivo may involve a similar non-enzymatic decomposition of collagen fibrils via the immunoglobulins themselves that we observe here ex vivo...
  3. pmc Decorin core protein (decoron) shape complements collagen fibril surface structure and mediates its binding
    Joseph P R O Orgel
    BioCAT and microCoSM Centres Pritzker Institute of Biomedical Science and Engineering, Illinois Institute of Technology, Chicago, Illinois, USA
    PLoS ONE 4:e7028. 2009
    ..This work helps us to understand collagen-decorin interactions and the molecular architecture of the fibrillar ECM in health and disease...
  4. pmc In situ D-periodic molecular structure of type II collagen
    Olga Antipova
    Center for Molecular Study of Condensed Soft Matter Centers microCoSM, Pritzker Institute of Biomedical Science and Engineering, Chicago, Illinois 60616, USA
    J Biol Chem 285:7087-96. 2010
    ..Transmission electron microscopy data show the close relationship between lamprey and mammalian collagen fibrils, even though the respective larger scale tissue architecture differs...
  5. ncbi request reprint Flanking polyproline sequences inhibit beta-sheet structure in polyglutamine segments by inducing PPII-like helix structure
    Gregory Darnell
    Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA
    J Mol Biol 374:688-704. 2007
    ..These structural observations may shed light on the threshold phenomenon of poly(Q) aggregation, and support the hypothesized evolution of "protective" poly(P) tracts adjacent to poly(Q) aggregation domains...
  6. pmc Collagen fibril architecture, domain organization, and triple-helical conformation govern its proteolysis
    Shiamalee Perumal
    Center for Synchrotron Radiation Research and Instrumentation, Department of Biological, Chemical, and Physical Sciences, Illinois Institute of Technology, 3101 South Dearborn Street, Chicago, IL 60616, USA
    Proc Natl Acad Sci U S A 105:2824-9. 2008
    ..Collagenase then binds to the substrate's "interaction domain," which facilitates the triple-helix unwinding/dissociation function of the enzyme before collagenolysis...
  7. ncbi request reprint Sequence context and modified hydrophobic moment plots help identify 'horizontal' surface helices in transmembrane protein structure prediction
    Joseph P R O Orgel
    Rosalind Franklin Structural Biology Laboratories, Department of Biochemistry, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, 3333 Green Bay Road, IL 60064, USA
    J Struct Biol 148:51-65. 2004
    ....