V E Schijns

Summary

Affiliation: Organon Laboratories Ltd

Publications

  1. ncbi request reprint Mice lacking IL-12 develop polarized Th1 cells during viral infection
    V E Schijns
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    J Immunol 160:3958-64. 1998
  2. ncbi request reprint Immunoadjuvant activities of E. coli- and plasmid-expressed recombinant chicken IFN-alpha/beta, IFN-gamma and IL-1beta in 1-day- and 3-week-old chickens
    V E Schijns
    Department of Vaccine Technology and Immunology, Intervet Int b v, P O Box 31, 5830 AA, Boxmeer, The Netherlands
    Vaccine 18:2147-54. 2000
  3. ncbi request reprint IFN-gamma receptor-deficient mice generate antiviral Th1-characteristic cytokine profiles but altered antibody responses
    V E Schijns
    Department of Infectious Diseases and Immunology, Veterinary Faculty, Utrecht University, The Netherlands
    J Immunol 153:2029-37. 1994
  4. ncbi request reprint Exacerbated viral hepatitis in IFN-gamma receptor-deficient mice is not suppressed by IL-12
    V E Schijns
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    J Immunol 157:815-21. 1996
  5. ncbi request reprint IL-12 stimulates an antiviral type 1 cytokine response but lacks adjuvant activity in IFN-gamma-receptor-deficient mice
    V E Schijns
    Department of Infectious Diseases and Immunology, Veterinary Faculty, Ultrecht University, The Netherlands
    J Immunol 155:2525-32. 1995
  6. ncbi request reprint Vaccination of pigs against pseudorabies virus with plasmid DNA encoding glycoprotein D
    B L Haagmans
    Department of Infectious Diseases and Immunology, Veterinary Faculty, Utrecht University, Netherlands
    Vaccine 17:1264-71. 1999
  7. ncbi request reprint Molecular cloning of cat interleukin-12
    V E Schijns
    Virology Unit, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    Immunogenetics 45:462-3. 1997
  8. ncbi request reprint Transforming growth factor beta production during rat cytomegalovirus infection
    B L Haagmans
    Department of Infectious Diseases and Immunology, Veterinary Faculty, Utrecht University, The Netherlands
    J Gen Virol 78:205-13. 1997
  9. ncbi request reprint Induction and direction of immune responses by vaccine adjuvants
    V E Schijns
    Department of Vaccine Technology and Immunology, Intervet International BV, Boxmeer, The Netherlands
    Crit Rev Immunol 21:75-85. 2001
  10. ncbi request reprint Molecular cloning and expression of cat interferon-gamma
    V E Schijns
    Virology Division, Department of Infectious Diseases and Immunology, Veterinary Faculty, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    Immunogenetics 42:440-1. 1995

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Mice lacking IL-12 develop polarized Th1 cells during viral infection
    V E Schijns
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    J Immunol 160:3958-64. 1998
    ..Our data suggest that viruses may selectively induce IFN-gamma production and Th1-type immune reactions even in the absence of IL-12...
  2. ncbi request reprint Immunoadjuvant activities of E. coli- and plasmid-expressed recombinant chicken IFN-alpha/beta, IFN-gamma and IL-1beta in 1-day- and 3-week-old chickens
    V E Schijns
    Department of Vaccine Technology and Immunology, Intervet Int b v, P O Box 31, 5830 AA, Boxmeer, The Netherlands
    Vaccine 18:2147-54. 2000
    ..Plasmids encoding chicken IL-beta or IFN-gamma had a minimal or inhibitory effect, respectively. These data indicate a potential for chicken cytokines as immunoadjuvant for particular types of chicken vaccine antigens...
  3. ncbi request reprint IFN-gamma receptor-deficient mice generate antiviral Th1-characteristic cytokine profiles but altered antibody responses
    V E Schijns
    Department of Infectious Diseases and Immunology, Veterinary Faculty, Utrecht University, The Netherlands
    J Immunol 153:2029-37. 1994
    ..However, it profoundly impairs the generation of protective antiviral Ab...
  4. ncbi request reprint Exacerbated viral hepatitis in IFN-gamma receptor-deficient mice is not suppressed by IL-12
    V E Schijns
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    J Immunol 157:815-21. 1996
    ..Furthermore, they emphasize the pivotal antiviral role of IFN-gamma in protection against acute coronavirus-induced hepatitis...
  5. ncbi request reprint IL-12 stimulates an antiviral type 1 cytokine response but lacks adjuvant activity in IFN-gamma-receptor-deficient mice
    V E Schijns
    Department of Infectious Diseases and Immunology, Veterinary Faculty, Ultrecht University, The Netherlands
    J Immunol 155:2525-32. 1995
    ..In wild-type mice administration of recombinant IFN-gamma but not IL-2 mimicked the immune-stimulating activity of IL-12; it is therefore likely that the IL-12 adjuvant activity is largely mediated by physiologic IFN-gamma...
  6. ncbi request reprint Vaccination of pigs against pseudorabies virus with plasmid DNA encoding glycoprotein D
    B L Haagmans
    Department of Infectious Diseases and Immunology, Veterinary Faculty, Utrecht University, Netherlands
    Vaccine 17:1264-71. 1999
    ..Thus, in the target animal, DNA vaccination with PRV-gD DNA induces protective immunity against challenge infection...
  7. ncbi request reprint Molecular cloning of cat interleukin-12
    V E Schijns
    Virology Unit, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    Immunogenetics 45:462-3. 1997
  8. ncbi request reprint Transforming growth factor beta production during rat cytomegalovirus infection
    B L Haagmans
    Department of Infectious Diseases and Immunology, Veterinary Faculty, Utrecht University, The Netherlands
    J Gen Virol 78:205-13. 1997
    ..The virus directly induced this cytokine since TGF-beta was produced upon RCMV infection in vitro. The induction of TGF-beta production may contribute to immunosuppression during CMV infection...
  9. ncbi request reprint Induction and direction of immune responses by vaccine adjuvants
    V E Schijns
    Department of Vaccine Technology and Immunology, Intervet International BV, Boxmeer, The Netherlands
    Crit Rev Immunol 21:75-85. 2001
    ..The nature of adjuvant-induced immune responses is discussed in relation to each concept...
  10. ncbi request reprint Molecular cloning and expression of cat interferon-gamma
    V E Schijns
    Virology Division, Department of Infectious Diseases and Immunology, Veterinary Faculty, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    Immunogenetics 42:440-1. 1995
  11. pmc Role of the individual interferon systems and specific immunity in mice in controlling systemic dissemination of attenuated pseudorabies virus infection
    P Grob
    Institute of Virology, University of Zurich, CH 8057 Zurich, Switzerland
    J Virol 73:4748-54. 1999
    ..We present evidence that mice with an intact gamma IFN system but without mature B and T cells were able to prevent systemic dissemination of gE-TK-PRV...
  12. ncbi request reprint Production of biologically active equine interleukin 12 through expression of p35, p40 and single chain IL-12 in mammalian and baculovirus expression systems
    E L McMonagle
    University of Glasgow Veterinary School, UK
    Equine Vet J 33:693-8. 2001
    ..Production of a bioactive species-specific IL-12 is a first step towards an investigation of its potential application in equine species...