Research Topics
| H H BerendsenSummaryAffiliation: Organon Laboratories Ltd Publications
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Detail Information
Publications
Mirtazapine enhances the effect of haloperidol on apomorphine-induced climbing behaviour in mice and attenuates haloperidol-induced catalepsy in ratsH H Berendsen
Department of Neuropharmacology, N V Organon, Oss, The Netherlands
Psychopharmacology (Berl) 135:284-9. 1998..The results obtained in these experiments suggest that co-treatment with mirtazapine may enhance the antipsychotic effect of haloperidol and reduce its extrapyramidal side effects, thereby widening its therapeutic window...
Antagonism of the 5-HT1A receptor stimulus in a conditioned taste aversion procedureH H Berendsen
Department of Neuropharmacology, N V Organon, Oss, Netherlands
Eur Neuropsychopharmacol 9:345-9. 1999..The results also indicate that the conditioned taste aversion paradigm can be used to test for antagonism of stimulus properties of compounds...
The role of serotonin in hot flushesH H Berendsen
Pharmacology Department, N V Organon, POB 20, 5340 BH, Oss, Netherlands
Maturitas 36:155-64. 2000..Especially the 5-HT(2A) receptor subtype may play a key role in the occurrence of hot flushes. A number of arguments that support this hypothesis are discussed...
Effect of tibolone and raloxifene on the tail temperature of oestrogen-deficient ratsH H Berendsen
Pharmacology Department, NV Organon, P O Box 20, 5340 BH, Oss, Netherlands
Eur J Pharmacol 419:47-54. 2001..This method of measuring tail temperature free of stress in ovariectomised rats may serve as a useful procedure for selecting compounds that are of potential use in the treatment of hot flushes...
Indirect in vivo 5-HT1A-agonistic effects of the new antidepressant mirtazapineH H Berendsen
Department of Neuropharmacology, N V Organon, Oss, The Netherlands
Psychopharmacology (Berl) 133:275-82. 1997..1-1.0 mg/kg). On the basis of these results, it can be concluded that mirtazapine has indirect 5-HT1A receptor agonistic properties which may play an important role in the therapeutic effect of this compound...
Effect of metergoline, fenfluramine, and 8-OHDPAT on catalepsy induced by haloperidol or morphineC L Broekkamp
Department CNS Pharmacology, Organon International B V, Oss, The Netherlands
Naunyn Schmiedebergs Arch Pharmacol 338:191-5. 1988..The antagonistic effect of 8-OHDPAT suggests a secondary, modulating role for 5-HT1A receptor mediated events in both types of catalepsy...
A peripheral 5-HT1D-like receptor involved in serotonergic induced hindlimb scratching in ratsH H Berendsen
Department of CNS Pharmacology, Organon International B V, Oss, The Netherlands
Eur J Pharmacol 194:201-8. 1991..Hindlimb scratching was not induced by i.c.v. injection of 5-MeOT.(ABSTRACT TRUNCATED AT 250 WORDS)..
