Natural history of HIV-associated pulmonary arterial hypertension: trends in the HAART eraMilos Opravil
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland
AIDS 22:S35-40. 2008
..Given recent improvements in the treatment of PAH, the early recognition of these individuals is essential...
- Prior therapy influences the efficacy of lamivudine monotherapy in patients with lamivudine-resistant HIV-1 infection
Milos Opravil
Division of Infectious Diseases, University Hospital of Zurich, Zurich, Switzerland
J Acquir Immune Defic Syndr 54:51-8. 2010
..This prospective study aimed to characterize the virologic and immunologic changes during monotherapy with lamivudine (3TC) in patients with limited options for a fully suppressive new therapy...
- CD4+ T cell count recovery in HIV type 1-infected patients is independent of class of antiretroviral therapy
Nina Khanna
Division of Infectious Diseases and Hospital Epidemiology, University Hospital, Basel, Switzerland
Clin Infect Dis 47:1093-101. 2008
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Impact of previous virological treatment failures and adherence on the outcome of antiretroviral therapy in 2007Marie Ballif
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
PLoS ONE 4:e8275. 2009
..Combination antiretroviral treatment (cART) has been very successful, especially among selected patients in clinical trials. The aim of this study was to describe outcomes of cART on the population level in a large national cohort...
Characteristics, determinants, and clinical relevance of CD4 T cell recovery to <500 cells/microL in HIV type 1-infected individuals receiving potent antiretroviral therapyGilbert R Kaufmann
Division of Infectious Diseases and Hospital Epidemiology, Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
Clin Infect Dis 41:361-72. 2005
..We studied the determinants and the clinical relevance of incomplete CD4 T cell restoration...
- Treatment initiation with zidovudine-containing potent antiretroviral therapy impairs CD4 cell count recovery but not clinical efficacy
Angela C Huttner
University Hospital of Zurich, Zurich, Switzerland
AIDS 21:939-46. 2007
..We examined the predictive factors for this phenomenon and assessed its impact on clinical progression during treatment in a large patient cohort...
- Tenofovir use is associated with a reduction in calculated glomerular filtration rates in the Swiss HIV Cohort Study
Christoph A Fux
Division of Infectious Diseases, University Hospital Berne, Berne, Switzerland
Antivir Ther 12:1165-73. 2007
..A growing number of case reports have described tenofovir (TDF)-related proximal renal tubulopathy and impaired calculated glomerular filtration rates (cGFR). We assessed TDF-associated changes in cGFR in a large observational HIV cohort...
- Tenofovir use is associated with an increase in serum alkaline phosphatase in the Swiss HIV Cohort Study
Christoph A Fux
Division of Infectious Diseases, University Hospital Berne and University of Berne, Berne, Switzerland
Antivir Ther 13:1077-82. 2008
..A few small studies have reported a positive correlation between renal phosphate losses, increased bone turnover and sAP...
- Effect of baseline CD4 cell count on the efficacy and safety of peginterferon Alfa-2a (40KD) plus ribavirin in patients with HIV/hepatitis C virus coinfection
Milos Opravil
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland
J Acquir Immune Defic Syndr 47:36-49. 2008
..The impact of baseline CD4 status on hepatitis C virus (HCV) treatment response among patients with HIV/HCV coinfection was investigated using data from a randomized study of peginterferon alfa-2a (40KD) + ribavirin (Peg-IFN/RBV)...
- CD4 T-lymphocyte recovery in individuals with advanced HIV-1 infection receiving potent antiretroviral therapy for 4 years: the Swiss HIV Cohort Study
Gilbert R Kaufmann
Basel Center for HIV Research, Division of Infectious Diseases, University Hospital, Basel, Switzerland
Arch Intern Med 163:2187-95. 2003
..Treatment interruptions, a poor virologic response, and older age were the major factors negatively affecting the recovery of CD4 T lymphocytes...
- Attenuated and nonproductive viral transcription in the lymphatic tissue of HIV-1-infected patients receiving potent antiretroviral therapy
Marek Fischer
Division of Infectious Diseases and Hospital Epidemiology, Department of Medicine, University Hospital Zurich, Zurich, Switzerland
J Infect Dis 189:273-85. 2004
..Thus, residual lymphoid HIV-1 RNA in patients receiving HAART indicates attenuated viral transcription in HIV-1-infected cells that lack virion production...
- Long-term safety of discontinuation of secondary prophylaxis against Pneumocystis pneumonia: prospective multicentre study
Claudine Zellweger
Division of Infectious Diseases, University Hospital of Berne, Berne, Switzerland
AIDS 18:2047-53. 2004
..3 cases per 100 patient-years. CONCLUSIONS: Discontinuation of secondary prophylaxis against P. jirovecii pneumonia is safe even in the long term in patients who have a sustained immunologic response on antiretroviral combination therapy...
- Optimized virus disruption improves detection of HIV-1 p24 in particles and uncovers a p24 reactivity in patients with undetectable HIV-1 RNA under long-term HAART
Jorg Schupbach
Swiss National Center for Retroviruses, University of Zurich, Zurich, Switzerland
J Med Virol 78:1003-10. 2006
..It also uncovers the presence of a p24 reactivity, whose identity remains to be determined, in a significant fraction of samples with undetectable HIV-1 RNA under long-term HAART...
- Equal amounts of intracellular and virion-enclosed hepatitis C virus RNA are associated with peripheral-blood mononuclear cells in vivo
Philipp Kaiser
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, 8032 Zurich, Switzerland
J Infect Dis 194:1713-23. 2006
..There was no evidence for persistent HCV infection in PBMCs after clearance of viremia in plasma...
- Clinical efficacy of early initiation of HAART in patients with asymptomatic HIV infection and CD4 cell count > 350 x 10(6) /l
Milos Opravil
Division of Infectious Diseases, University Hospitals of Zurich, Switzerland
AIDS 16:1371-81. 2002
..However, the risk of severe clinical events with deferred therapy was low and must be counter balanced against the burden and toxicity of HAART...
- Impact of genotypic resistance testing on selection of salvage regimen in clinical practice
Stefan Haupts
Divisione of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland
Antivir Ther 8:443-54. 2003
..CONCLUSIONS: This study suggests that treatment choices including genotype and decision support software were virologically superior to those based on drug history only...
- Implementation of raltegravir in routine clinical practice: selection criteria for choosing this drug, virologic response rates, and characteristics of failures
Alexandra U Scherrer
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
J Acquir Immune Defic Syndr 53:464-71. 2010
..Raltegravir (RAL) achieved remarkable virologic suppression rates in randomized-clinical trials, but today efficacy data and factors for treatment failures in a routine clinical care setting are limited...
- Eligibility for and outcome of hepatitis C treatment of HIV-coinfected individuals in clinical practice: the Swiss HIV cohort study
Annelies S Zinkernagel
Division of Infectious Diseases and Hospital Epidemiology, Department of Internal Medicine, University Hospital, Zurich, Switzerland
Antivir Ther 11:131-42. 2006
..CONCLUSIONS: Despite clinical and psychosocial obstacles encountered in clinical practice, HCV treatment in HIV-coinfected individuals is feasible with results similar to those obtained in RCTs...
- Higher CNS penetration-effectiveness of long-term combination antiretroviral therapy is associated with better HIV-1 viral suppression in cerebrospinal fluid
Alexia Cusini
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
J Acquir Immune Defic Syndr 62:28-35. 2013
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- Effect of individual cognitive behaviour intervention on adherence to antiretroviral therapy: prospective randomized trial
Rainer Weber
Division of Infectious Diseases and Hospital Epidemiology, University Hospital, Zurich, Switzerland
Antivir Ther 9:85-95. 2004
..A high level of adherence to antiretroviral therapy is required for complete suppression of HIV replication, immunological and clinical effectiveness. We investigated whether cognitive behaviour therapy can improve medication adherence...
- HIV-specific cellular immune response is inversely correlated with disease progression as defined by decline of CD4+ T cells in relation to HIV RNA load
Annette Oxenius
Institute for Microbiology, Eidgenossische Technische Hochschule Zurich, Zurich, Switzerland
J Infect Dis 189:1199-208. 2004
..Slower progression was not related to polymorphisms in CCR genes, HLA genotype, or GB virus C coinfection. These data suggest that HIV-specific T cell responses are involved in protecting the host from disease progression...
- HIV-1 p24 antigen is a significant inverse correlate of CD4 T-cell change in patients with suppressed viremia under long-term antiretroviral therapy
Jorg Schupbach
Swiss National Center for Retroviruses, University of Zurich, Zurich, Switzerland
J Acquir Immune Defic Syndr 33:292-9. 2003
..Comparison of p24 antigen and HIV-1 RNA concentrations indicate that the p24 antigen detected in these samples is not associated with viral RNA-containing particles and may originate from other compartments of virus expression...
- Residual cell-associated unspliced HIV-1 RNA in peripheral blood of patients on potent antiretroviral therapy represents intracellular transcripts
Marek Fischer
Department of Medicine, University Hospital Zurich, Switzerland
Antivir Ther 7:91-103. 2002
..As shown by limiting dilution analysis, HIV-1 infected cells with such a repressed viral transcription pattern were observed at high frequencies in PBMC from untreated patients...
- Pulmonary arterial hypertension related to HIV infection: improved hemodynamics and survival associated with antiretroviral therapy
Jean-Philippe Zuber
University and Cantonal Hospitals of Zurich, Zurich, Switzerland
Clin Infect Dis 38:1178-85. 2004
..7 years. HAART significantly decreased mortality due to PAHRH as well as other causes. This study suggests a beneficial effect of combination ART in patients with PAHRH...
- A randomized trial of simplified maintenance therapy with abacavir, lamivudine, and zidovudine in human immunodeficiency virus infection
Milos Opravil
Division of Infectious Diseases, University Hospital, CH 8091 Zurich, Switzerland
J Infect Dis 185:1251-60. 2002
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- Acute interstitial nephritis of HIV-positive patients under atazanavir and tenofovir therapy in a retrospective analysis of kidney biopsies
Simone Schmid
Department of Pathology, Institute of Surgical Pathology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
Virchows Arch 450:665-70. 2007
..We conclude that acute interstitial nephritis and consecutive acute renal failure is a relevant side effect of atazanavir and tenofovir therapy in HIV-positive patients...
- Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study
Jacques Fellay
Division of Infectious Diseases, University Hospital of Lausanne, Lausanne, Switzerland
Lancet 359:30-6. 2002
..This variability could have a genetic basis. We did a pharmacogenetics study to analyse the association between response to antiretroviral treatment and allelic variants of several genes...
