Efficacy and safety of microwave ablation for primary and secondary liver malignancies: a systematic reviewSeok Ling Ong
Department of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester NHS Trust, Leicester, UK
Eur J Gastroenterol Hepatol 21:599-605. 2009
..Future advances in the applicator design and treatment monitoring may further improve its efficacy and widen the indications...
- The porcine hepatic arterial supply, its variations and their influence on the extracorporeal perfusion of the liver
Gianpiero Gravante
Department of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester, Leicester, United Kingdom
J Surg Res 168:56-61. 2011
..Variations in the porcine hepatic vasculature may contribute to the outcome of experiments based on liver perfusion models. We studied the hepatic artery (HA), variations of its branches, and the correlation with the resultant perfusion...
- Bile changes after liver surgery: experimental and clinical lessons for future applications
Gianpiero Gravante
Department of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester, Leicester, UK
Dig Surg 27:450-60. 2010
..The aim of this review is to summarize the available evidence for changes in bile composition following liver surgery and assess their use in predicting post-operative complications...
- Use of the recanalised umbilical vein for islet autotransplantation following total pancreatectomy
Cristina Pollard
Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, UK
Pancreatology 11:233-9. 2011
..We originally infused islets into the liver via the middle or right colic veins, but since 2005 we have used the recanalised umbilical vein. Here, we describe the technique, the advantages and the early results achieved...
Surrogate markers of resectability in patients undergoing exploration of potentially resectable pancreatic adenocarcinomaS L Ong
Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Gwendolen Road, Leicester LE4 5PW, UK
J Gastrointest Surg 12:1068-73. 2008
..Preoperative serology including platelet count, NLR, CA19.9, and CA19.9-bilirubin ratio may be used as additional discriminators of resectability particularly for high-risk patients...
- Elevation of carbohydrate antigen 19.9 in benign hepatobiliary conditions and its correlation with serum bilirubin concentration
S L Ong
Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Gwendolen Road, Leicester, LE4 5PW, UK
Dig Dis Sci 53:3213-7. 2008
..9 and serum bilirubin concentration in patients with benign conditions and to determine the frequency of a false-positive increase in CA19.9 in patients being investigated for potential HPB malignancies...
- A fuller understanding of pancreatic neuroendocrine tumours combined with aggressive management improves outcome
S L Ong
Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, UK
Pancreatology 9:583-600. 2009
..The terms 'islet cell tumours' and 'carcinoids' of the pancreas should be avoided. The aim of this review is to offer an overview of the history and diagnosis of PNETs followed by a discussion of the available treatment options...
- Ultrasound changes within the liver after total pancreatectomy and intrahepatic islet cell autotransplantation
Seok L Ong
Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, United Kingdom
Transplantation 85:1773-7. 2008
..Awareness of the potential changes in the appearance of the liver on ultrasonography (USS), together with an assessment of liver function, is important in the postoperative surveillance of these patients...
- IgG4-positive sclerosing cholangitis following autoimmune pancreatitis with deranged CA19.9
Seok L Ong
University Hospitals of Leicester, Leicester, United Kingdom
Int J Surg Pathol 19:84-7. 2011
..9, raised the concern of malignancy. The uncertainty of the diagnosis was resolved when AIP-SC was confirmed on liver biopsy, with a concomitantly elevated serum IgG(4) level. The disease went into remission with steroid treatment...
- The autologous normothermic ex vivo perfused porcine liver-kidney model: improving the circuit's biochemical and acid-base environment
Wen Yuan Chung
Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, University of Leicester, Gwendolen Rd, Leicester LE5 4PW, UK
Am J Surg 204:518-26. 2012
..We have assessed the influence of the addition of a porcine kidney to the circuit...
- Addition of a kidney to the normothermic ex vivo perfused porcine liver model does not increase cytokine response
Wen Yuan Chung
Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, University of Leicester, Gwendolen Road, Leicester LE5 4PW, UK
J Artif Organs 15:290-4. 2012
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- Changes in acid-base balance during electrolytic ablation in an ex vivo perfused liver model
Gianpiero Gravante
Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester LE5 4PW, UK
Am J Surg 204:666-70. 2012
..An ex vivo perfused liver model was used to assess the systemic effects of EA on the acid-base balance without the influence of compensatory organs (lungs and kidneys)...
- Cytokine response of electrolytic ablation in an ex vivo perfused liver model
Gianpiero Gravante
Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, UK
ANZ J Surg 80:537-41. 2010
..Study of an ex vivo liver model could allow for the evaluation of this response without the influence of confounding systemic factors...
- Patterns of histological changes following hepatic electrolytic ablation in an ex-vivo perfused model
Gianpiero Gravante
Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, UK
Pathol Oncol Res 18:1085-9. 2012
..Further studies should obtain more information about the influence of adjacent biliary and vascular structures so that appropriate clinical trials can be designed...
- Inaccuracy of fine-needle biopsy in the diagnosis of solitary fibrous tumour of the liver
Jane Jingyao Chen
Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, UK
Asian J Surg 31:195-8. 2008
..We report a case of SFT of the liver and highlight the potential inaccuracy of percutaneous biopsy in the diagnosis of large solitary liver tumours...
- Effects of hypoxia due to isovolemic hemodilution on an ex vivo normothermic perfused liver model
Gianpiero Gravante
Department of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester, Leicester, United Kingdom
J Surg Res 160:73-80. 2010
..Theoretically an ex vivo perfused model of the liver should, by dissociating the organ from the extrinsic regulatory mechanisms, allow a better and unequivocal analysis of changes obtained...
- Predictors of severity and survival in acute pancreatitis: validation of the efficacy of early warning scores
Giuseppe Garcea
Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, United Kingdom
Pancreas 37:e54-61. 2008
..This study examined EWS from a larger group of patients to confirm if this predictive value held true...
History, ethics, advantages and limitations of experimental models for hepatic ablationSeok Ling Ong
Seok Ling Ong, Gianpiero Gravante, Matthew S Metcalfe, Ashley R Dennison, Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester LE5 4PW, United Kingdom
World J Gastroenterol 19:147-54. 2013
..Isolated perfused ex vivo liver models have been used to study drug toxicity, liver failure, organ transplantation and hepatic ablation and combine advantages of both previous models...
- Immunoregulatory effects of liver ablation therapies for the treatment of primary and metastatic liver malignancies
Gianpiero Gravante
Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, University Hospitals of Leicester, Leicester, UK
Liver Int 29:18-24. 2009
..Immunomodulatory approaches have the potential to augment the initial immune stimulation and this combined approach could pave the way to a more selective and specific method of treating liver tumours...
- Caveat reporting in ultrasound interpretation of surgical pathology: a comparison of sonographer versus radiologist
Giuseppe Garcea
Cancer Studies and Molecular Medicine, Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
J Eval Clin Pract 16:97-9. 2010
..This study compared ultrasound (USS) reports generated by radiologists and sonographers to determine if any significant or clinically relevant differences existed...
- Cystic lesions of the pancreas. A diagnostic and management dilemma
G Garcea
Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, UK
Pancreatology 8:236-51. 2008
..The exact diagnostic and management pathway of these cysts remains problematic and this review attempts to provide an overview of the pathology underlying pancreatic cystic lesions and suggests appropriate methods of management...
- Evaluation of the prognostic value of systemic inflammation and socioeconomic deprivation in patients with resectable colorectal liver metastases
C P Neal
Cancer Biomarkers and Prevention Group, Biocentre, Department of Biochemistry and Oncology, University of Leicester, Leicester, United Kingdom
Eur J Cancer 45:56-64. 2009
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- Prediction of mortality in acute pancreatitis: a systematic review of the published evidence
G Gravante
Department of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester, Leicester, UK
Pancreatology 9:601-14. 2009
..With the exception of the APACHE II, the other scores and indexes do not have a high degree of sensitivity, specificity and predictive values...
- Progression of early warning scores (EWS) in patients with acute pancreatitis: a re-evaluation of a retrospective cohort of patients
G Garcea
Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
Postgrad Med J 84:271-5. 2008
..Early warning scores (EWS) is a physiological scoring system measured hourly. This study determined how progression of EWS affected outcome in acute pancreatitis...
- Tumour characteristics predictive of survival following resection for ductal adenocarcinoma of the head of pancreas
G Garcea
Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Gwendolen Road, Leicester, UK
Eur J Surg Oncol 33:892-7. 2007
..This study investigated our survival rates following pancreatic resection and examined clinicopathological predictors of survival...
