Olufunmilayo I Olopade

Summary

Publications

  1. ncbi request reprint Breast cancer genetics in African Americans
    Olufunmilayo I Olopade
    Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois 60637, USA
    Cancer 97:236-45. 2003
  2. doi request reprint High prevalence of BRCA1 and BRCA2 mutations in unselected Nigerian breast cancer patients
    James D Fackenthal
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Int J Cancer 131:1114-23. 2012
  3. pmc MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11
    Jessica Bockhorn
    The Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA
    Nat Commun 4:1393. 2013
  4. pmc Power spectral analysis of mammographic parenchymal patterns for breast cancer risk assessment
    Hui Li
    Department of Radiology, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    J Digit Imaging 21:145-52. 2008
  5. ncbi request reprint Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 and breast cancer risk in Africans
    Dezheng Huo
    Department of Health Studies, University of Chicago, Chicago, IL, USA
    Breast Cancer Res Treat 110:367-76. 2008
  6. pmc c-Myc activates BRCA1 gene expression through distal promoter elements in breast cancer cells
    Yinghua Chen
    Center for Clinical Cancer Genetics and Global Health, Department of Medicine, University of Chicago, Chicago, IL, USA
    BMC Cancer 11:246. 2011
  7. pmc Lack of association between common single nucleotide polymorphisms in the TERT-CLPTM1L locus and breast cancer in women of African ancestry
    Yonglan Zheng
    Department of Medicine, The University of Chicago, 900 E 57th Street, KCBD Building 8113D, Chicago, IL 60637, USA
    Breast Cancer Res Treat 132:341-5. 2012
  8. doi request reprint Recurrent BRCA1 and BRCA2 mutations in breast cancer patients of African ancestry
    Jing Zhang
    Center for Clinical Cancer Genetics and Global Health, Department of Medicine, The University of Chicago, Chicago, IL, USA
    Breast Cancer Res Treat 134:889-94. 2012
  9. pmc Microsatellites in the estrogen receptor (ESR1, ESR2) and androgen receptor (AR) genes and breast cancer risk in African American and Nigerian women
    Yonglan Zheng
    Center for Clinical Cancer Genetics and Global Health, Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 7:e40494. 2012
  10. doi request reprint A signature of balancing selection in the region upstream to the human UGT2B4 gene and implications for breast cancer risk
    Chang Sun
    Department of Human Genetics, University of Chicago, 920 E 58th Street, Chicago, IL 60637, USA
    Hum Genet 130:767-75. 2011

Collaborators

Detail Information

Publications113 found, 100 shown here

  1. ncbi request reprint Breast cancer genetics in African Americans
    Olufunmilayo I Olopade
    Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois 60637, USA
    Cancer 97:236-45. 2003
    ..An overview of the state of genetic testing for BRCA1 and BRCA2 genes was presented at the Summit Meeting on Breast Cancer Among African American women...
  2. doi request reprint High prevalence of BRCA1 and BRCA2 mutations in unselected Nigerian breast cancer patients
    James D Fackenthal
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Int J Cancer 131:1114-23. 2012
    ....
  3. pmc MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11
    Jessica Bockhorn
    The Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA
    Nat Commun 4:1393. 2013
    ..Identification of a novel microRNA-mediated pathway that regulates chemoresistance in breast cancer will facilitate the development of novel therapeutic strategies...
  4. pmc Power spectral analysis of mammographic parenchymal patterns for breast cancer risk assessment
    Hui Li
    Department of Radiology, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    J Digit Imaging 21:145-52. 2008
    ..The purpose of the study was to evaluate the usefulness of power law spectral analysis on mammographic parenchymal patterns in breast cancer risk assessment...
  5. ncbi request reprint Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 and breast cancer risk in Africans
    Dezheng Huo
    Department of Health Studies, University of Chicago, Chicago, IL, USA
    Breast Cancer Res Treat 110:367-76. 2008
    ....
  6. pmc c-Myc activates BRCA1 gene expression through distal promoter elements in breast cancer cells
    Yinghua Chen
    Center for Clinical Cancer Genetics and Global Health, Department of Medicine, University of Chicago, Chicago, IL, USA
    BMC Cancer 11:246. 2011
    ..In this report, we used cultured breast cancer cells to examine the mechanisms of transcriptional activation of BRCA1 by c-Myc...
  7. pmc Lack of association between common single nucleotide polymorphisms in the TERT-CLPTM1L locus and breast cancer in women of African ancestry
    Yonglan Zheng
    Department of Medicine, The University of Chicago, 900 E 57th Street, KCBD Building 8113D, Chicago, IL 60637, USA
    Breast Cancer Res Treat 132:341-5. 2012
    ....
  8. doi request reprint Recurrent BRCA1 and BRCA2 mutations in breast cancer patients of African ancestry
    Jing Zhang
    Center for Clinical Cancer Genetics and Global Health, Department of Medicine, The University of Chicago, Chicago, IL, USA
    Breast Cancer Res Treat 134:889-94. 2012
    ....
  9. pmc Microsatellites in the estrogen receptor (ESR1, ESR2) and androgen receptor (AR) genes and breast cancer risk in African American and Nigerian women
    Yonglan Zheng
    Center for Clinical Cancer Genetics and Global Health, Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 7:e40494. 2012
    ....
  10. doi request reprint A signature of balancing selection in the region upstream to the human UGT2B4 gene and implications for breast cancer risk
    Chang Sun
    Department of Human Genetics, University of Chicago, 920 E 58th Street, Chicago, IL 60637, USA
    Hum Genet 130:767-75. 2011
    ..81-1.28; homozygous OR 1.50, 95% CI 1.15-1.95]. Our results provide new insights into UGT2B4 sequence variation and indicate that a signal of natural selection may lead to the identification of disease susceptibility variants...
  11. doi request reprint Evidence for an ancient BRCA1 mutation in breast cancer patients of Yoruban ancestry
    Bifeng Zhang
    Department of Medicine, Center for Clinical Cancer Genetics, University of Chicago, MC 2115, 5830 S Ellis Ave, Chicago, IL 60637, USA
    Fam Cancer 8:15-22. 2009
    ..Still, identifying such mutations could be important for designing genetic testing strategies for high-risk breast/ovarian cancer families in non-founder populations...
  12. doi request reprint CpG island methylation affects accessibility of the proximal BRCA1 promoter to transcription factors
    Jinhua Xu
    Department of Medicine, Center for Clinical Cancer Genetics, University of Chicago, Chicago, IL, 60637 1463, USA
    Breast Cancer Res Treat 120:593-601. 2010
    ..This indicates that reduced accessibility of transcription factors to the methylated promoter is one of the mechanisms for down-regulation of BRCA1 in heavily methylated cancer cells...
  13. pmc Fine mapping of breast cancer genome-wide association studies loci in women of African ancestry identifies novel susceptibility markers
    Yonglan Zheng
    Department of Medicine, Center for Clinical Cancer Genetics and Global Health, The University of Chicago, Chicago, IL 60637, USA
    Carcinogenesis 34:1520-8. 2013
    ..Future studies and new GWAS in women of African ancestry hold promise to discover additional variants for breast cancer susceptibility with clinical implications throughout the African diaspora. ..
  14. doi request reprint Searching for large genomic rearrangements of the BRCA1 gene in a Nigerian population
    Jing Zhang
    Section of Hematology Oncology, Department of Medicine, The University of Chicago, 900 E 57th Street, KCBD Room 8240, Chicago, IL 60637, USA
    Breast Cancer Res Treat 124:573-7. 2010
    ..These data suggest that while BRCA1 genomic rearrangement exists, they do not contribute significantly to BRCA1-associated risk in the Nigerian population...
  15. ncbi request reprint Estrogen receptor alpha, BRCA1, and FANCF promoter methylation occur in distinct subsets of sporadic breast cancers
    Minjie Wei
    Section of Hematology Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637 1463, USA
    Breast Cancer Res Treat 111:113-20. 2008
    ..These data suggest that unlike FANCF, both ER and BRCA1 are specifically targeted for methylation in sporadic breast cancers, a phenomenon that should be explored for development of novel diagnostic and therapeutic approaches...
  16. pmc Evaluation of 19 susceptibility loci of breast cancer in women of African ancestry
    Dezheng Huo
    Department of Health Studies, University of Chicago, 5841 South Maryland Avenue, MC 2007, Chicago, IL 60637, USA
    Carcinogenesis 33:835-40. 2012
    ..Further fine-mapping studies in women of African ancestry will be needed to reveal additional and causal variants for breast cancer...
  17. pmc Genetic susceptibility to type 2 diabetes and breast cancer risk in women of European and African ancestry
    Ningqi Hou
    Department of Health Studies, University of Chicago, Chicago, Illinois 60637, USA
    Cancer Epidemiol Biomarkers Prev 21:552-6. 2012
    ..Epidemiologic studies have reported a positive association between type 2 diabetes (T2D) and breast cancer risk, independent of body weight...
  18. pmc Uptake and timing of bilateral prophylactic salpingo-oophorectomy among BRCA1 and BRCA2 mutation carriers
    Angela R Bradbury
    University of Chicago Center for Clinical Cancer Genetics, University of Chicago, Chicago, Illinois, USA
    Genet Med 10:161-6. 2008
    ..To evaluate prophylactic salpingo-oophorectomy uptake and timing among BRCA1/2 mutation carriers in a cancer risk assessment program...
  19. ncbi request reprint Computerized analysis of mammographic parenchymal patterns for assessing breast cancer risk: effect of ROI size and location
    Hui Li
    Department of Radiology, The University of Chicago, Chicago, Illinois 60637, USA
    Med Phys 31:549-55. 2004
    ..However, we failed to show a statistically significant decrease in the performance of the computerized texture features with decreasing ROI size for the range studied...
  20. pmc Fourier component imaging of water resonance in the human breast provides markers for malignancy
    Milica Medved
    Department of Radiology, University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Phys Med Biol 54:5767-79. 2009
    ..83. In the human breast, an inhomogeneously broadened water resonance can serve as a correlate marker for malignancy and is likely to reflect the underlying anatomy or physiology...
  21. ncbi request reprint Fractal analysis of mammographic parenchymal patterns in breast cancer risk assessment
    Hui Li
    Department of Radiology, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Acad Radiol 14:513-21. 2007
    ..To evaluate fractal-based computerized image analyses of mammographic parenchymal patterns in the task of differentiating between women at high risk and women at low risk for developing breast cancer...
  22. ncbi request reprint BRCA1 promoter methylation in sporadic breast cancer is associated with reduced BRCA1 copy number and chromosome 17 aneusomy
    Minjie Wei
    Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago, Chicago, Illinois 60637 1463, USA
    Cancer Res 65:10692-9. 2005
    ..Our data support a model of carcinogenesis in which BRCA1 promoter methylation may serve as a "first hit," much like an inherited germ line mutation, and promote tumor progression down a restricted set of molecular pathways...
  23. doi request reprint Classification of breast lesions pre-contrast injection using water resonance lineshape analysis
    Abbie M Wood
    Department of Radiology, University of Chicago, Chicago, IL, USA
    NMR Biomed 26:569-77. 2013
    ..In addition, this approach may provide an alternative to DCE MRI in women who are at risk for adverse reactions to contrast media...
  24. pmc Novel germline PALB2 truncating mutations in African American breast cancer patients
    Yonglan Zheng
    Center for Clinical Cancer Genetics and Global Health, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Cancer 118:1362-70. 2012
    ..Truncating mutations in the PALB2 gene reportedly are enriched in patients with Fanconi anemia and breast cancer in various populations...
  25. pmc Molecular analysis of colorectal tumors within a diverse patient cohort at a single institution
    BROOKE E SYLVESTER
    Center for Clinical Cancer Genetics and Global Health, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Clin Cancer Res 18:350-9. 2012
    ....
  26. pmc Non-contrast enhanced MRI for evaluation of breast lesions: comparison of non-contrast enhanced high spectral and spatial resolution (HiSS) images versus contrast enhanced fat-suppressed images
    Milica Medved
    Department of Radiology, MC2026, 5841 S Maryland Avenue, University of Chicago, Chicago, IL 60637, USA
    Acad Radiol 18:1467-74. 2011
    ....
  27. ncbi request reprint Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations
    James D Fackenthal
    Department of Medicine and Center for Clinical Cancer Genetics, University of Chicago, Box MC2115, 5841 S Maryland Avenue, Chicago, Illinois 60615, USA
    Nat Rev Cancer 7:937-48. 2007
    ..Although estimates of both mutation prevalence and mutation penetrance rates are inconsistent and occasionally controversial, understanding them is crucial for providing accurate risk information to each patient...
  28. pmc Population differences in breast cancer: survey in indigenous African women reveals over-representation of triple-negative breast cancer
    Dezheng Huo
    Center for Clinical Cancer Genetics and Global Health, Department of Medicine, Section of Hematology Oncology, University of Chicago, 5841 S Maryland Ave, MC 2115, Chicago, IL 60637, USA
    J Clin Oncol 27:4515-21. 2009
    ..In the first study of its kind, we determined the distribution of molecular subtypes of invasive breast tumors in indigenous black women in West Africa...
  29. pmc Differential allelic expression of c.1568C > A at UGT2B15 is due to variation in a novel cis-regulatory element in the 3'UTR
    Chang Sun
    Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Gene 481:24-8. 2011
    ..Considering the importance of UGT2B15 in metabolism, we proposed that this SNP might contribute to multiple cancer risk and variability in drug response...
  30. pmc Computerized analysis of mammographic parenchymal patterns on a large clinical dataset of full-field digital mammograms: robustness study with two high-risk datasets
    Hui Li
    Department of Radiology, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    J Digit Imaging 25:591-8. 2012
    ....
  31. ncbi request reprint Fat suppression with spectrally selective inversion vs. high spectral and spatial resolution MRI of breast lesions: qualitative and quantitative comparisons
    Xiaobing Fan
    Department of Radiology, University of Chicago, Chicago, Illinois 60637, USA
    J Magn Reson Imaging 24:1311-5. 2006
    ..To compare conventional fat-suppressed MR images of the breast to images derived from high spectral and spatial resolution MR data. Image quality and the level of fat suppression are compared qualitatively and quantitatively...
  32. pmc Prediction of BRCA Mutations Using the BRCAPRO Model in Clinic-Based African American, Hispanic, and Other Minority Families in the United States
    Dezheng Huo
    Center for Clinical Cancer Genetics and Global Health, Department of Medicine, Section of Hematology Oncology, University of Chicago, 5841 S Maryland Ave, MC 2115, Chicago, IL 60637, USA
    J Clin Oncol 27:1184-90. 2009
    ..We also assessed the clinical utility of mutation status of probands (the first individual tested in a family) in the recommendation of BRCA mutation testing for other at-risk family members...
  33. ncbi request reprint High spectral and spatial resolution MRI of breast lesions: preliminary clinical experience
    Milica Medved
    Department of Radiology, The University of Chicago, 5841 S Maryland Avenue, MC 2026, Chicago, IL 60637, USA
    AJR Am J Roentgenol 186:30-7. 2006
    ..To test HiSS in the clinical setting, we used HiSS MRI to image 30 women with suspicious breast lesions...
  34. pmc Clinical implementation of a multislice high spectral and spatial resolution-based MRI sequence to achieve unilateral full-breast coverage
    Milica Medved
    Department of Radiology, The University of Chicago, Chicago, IL 60637, USA
    Magn Reson Imaging 28:16-21. 2010
    ..Thus, we show that volumetric HiSS imaging can conserve the advantages of single-slice HiSS imaging and that further technical development of volumetric HiSS is desirable...
  35. ncbi request reprint Computerized texture analysis of mammographic parenchymal patterns of digitized mammograms
    Hui Li
    Department of Radiology, The University of Chicago, 5841 S Maryland Ave, MC2026, Chicago, IL 60637, USA
    Acad Radiol 12:863-73. 2005
    ..Thus, computerized texture analysis of breast parenchymal patterns on mammograms may be useful in assessing breast cancer risk...
  36. doi request reprint Screening RAD51C nucleotide alterations in patients with a family history of breast and ovarian cancer
    Yonglan Zheng
    Center for Clinical Cancer Genetics and Global Health, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Breast Cancer Res Treat 124:857-61. 2010
    ..Nonetheless, larger studies in diverse populations to fully investigate the mutation spectrum of the RAD51C gene are needed...
  37. pmc Germline mutational analysis of the C19orf62 gene in African-American women with breast cancer
    Yonglan Zheng
    Center for Clinical Cancer Genetics and Global Health, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Breast Cancer Res Treat 127:871-7. 2011
    ..However, the possibility that mutations in C19orf62 contribute to breast cancer risk warrants further studies in large diverse populations...
  38. ncbi request reprint Genetic testing in an ethnically diverse cohort of high-risk women: a comparative analysis of BRCA1 and BRCA2 mutations in American families of European and African ancestry
    Rita Nanda
    Center for Clinical Cancer Genetics, Section of Hematology Oncology, Department of Medicine, University of Chicago Medical Center, Chicago, Ill 60637 1470, USA
    JAMA 294:1925-33. 2005
    ..Ten years after BRCA1 and BRCA2 were first identified as major breast cancer susceptibility genes, the spectrum of mutations and modifiers of risk among many ethnic minorities remain undefined...
  39. ncbi request reprint MYC is amplified in BRCA1-associated breast cancers
    Tatyana A Grushko
    Section of Hematology Oncology, Department of Medicine, Committees on Genetics and Cancer Biology, University of Chicago, Chicago, Illinois 60637 1463, USA
    Clin Cancer Res 10:499-507. 2004
    ....
  40. ncbi request reprint Efficacy of risk-reducing salpingo-oophorectomy in women with BRCA-1 and BRCA-2 mutations
    Olufunmilayo I Olopade
    Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois 60637, USA
    Breast J 10:S5-9. 2004
    ....
  41. ncbi request reprint Family history of pancreatic cancer in a high-risk cancer clinic: implications for risk assessment
    Michael J Hall
    Department of Medicine, Columbia University College of Physicians and Surgeons, Mailman School of Public Health, New York, NY 10032, USA
    J Genet Couns 17:365-72. 2008
    ..In risk assessment for HBOS, identifying a family history of PC should strongly raise the suspicion of an unrecognized BRCA1/2 mutation...
  42. ncbi request reprint Colorectal cancer model of health disparities: understanding mortality differences in minority populations
    Blase N Polite
    Section of Hematology Oncology, Department of Medicine, The University of Chicago, Chicago, IL, USA
    J Clin Oncol 24:2179-87. 2006
    ..Finally, areas of ongoing and future research and policy initiatives aimed at reducing disparities are discussed...
  43. doi request reprint Glucocorticoid receptor expression in breast cancer associates with older patient age
    Larissa Belova
    Department of Medicine, The University of Chicago, MC2115, Chicago, IL 60637, USA
    Breast Cancer Res Treat 116:441-7. 2009
    ..Prospective examination of GR expression in tumors should be considered to determine whether GR contributes to long-term clinical outcome...
  44. ncbi request reprint Using genetic analysis to individualize preventive measures for breast and ovarian cancers
    Olufunmilayo I Olopade
    Center for Clinical Cancer Genetics at the University of Chicago, Chicago, IL, USA
    Nat Clin Pract Oncol 3:182-3. 2006
  45. pmc Echo-planar spectroscopic imaging (EPSI) of the water resonance structure in human breast using sensitivity encoding (SENSE)
    Milica Medved
    Department of Radiology, University of Chicago, Chicago, Illinois 60637, USA
    Magn Reson Med 63:1557-63. 2010
    ..This is the first application of the sensitivity encoding algorithm to characterize the structure of the water resonance at high spatial resolution...
  46. ncbi request reprint How often do BRCA mutation carriers tell their young children of the family's risk for cancer? A study of parental disclosure of BRCA mutations to minors and young adults
    Angela R Bradbury
    Department of Medicine, Section of Hematology Oncology, University of Chicago, Chicago, IL, USA
    J Clin Oncol 25:3705-11. 2007
    ..Yet, many BRCA mutation carriers discuss their results with their children. This study describes the prevalence and experiences of parental communication of BRCA results to children under the age of 25 years old...
  47. pmc Pilot study demonstrating potential association between breast cancer image-based risk phenotypes and genomic biomarkers
    Hui Li
    Departments of Radiology, Human Genetics, Health Studies, and Medicine, The University of Chicago, Chicago, Illinois 60637
    Med Phys 41:031917. 2014
    ....
  48. ncbi request reprint Mortality after bilateral salpingo-oophorectomy in BRCA1 and BRCA2 mutation carriers: a prospective cohort study
    Susan M Domchek
    Abramson Cancer Centre, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Lancet Oncol 7:223-9. 2006
    ..However, the reduction in mortality after this surgery is unclear. We aimed to assess whether BPSO improves overall mortality or cancer-specific mortality in BRCA1 and BRCA2 mutation carriers...
  49. ncbi request reprint Fourier components of inhomogeneously broadened water resonances in breast: a new source of MRI contrast
    Milica Medved
    Department of Radiology, University of Chicago, Chicago, Illinois 60637, USA
    Magn Reson Med 52:193-6. 2004
    ..The synthesis of water Fourier component images from high spectral and spatial resolution data may provide a new form of contrast, and increase sensitivity to subvoxel physiology and anatomy...
  50. doi request reprint Epidermal growth factor receptor in triple-negative and basal-like breast cancer: promising clinical target or only a marker?
    Monika L Burness
    Section of Hematology Oncology, Center for Clinical Cancer Genetics and Global Health, University of Chicago, Chicago, IL 60637, USA
    Cancer J 16:23-32. 2010
    ....
  51. pmc Genomewide scan for loss of heterozygosity and chromosomal amplification in breast carcinoma using single-nucleotide polymorphism arrays
    Maria Argos
    Department of Health Studies, University of Chicago, 5841 S Maryland Avenue, MC 2007, Chicago, IL 60637, USA
    Cancer Genet Cytogenet 182:69-74. 2008
    ..The present study demonstrates a feasible methodological approach for the assessment of LOH and copy number changes...
  52. ncbi request reprint Genetic susceptibility to breast cancer
    Angela R Bradbury
    Section of Hematology Oncology, University of Chicago, Chicago, IL, USA
    Rev Endocr Metab Disord 8:255-67. 2007
    ....
  53. pmc Expression and sub-cellular localization of an epigenetic regulator, co-activator arginine methyltransferase 1 (CARM1), is associated with specific breast cancer subtypes and ethnicity
    Melissa B Davis
    The Institute for Genomics and Systems Biology, University of Chicago Biological Sciences Division, Chicago, IL 60637, USA
    Mol Cancer 12:40. 2013
    ..We investigated CARM1 levels and localization across breast cancer tumors in a cohort of patients of either European or African ancestry...
  54. pmc Molecular phenotype predicts sensitivity of squamous cell carcinoma of the head and neck to epidermal growth factor receptor inhibition
    Natalie R Young
    Department of Medicine and Comprehensive Cancer Center, University of Chicago, Chicago, IL 60637, USA
    Mol Oncol 7:359-68. 2013
    ..Taken together this suggests that constitutively active AKT is a mechanism of intrinsic gefitinib resistance in SCCHN. This resistance can be overcome through targeting of the PI3K/AKT pathway in combination with EGFR inhibition...
  55. ncbi request reprint UDP-Glucuronosyltransferase 1A1 gene polymorphisms and total bilirubin levels in an ethnically diverse cohort of women
    Andrew L Hong
    Department of Medicine, Section of Hematology Oncology, University of Chicago, 5841 S Maryland Ave, MC 2115, Chicago, IL 60637, USA
    Drug Metab Dispos 35:1254-61. 2007
    ..These data have implications for the design of epidemiologic studies of cancer susceptibility and pharmacogenetic studies for adverse drug reactions in populations of African ancestry...
  56. pmc Epidermal growth factor receptor inhibitor gefitinib added to chemoradiotherapy in locally advanced head and neck cancer
    Ezra E W Cohen
    Department of Medicine, University of Chicago, Chicago, IL, USA
    J Clin Oncol 28:3336-43. 2010
    ....
  57. pmc Concordance in histological and biological parameters between first and second primary breast cancers
    Dezheng Huo
    Department of Health Studies, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Cancer 117:907-15. 2011
    ..Women with breast cancer are more likely to have a second breast cancer than women in the general population are to have a primary cancer. However, the biological relationship between primary and second breast cancers is not clear...
  58. pmc Wnt/beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome
    Andrey I Khramtsov
    University of Chicago, Department of Medicine, Chicago, IL 60637, USA
    Am J Pathol 176:2911-20. 2010
    ....
  59. ncbi request reprint Disparities in genetic testing: thinking outside the BRCA box
    Michael J Hall
    Department of Medicine, Mailman School of Public Health, Columbia University, New York, NY, USA
    J Clin Oncol 24:2197-203. 2006
    ..The importance of expanded testing in underserved populations is emphasized...
  60. doi request reprint Parent opinions regarding the genetic testing of minors for BRCA1/2
    Angela R Bradbury
    University of Chicago, Chicago, IL, USA
    J Clin Oncol 28:3498-505. 2010
    ..Thus, we evaluated parent opinions regarding BRCA1/2 testing of minors, in general, and hypothetically, for parents' own minor child...
  61. ncbi request reprint Advances in breast cancer: pathways to personalized medicine
    Olufunmilayo I Olopade
    Department of Medicine, Section of Hematology Oncology, Center for Clinical Cancer Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Clin Cancer Res 14:7988-99. 2008
    ..The five articles in this edition of CCR Focus highlight recent advances and future directions on the pathway to individualized approaches for the early detection, treatment, and prevention of breast cancer...
  62. pmc Allelic imbalance (AI) identifies novel tissue-specific cis-regulatory variation for human UGT2B15
    Chang Sun
    Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Hum Mutat 31:99-107. 2010
    ..Our results provide a good example for how AI can be used to identify cis-regulatory variation and gain insights into the tissue specific regulation of gene expression...
  63. pmc MYC in breast tumor progression
    Yinghua Chen
    Department of Medicine, Center for Clinical Cancer Genetics, University of Chicago, Chicago, IL 60637, USA
    Expert Rev Anticancer Ther 8:1689-98. 2008
    ..MYC amplification is emerging as an important predictor of response to HER2-targeted therapies and its role in BRCA1-associated breast cancer makes it an important target in basal-like/triple-negative breast cancers...
  64. doi request reprint Hidden dangers: a cryptic exon disrupts BRCA2 mRNA
    James D Fackenthal
    Center for Clinical Cancer Genetics and Global Health, The University of Chicago Medical Center, Chicago, IL 60637, USA
    Clin Cancer Res 18:4865-7. 2012
    ..The mutation lies deep within an intron and would not have been detected by conventional screening methods. In the future, more mutations may be discovered by direct mRNA analysis...
  65. pmc Genomic analysis of estrogen cascade reveals histone variant H2A.Z associated with breast cancer progression
    Sujun Hua
    Joint Institute for Genomics and Systems Biology, The University of Chicago and Argonne National Laboratory, Chicago, IL, USA
    Mol Syst Biol 4:188. 2008
    ..This integrated approach has accelerated the identification of a molecule linked to breast cancer progression, has implications for diagnostic and therapeutic interventions, and can be applied to a wide range of cancers...
  66. pmc Translational integrity and continuity: personalized biomedical data integration
    Xiaoming Wang
    Biomedical Informatics Core, Computation Institute, University of Chicago, 950 E 61st Street, Room 334, Chicago, IL 60637, USA
    J Biomed Inform 42:100-12. 2009
    ..In its current stage, TraM relies on a semi-automated mechanism to standardize and restructure source data for data integration and thus does not support real-time data application...
  67. ncbi request reprint Phase I trial of erlotinib-based multimodality therapy for inoperable stage III non-small cell lung cancer
    Nicholas W Choong
    Section of Hematology Oncology and Phase II Network, University of Chicago Medical Center, MC 2115, 5841, S Maryland Avenue, Chicago, Illinois, USA
    J Thorac Oncol 3:1003-11. 2008
    ..This Phase I trial aimed to determine the maximum-tolerated-dose of erlotinib administered with two standard chemoradiotherapy regimens for non-small cell lung cancer...
  68. ncbi request reprint Colorectal cancer and race: understanding the differences in outcomes between African Americans and whites
    Blase N Polite
    Section of Hematology Oncology, Department of Medicine, The University of Chicago Medical Center, 5841 South Maryland Avenue, MC 2115, Chicago, IL 60637 1470, USA
    Med Clin North Am 89:771-93. 2005
    ..The task now becomes to continue to understand the reasons for the disparities and ultimately to come up with workable solutions so that the amazing progress in CRC treatment benefits all groups in this country...
  69. pmc Performance of Lynch syndrome predictive models in a multi-center US referral population
    Omar Khan
    Department of Medicine, Section of Gastroenterology, University of Chicago Medical Center, Illinois 60637, USA
    Am J Gastroenterol 106:1822-7; quiz 1828. 2011
    ..However, these models remain to be externally validated in the United States. Therefore, we evaluated the test characteristics of Lynch syndrome predictive models in a tertiary referral group at two US academic centers...
  70. ncbi request reprint Risk assessment and genetic testing for ovarian cancer
    Cassandra Gulden
    Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago Medical Center, IL 60637, USA
    AJR Am J Roentgenol 194:309-10. 2010
    ..In this review, strategies for identifying high-risk individuals and the clinical utility of genetic testing for BRCA1 and BRCA2 will be discussed...
  71. ncbi request reprint Breast cancer and race: a rising tide does not lift all boats equally
    Blase N Polite
    Section of Hematology Oncology, Department of Medicine, University of Chicago, IL 60637, USA
    Perspect Biol Med 48:S166-75. 2005
    ..This paper discusses the factors that may contribute to differences in survival and differences in stage at diagnosis between African American and white women...
  72. pmc BRCA2 T2722R is a deleterious allele that causes exon skipping
    James D Fackenthal
    Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago Medical Center, Chicago, IL, 60637, USA
    Am J Hum Genet 71:625-31. 2002
    ....
  73. ncbi request reprint FANCF methylation contributes to chemoselectivity in ovarian cancer
    Olufunmilayo I Olopade
    Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago Medical Center, IL 60637, USA
    Cancer Cell 3:417-20. 2003
    ..Disruption of the pathway occurs de novo in ovarian cancers and may contribute to selective sensitivity to platinum salts...
  74. ncbi request reprint Single-day FISH procedure for paraffin-embedded tissue sections using a microwave oven
    Karin K Ridderstråle
    University of Chicago, Chicago, IL 60637 1463, USA
    Biotechniques 39:316, 318, 320. 2005
  75. pmc Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma
    Timothy Best
    Committee on Cancer Biology, University of Chicago, Chicago, Illinois, USA
    Nat Med 17:941-3. 2011
    ..These data suggest a new gene-exposure interaction that may implicate PRDM1 in the etiology of radiation therapy-induced SMNs...
  76. pmc CYP2D6 genotyping and tamoxifen: an unfinished story in the quest for personalized medicine
    Jonas A de Souza
    Department of Medicine, The University of Chicago Comprehensive Cancer Center, Chicago, IL 60637, USA
    Semin Oncol 38:263-73. 2011
    ....
  77. ncbi request reprint Computerized analysis of digitized mammograms of BRCA1 and BRCA2 gene mutation carriers
    Zhimin Huo
    Department of Radiology, University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Radiology 225:519-26. 2002
    ..To evaluate, by using computer image analysis, the mammographic density patterns of women with germ-line mutations in BRCA1 and BRCA2 genes in comparison with those of women at low risk of developing breast cancer...
  78. pmc MYC and Breast Cancer
    Jinhua Xu
    Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago, Chicago, IL, USA
    Genes Cancer 1:629-40. 2010
    ..Targeting MYC-regulated pathways in combination with inhibitors of other oncogenic pathways may provide a promising therapeutic strategy for breast cancer, the basal-like subtype in particular...
  79. ncbi request reprint The effect of varying spectral resolution on the quality of high spectral and spatial resolution magnetic resonance images of the breast
    Milica Medved
    Department of Radiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Magn Reson Imaging 18:442-8. 2003
    ..To evaluate the effect of varying spectral resolution on image quality of high spectral and spatial resolution (HiSS) images...
  80. ncbi request reprint Molecular-cytogenetic analysis of HER-2/neu gene in BRCA1-associated breast cancers
    Tatyana A Grushko
    Section of Hematology Oncology, Department of Medicine, Committee on Genetics, University of Chicago, Chicago, Illinois 60637 1463, USA
    Cancer Res 62:1481-8. 2002
    ....
  81. ncbi request reprint Racial and ethnic disparities in breast cancer: a multilevel perspective
    Christopher M Masi
    Section of General Internal Medicine, University of Chicago, M C 2007, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Med Clin North Am 89:753-70. 2005
    ..Efforts to reduce breast cancer incidence and disparities must consider societal and individual factors and the important effects these factors can have on normal cell function...
  82. ncbi request reprint Racial differences in genetic factors associated with breast cancer
    Foluso O Ademuyiwa
    Section of Hematology Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Cancer Metastasis Rev 22:47-53. 2003
    ....
  83. pmc "Why take it if you don't have anything?" breast cancer risk perceptions and prevention choices at a public hospital
    Talya Salant
    Pritzker Medical School and History of Culture, University of Chicago, Chicago, IL 60637, USA
    J Gen Intern Med 21:779-85. 2006
    ..Qualitative methods explore the complex meanings and logics of risk and prevention that quantitative approaches overlook...
  84. ncbi request reprint Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations
    Timothy R Rebbeck
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    N Engl J Med 346:1616-22. 2002
    ..We investigated whether this procedure reduces the risk of cancers of the coelomic epithelium and breast in women who carry such mutations...
  85. ncbi request reprint Pretest prediction of BRCA1 or BRCA2 mutation by risk counselors and the computer model BRCAPRO
    David M Euhus
    The University of Texas Southwestern Medical Center at Dallas, 75390 9155, USA
    J Natl Cancer Inst 94:844-51. 2002
    ..We measured the performance of eight cancer risk counselors and of a computer model, BRCAPRO, at identifying families likely to carry a BRCA gene mutation...
  86. ncbi request reprint Direct-to-consumer marketing of genetic tests for cancer: buyer beware
    Stacy Gray
    J Clin Oncol 21:3191-3. 2003
  87. pmc AURKA F31I polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a consortium of investigators of modifiers of BRCA1/2 study
    Fergus J Couch
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 16:1416-21. 2007
    ..In summary, the F31I polymorphism in AURKA is not associated with a modified risk of breast cancer in BRCA1 and BRCA2 carriers...
  88. ncbi request reprint Genetic testing in diverse populations: are researchers doing enough to get out the correct message?
    Dezheng Huo
    JAMA 298:2910-1. 2007
  89. ncbi request reprint Bilateral prophylactic mastectomy reduces breast cancer risk in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group
    Timothy R Rebbeck
    Center for Clinical Epidemiology and Biostatistics, Abramson Family Cancer Research Institute, The University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    J Clin Oncol 22:1055-62. 2004
    ..Thus, we estimated the degree of breast cancer risk reduction after surgery in women who carry these mutations...
  90. doi request reprint Should genetic testing for BRCA1/2 be permitted for minors? Opinions of BRCA mutation carriers and their adult offspring
    Angela R Bradbury
    Fox Chase Cancer, Division of Population Science, Philadelphia, PA 19111, USA
    Am J Med Genet C Semin Med Genet 148:70-7. 2008
    ....
  91. pmc Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers
    Antonis C Antoniou
    Cancer Research UK, Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK
    Am J Hum Genet 82:937-48. 2008
    ....
  92. ncbi request reprint Contralateral breast cancer in BRCA1 and BRCA2 mutation carriers
    Kelly Metcalfe
    Centre for Research on Women s Health, Women s College Hospital, Toronto, Ontario, Canada
    J Clin Oncol 22:2328-35. 2004
    ..To estimate the risk of contralateral breast cancer in BRCA1 and BRCA2 carriers after diagnosis and to determine which factors are predictive of the risk of a second primary breast cancer...
  93. pmc Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers
    Eitan Friedman
    The Suzanne Levy Gertner Oncogenetics Unit, The Chaim Sheba Medical Center, Tel Hashomer, Israel, and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Breast Cancer Res 8:R15. 2006
    ....
  94. ncbi request reprint Correlates of depressive symptoms among women seeking cancer genetic counseling and risk assessment at a high-risk cancer clinic
    Molly Middlecamp Kodl
    Minneapolis VA Medical Center, Minneapolis, Minnesota 55417, USA
    J Genet Couns 15:267-76. 2006
    ..Given the known associations between depression, health behaviors such as cancer screening, and potential responses to the genetic testing process, assessment of mood disturbance remains an important consideration for genetic counselors...
  95. ncbi request reprint Ten-year multi-institutional results of breast-conserving surgery and radiotherapy in BRCA1/2-associated stage I/II breast cancer
    Lori J Pierce
    Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, MI 48109 0010, USA
    J Clin Oncol 24:2437-43. 2006
    ..We compared the outcome of breast-conserving surgery and radiotherapy in BRCA1/2 mutation carriers with breast cancer versus that of matched sporadic controls...
  96. ncbi request reprint Age at menarche and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
    Joanne Kotsopoulos
    Centre for Research in Women s Health, University of Toronto, Women s College Hospital, 790 Bay Street, 7th Floor, Totonto, Ontario M5G 1N8, Canada
    Cancer Causes Control 16:667-74. 2005
    ..46; 95% CI 0.30-0.69). This study implicates early age at menarche as a determinant of breast cancer among women with a BRCA1 mutation...
  97. ncbi request reprint Effect of short-term hormone replacement therapy on breast cancer risk reduction after bilateral prophylactic oophorectomy in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group
    Timothy R Rebbeck
    Center for Clinical Epidemiology and Biostatistics, The University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Clin Oncol 23:7804-10. 2005
    ..Thus, we evaluated whether the breast cancer risk reduction conferred by BPO in BRCA1/2 mutation carriers is altered by use of post-BPO HRT...
  98. pmc Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts
    Daphne W Bell
    Massachusetts General Hospital Cancer Center, Charlestown, MA, USA
    Int J Cancer 121:2661-7. 2007
    ....
  99. ncbi request reprint Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma
    Chad A Livasy
    Department of Pathology and Lab Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Mod Pathol 19:264-71. 2006
    ..These findings should further assist in the identification of basal-like carcinomas in clinical specimens, facilitating treatment and epidemiologic studies of this tumor subtype...
  100. pmc A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies
    David S Shames
    Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
    PLoS Med 3:e486. 2006
    ....
  101. pmc RAD51 135G-->C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies
    Antonis C Antoniou
    Cancer Research UK, Genetic Epidemiology Unit, Strangeways Research Laboratory, Cambridge, CB1 8RN, UK
    Am J Hum Genet 81:1186-200. 2007
    ..Thus, 135G-->C may modify the risk of breast cancer in BRCA2 mutation carriers by altering the expression of RAD51. RAD51 is the first gene to be reliably identified as a modifier of risk among BRCA1/2 mutation carriers...