Breast cancer genetics in African AmericansOlufunmilayo I Olopade
Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois 60637, USA
Cancer 97:236-45. 2003
..An overview of the state of genetic testing for BRCA1 and BRCA2 genes was presented at the Summit Meeting on Breast Cancer Among African American women...
High prevalence of BRCA1 and BRCA2 mutations in unselected Nigerian breast cancer patientsJames D Fackenthal
Department of Medicine, University of Chicago, Chicago, IL 60637, USA
Int J Cancer 131:1114-23. 2012
....
- Lack of association between common single nucleotide polymorphisms in the TERT-CLPTM1L locus and breast cancer in women of African ancestry
Yonglan Zheng
Department of Medicine, The University of Chicago, 900 E 57th Street, KCBD Building 8113D, Chicago, IL 60637, USA
Breast Cancer Res Treat 132:341-5. 2012
....
Power spectral analysis of mammographic parenchymal patterns for breast cancer risk assessmentHui Li
Department of Radiology, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
J Digit Imaging 21:145-52. 2008
..The purpose of the study was to evaluate the usefulness of power law spectral analysis on mammographic parenchymal patterns in breast cancer risk assessment...
- Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 and breast cancer risk in Africans
Dezheng Huo
Department of Health Studies, University of Chicago, Chicago, IL, USA
Breast Cancer Res Treat 110:367-76. 2008
....
- Evidence for an ancient BRCA1 mutation in breast cancer patients of Yoruban ancestry
Bifeng Zhang
Department of Medicine, Center for Clinical Cancer Genetics, University of Chicago, MC 2115, 5830 S Ellis Ave, Chicago, IL 60637, USA
Fam Cancer 8:15-22. 2009
..Still, identifying such mutations could be important for designing genetic testing strategies for high-risk breast/ovarian cancer families in non-founder populations...
- A signature of balancing selection in the region upstream to the human UGT2B4 gene and implications for breast cancer risk
Chang Sun
Department of Human Genetics, University of Chicago, 920 E 58th Street, Chicago, IL 60637, USA
Hum Genet 130:767-75. 2011
..81-1.28; homozygous OR 1.50, 95% CI 1.15-1.95]. Our results provide new insights into UGT2B4 sequence variation and indicate that a signal of natural selection may lead to the identification of disease susceptibility variants...
- Microsatellites in the estrogen receptor (ESR1, ESR2) and androgen receptor (AR) genes and breast cancer risk in African American and Nigerian women
Yonglan Zheng
Center for Clinical Cancer Genetics and Global Health, Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
PLoS ONE 7:e40494. 2012
....
- c-Myc activates BRCA1 gene expression through distal promoter elements in breast cancer cells
Yinghua Chen
Center for Clinical Cancer Genetics and Global Health, Department of Medicine, University of Chicago, Chicago, IL, USA
BMC Cancer 11:246. 2011
..In this report, we used cultured breast cancer cells to examine the mechanisms of transcriptional activation of BRCA1 by c-Myc...
- Searching for large genomic rearrangements of the BRCA1 gene in a Nigerian population
Jing Zhang
Section of Hematology Oncology, Department of Medicine, The University of Chicago, 900 E 57th Street, KCBD Room 8240, Chicago, IL 60637, USA
Breast Cancer Res Treat 124:573-7. 2010
..These data suggest that while BRCA1 genomic rearrangement exists, they do not contribute significantly to BRCA1-associated risk in the Nigerian population...
- Evaluation of 19 susceptibility loci of breast cancer in women of African ancestry
Dezheng Huo
Department of Health Studies, University of Chicago, 5841 South Maryland Avenue, MC 2007, Chicago, IL 60637, USA
Carcinogenesis 33:835-40. 2012
..Further fine-mapping studies in women of African ancestry will be needed to reveal additional and causal variants for breast cancer...
- Recurrent BRCA1 and BRCA2 mutations in breast cancer patients of African ancestry
Jing Zhang
Center for Clinical Cancer Genetics and Global Health, Department of Medicine, The University of Chicago, Chicago, IL, USA
Breast Cancer Res Treat 134:889-94. 2012
....
- CpG island methylation affects accessibility of the proximal BRCA1 promoter to transcription factors
Jinhua Xu
Department of Medicine, Center for Clinical Cancer Genetics, University of Chicago, Chicago, IL, 60637 1463, USA
Breast Cancer Res Treat 120:593-601. 2010
..This indicates that reduced accessibility of transcription factors to the methylated promoter is one of the mechanisms for down-regulation of BRCA1 in heavily methylated cancer cells...
- Genetic susceptibility to type 2 diabetes and breast cancer risk in women of European and African ancestry
Ningqi Hou
Department of Health Studies, University of Chicago, Chicago, Illinois 60637, USA
Cancer Epidemiol Biomarkers Prev 21:552-6. 2012
..Epidemiologic studies have reported a positive association between type 2 diabetes (T2D) and breast cancer risk, independent of body weight...
- BRCA1 promoter methylation in sporadic breast cancer is associated with reduced BRCA1 copy number and chromosome 17 aneusomy
Minjie Wei
Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago, Chicago, Illinois 60637-1463, USA
Cancer Res 65:10692-9. 2005
..Our data support a model of carcinogenesis in which BRCA1 promoter methylation may serve as a "first hit," much like an inherited germ line mutation, and promote tumor progression down a restricted set of molecular pathways...
- Computerized analysis of mammographic parenchymal patterns for assessing breast cancer risk: effect of ROI size and location
Hui Li
Department of Radiology, The University of Chicago, Chicago, Illinois 60637, USA
Med Phys 31:549-55. 2004
..However, we failed to show a statistically significant decrease in the performance of the computerized texture features with decreasing ROI size for the range studied...
- Fractal analysis of mammographic parenchymal patterns in breast cancer risk assessment
Hui Li
Department of Radiology, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
Acad Radiol 14:513-21. 2007
..To evaluate fractal-based computerized image analyses of mammographic parenchymal patterns in the task of differentiating between women at high risk and women at low risk for developing breast cancer...
- Fourier component imaging of water resonance in the human breast provides markers for malignancy
Milica Medved
Department of Radiology, University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
Phys Med Biol 54:5767-79. 2009
..83. In the human breast, an inhomogeneously broadened water resonance can serve as a correlate marker for malignancy and is likely to reflect the underlying anatomy or physiology...
- Uptake and timing of bilateral prophylactic salpingo-oophorectomy among BRCA1 and BRCA2 mutation carriers
Angela R Bradbury
University of Chicago Center for Clinical Cancer Genetics, University of Chicago, Chicago, Illinois, USA
Genet Med 10:161-6. 2008
..To evaluate prophylactic salpingo-oophorectomy uptake and timing among BRCA1/2 mutation carriers in a cancer risk assessment program...
- Novel germline PALB2 truncating mutations in African American breast cancer patients
Yonglan Zheng
Center for Clinical Cancer Genetics and Global Health, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
Cancer 118:1362-70. 2012
..Truncating mutations in the PALB2 gene reportedly are enriched in patients with Fanconi anemia and breast cancer in various populations...
- Molecular analysis of colorectal tumors within a diverse patient cohort at a single institution
BROOKE E SYLVESTER
Center for Clinical Cancer Genetics and Global Health, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
Clin Cancer Res 18:350-9. 2012
....
- Non-contrast enhanced MRI for evaluation of breast lesions: comparison of non-contrast enhanced high spectral and spatial resolution (HiSS) images versus contrast enhanced fat-suppressed images
Milica Medved
Department of Radiology, MC2026, 5841 S Maryland Avenue, University of Chicago, Chicago, IL 60637, USA
Acad Radiol 18:1467-74. 2011
....
- Estrogen receptor alpha, BRCA1, and FANCF promoter methylation occur in distinct subsets of sporadic breast cancers
Minjie Wei
Section of Hematology Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637 1463, USA
Breast Cancer Res Treat 111:113-20. 2008
..These data suggest that unlike FANCF, both ER and BRCA1 are specifically targeted for methylation in sporadic breast cancers, a phenomenon that should be explored for development of novel diagnostic and therapeutic approaches...
- Differential allelic expression of c.1568C > A at UGT2B15 is due to variation in a novel cis-regulatory element in the 3'UTR
Chang Sun
Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
Gene 481:24-8. 2011
..Considering the importance of UGT2B15 in metabolism, we proposed that this SNP might contribute to multiple cancer risk and variability in drug response...
- Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations
James D Fackenthal
Department of Medicine and Center for Clinical Cancer Genetics, University of Chicago, Box MC2115, 5841 S Maryland Avenue, Chicago, Illinois 60615, USA
Nat Rev Cancer 7:937-48. 2007
..Although estimates of both mutation prevalence and mutation penetrance rates are inconsistent and occasionally controversial, understanding them is crucial for providing accurate risk information to each patient...
- Population differences in breast cancer: survey in indigenous African women reveals over-representation of triple-negative breast cancer
Dezheng Huo
Center for Clinical Cancer Genetics and Global Health, Department of Medicine, Section of Hematology Oncology, University of Chicago, 5841 S Maryland Ave, MC 2115, Chicago, IL 60637, USA
J Clin Oncol 27:4515-21. 2009
..In the first study of its kind, we determined the distribution of molecular subtypes of invasive breast tumors in indigenous black women in West Africa...
- Computerized analysis of mammographic parenchymal patterns on a large clinical dataset of full-field digital mammograms: robustness study with two high-risk datasets
Hui Li
Department of Radiology, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
J Digit Imaging 25:591-8. 2012
....
- Screening RAD51C nucleotide alterations in patients with a family history of breast and ovarian cancer
Yonglan Zheng
Center for Clinical Cancer Genetics and Global Health, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
Breast Cancer Res Treat 124:857-61. 2010
..Nonetheless, larger studies in diverse populations to fully investigate the mutation spectrum of the RAD51C gene are needed...
- Fat suppression with spectrally selective inversion vs. high spectral and spatial resolution MRI of breast lesions: qualitative and quantitative comparisons
Xiaobing Fan
Department of Radiology, University of Chicago, Chicago, Illinois 60637, USA
J Magn Reson Imaging 24:1311-5. 2006
..HiSS allowed detection of lesions and evaluation of lesion morphology prior to contrast media injection. J. Magn. Reson. Imaging 2006. (c) 2006 Wiley-Liss, Inc...
- High spectral and spatial resolution MRI of breast lesions: preliminary clinical experience
Milica Medved
Department of Radiology, The University of Chicago, 5841 S Maryland Avenue, MC 2026, Chicago, IL 60637, USA
AJR Am J Roentgenol 186:30-7. 2006
..This information and information about the effect of contrast agents could potentially improve the specificity of breast MRI...
- Clinical implementation of a multislice high spectral and spatial resolution-based MRI sequence to achieve unilateral full-breast coverage
Milica Medved
Department of Radiology, The University of Chicago, Chicago, IL 60637, USA
Magn Reson Imaging 28:16-21. 2010
..Thus, we show that volumetric HiSS imaging can conserve the advantages of single-slice HiSS imaging and that further technical development of volumetric HiSS is desirable...
- Computerized texture analysis of mammographic parenchymal patterns of digitized mammograms
Hui Li
Department of Radiology, The University of Chicago, 5841 S Maryland Ave, MC2026, Chicago, IL 60637, USA
Acad Radiol 12:863-73. 2005
..Thus, computerized texture analysis of breast parenchymal patterns on mammograms may be useful in assessing breast cancer risk...
- Prediction of BRCA Mutations Using the BRCAPRO Model in Clinic-Based African American, Hispanic, and Other Minority Families in the United States
Dezheng Huo
Center for Clinical Cancer Genetics and Global Health, Department of Medicine, Section of Hematology Oncology, University of Chicago, 5841 S Maryland Ave, MC 2115, Chicago, IL 60637, USA
J Clin Oncol 27:1184-90. 2009
..We also assessed the clinical utility of mutation status of probands (the first individual tested in a family) in the recommendation of BRCA mutation testing for other at-risk family members...
- MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11
Jessica Bockhorn
The Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA
Nat Commun 4:1393. 2013
..Identification of a novel microRNA-mediated pathway that regulates chemoresistance in breast cancer will facilitate the development of novel therapeutic strategies...
- Mortality after bilateral salpingo-oophorectomy in BRCA1 and BRCA2 mutation carriers: a prospective cohort study
Susan M Domchek
Abramson Cancer Centre, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6021, USA
Lancet Oncol 7:223-9. 2006
..Together, these data could give information to women who are considering genetic testing...
- Genetic testing in an ethnically diverse cohort of high-risk women: a comparative analysis of BRCA1 and BRCA2 mutations in American families of European and African ancestry
Rita Nanda
Center for Clinical Cancer Genetics, Section of Hematology/Oncology, Department of Medicine, University of Chicago Medical Center, Chicago, Ill 60637-1470, USA
JAMA 294:1925-33. 2005
..Irrespective of ancestry, early age at diagnosis and a family history of breast and ovarian cancer are the most powerful predictors of mutation status and should be used to guide clinical decision making...
- Germline mutational analysis of the C19orf62 gene in African-American women with breast cancer
Yonglan Zheng
Center for Clinical Cancer Genetics and Global Health, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
Breast Cancer Res Treat 127:871-7. 2011
..However, the possibility that mutations in C19orf62 contribute to breast cancer risk warrants further studies in large diverse populations...
- Glucocorticoid receptor expression in breast cancer associates with older patient age
Larissa Belova
Department of Medicine, The University of Chicago, MC2115, Chicago, IL 60637, USA
Breast Cancer Res Treat 116:441-7. 2009
..Prospective examination of GR expression in tumors should be considered to determine whether GR contributes to long-term clinical outcome...
- Family history of pancreatic cancer in a high-risk cancer clinic: implications for risk assessment
Michael J Hall
Department of Medicine, Columbia University College of Physicians and Surgeons, Mailman School of Public Health, New York, NY 10032, USA
J Genet Couns 17:365-72. 2008
..In risk assessment for HBOS, identifying a family history of PC should strongly raise the suspicion of an unrecognized BRCA1/2 mutation...
- How often do BRCA mutation carriers tell their young children of the family's risk for cancer? A study of parental disclosure of BRCA mutations to minors and young adults
Angela R Bradbury
Department of Medicine, Section of Hematology Oncology, University of Chicago, Chicago, IL, USA
J Clin Oncol 25:3705-11. 2007
..Yet, many BRCA mutation carriers discuss their results with their children. This study describes the prevalence and experiences of parental communication of BRCA results to children under the age of 25 years old...
- Colorectal cancer model of health disparities: understanding mortality differences in minority populations
Blase N Polite
Section of Hematology Oncology, Department of Medicine, The University of Chicago, Chicago, IL, USA
J Clin Oncol 24:2179-87. 2006
..Finally, areas of ongoing and future research and policy initiatives aimed at reducing disparities are discussed...
- Efficacy of risk-reducing salpingo-oophorectomy in women with BRCA-1 and BRCA-2 mutations
Olufunmilayo I Olopade
Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois 60637, USA
Breast J 10:S5-9. 2004
....
- Echo-planar spectroscopic imaging (EPSI) of the water resonance structure in human breast using sensitivity encoding (SENSE)
Milica Medved
Department of Radiology, University of Chicago, Chicago, Illinois 60637, USA
Magn Reson Med 63:1557-63. 2010
..This is the first application of the sensitivity encoding algorithm to characterize the structure of the water resonance at high spatial resolution...
- Using genetic analysis to individualize preventive measures for breast and ovarian cancers
Olufunmilayo I Olopade
Center for Clinical Cancer Genetics at the University of Chicago, Chicago, IL, USA
Nat Clin Pract Oncol 3:182-3. 2006
- Genomewide scan for loss of heterozygosity and chromosomal amplification in breast carcinoma using single-nucleotide polymorphism arrays
Maria Argos
Department of Health Studies, University of Chicago, 5841 S Maryland Avenue, MC 2007, Chicago, IL 60637, USA
Cancer Genet Cytogenet 182:69-74. 2008
..The present study demonstrates a feasible methodological approach for the assessment of LOH and copy number changes...
- Fourier components of inhomogeneously broadened water resonances in breast: a new source of MRI contrast
Milica Medved
Department of Radiology, University of Chicago, Chicago, Illinois 60637, USA
Magn Reson Med 52:193-6. 2004
..The synthesis of water Fourier component images from high spectral and spatial resolution data may provide a new form of contrast, and increase sensitivity to subvoxel physiology and anatomy...
- Epidermal growth factor receptor in triple-negative and basal-like breast cancer: promising clinical target or only a marker?
Monika L Burness
Section of Hematology Oncology, Center for Clinical Cancer Genetics and Global Health, University of Chicago, Chicago, IL 60637, USA
Cancer J 16:23-32. 2010
....
- MYC is amplified in BRCA1-associated breast cancers
Tatyana A Grushko
Section of Hematology Oncology, Department of Medicine, Committees on Genetics and Cancer Biology, University of Chicago, Chicago, Illinois 60637 1463, USA
Clin Cancer Res 10:499-507. 2004
....
- Genetic susceptibility to breast cancer
Angela R Bradbury
Section of Hematology Oncology, University of Chicago, Chicago, IL, USA
Rev Endocr Metab Disord 8:255-67. 2007
....
- UDP-Glucuronosyltransferase 1A1 gene polymorphisms and total bilirubin levels in an ethnically diverse cohort of women
Andrew L Hong
Department of Medicine, Section of Hematology Oncology, University of Chicago, 5841 S Maryland Ave, MC 2115, Chicago, IL 60637, USA
Drug Metab Dispos 35:1254-61. 2007
..These data have implications for the design of epidemiologic studies of cancer susceptibility and pharmacogenetic studies for adverse drug reactions in populations of African ancestry...
- Advances in breast cancer: pathways to personalized medicine
Olufunmilayo I Olopade
Department of Medicine, Section of Hematology Oncology, Center for Clinical Cancer Genetics, University of Chicago, Chicago, Illinois 60637, USA
Clin Cancer Res 14:7988-99. 2008
..The five articles in this edition of CCR Focus highlight recent advances and future directions on the pathway to individualized approaches for the early detection, treatment, and prevention of breast cancer...
- Epidermal growth factor receptor inhibitor gefitinib added to chemoradiotherapy in locally advanced head and neck cancer
Ezra E W Cohen
Department of Medicine, University of Chicago, Chicago, IL, USA
J Clin Oncol 28:3336-43. 2010
....
- Wnt/beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome
Andrey I Khramtsov
University of Chicago, Department of Medicine, Chicago, IL 60637, USA
Am J Pathol 176:2911-20. 2010
....
- Parent opinions regarding the genetic testing of minors for BRCA1/2
Angela R Bradbury
University of Chicago, Chicago, IL, USA
J Clin Oncol 28:3498-505. 2010
..Thus, we evaluated parent opinions regarding BRCA1/2 testing of minors, in general, and hypothetically, for parents' own minor child...
- Concordance in histological and biological parameters between first and second primary breast cancers
Dezheng Huo
Department of Health Studies, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
Cancer 117:907-15. 2011
..Women with breast cancer are more likely to have a second breast cancer than women in the general population are to have a primary cancer. However, the biological relationship between primary and second breast cancers is not clear...
- Disparities in genetic testing: thinking outside the BRCA box
Michael J Hall
Department of Medicine, Mailman School of Public Health, Columbia University, New York, NY, USA
J Clin Oncol 24:2197-203. 2006
..The importance of expanded testing in underserved populations is emphasized...
- Hidden dangers: a cryptic exon disrupts BRCA2 mRNA
James D Fackenthal
Center for Clinical Cancer Genetics and Global Health, The University of Chicago Medical Center, Chicago, IL 60637, USA
Clin Cancer Res 18:4865-7. 2012
..The mutation lies deep within an intron and would not have been detected by conventional screening methods. In the future, more mutations may be discovered by direct mRNA analysis...
- Translational integrity and continuity: personalized biomedical data integration
Xiaoming Wang
Biomedical Informatics Core, Computation Institute, University of Chicago, 950 E 61st Street, Room 334, Chicago, IL 60637, USA
J Biomed Inform 42:100-12. 2009
..In its current stage, TraM relies on a semi-automated mechanism to standardize and restructure source data for data integration and thus does not support real-time data application...
- Risk assessment and genetic testing for ovarian cancer
Cassandra Gulden
Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago Medical Center, IL 60637, USA
AJR Am J Roentgenol 194:309-10. 2010
....
- Genomic analysis of estrogen cascade reveals histone variant H2A.Z associated with breast cancer progression
Sujun Hua
Joint Institute for Genomics and Systems Biology, The University of Chicago and Argonne National Laboratory, Chicago, IL, USA
Mol Syst Biol 4:188. 2008
..This integrated approach has accelerated the identification of a molecule linked to breast cancer progression, has implications for diagnostic and therapeutic interventions, and can be applied to a wide range of cancers...
- Phase I trial of erlotinib-based multimodality therapy for inoperable stage III non-small cell lung cancer
Nicholas W Choong
Section of Hematology Oncology and Phase II Network, University of Chicago Medical Center, MC 2115, 5841, S Maryland Avenue, Chicago, Illinois, USA
J Thorac Oncol 3:1003-11. 2008
..This Phase I trial aimed to determine the maximum-tolerated-dose of erlotinib administered with two standard chemoradiotherapy regimens for non-small cell lung cancer...
- Colorectal cancer and race: understanding the differences in outcomes between African Americans and whites
Blase N Polite
Section of Hematology Oncology, Department of Medicine, The University of Chicago Medical Center, 5841 South Maryland Avenue, MC 2115, Chicago, IL 60637 1470, USA
Med Clin North Am 89:771-93. 2005
..The task now becomes to continue to understand the reasons for the disparities and ultimately to come up with workable solutions so that the amazing progress in CRC treatment benefits all groups in this country...
- Performance of Lynch syndrome predictive models in a multi-center US referral population
Omar Khan
Department of Medicine, Section of Gastroenterology, University of Chicago Medical Center, Illinois 60637, USA
Am J Gastroenterol 106:1822-7; quiz 1828. 2011
..However, these models remain to be externally validated in the United States. Therefore, we evaluated the test characteristics of Lynch syndrome predictive models in a tertiary referral group at two US academic centers...
- BRCA2 T2722R is a deleterious allele that causes exon skipping
James D Fackenthal
Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago Medical Center, Chicago, IL, 60637, USA
Am J Hum Genet 71:625-31. 2002
....
- Breast cancer and race: a rising tide does not lift all boats equally
Blase N Polite
Section of Hematology/Oncology, Department of Medicine, University of Chicago, IL 60637, USA
Perspect Biol Med 48:S166-75. 2005
..This paper discusses the factors that may contribute to differences in survival and differences in stage at diagnosis between African American and white women...
- MYC in breast tumor progression
Yinghua Chen
Department of Medicine, Center for Clinical Cancer Genetics, University of Chicago, Chicago, IL 60637, USA
Expert Rev Anticancer Ther 8:1689-98. 2008
..MYC amplification is emerging as an important predictor of response to HER2-targeted therapies and its role in BRCA1-associated breast cancer makes it an important target in basal-like/triple-negative breast cancers...
- Allelic imbalance (AI) identifies novel tissue-specific cis-regulatory variation for human UGT2B15
Chang Sun
Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA
Hum Mutat 31:99-107. 2010
..Our results provide a good example for how AI can be used to identify cis-regulatory variation and gain insights into the tissue specific regulation of gene expression...
- FANCF methylation contributes to chemoselectivity in ovarian cancer
Olufunmilayo I Olopade
Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago Medical Center, IL 60637, USA
Cancer Cell 3:417-20. 2003
..Disruption of the pathway occurs de novo in ovarian cancers and may contribute to selective sensitivity to platinum salts...
- Computerized analysis of digitized mammograms of BRCA1 and BRCA2 gene mutation carriers
Zhimin Huo
Department of Radiology, University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
Radiology 225:519-26. 2002
..Our computer-extracted features may be useful as radiographic markers for identifying women at high risk for breast cancer...
- MYC and Breast Cancer
Jinhua Xu
Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago, Chicago, IL, USA
Genes Cancer 1:629-40. 2010
..Targeting MYC-regulated pathways in combination with inhibitors of other oncogenic pathways may provide a promising therapeutic strategy for breast cancer, the basal-like subtype in particular...
- Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma
Timothy Best
Committee on Cancer Biology, University of Chicago, Chicago, Illinois, USA
Nat Med 17:941-3. 2011
..These data suggest a new gene-exposure interaction that may implicate PRDM1 in the etiology of radiation therapy-induced SMNs...
- The effect of varying spectral resolution on the quality of high spectral and spatial resolution magnetic resonance images of the breast
Milica Medved
Department of Radiology, The University of Chicago, Chicago, Illinois 60637, USA
J Magn Reson Imaging 18:442-8. 2003
..To evaluate the effect of varying spectral resolution on image quality of high spectral and spatial resolution (HiSS) images...
- Single-day FISH procedure for paraffin-embedded tissue sections using a microwave oven
Karin K Ridderstråle
University of Chicago, Chicago, IL 60637 1463, USA
Biotechniques 39:316, 318, 320. 2005
- CYP2D6 genotyping and tamoxifen: an unfinished story in the quest for personalized medicine
Jonas A de Souza
Department of Medicine, The University of Chicago Comprehensive Cancer Center, Chicago, IL 60637, USA
Semin Oncol 38:263-73. 2011
....
- Molecular-cytogenetic analysis of HER-2/neu gene in BRCA1-associated breast cancers
Tatyana A Grushko
Section of Hematology/Oncology, Department of Medicine, Committee on Genetics, University of Chicago, Chicago, Illinois 60637-1463, USA
Cancer Res 62:1481-8. 2002
....
- Racial differences in genetic factors associated with breast cancer
Foluso O Ademuyiwa
Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
Cancer Metastasis Rev 22:47-53. 2003
....
- "Why take it if you don't have anything?" breast cancer risk perceptions and prevention choices at a public hospital
Talya Salant
Pritzker Medical School and History of Culture, University of Chicago, Chicago, IL 60637, USA
J Gen Intern Med 21:779-85. 2006
..Qualitative methods explore the complex meanings and logics of risk and prevention that quantitative approaches overlook...
- Racial and ethnic disparities in breast cancer: a multilevel perspective
Christopher M Masi
Section of General Internal Medicine, University of Chicago, M C 2007, 5841 South Maryland Avenue, Chicago, IL 60637, USA
Med Clin North Am 89:753-70. 2005
..Efforts to reduce breast cancer incidence and disparities must consider societal and individual factors and the important effects these factors can have on normal cell function...
- Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations
Timothy R Rebbeck
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
N Engl J Med 346:1616-22. 2002
..We investigated whether this procedure reduces the risk of cancers of the coelomic epithelium and breast in women who carry such mutations...
- Pretest prediction of BRCA1 or BRCA2 mutation by risk counselors and the computer model BRCAPRO
David M Euhus
The University of Texas Southwestern Medical Center at Dallas, 75390 9155, USA
J Natl Cancer Inst 94:844-51. 2002
..We measured the performance of eight cancer risk counselors and of a computer model, BRCAPRO, at identifying families likely to carry a BRCA gene mutation...
- Direct-to-consumer marketing of genetic tests for cancer: buyer beware
Stacy Gray
J Clin Oncol 21:3191-3. 2003
- Contralateral breast cancer in BRCA1 and BRCA2 mutation carriers
Kelly Metcalfe
Centre for Research on Women' s Health, Women's College Hospital, Toronto, Ontario, Canada
J Clin Oncol 22:2328-35. 2004
..6% for BRCA2 carriers. CONCLUSION: The risk of contralateral breast cancer in women with a BRCA mutation is approximately 40% at 10 years, and is reduced in women who take tamoxifen or who undergo an oophorectomy...
- Age at menarche and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
Joanne Kotsopoulos
Centre for Research in Women s Health, University of Toronto, Women s College Hospital, 790 Bay Street, 7th Floor, Totonto, Ontario M5G 1N8, Canada
Cancer Causes Control 16:667-74. 2005
..46; 95% CI 0.30-0.69). This study implicates early age at menarche as a determinant of breast cancer among women with a BRCA1 mutation...
- Effect of short-term hormone replacement therapy on breast cancer risk reduction after bilateral prophylactic oophorectomy in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group
Timothy R Rebbeck
Center for Clinical Epidemiology and Biostatistics, The University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
J Clin Oncol 23:7804-10. 2005
..Thus, we evaluated whether the breast cancer risk reduction conferred by BPO in BRCA1/2 mutation carriers is altered by use of post-BPO HRT...
- Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers
Eitan Friedman
The Suzanne Levy Gertner Oncogenetics Unit, The Chaim Sheba Medical Center, Tel Hashomer, Israel, and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Breast Cancer Res 8:R15. 2006
....
- Ten-year multi-institutional results of breast-conserving surgery and radiotherapy in BRCA1/2-associated stage I/II breast cancer
Lori J Pierce
Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, MI 48109 0010, USA
J Clin Oncol 24:2437-43. 2006
..We compared the outcome of breast-conserving surgery and radiotherapy in BRCA1/2 mutation carriers with breast cancer versus that of matched sporadic controls...
- Correlates of depressive symptoms among women seeking cancer genetic counseling and risk assessment at a high-risk cancer clinic
Molly Middlecamp Kodl
Minneapolis VA Medical Center, Minneapolis, Minnesota 55417, USA
J Genet Couns 15:267-76. 2006
..Given the known associations between depression, health behaviors such as cancer screening, and potential responses to the genetic testing process, assessment of mood disturbance remains an important consideration for genetic counselors...
- AURKA F31I polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a consortium of investigators of modifiers of BRCA1/2 study
Fergus J Couch
Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA
Cancer Epidemiol Biomarkers Prev 16:1416-21. 2007
..In summary, the F31I polymorphism in AURKA is not associated with a modified risk of breast cancer in BRCA1 and BRCA2 carriers...
- Should genetic testing for BRCA1/2 be permitted for minors? Opinions of BRCA mutation carriers and their adult offspring
Angela R Bradbury
Fox Chase Cancer, Division of Population Science, Philadelphia, PA 19111, USA
Am J Med Genet C Semin Med Genet 148:70-7. 2008
....
- Genetic testing in diverse populations: are researchers doing enough to get out the correct message?
Dezheng Huo
JAMA 298:2910-1. 2007
- Bilateral prophylactic mastectomy reduces breast cancer risk in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group
Timothy R Rebbeck
Center for Clinical Epidemiology and Biostatistics, Abramson Family Cancer Research Institute, The University of Pennsylvania, Philadelphia, PA 19104-6021, USA
J Clin Oncol 22:1055-62. 2004
..CONCLUSION: Bilateral prophylactic mastectomy reduces the risk of breast cancer in women with BRCA1/2 mutations by approximately 90%...
- Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers
Antonis C Antoniou
Cancer Research UK, Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK
Am J Hum Genet 82:937-48. 2008
....
- Obesity and height in urban Nigerian women with breast cancer
Clement A Adebamowo
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Ann Epidemiol 13:455-61. 2003
..To examine the relationship between obesity, height, and breast cancer in an urban Nigerian population...
- EDD, the human orthologue of the hyperplastic discs tumour suppressor gene, is amplified and overexpressed in cancer
Jennifer L Clancy
Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW 2010, Australia
Oncogene 22:5070-81. 2003
..These results demonstrate that AI at the EDD locus is common in a diversity of carcinomas and that the EDD gene is frequently overexpressed in breast and ovarian cancer, implying a potential role in cancer progression...
- Estrogen receptor status in BRCA1- and BRCA2-related breast cancer: the influence of age, grade, and histological type
William D Foulkes
Departments of Oncology, Sir M B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
Clin Cancer Res 10:2029-34. 2004
..The relationship between ER status and other clinical features of hereditary breast cancers has not been well studied...
- Genetic variation in IGFBP2 and IGFBP5 is associated with breast cancer in populations of African descent
Chad P Garner
Department of Epidemiology, University of California Irvine, 224 Irvine Hall, Irvine, CA, 92697 7550, USA
Hum Genet 123:247-55. 2008
..0038 and P = 0.01 in African-Americans and Nigerians, respectively. This study is the first to report associations between genetic variants in IGFBP2 and IGFBP5 and breast cancer risk...
- Common variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast cancer
Simon N Stacey
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Nat Genet 40:703-6. 2008
..The nearest gene, MRPS30, was previously implicated in apoptosis, ER-positive tumors and favorable prognosis. A recently reported signal in FGFR2 was also found to associate specifically with ER-positive breast cancer...
- Confronting genetic testing disparities: knowledge is power
Michael Hall
JAMA 293:1783-5. 2005
- Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
Jason I Herschkowitz
Lineberger Comprehensive Cancer Center
Genome Biol 8:R76. 2007
..To address this need, we characterized mammary tumor gene expression profiles from 13 different murine models using DNA microarrays and compared the resulting data to those from human breast tumors...
- RASSF1A polymorphism A133S is associated with early onset breast cancer in BRCA1/2 mutation carriers
Boning Gao
Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390 8593, USA
Cancer Res 68:22-5. 2008
..Our results warrant a large-scale study to examine the effect of the A133S polymorphism in the development of breast and other types of cancers...
- Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma
Chad A Livasy
Department of Pathology and Lab Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
Mod Pathol 19:264-71. 2006
..These findings should further assist in the identification of basal-like carcinomas in clinical specimens, facilitating treatment and epidemiologic studies of this tumor subtype...
