- Acute pathological laughter
Darin T Okuda
Division of Neurology, University of California at San Francisco, San Francisco, California 94117, USA
Mov Disord 20:1389-90. 2005
..The etiology of this condition remains theoretical; however, the results here provide further insights into the pathways of emotional control...
- Hypergraphia in the age of computers
Darin T Okuda
Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
Neurology 62:2329-30. 2004
- Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis
Sergio E Baranzini
Department of Neurology, School of Medicine, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0435, USA
Brain 133:2603-11. 2010
..Spectroscopy-based imaging provides a novel quantitative endophenotype for genetic association studies directed towards identifying new factors that contribute to the heterogeneity of clinical expression of multiple sclerosis...
- Vitamin D status predicts new brain magnetic resonance imaging activity in multiple sclerosis
Ellen M Mowry
Multiple Sclerosis Center, Department of Neurology, University of California at San Francisco, San Francisco, CA, USA
Ann Neurol 72:234-40. 2012
..We sought to determine whether vitamin D status is associated with developing new T2 lesions or contrast-enhancing lesions on brain magnetic resonance imaging (MRI) in relapsing multiple sclerosis (MS)...
- Switching multiple sclerosis patients with breakthrough disease to second-line therapy
Multiple Sclerosis Center, Department of Neurology, University of California San Francisco, San Francisco, California, USA
PLoS ONE 6:e16664. 2011
..The effect of natalizumab monotherapy in patients with breakthrough disease is unknown...
- Quantitative in vivo magnetic resonance imaging of multiple sclerosis at 7 Tesla with sensitivity to iron
Kathryn E Hammond
University of California San Francisco Berkeley Joint Graduate Group in Bioengineering, University of California San Francisco, San Francisco, CA, USA
Ann Neurol 64:707-13. 2008
..The purpose of this study was to quantify local field shifts in MS and to investigate their relation to disease duration and disability status...
- Unanticipated demyelinating pathology of the CNS
Darin T Okuda
Department of Neurology, UCSF Multiple Sclerosis Center, University of Caifornia, San Francisco, San Francisco, CA 94117, USA
Nat Rev Neurol 5:591-7. 2009
..In addition, I discuss the estimated prevalence of demyelinating pathology, the currently proposed criteria for its identification, implications for therapeutic intervention, and predictors of disease progression...
- Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis
Sergio E Baranzini
Department of Neurology, University of California, San Francisco, CA 94143 0435, USA
Hum Mol Genet 18:767-78. 2009
..Gene ontology-based analysis shows a functional dichotomy between genes involved in the susceptibility pathway and those affecting the clinical phenotype...
- Difference in disease burden and activity in pediatric patients on brain magnetic resonance imaging at time of multiple sclerosis onset vs adults
UCSF Regional Pediatric Multiple Sclerosis Center, 350 Parnassus Ave, Ste 908, San Francisco, CA 94117, USA
Arch Neurol 66:967-71. 2009
..To compare initial brain magnetic resonance imaging (MRI) characteristics of children and adults at multiple sclerosis (MS) onset...
- Abrogation of T cell quiescence characterizes patients at high risk for multiple sclerosis after the initial neurological event
Jean Christophe Corvol
Departments of Neurology and Radiology, University of California, San Francisco, CA 94143 0435, USA
Proc Natl Acad Sci U S A 105:11839-44. 2008
..These results indicate that CIS patients at high risk of conversion have impaired regulation of T cell quiescence, possibly resulting in earlier activation of pathogenic CD4(+) cells...
- Connecting white matter injury and thalamic atrophy in clinically isolated syndromes
Roland G Henry
Department of Radiology and Biomedical Imaging, University of California at San Francisco, USA
J Neurol Sci 282:61-6. 2009
..66, p<0.001), a finding not observed in regions outside the thalamocortical white matter. These results provide compelling evidence for a direct relationship between white matter lesions and thalamic atrophy in CIS patients...