Kutluk H Oktay

Summary

Publications

  1. pmc Enhancement of neoangiogenesis and follicle survival by sphingosine-1-phosphate in human ovarian tissue xenotransplants
    Reza Soleimani
    Laboratory of Molecular Reproduction, Institute for Fertility Preservation, Department of Obstetrics and Gynecology, New York Medical College, Valhalla, New York, United States of America
    PLoS ONE 6:e19475. 2011
  2. pmc Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise
    Reza Soleimani
    Laboratory of Molecular Reproduction, Institute for Fertility Preservation, Department of Obstetrics and Gynecology, New York Medical College, Valhalla, New York, USA
    Aging (Albany NY) 3:782-93. 2011
  3. doi request reprint Fertility preservation for patients with cancer: American Society of Clinical Oncology clinical practice guideline update
    Alison W Loren
    Institute for Fertility Preservation, New York Medical College, Rye, NY, USA
    J Clin Oncol 31:2500-10. 2013
  4. pmc Fertility preservation and pregnancy in women with and without BRCA mutation-positive breast cancer
    Kenny A Rodriguez-Wallberg
    Institute for Fertility Preservation, Rye, New York 10580, USA
    Oncologist 17:1409-17. 2012
  5. doi request reprint Four spontaneous pregnancies and three live births following subcutaneous transplantation of frozen banked ovarian tissue: what is the explanation?
    Kutluk Oktay
    Department of Obstetrics and Gynecology, Institute for Fertility Preservation, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
    Fertil Steril 95:804.e7-10. 2011
  6. doi request reprint Fertility preservation by ovarian stimulation and oocyte cryopreservation in a 14-year-old adolescent with Turner syndrome mosaicism and impending premature ovarian failure
    Kutluk Oktay
    Institute for Fertility Preservation, Department of Obstetrics and Gynecology, NY Medical College Westchester Medical Center, Valhalla, New York 10595, USA
    Fertil Steril 94:753.e15-9. 2010
  7. pmc Association of BRCA1 mutations with occult primary ovarian insufficiency: a possible explanation for the link between infertility and breast/ovarian cancer risks
    Kutluk Oktay
    Institute for Fertility Preservation, Department of Obstetrics and Gynecology, New York Medical College Westchester Medical Center, Valhalla, NY 10595, USA
    J Clin Oncol 28:240-4. 2010
  8. doi request reprint Chemotherapy and amenorrhea: risks and treatment options
    Kutluk Oktay
    Department of Obstetrics and Gynecology, New York Medical College, Valhalla, New York, USA
    Curr Opin Obstet Gynecol 20:408-15. 2008
  9. doi request reprint Ovarian cryopreservation and transplantation for fertility preservation for medical indications: report of an ongoing experience
    Kutluk Oktay
    Department of Obstetrics and Gynecology, New York Medical College, Valhalla, New York and Institute for Fertility Preservation, Center for Human Reproduction, New York, New York 10021, USA
    Fertil Steril 93:762-8. 2010
  10. doi request reprint Who is the best candidate for oocyte cryopreservation research?
    Kutluk Oktay
    Department of Obstetrics and Gynecology, New York Medical College, Valhhala, New York, USA
    Fertil Steril 93:13-5. 2010

Collaborators

Detail Information

Publications67

  1. pmc Enhancement of neoangiogenesis and follicle survival by sphingosine-1-phosphate in human ovarian tissue xenotransplants
    Reza Soleimani
    Laboratory of Molecular Reproduction, Institute for Fertility Preservation, Department of Obstetrics and Gynecology, New York Medical College, Valhalla, New York, United States of America
    PLoS ONE 6:e19475. 2011
    ..Sphingosine-1-phosphate holds great promise to clinically enhance the survival and longevity of human autologous ovarian transplants...
  2. pmc Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise
    Reza Soleimani
    Laboratory of Molecular Reproduction, Institute for Fertility Preservation, Department of Obstetrics and Gynecology, New York Medical College, Valhalla, New York, USA
    Aging (Albany NY) 3:782-93. 2011
    ..These effects may have clinical implications in aging both for premenopausal and postmenopausal cancer survivors...
  3. doi request reprint Fertility preservation for patients with cancer: American Society of Clinical Oncology clinical practice guideline update
    Alison W Loren
    Institute for Fertility Preservation, New York Medical College, Rye, NY, USA
    J Clin Oncol 31:2500-10. 2013
    ..To update guidance for health care providers about fertility preservation for adults and children with cancer...
  4. pmc Fertility preservation and pregnancy in women with and without BRCA mutation-positive breast cancer
    Kenny A Rodriguez-Wallberg
    Institute for Fertility Preservation, Rye, New York 10580, USA
    Oncologist 17:1409-17. 2012
    ..Overall, the last decade has brought many options for women with breast cancer considering fertility preservation, but numerous challenges remain. The presence of BRCA mutations further contributes to these challenges...
  5. doi request reprint Four spontaneous pregnancies and three live births following subcutaneous transplantation of frozen banked ovarian tissue: what is the explanation?
    Kutluk Oktay
    Department of Obstetrics and Gynecology, Institute for Fertility Preservation, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
    Fertil Steril 95:804.e7-10. 2011
    ..To report the long-term follow-up of an experimental heterotopic ovarian transplantation with frozen-thawed ovarian tissue...
  6. doi request reprint Fertility preservation by ovarian stimulation and oocyte cryopreservation in a 14-year-old adolescent with Turner syndrome mosaicism and impending premature ovarian failure
    Kutluk Oktay
    Institute for Fertility Preservation, Department of Obstetrics and Gynecology, NY Medical College Westchester Medical Center, Valhalla, New York 10595, USA
    Fertil Steril 94:753.e15-9. 2010
    ..To report a novel approach to fertility preservation in adolescents with Turner syndrome mosaicism by repeated controlled ovarian stimulation and oocyte cryopreservation...
  7. pmc Association of BRCA1 mutations with occult primary ovarian insufficiency: a possible explanation for the link between infertility and breast/ovarian cancer risks
    Kutluk Oktay
    Institute for Fertility Preservation, Department of Obstetrics and Gynecology, New York Medical College Westchester Medical Center, Valhalla, NY 10595, USA
    J Clin Oncol 28:240-4. 2010
    ..Because infertility is associated with breast and ovarian cancer risks, we hypothesized that the mutations in the BRCA gene may be associated with low response to fertility treatments...
  8. doi request reprint Chemotherapy and amenorrhea: risks and treatment options
    Kutluk Oktay
    Department of Obstetrics and Gynecology, New York Medical College, Valhalla, New York, USA
    Curr Opin Obstet Gynecol 20:408-15. 2008
    ..The purpose of this study is to review the impact of chemotherapy on fertility and to update the reader on the current state of fertility preservation techniques...
  9. doi request reprint Ovarian cryopreservation and transplantation for fertility preservation for medical indications: report of an ongoing experience
    Kutluk Oktay
    Department of Obstetrics and Gynecology, New York Medical College, Valhalla, New York and Institute for Fertility Preservation, Center for Human Reproduction, New York, New York 10021, USA
    Fertil Steril 93:762-8. 2010
    ..To assess the indications, safety, utilization, and success of ovarian tissue freezing and transplantation...
  10. doi request reprint Who is the best candidate for oocyte cryopreservation research?
    Kutluk Oktay
    Department of Obstetrics and Gynecology, New York Medical College, Valhhala, New York, USA
    Fertil Steril 93:13-5. 2010
    ..This article discusses the controversial aspects of selecting candidates for oocyte cryopreservation research...
  11. ncbi request reprint Fertility preservation in gynecologic cancers
    Kutluk Oktay
    Department of Obstetrics and Gynecology, Joan and Sanford I Weill Medical College of Cornell University, New York, NY 10021, USA
    Curr Opin Oncol 19:506-11. 2007
    ..This review focuses on the current options for fertility preservation in young women facing the risk of premature ovarian failure and infertility as a sequel to the treatment of gynecologic cancer...
  12. doi request reprint Fertility preservation medicine: a new field in the care of young cancer survivors
    Kutluk Oktay
    Department of Obstetrics and Gynecology, New York Medical College, Valhalla, New York, USA
    Pediatr Blood Cancer 53:267-73. 2009
    ..For adult survivors of childhood cancer who experienced reproductive failure, third party reproduction techniques are highly successful...
  13. ncbi request reprint In vitro maturation of germinal vesicle oocytes recovered after premature luteinizing hormone surge: description of a novel approach to fertility preservation
    Kutluk Oktay
    Department of Obstetrics and Gynecology, Center for Reproductive Medicine and Infertility, Weill Medical College, Cornell University, New York, New York 10021, USA
    Fertil Steril 89:228.e19-22. 2008
    ..To report a novel approach to fertility preservation by in vitro maturation and embryo cryopreservation after LH surge and ovulation...
  14. pmc GnRH agonist trigger for women with breast cancer undergoing fertility preservation by aromatase inhibitor/FSH stimulation
    Kutluk Oktay
    Department of Obstetrics and Gynecology, Division of Reproductive Medicine and Institute for Fertility Preservation, New York Medical College Westchester Medical Center, Valhalla, NY 10595, USA
    Reprod Biomed Online 20:783-8. 2010
    ..GnRHa trigger improves outcomes by increasing the yield of mature oocytes and embryos in aromatase inhibitor cycles and also decreases the post-trigger oestradiol exposure as well as OHSS risks in women with breast cancer...
  15. ncbi request reprint Ovarian cryopreservation
    K Jeong
    Department of Obstetrics and Gynecology, Ewha Womans University, Seoul, Korea
    Minerva Med 103:37-46. 2012
    ..Earlier team approach of oncologists and reproductive endocrinologists may provide a more successful and professional way of fertility preservation...
  16. ncbi request reprint Absence of conclusive evidence for the safety and efficacy of gonadotropin-releasing hormone analogue treatment in protecting against chemotherapy-induced gonadal injury
    Kutluk Oktay
    Department of Obstetrics and Gynecology, Joan and Sanford I Weill Medical College of Cornell University, 505 East 70th Street, HT 340, New York, New York 10021, USA
    Oncologist 12:1055-66. 2007
    ..In this manuscript, we debate the rationale for the effectiveness of GnRH analogue coadministration in preservation of fertility by reviewing the literature, and provide preliminary data to support our views...
  17. doi request reprint Fertility preservation for breast cancer patients
    Ozgur Oktem
    Department of Obstetrics and Gynecology, Laboratory of Molecular Reproduction and Fertility Preservation, New York Medical College, Valhalla, New York 10595, USA
    Semin Reprod Med 27:486-92. 2009
    ..Ovarian tissue freezing could also be an option in breast cancer patients who do not wish or have a time for an in vitro fertilization cycle, which requires 10 to 14 days of ovarian stimulation...
  18. doi request reprint Safety of fertility preservation by ovarian stimulation with letrozole and gonadotropins in patients with breast cancer: a prospective controlled study
    Amr A Azim
    Department of Obstetrics and Gynecology, New York Medical College, Valhalla, New York, USA
    J Clin Oncol 26:2630-5. 2008
    ....
  19. ncbi request reprint Relative potencies of anastrozole and letrozole to suppress estradiol in breast cancer patients undergoing ovarian stimulation before in vitro fertilization
    Amr A Azim
    Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Clin Endocrinol Metab 92:2197-200. 2007
    ..Breast cancer patients undergoing controlled ovarian hyperstimulation (COH) for embryo or oocyte cryopreservation should be induced by the method that leads to the least increase in estradiol (E(2)) levels...
  20. ncbi request reprint Embryo development after heterotopic transplantation of cryopreserved ovarian tissue
    Kutluk Oktay
    Center for Reproductive Medicine and Infertility, Joan and Sanford I Weill Medical College of Cornell University, 505 East 70th Street, HT 340, New York, NY 10021, USA
    Lancet 363:837-40. 2004
    ..One of the ways to possibly preserve fertility before these treatments is to cryopreserve ovarian tissue for later transplantation. We aimed to restore fertility by cryopreservation and transplantation of ovarian tissue...
  21. ncbi request reprint Letrozole reduces estrogen and gonadotropin exposure in women with breast cancer undergoing ovarian stimulation before chemotherapy
    Kutluk Oktay
    Fertility Preservation Program, Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, 505 East 70th Street, Suite HT300, New York, NY 10021, USA
    J Clin Endocrinol Metab 91:3885-90. 2006
    ..Women with breast cancer are not typically offered embryo or oocyte cryopreservation to preserve their fertility before chemotherapy because of the potential risks associated with high estrogen levels arising from ovarian stimulation...
  22. ncbi request reprint Fertility preservation in young women undergoing breast cancer therapy
    Murat Sonmezer
    Fertility Preservation Program, Center for Reproductive Medicine and Infertility, Department of Obstetrics and Gynecology, Joan and Sanford I Weill Medical College of Cornell University, New York, New York, USA
    Oncologist 11:422-34. 2006
    ..The benefit of ovarian protection by gonadotropin-releasing hormone analogues is unproven and unlikely, and thus this treatment should not be offered as the sole method of fertility preservation...
  23. ncbi request reprint An individualized approach to fertility preservation in women with cancer
    Kutluk Oktay
    Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Support Oncol 4:181-2, 184. 2006
  24. ncbi request reprint Letrozole for ovulation induction and fertility preservation by embryo cryopreservation in young women with endometrial carcinoma
    Amr Azim
    Fertility Preservation Program, Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, New York 10021, USA
    Fertil Steril 88:657-64. 2007
    ..To reduce estrogen exposure in women with endometrial cancer undergoing in vitro fertilization using an aromatase inhibitor...
  25. doi request reprint Impact of breast cancer chemotherapy on ovarian reserve: a prospective observational analysis by menstrual history and ovarian reserve markers
    Andrea Reh
    Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York Presbyterian Weill Cornell Medical Center, New York, New York 10021, USA
    Fertil Steril 90:1635-9. 2008
    ..To determine whether addition of taxanes to anthracycline and cyclophosphamide regimens impact ovarian function as assessed by menstrual history and ovarian reserve markers...
  26. ncbi request reprint Preservation of menstrual function in adolescent and young females
    Ozgur Oktem
    Department of Obstetrics and Gynecology, New York Medical College, Valhalla, New York, USA
    Ann N Y Acad Sci 1135:237-43. 2008
    ..In this review, we discuss and outline the current strategies and the future directions of fertility preservation and ovarian cryopreservation and transplantation in adolescents and young females...
  27. ncbi request reprint Fertility preservation in breast cancer patients: a prospective controlled comparison of ovarian stimulation with tamoxifen and letrozole for embryo cryopreservation
    Kutluk Oktay
    The Center for Reproductive Medicine and Infertility, Department of Obstetrics and Gynecology, Joan and Sanford I Weill Medical College of Cornell University, 505 E 70th St, HT 340, New York, NY 10021, USA
    J Clin Oncol 23:4347-53. 2005
    ..To develop safe ovarian stimulation methods to perform in vitro fertilization (IVF) in breast cancer patients who wish to preserve their fertility via embryo cryopreservation before chemotherapy...
  28. ncbi request reprint Fertility preservation: an emerging discipline in the care of young patients with cancer
    Kutluk Oktay
    Center for Reproductive Medicine and Infertility, Department of Obstetrics and Gynecology, Joan and Sanford I Weill Medical College of Cornell University, 505 East 70th Street, HT 340, New York, NY 10021, USA
    Lancet Oncol 6:192-3. 2005
  29. pmc Value of early referral to fertility preservation in young women with breast cancer
    Sanghoon Lee
    Institute for Fertility Preservation, New York Medical College Westchester Medical Center, Valhalla, NY 10595, USA
    J Clin Oncol 28:4683-6. 2010
    ..To determine whether early referral to reproductive specialists improves fertility preservation (FP) outcomes and reduces delay in adjuvant treatment in young women with breast cancer...
  30. ncbi request reprint Ovarian tissue banking for cancer patients: fertility preservation, not just ovarian cryopreservation
    Kutluk Oktay
    The Center for Reproductive Medicine and Infertility, Joan and Sanford I Weill Medical College of Cornell University, 505 East 70th Street, HT 340, New York, NY 10021, USA
    Hum Reprod 19:477-80. 2004
    ..Fertility preservation should be an integral part of improving the quality of life in cancer survivors; however, it is neither possible nor ethical to recommend the same recipe for every cancer patient...
  31. ncbi request reprint Preliminary experience with orthotopic and heterotopic transplantation of ovarian cortical strips
    Kutluk H Oktay
    Department of Reproductive Medicine, Joan and Sanford I Weill Medical College of Cornell University, New York, New York 10021, USA
    Semin Reprod Med 20:63-74. 2002
    ..Synchronization between the laboratory and the operating room will be detailed to provide guidance for clinicians who are contemplating ovarian transplantation with previously frozen ovarian tissue...
  32. ncbi request reprint Restoration of ovarian endocrine function by ovarian transplantation
    Munire Akar
    The Center for Reproductive Medicine and Infertility, Joan and Sanford I Weill Medical College of Cornell University, 505 East 70 th Street, HT 340, New York, New York 10021, USA
    Trends Endocrinol Metab 16:374-80. 2005
    ..As survival rates for young cancer patients improve, protection against iatrogenic infertility caused by chemotherapy or radiotherapy assumes a higher priority...
  33. ncbi request reprint Fertility preservation in female patients
    Murat Sonmezer
    Ankara University School of Medicine, Ankara, Turkey and The Center for Reproductive Medicine and Infertility, Department of Obstetrics and Gynecology, Joan and Sanford I Weill Medical College of Cornell University, New York, NY 10021, USA
    Hum Reprod Update 10:251-66. 2004
    ..All current, emerging, experimental as well as controversial approaches are reviewed. A comprehensive algorithm to manage fertility preservation through an individualized approach is presented...
  34. doi request reprint Correlation of triple repeats on the FMR1 (fragile X) gene to ovarian reserve: a new infertility test?
    Norbert Gleicher
    The Center for Human Reproduction, 21 East 69th Street, New York, NY 10021, USA
    Acta Obstet Gynecol Scand 88:1024-30. 2009
    ..To determine to what degree the number of triple Cytosine/Guanine/Guanine (CGG) repeats on the FMR1 (fragile X) gene correlate with specific ovarian reserve parameters, and potentially facilitate infertility diagnosis...
  35. ncbi request reprint Relevance of triple CGG repeats in the FMR1 gene to ovarian reserve
    Norbert Gleicher
    Center for Human Reproduction, New York, USA
    Reprod Biomed Online 19:385-90. 2009
    ..001). Approximately 29-30 CGG repeats appear reflective of normal ovarian reserve, with higher and lower counts denoting similar risks towards premature ovarian senescence...
  36. ncbi request reprint The potential of ovarian tissue transplant to preserve fertility
    Kutluk Oktay
    Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, 505 East 70th Street, HT 340, New York, NY10021, USA
    Expert Opin Biol Ther 2:361-70. 2002
    ..However, the major improvement in the efficiency of ovarian transplantation is anticipated to come from research exploring the revascularisation process...
  37. ncbi request reprint A technique for transplantation of ovarian cortical strips to the forearm
    Kutluk Oktay
    The Center for Reproductive Medicine and Infertility, Joan and Sanford I Weill Medical College of Cornell University, New York, New York 10021, USA
    Fertil Steril 80:193-8. 2003
    ..To describe a forearm heterotopic ovarian transplantation technique...
  38. ncbi request reprint Efficiency of oocyte cryopreservation: a meta-analysis
    Kutluk Oktay
    Fertility Preservation Program at Center for Reproductive Medicine and Infertility, New York, New York, USA
    Fertil Steril 86:70-80. 2006
    ..To determine the efficiency of oocyte cryopreservation relative to IVF with unfrozen oocytes...
  39. ncbi request reprint Ovarian tissue cryopreservation: benefits and risks
    Murat Sonmezer
    The Center for Reproductive Medicine and Infertility, The Weill Medical College of Cornell University, New York, NY 10021, USA
    Cell Tissue Res 322:125-32. 2005
    ..The objective of this manuscript is to review the indications, risks and benefits of ovarian tissue cryopreservation...
  40. doi request reprint Can the FMR1 (fragile X) gene serve as predictor of response to ovarian stimulation?
    Norbert Gleicher
    Center for Human Reproduction, 21 East 69th Street, New York, NY 10021, USA
    Reprod Sci 16:462-7. 2009
    ..03). This supports FMR1 testing as useful in fertility practice and suggests why response rates to increasing stimulation with gonadotropins may vary...
  41. ncbi request reprint Spontaneous conceptions and live birth after heterotopic ovarian transplantation: is there a germline stem cell connection?
    Kutluk Oktay
    Fertility Preservation Program, Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, NY 10021, USA
    Hum Reprod 21:1345-8. 2006
    ....
  42. ncbi request reprint Normal female phenotype and ovarian development despite the ovarian expression of the sex-determining region of Y chromosome (SRY) in a 46,XX/69,XXY diploid/triploid mosaic child conceived after in vitro fertilization-intracytoplasmic sperm injection
    Ozgur Oktem
    Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, 505 East 70th Street, Suite HT300, New York, New York 10021, USA
    J Clin Endocrinol Metab 92:1008-14. 2007
    ..All phenotypic females with diploid/triploid mosaic reported so far had 46,XX/69,XXX karyotype...
  43. ncbi request reprint Oocyte and ovarian tissue cryopreservation: indications, techniques, and applications
    Mousa Issa Shamonki
    Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, New York, USA
    Semin Reprod Med 23:266-76. 2005
    ..The objective of this manuscript is to review the basic aspects of oocyte and ovarian tissue cryopreservation, and to discuss the current and future applications of these technologies in fertility preservation...
  44. doi request reprint The ovary: anatomy and function throughout human life
    Ozgur Oktem
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, New York Medical College, Munger Pavilion Room 617, Valhalla, NY 10595, USA
    Ann N Y Acad Sci 1127:1-9. 2008
    ..Therefore, the objective of this review article is to provide brief and updated information on the molecular basis of the events that control gonadal development, germ cell formation, folliculogenesis, and ovulation...
  45. ncbi request reprint Ovarian transplantation in humans: indications, techniques and the risk of reseeding cancer
    Kutluk Oktay
    Center for Reproductive Medicine and Fertility, Weill Medical College, Cornell University, 505 E 70th Street, New York, NY 10021, USA
    Eur J Obstet Gynecol Reprod Biol 113:S45-7. 2004
    ..However, the major improvement in the efficiency of ovarian transplantation is anticipated to come from research exploring the revascularization process...
  46. doi request reprint Is the immunological noise of abnormal autoimmunity an independent risk factor for premature ovarian aging?
    Norbert Gleicher
    Center for Human Reproduction New York and the Foundation for Reproductive Medicine, New York, NY, USA
    Menopause 16:760-4. 2009
    ..To what degree milder forms of premature ovarian aging are also associated with these two etiologies is, however, unknown...
  47. ncbi request reprint Immunohistochemical analysis of tyrosine phosphorylation and AP-1 transcription factors c-Jun, Jun D, and Fos family during early ovarian follicle development in the mouse
    Kutluk H Oktay
    Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, New York 10021, USA
    Appl Immunohistochem Mol Morphol 12:364-9. 2004
    ..Collectively, these data indicate that phosphotyrosine signaling and AP-1 transcription factors are intimately involved in early stages of ovarian follicle growth...
  48. doi request reprint Do etiologies of premature ovarian aging (POA) mimic those of premature ovarian failure (POF)?
    Norbert Gleicher
    Center for Human Reproduction, 21 East 69th Street, New York, NY 10021, USA
    Hum Reprod 24:2395-400. 2009
    ..It is unknown whether etiologies differ between milder forms of premature ovarian senescence (the acronym given here 'premature ovarian aging, POA'), and premature ovarian failure (POF)...
  49. doi request reprint Current knowledge in the renewal capability of germ cells in the adult ovary
    Ozgur Oktem
    Laboratory of Molecular Reproduction and Fertility Preservation, Department of Obstetrics and Gynecology, New York Medical College, Valhalla, New York 10595, USA
    Birth Defects Res C Embryo Today 87:90-5. 2009
    ....
  50. ncbi request reprint A novel ovarian xenografting model to characterize the impact of chemotherapy agents on human primordial follicle reserve
    Ozgur Oktem
    Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Cancer Res 67:10159-62. 2007
    ..Human ovarian xenografting is a promising model to characterize the gonadotoxic effects of current and emerging cancer drugs without a need for lengthy clinical studies...
  51. doi request reprint Stem cells: a perspective on oocytes
    Ozgur Oktem
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, New York Medical College, Munger Pavilion Room 617, Valhalla, NY 10595, USA
    Ann N Y Acad Sci 1127:20-6. 2008
    ..We place special emphasis on studies that challenge the current dogma in reproductive biology that female mammals are born with a set number of nonrenewable germ cells in the ovary by showing germ cell renewal in the adult ovary...
  52. ncbi request reprint The role of extracellular matrix and activin-A in in vitro growth and survival of murine preantral follicles
    Ozgur Oktem
    Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, New York 10021, USA
    Reprod Sci 14:358-66. 2007
    ..These data may suggest that 3-dimensional culture with extracellular matrix and activin-A provides a better milieu for in vitro growth and survival of preantral follicles in immature mice...
  53. ncbi request reprint Focal adhesion kinase as a marker of malignant phenotype in breast and cervical carcinomas
    Maja H Oktay
    Department of Pathology, Montefiore Medical Center and Albert Einstein College of Medicine, New York, NY 10467, USA
    Hum Pathol 34:240-5. 2003
    ..We conclude that FAK overexpression is not restricted to invasive phenotype, but rather appears to be a marker for malignant transformation...
  54. ncbi request reprint Quantitative assessment of the impact of chemotherapy on ovarian follicle reserve and stromal function
    Ozgur Oktem
    Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Cancer 110:2222-9. 2007
    ..The aim was to quantify the impact of chemotherapy on primordial follicle reserve and stromal function in human ovary with a prospective controlled quantitative histologic and in vitro study...
  55. ncbi request reprint Regeneration of oocytes after chemotherapy: connecting the evidence from mouse to human
    Kutluk Oktay
    J Clin Oncol 25:3185-7. 2007
  56. ncbi request reprint Livebirth after cryopreserved ovarian tissue autotransplantation
    Kutluk Oktay
    Lancet 364:2091-2; author reply 2092-3. 2004
  57. ncbi request reprint Successful human ovarian autotransplantation to the upper arm
    Kutluk Oktay
    Cancer 103:1982-3; author reply 1983. 2005
  58. ncbi request reprint Fertility preservation in women undergoing cancer treatment
    Kutluk Oktay
    Lancet 363:1830. 2004
  59. ncbi request reprint Further evidence on the safety and success of ovarian stimulation with letrozole and tamoxifen in breast cancer patients undergoing in vitro fertilization to cryopreserve their embryos for fertility preservation
    Kutluk Oktay
    J Clin Oncol 23:3858-9. 2005
  60. ncbi request reprint Measuring the impact of chemotherapy on fertility in women with breast cancer
    Kutluk Oktay
    J Clin Oncol 24:4044-6. 2006
  61. pmc The expression of cyclin-dependent kinase inhibitors p15, p16, p21, and p27 during ovarian follicle growth initiation in the mouse
    Aykut Bayrak
    Department of Anatomy and Cell Biology, State University of New York Health Science Center, Brooklyn, NY, USA
    Reprod Biol Endocrinol 1:41. 2003
    ..Cyclins regulate the cell cycle in association with cyclin dependent kinases (CDKs). CDKs are under inhibitory control of cyclin dependent kinase inhibitors (CDKIs)...
  62. ncbi request reprint 'Ovarian cryopreservation versus ovarian suppression by GnRH analogues: primum non nocere': reply
    Kutluk Oktay
    Hum Reprod 19:1681-3. 2004
  63. ncbi request reprint Phenotypic features of 46, XX females with StAR protein mutations
    Amrit Bhangoo
    Pediatric Endocrinology Division of Infant s and Children s Hospital of Brooklyn at Maimonides, Brooklyn, NY 11219, USA
    Pediatr Endocrinol Rev 5:633-41. 2007
    ..The mechanism of the lesion in the ovary remains to be understood completely...
  64. ncbi request reprint Evidence for limiting ovarian tissue harvesting for the purpose of transplantation to women younger than 40 years of age
    Kutluk Oktay
    J Clin Endocrinol Metab 87:1907-8. 2002
  65. ncbi request reprint Ovarian cryopreservation with transposition of a contralateral ovary: a combined approach for fertility preservation in women receiving pelvic radiation
    J Ryan Martin
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Fertil Steril 87:189.e5-7. 2007
    ..To describe a technique of fertility preservation by ovarian transposition combined with ovarian cryopreservation in the setting of oncologic pelvic radiation for a reproductive age woman...
  66. ncbi request reprint American Society of Clinical Oncology recommendations on fertility preservation in cancer patients
    Stephanie J Lee
    Dana Farber Cancer Institute, Boston, MA, USA
    J Clin Oncol 24:2917-31. 2006
    ..To develop guidance to practicing oncologists about available fertility preservation methods and related issues in people treated for cancer...