Morihito Okada

Summary

Publications

  1. ncbi Evolution of surgical outcomes for nonsmall cell lung cancer: time trends in 1465 consecutive patients undergoing complete resection
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    Ann Thorac Surg 77:1926-30; discussion 1931. 2004
  2. doi Surgical treatment of clinical N1 non-small cell lung cancer: ongoing controversy over diagnosis and prognosis
    Kei Miyoshi
    Department of Thoracic Surgery, Hyogo Cancer Center for Adults, Akashi, Japan
    Surg Today 40:428-32. 2010
  3. ncbi Prognostic significance of perioperative serum carcinoembryonic antigen in non-small cell lung cancer: analysis of 1,000 consecutive resections for clinical stage I disease
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    Ann Thorac Surg 78:216-21. 2004
  4. ncbi Effect of histologic type and smoking status on interpretation of serum carcinoembryonic antigen value in non-small cell lung carcinoma
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    Ann Thorac Surg 78:1004-9; discussion 1009-10. 2004
  5. ncbi Novel marker D2-40, combined with calretinin, CEA, and TTF-1: an optimal set of immunodiagnostic markers for pleural mesothelioma
    Takeshi Mimura
    Department of Cardiothoracic Surgery, Kobe University Medical School, Kobe City, Hyogo, Japan
    Cancer 109:933-8. 2007
  6. ncbi Effect of tumor size on prognosis in patients with non-small cell lung cancer: the role of segmentectomy as a type of lesser resection
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Japan
    J Thorac Cardiovasc Surg 129:87-93. 2005
  7. ncbi Border between N1 and N2 stations in lung carcinoma: lessons from lymph node metastatic patterns of lower lobe tumors
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Japan
    J Thorac Cardiovasc Surg 129:825-30. 2005
  8. ncbi Long-term survival and prognostic factors of five-year survivors with complete resection of non-small cell lung carcinoma
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Kitaohji cho 13 70, Akashi City 673 5885, Hyogo, Japan
    J Thorac Cardiovasc Surg 126:558-62. 2003
  9. ncbi Pleomorphic carcinoma of the lung: a surgical outcome
    Tsuyoshi Yuki
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    J Thorac Cardiovasc Surg 134:399-404. 2007
  10. ncbi Selective mediastinal lymphadenectomy for clinico-surgical stage I non-small cell lung cancer
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    Ann Thorac Surg 81:1028-32. 2006

Collaborators

Detail Information

Publications40

  1. ncbi Evolution of surgical outcomes for nonsmall cell lung cancer: time trends in 1465 consecutive patients undergoing complete resection
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    Ann Thorac Surg 77:1926-30; discussion 1931. 2004
    ..We reviewed our experience to evaluate time trends of surgical outcomes in patients with nonsmall cell lung cancer...
  2. doi Surgical treatment of clinical N1 non-small cell lung cancer: ongoing controversy over diagnosis and prognosis
    Kei Miyoshi
    Department of Thoracic Surgery, Hyogo Cancer Center for Adults, Akashi, Japan
    Surg Today 40:428-32. 2010
    ..We conducted this study to evaluate the surgical results of cN1 disease and to attempt to clarify the delicate issues surrounding its diagnosis and prognosis...
  3. ncbi Prognostic significance of perioperative serum carcinoembryonic antigen in non-small cell lung cancer: analysis of 1,000 consecutive resections for clinical stage I disease
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    Ann Thorac Surg 78:216-21. 2004
    ..We evaluated perioperative CEA values with regard to surgical results in a large number of patients to clarify its merit...
  4. ncbi Effect of histologic type and smoking status on interpretation of serum carcinoembryonic antigen value in non-small cell lung carcinoma
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    Ann Thorac Surg 78:1004-9; discussion 1009-10. 2004
    ..This study was undertaken to determine whether the prognostic value of CEA differs according to histologic type in a large group of patients with clinical early-stage lung cancer, and how smoking influences its value...
  5. ncbi Novel marker D2-40, combined with calretinin, CEA, and TTF-1: an optimal set of immunodiagnostic markers for pleural mesothelioma
    Takeshi Mimura
    Department of Cardiothoracic Surgery, Kobe University Medical School, Kobe City, Hyogo, Japan
    Cancer 109:933-8. 2007
    ..The current study was designed to identify an immunodiagnostic panel for pleural mesothelioma...
  6. ncbi Effect of tumor size on prognosis in patients with non-small cell lung cancer: the role of segmentectomy as a type of lesser resection
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Japan
    J Thorac Cardiovasc Surg 129:87-93. 2005
    ..Therefore, we investigated the relationships between tumor dimension and clinical and follow-up data, as well as surgical procedure in particular...
  7. ncbi Border between N1 and N2 stations in lung carcinoma: lessons from lymph node metastatic patterns of lower lobe tumors
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Japan
    J Thorac Cardiovasc Surg 129:825-30. 2005
    ..We examined the spread pattern of lymph node metastases, investigated the prognosis according to the level of the involved nodes, and conclusively analyzed the border between N1 and N2 stations...
  8. ncbi Long-term survival and prognostic factors of five-year survivors with complete resection of non-small cell lung carcinoma
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Kitaohji cho 13 70, Akashi City 673 5885, Hyogo, Japan
    J Thorac Cardiovasc Surg 126:558-62. 2003
    ..We analyzed the long-term follow-up data on cancer-related death in 5-year survivors of complete resection of their non-small cell lung cancer and examined the prognostic factors having an impact on subsequent survival...
  9. ncbi Pleomorphic carcinoma of the lung: a surgical outcome
    Tsuyoshi Yuki
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    J Thorac Cardiovasc Surg 134:399-404. 2007
    ..Reported prognoses are heterogeneous, and optimal treatment remains undefined...
  10. ncbi Selective mediastinal lymphadenectomy for clinico-surgical stage I non-small cell lung cancer
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    Ann Thorac Surg 81:1028-32. 2006
    ..This study was designed to evaluate the possibility of lesser mediastinal dissection for early-stage lung cancer...
  11. ncbi Correlation between computed tomographic findings, bronchioloalveolar carcinoma component, and biologic behavior of small-sized lung adenocarcinomas
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Kitaohji cho 13 70, Akashi City 673 8558, Hyogo, Japan
    J Thorac Cardiovasc Surg 127:857-61. 2004
    ..In addition, we attempted to predict which patients were suitable for a lesser resection...
  12. ncbi [Current status and future direction of Japan's clinical trial for malignant pleural mesothelioma]
    Seiki Hasegawa
    Department of Thoracic Surgery, Hyogo College of Medicine, Mukogawa cho, Nishinomiya, Japan
    Nihon Eiseigaku Zasshi 66:558-61. 2011
    ..Primary endpoints are macroscopic complete resection rate by EPP and treatment-related mortality for trimodality therapy. The study was initiated in May 2008 and patient enrollment was finished in November 2010...
  13. ncbi Pleural lavage cytology in non-small cell lung cancer: lessons from 1000 consecutive resections
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    J Thorac Cardiovasc Surg 126:1911-5. 2003
    ..We therefore performed a large prospective trial of pleural lavage cytology to elucidate its importance...
  14. doi Prognostic role of positron emission tomography and high-resolution computed tomography in clinical stage IA lung adenocarcinoma
    Hirofumi Uehara
    Department of Thoracic Surgery, Cancer Institute Hospital, Tokyo, Japan
    Ann Thorac Surg 96:1958-65. 2013
    ....
  15. ncbi Resection of chest wall invasion in patients with non-small cell lung cancer
    Hidehito Matsuoka
    Department of Surgery, Hyogo Prefectural Kaibara Hospital, Kaibara, Hyogo, Japan
    Eur J Cardiothorac Surg 26:1200-4. 2004
    ..It is unsolved whether the depth of chest wall involvement or the type of resection (extrapleural or en bloc) affects long-term survival...
  16. ncbi Sleeve segmentectomy for non-small cell lung carcinoma
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    J Thorac Cardiovasc Surg 128:420-4. 2004
    ..We evaluated the efficiency of this atypical type of bronchoplasty...
  17. doi Value of integrated positron emission tomography revised using a phantom study to evaluate malignancy grade of lung adenocarcinoma: a multicenter study
    Haruhiko Nakayama
    Department of Thoracic Surgery, Kanagawa Cancer Center, Yokohama, Japan
    Cancer 116:3170-7. 2010
    ....
  18. ncbi A novel video-assisted anatomic segmentectomy technique: selective segmental inflation via bronchofiberoptic jet followed by cautery cutting
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    J Thorac Cardiovasc Surg 133:753-8. 2007
    ..We have generated a new technique that improves the identification of the intersegmental border and whose clinical utility we evaluate in this study...
  19. ncbi Discrepancy of computed tomographic image between lung and mediastinal windows as a prognostic implication in small lung adenocarcinoma
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Japan
    Ann Thorac Surg 76:1828-32; discussion 1832. 2003
    ..There have been no proven preoperative indicators for postoperative survival of patients with an adenocarcinoma, the incidence of which has been increasing lately...
  20. ncbi Associations among bronchioloalveolar carcinoma components, positron emission tomographic and computed tomographic findings, and malignant behavior in small lung adenocarcinomas
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    J Thorac Cardiovasc Surg 133:1448-54. 2007
    ....
  21. ncbi Hybrid surgical approach of video-assisted minithoracotomy for lung cancer: significance of direct visualization on quality of surgery
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Kitaohji cho13 70, Akashi City 673 8558, Hyogo, Japan
    Chest 128:2696-701. 2005
    ..The aim of this study is to evaluate the usefulness of hybrid VATS...
  22. ncbi Functional advantage after radical segmentectomy versus lobectomy for lung cancer
    Hiroaki Harada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi, Japan
    Ann Thorac Surg 80:2041-5. 2005
    ..The purpose of this study was to evaluate the degree of postoperative functional loss in patients undergoing segmentectomy or lobectomy for lung cancer...
  23. ncbi Bronchoplasty for bronchial carcinoid tumor without removing lung parenchyma
    Kazuya Uchino
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi, Japan
    Jpn J Thorac Cardiovasc Surg 54:345-7. 2006
    ..We performed bronchial resection with atypical bronchoplasty, which preserves lung parenchyma in cases of s-T1N0M0 disease. The patient has had no evidence of recurrence 7 years after surgery...
  24. ncbi Management of air leak after pulmonary resection
    Toshihiko Sakamoto
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi, Hyogo, Japan
    Jpn J Thorac Cardiovasc Surg 52:292-5. 2004
    ..We prospectively evaluated the efficacy of water seal in the management of air leak after pulmonary resection...
  25. doi A phase III randomized trial of lobectomy versus limited resection for small-sized peripheral non-small cell lung cancer (JCOG0802/WJOG4607L)
    Kenichi Nakamura
    Department of Thoracic Surgery, Kanagawa Cancer Center, 1 1 2, Nakao, Asahi ku, Yokohama 241 0815, Japan
    Jpn J Clin Oncol 40:271-4. 2010
    ..This study is one of the first intergroup studies in Japan between the Japan Clinical Oncology Group and the West Japan Oncology Group...
  26. ncbi Characteristics and prognosis of patients after resection of nonsmall cell lung carcinoma measuring 2 cm or less in greatest dimension
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    Cancer 98:535-41. 2003
    ..Therefore, in the current study, the authors analyzed the clinical characteristics of patients who underwent complete resection of these lung tumors, the follow-up data, and the significant prognostic factors...
  27. ncbi Radical sublobar resection for small-sized non-small cell lung cancer: a multicenter study
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    J Thorac Cardiovasc Surg 132:769-75. 2006
    ..We sought to compare sublobar resection (segmentectomy or wedge resection) with lobar resection to test which one is the appropriate procedure for such lesions...
  28. ncbi [Radical sublobar resection via hybrid video-assisted thoracic surgery (VATS) for small-sized non-small cell lung cancer]
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi, Japan
    Kyobu Geka 59:724-9. 2006
    ..The combination of sublobar resection and hybrid VATS might be an alternative as a much less invasive standard operation for patients with small peripheral lung cancers...
  29. ncbi Clinical implication and prognostic significance of the tumor suppressor TSLC1 gene detected in adenocarcinoma of the lung
    Kazuya Uchino
    Department of Cardiothoracic Surgery, Kobe University Medical School, Kobe, Hyogo, Japan
    Cancer 98:1002-7. 2003
    ..The current study was designed to evaluate whether the TSLC1 gene can serve as a target for the prognostic determination of patients with pulmonary adenocarcinoma...
  30. ncbi [Extended segmentectomy for small-sized peripheral CN0 non-small cell lung cancer]
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi, Japan
    Nihon Geka Gakkai Zasshi 106:395-9. 2005
    ..However, patient selection with intraoperative pathologic examination and accurate technique with wide lesion margins must be strictly adhered to...
  31. doi Radical sublobar resection for lung cancer
    Morihito Okada
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8553, Japan
    Gen Thorac Cardiovasc Surg 56:151-7. 2008
    ..A foundation is thus established for starting a new series of randomized controlled trials, which could bring about revolutionary changes to surgery for lung cancer in the era of early detection...
  32. ncbi A feasibility study of induction pemetrexed plus cisplatin followed by extrapleural pneumonectomy and postoperative hemithoracic radiation for malignant pleural mesothelioma
    Takeharu Yamanaka
    Division of Respiratory Medicine, Department of Internal Medicine, Hyogo College of Medicine, 1 1 Mukogawa, Nishinomiya, Hyogo, Japan
    Jpn J Clin Oncol 39:186-8. 2009
    ..Secondary endpoints include treatment completion rate, adverse events, response rate by chemotherapy and 2-year overall and relapse-free survival...
  33. ncbi Expression of the TSLC1 adhesion molecule in pulmonary epithelium and its down-regulation in pulmonary adenocarcinoma other than bronchioloalveolar carcinoma
    Akihiko Ito
    Department of Pathology, Osaka University Medical School, Suita, Osaka, Japan
    Lab Invest 83:1175-83. 2003
    ..Thus, the present results not only support the hypothesis that TSLC1 is a tumor suppressor of NSCLC but also suggest that preserved integrity of TSLC1 may contribute to less invasive phenotypes of lepidic growth tumor cells...
  34. doi A feasibility study of postoperative adjuvant therapy of carboplatin and weekly paclitaxel for completely resected non-small cell lung cancer
    Yoshinori Yamashita
    Department of Surgery, Hiroshima City Asa Hospital, Hiroshima, Japan
    J Thorac Oncol 3:612-6. 2008
    ..The purpose of the study was to test the feasibility of adjuvant chemotherapy with carboplatin and separate weekly paclitaxel after complete resection of pStage IB, II, IIIA NSCLC in a multicenter study...
  35. ncbi Radical surgery for malignant pleural mesothelioma: results and prognosis
    Morihito Okada
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima City, Hiroshima, 734 8553, Japan
    Interact Cardiovasc Thorac Surg 7:102-6. 2008
    ..Although P/D appears to be acceptable in early stages, we encourage EPP, en bloc resection without entering the pleural cavity with intent for curability, which provides oncologically complete resection of all disease...
  36. ncbi Increased expression of connexin 26 in the invasive component of lung squamous cell carcinoma: significant correlation with poor prognosis
    Akihiko Ito
    Department of Surgical Pathology, Kobe University Medical School, Kobe, Hyogo 650 0017, Japan
    Cancer Lett 234:239-48. 2006
    ..0338) and vascular invasion (P=0.0191) were independent, significant prognostic predictors. These results suggest that C x 26 may represent an essential effector for controlling the biological aggressiveness of lung SCC tumor...
  37. ncbi Complications and outcomes after pulmonary resection for cancer in patients 80 to 89 years of age
    Hidehito Matsuoka
    Department of Surgery, Hyogo Prefectural Kaibara Hospital, Kaibara 5208 1, Kaibara cho, Tanba city, Hyogo 669 3395, Japan
    Eur J Cardiothorac Surg 28:380-3. 2005
    ..Patients 80 years or older often present with potentially resectable cases of non-small cell lung cancer. Whether such patients should undergo surgical treatment is becoming increasingly important in this rapidly aging society...
  38. ncbi Dose-finding study of anti-CD25 antibody for targeting regulatory T cells in locoregional immunotherapy of malignant effusion
    Makoto Okawaki
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Kasumi 1 2 3, Minami hu, Hiroshima 734 8551, Japan
    Hiroshima J Med Sci 57:37-46. 2008
    ....
  39. pmc PKCbeta regulates ischemia/reperfusion injury in the lung
    Tomoyuki Fujita
    Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Clin Invest 113:1615-23. 2004
    ..These findings elucidate key roles for PKCbetaII activation in I/R by coordinated activation of MAPKs (ERK1/2, JNK) and Egr-1...
  40. ncbi Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activation suppresses ischemic induction of Egr-1 and its inflammatory gene targets
    Morihito Okada
    College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    FASEB J 16:1861-8. 2002
    ..These data reveal a new mechanism whereby PPAR-gamma activation may decrease tissue inflammation in response to an ischemic insult...