Morihito Okada

Summary

Publications

  1. ncbi request reprint Selective mediastinal lymphadenectomy for clinico-surgical stage I non-small cell lung cancer
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    Ann Thorac Surg 81:1028-32. 2006
  2. ncbi request reprint Hybrid surgical approach of video-assisted minithoracotomy for lung cancer: significance of direct visualization on quality of surgery
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Kitaohji cho13 70, Akashi City 673 8558, Hyogo, Japan
    Chest 128:2696-701. 2005
  3. ncbi request reprint Border between N1 and N2 stations in lung carcinoma: lessons from lymph node metastatic patterns of lower lobe tumors
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Japan
    J Thorac Cardiovasc Surg 129:825-30. 2005
  4. ncbi request reprint Effect of tumor size on prognosis in patients with non-small cell lung cancer: the role of segmentectomy as a type of lesser resection
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Japan
    J Thorac Cardiovasc Surg 129:87-93. 2005
  5. ncbi request reprint Sleeve segmentectomy for non-small cell lung carcinoma
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    J Thorac Cardiovasc Surg 128:420-4. 2004
  6. ncbi request reprint Effect of histologic type and smoking status on interpretation of serum carcinoembryonic antigen value in non-small cell lung carcinoma
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    Ann Thorac Surg 78:1004-9; discussion 1009-10. 2004
  7. ncbi request reprint Radical sublobar resection for small-sized non-small cell lung cancer: a multicenter study
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    J Thorac Cardiovasc Surg 132:769-75. 2006
  8. ncbi request reprint A novel video-assisted anatomic segmentectomy technique: selective segmental inflation via bronchofiberoptic jet followed by cautery cutting
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    J Thorac Cardiovasc Surg 133:753-8. 2007
  9. doi request reprint Radical sublobar resection for lung cancer
    Morihito Okada
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8553, Japan
    Gen Thorac Cardiovasc Surg 56:151-7. 2008
  10. ncbi request reprint Correlation between computed tomographic findings, bronchioloalveolar carcinoma component, and biologic behavior of small-sized lung adenocarcinomas
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Kitaohji cho 13 70, Akashi City 673 8558, Hyogo, Japan
    J Thorac Cardiovasc Surg 127:857-61. 2004

Detail Information

Publications89

  1. ncbi request reprint Selective mediastinal lymphadenectomy for clinico-surgical stage I non-small cell lung cancer
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    Ann Thorac Surg 81:1028-32. 2006
    ..This study was designed to evaluate the possibility of lesser mediastinal dissection for early-stage lung cancer...
  2. ncbi request reprint Hybrid surgical approach of video-assisted minithoracotomy for lung cancer: significance of direct visualization on quality of surgery
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Kitaohji cho13 70, Akashi City 673 8558, Hyogo, Japan
    Chest 128:2696-701. 2005
    ..The aim of this study is to evaluate the usefulness of hybrid VATS...
  3. ncbi request reprint Border between N1 and N2 stations in lung carcinoma: lessons from lymph node metastatic patterns of lower lobe tumors
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Japan
    J Thorac Cardiovasc Surg 129:825-30. 2005
    ..We examined the spread pattern of lymph node metastases, investigated the prognosis according to the level of the involved nodes, and conclusively analyzed the border between N1 and N2 stations...
  4. ncbi request reprint Effect of tumor size on prognosis in patients with non-small cell lung cancer: the role of segmentectomy as a type of lesser resection
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Japan
    J Thorac Cardiovasc Surg 129:87-93. 2005
    ..Therefore, we investigated the relationships between tumor dimension and clinical and follow-up data, as well as surgical procedure in particular...
  5. ncbi request reprint Sleeve segmentectomy for non-small cell lung carcinoma
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    J Thorac Cardiovasc Surg 128:420-4. 2004
    ..We evaluated the efficiency of this atypical type of bronchoplasty...
  6. ncbi request reprint Effect of histologic type and smoking status on interpretation of serum carcinoembryonic antigen value in non-small cell lung carcinoma
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    Ann Thorac Surg 78:1004-9; discussion 1009-10. 2004
    ..This study was undertaken to determine whether the prognostic value of CEA differs according to histologic type in a large group of patients with clinical early-stage lung cancer, and how smoking influences its value...
  7. ncbi request reprint Radical sublobar resection for small-sized non-small cell lung cancer: a multicenter study
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    J Thorac Cardiovasc Surg 132:769-75. 2006
    ..We sought to compare sublobar resection (segmentectomy or wedge resection) with lobar resection to test which one is the appropriate procedure for such lesions...
  8. ncbi request reprint A novel video-assisted anatomic segmentectomy technique: selective segmental inflation via bronchofiberoptic jet followed by cautery cutting
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    J Thorac Cardiovasc Surg 133:753-8. 2007
    ..We have generated a new technique that improves the identification of the intersegmental border and whose clinical utility we evaluate in this study...
  9. doi request reprint Radical sublobar resection for lung cancer
    Morihito Okada
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8553, Japan
    Gen Thorac Cardiovasc Surg 56:151-7. 2008
    ..A foundation is thus established for starting a new series of randomized controlled trials, which could bring about revolutionary changes to surgery for lung cancer in the era of early detection...
  10. ncbi request reprint Correlation between computed tomographic findings, bronchioloalveolar carcinoma component, and biologic behavior of small-sized lung adenocarcinomas
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Kitaohji cho 13 70, Akashi City 673 8558, Hyogo, Japan
    J Thorac Cardiovasc Surg 127:857-61. 2004
    ..In addition, we attempted to predict which patients were suitable for a lesser resection...
  11. ncbi request reprint Characteristics and prognosis of patients after resection of nonsmall cell lung carcinoma measuring 2 cm or less in greatest dimension
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    Cancer 98:535-41. 2003
    ..Therefore, in the current study, the authors analyzed the clinical characteristics of patients who underwent complete resection of these lung tumors, the follow-up data, and the significant prognostic factors...
  12. ncbi request reprint Associations among bronchioloalveolar carcinoma components, positron emission tomographic and computed tomographic findings, and malignant behavior in small lung adenocarcinomas
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    J Thorac Cardiovasc Surg 133:1448-54. 2007
    ....
  13. ncbi request reprint Discrepancy of computed tomographic image between lung and mediastinal windows as a prognostic implication in small lung adenocarcinoma
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Japan
    Ann Thorac Surg 76:1828-32; discussion 1832. 2003
    ..There have been no proven preoperative indicators for postoperative survival of patients with an adenocarcinoma, the incidence of which has been increasing lately...
  14. ncbi request reprint Pleural lavage cytology in non-small cell lung cancer: lessons from 1000 consecutive resections
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    J Thorac Cardiovasc Surg 126:1911-5. 2003
    ..We therefore performed a large prospective trial of pleural lavage cytology to elucidate its importance...
  15. doi request reprint Prediction of pathologic node-negative clinical stage IA lung adenocarcinoma for optimal candidates undergoing sublobar resection
    Yasuhiro Tsutani
    Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan
    J Thorac Cardiovasc Surg 144:1365-71. 2012
    ..Patients with pathologic node-negative early lung cancer may be optimal candidates for sublobar resection. We aimed to identify predictors of pathologic lymph node involvement in clinical stage IA lung adenocarcinoma...
  16. ncbi request reprint Sublobar resection for lung adenocarcinoma meeting node-negative criteria on preoperative imaging
    Yasuhiro Tsutani
    Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan
    Ann Thorac Surg 97:1701-7. 2014
    ..8 cm on high-resolution computed tomography or maximum standardized uptake value of less than 1.5 on [18F]-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography...
  17. doi request reprint Oncologic outcomes of segmentectomy compared with lobectomy for clinical stage IA lung adenocarcinoma: propensity score-matched analysis in a multicenter study
    Yasuhiro Tsutani
    Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan
    J Thorac Cardiovasc Surg 146:358-64. 2013
    ..Our objective was to compare the oncologic outcomes of lobectomy and segmentectomy for clinical stage IA lung adenocarcinoma...
  18. ncbi request reprint Role of lymphatic invasion in the prognosis of patients with clinical node-negative and pathologic node-positive lung adenocarcinoma
    Takahiro Mimae
    Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan
    J Thorac Cardiovasc Surg 147:1820-6. 2014
    ..Some patients with clinical T1 N0 M0 lung adenocarcinoma have pathologic lymph node metastasis. However, neither the precise prognosis nor the factors predictive of the prognosis of such patients have yet been identified...
  19. doi request reprint Prognostic significance of using solid versus whole tumor size on high-resolution computed tomography for predicting pathologic malignant grade of tumors in clinical stage IA lung adenocarcinoma: a multicenter study
    Yasuhiro Tsutani
    Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan
    J Thorac Cardiovasc Surg 143:607-12. 2012
    ....
  20. doi request reprint Esophageal bypass operation prior to definitive chemoradiotherapy in advanced esophageal cancer with tracheobronchial invasion
    Jun Hihara
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan Electronic address
    Ann Thorac Surg 97:290-5. 2014
    ..The aim of this study was to examine the clinical outcome of esophageal bypass surgery prior to chemoradiotherapy...
  21. doi request reprint The prognostic role of pathologic invasive component size, excluding lepidic growth, in stage I lung adenocarcinoma
    Yasuhiro Tsutani
    Department of Surgical Oncology, Hiroshima University, Hiroshima City, Hiroshima, Japan
    J Thorac Cardiovasc Surg 146:580-5. 2013
    ..We performed an investigation of the prognostic significance of the invasive component size, excluding lepidic growth, in lung adenocarcinoma patients...
  22. doi request reprint Surgical treatment of clinical N1 non-small cell lung cancer: ongoing controversy over diagnosis and prognosis
    Kei Miyoshi
    Department of Thoracic Surgery, Hyogo Cancer Center for Adults, Akashi, Japan
    Surg Today 40:428-32. 2010
    ..We conducted this study to evaluate the surgical results of cN1 disease and to attempt to clarify the delicate issues surrounding its diagnosis and prognosis...
  23. doi request reprint Involvement of homologous recombination in the synergism between cisplatin and poly (ADP-ribose) polymerase inhibition
    Kenji Sakogawa
    Department of Cellular Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
    Cancer Sci 104:1593-9. 2013
    ..Understanding these mechanisms could be useful for improving the clinical outcome of ESCC patients who suffer from aggressive disease that presently lacks effective treatment options. ..
  24. ncbi request reprint Targeting of CD4+CD25high cells while preserving CD4+CD25low cells with low-dose chimeric anti-CD25 antibody in adoptive immunotherapy of cancer
    Riki Okita
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734 8553, Japan
    Int J Oncol 34:563-72. 2009
    ..The host conditioning with low-dose basiliximab may augment the efficacy of AIT for cancer using activated autologous lymphocytes...
  25. pmc Leiomyosarcoma of the sigmoid colon with multiple liver metastases and gastric cancer: a case report
    Yoichi Hamai
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    BMC Gastroenterol 12:98. 2012
    ..Here, we present an unusual case of LMS of the sigmoid colon with liver metastases and gastric cancer. The survival of this patient was prolonged by a combined modality therapy involving chemotherapy and surgery...
  26. ncbi request reprint [A resected case of complete response after treatment with S-1 for recurrent squamous cell carcinoma component of the breast]
    Yoshie Kobayashi
    Dept of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University
    Gan To Kagaku Ryoho 39:1403-6. 2012
    ..No residual primary carcinoma foci was found in the resected specimen; therefore, the pathological diagnosis revealed complete response for the squamous cell carcinoma component...
  27. ncbi request reprint Prognostic significance of perioperative serum carcinoembryonic antigen in non-small cell lung cancer: analysis of 1,000 consecutive resections for clinical stage I disease
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    Ann Thorac Surg 78:216-21. 2004
    ..We evaluated perioperative CEA values with regard to surgical results in a large number of patients to clarify its merit...
  28. doi request reprint Multicenter analysis of high-resolution computed tomography and positron emission tomography/computed tomography findings to choose therapeutic strategies for clinical stage IA lung adenocarcinoma
    Morihito Okada
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Minami Ku, Hiroshima, Japan
    J Thorac Cardiovasc Surg 141:1384-91. 2011
    ....
  29. doi request reprint Difference in prognostic significance of maximum standardized uptake value on [18F]-fluoro-2-deoxyglucose positron emission tomography between adenocarcinoma and squamous cell carcinoma of the lung
    Yasuhiro Tsutani
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Jpn J Clin Oncol 41:890-6. 2011
    ..This study evaluates the prognostic significance of [18F]-fluoro-2-deoxyglucose positron emission tomography/computed tomography findings according to histological subtypes in patients with completely resected non-small cell lung cancer...
  30. ncbi request reprint Novel marker D2-40, combined with calretinin, CEA, and TTF-1: an optimal set of immunodiagnostic markers for pleural mesothelioma
    Takeshi Mimura
    Department of Cardiothoracic Surgery, Kobe University Medical School, Kobe City, Hyogo, Japan
    Cancer 109:933-8. 2007
    ..The current study was designed to identify an immunodiagnostic panel for pleural mesothelioma...
  31. doi request reprint Advanced esophageal cancer with an esophago-bronchial fistula successfully treated by chemoradiotherapy following esophageal bypass surgery: report of a case
    Yoshiro Aoki
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8551, Japan
    Surg Today 42:1088-90. 2012
    ....
  32. doi request reprint Non-small-cell lung cancer prognosis using carcinoembryonic antigen levels in pleural lavage fluid
    Yasuhiro Tsutani
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
    Eur J Cardiothorac Surg 42:e96-101. 2012
    ..The study aimed to evaluate the prognostic significance of carcinoembryonic antigen levels in pleural lavage fluid (p-CEA) in patients with completely resected non-small-cell lung cancer (NSCLC)...
  33. doi request reprint Prognostic role of positron emission tomography and high-resolution computed tomography in clinical stage IA lung adenocarcinoma
    Hirofumi Uehara
    Department of Thoracic Surgery, Cancer Institute Hospital, Tokyo, Japan
    Ann Thorac Surg 96:1958-65. 2013
    ....
  34. doi request reprint Laparoscopic thoracic duct clipping for persistent chylothorax after extrapleural pneumonectomy
    Norifumi Tsubokawa
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
    Ann Thorac Surg 93:e131-2. 2012
    ..A laparoscopic approach proved effective and resolved the chylothorax. Thus, laparoscopic thoracic duct clipping is considered very useful for treating chylothorax...
  35. ncbi request reprint Long-term survival and prognostic factors of five-year survivors with complete resection of non-small cell lung carcinoma
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Kitaohji cho 13 70, Akashi City 673 5885, Hyogo, Japan
    J Thorac Cardiovasc Surg 126:558-62. 2003
    ..We analyzed the long-term follow-up data on cancer-related death in 5-year survivors of complete resection of their non-small cell lung cancer and examined the prognostic factors having an impact on subsequent survival...
  36. ncbi request reprint [Adjuvant surgery for advanced gastric cancer]
    Junya Taomoto
    Dept of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University
    Gan To Kagaku Ryoho 37:263-6. 2010
    ..The purpose of this study was to evaluate the efficacy of(adjuvant)surgery following the response to chemotherapy for advanced gastric cancer...
  37. ncbi request reprint Role of FDG-PET/CT in evaluating surgical outcomes of operable breast cancer--usefulness for malignant grade of triple-negative breast cancer
    Masahiro Ohara
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima City, Hiroshima 734 0037, Japan
    Breast 22:958-63. 2013
    ..The aim of this study was to evaluate the significance of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) for speculating the malignant level and prognostic value of operable breast cancers...
  38. ncbi request reprint Treatment outcomes and prognostic factors for thoracic esophageal cancer with clinical evidence of adjacent organ invasion
    Yoichi Hamai
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Anticancer Res 33:3495-502. 2013
    ..We aimed to determine which prognostic factors are involved in the management of locally advanced esophageal cancer with adjacent organ invasion...
  39. doi request reprint Solid tumors versus mixed tumors with a ground-glass opacity component in patients with clinical stage IA lung adenocarcinoma: prognostic comparison using high-resolution computed tomography findings
    Yasuhiro Tsutani
    Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan
    J Thorac Cardiovasc Surg 146:17-23. 2013
    ..This study aimed to compare malignant behavior and prognosis between solid tumors and mixed tumors with a ground-glass opacity component on high-resolution computed tomography...
  40. ncbi request reprint Pleomorphic carcinoma of the lung: a surgical outcome
    Tsuyoshi Yuki
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    J Thorac Cardiovasc Surg 134:399-404. 2007
    ..Reported prognoses are heterogeneous, and optimal treatment remains undefined...
  41. doi request reprint Rapamycin enhances chemotherapy-induced cytotoxicity by inhibiting the expressions of TS and ERK in gastric cancer cells
    Hideo Shigematsu
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hirsoshima University, Japan
    Int J Cancer 126:2716-25. 2010
    ..These results strongly indicate that the mTOR inhibitor can enhance the potentiation of TXT and 5-Fu or S-1 and can serve as a new therapeutic tool for advanced and recurrent gastric cancer patients...
  42. ncbi request reprint Evolution of surgical outcomes for nonsmall cell lung cancer: time trends in 1465 consecutive patients undergoing complete resection
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
    Ann Thorac Surg 77:1926-30; discussion 1931. 2004
    ..We reviewed our experience to evaluate time trends of surgical outcomes in patients with nonsmall cell lung cancer...
  43. doi request reprint Technical feasibility and cosmetic advantage of hybrid endoscopy-assisted breast-conserving surgery for breast cancer patients
    Shinji Ozaki
    Department of Surgical Oncology Research, Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
    J Laparoendosc Adv Surg Tech A 23:91-9. 2013
    ..The purpose of this study was retrospectively to analyze the clinical outcome of hybrid EBCS and compare the cosmetic outcomes between hybrid EBCS and conventional breast-conserving surgery (CBCS)...
  44. doi request reprint Memorial Sloan-Kettering Cancer Center Nomogram to predict the risk of non-sentinel lymph node metastasis in Japanese breast cancer patients
    Tatsunari Sasada
    Division of Frontier Medical Science, Department of Surgery, Programs for Biomedical Research, Graduate School of Biomedical Science, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8551, Japan
    Surg Today 42:245-9. 2012
    ..Many validation studies have been performed to evaluate the accuracy of the nomogram in Western populations, but not in Asians. We conducted this study to establish the accuracy of the nomogram in a Japanese population...
  45. doi request reprint Neoadjuvant chemoradiotherapy with docetaxel, cisplatin, and 5-fluorouracil for esophageal cancer
    Manabu Emi
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Kasumi 1 2 3, Minami Ku, Hiroshima, 734 8553, Japan
    Cancer Chemother Pharmacol 69:1499-505. 2012
    ..We aimed to evaluate the safety, tolerability, and efficacy of combination preoperative chemoradiotherapy as first-line treatment in patients with advanced esophageal cancer...
  46. doi request reprint Fibrinogen/thrombin-based collagen fleece (TachoComb(R)) promotes regeneration in pulmonary arterial injury
    Takuhiro Ikeda
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
    Eur J Cardiothorac Surg 41:926-32. 2012
    ..The progression of vessel restoration with TC has not been elucidated. In this study, we investigate details of the healing process with TC after PA injury using a canine model...
  47. doi request reprint Suggestive synchronous triple squamous cell carcinoma of the lung in the same lobe
    Riki Okita
    Department of General Thoracic Surgery, Hiroshima University Hospital, Hiroshima, Japan
    Gen Thorac Cardiovasc Surg 58:427-30. 2010
    ..The analysis of epidermal growth factor receptor-tyrosine kinase mutations showed no mutation in each tumor. However, pathological findings and the positive rate of immunochemical reaction of p53 and Ki-67 were different in each tumor...
  48. ncbi request reprint Radical surgery for malignant pleural mesothelioma: results and prognosis
    Morihito Okada
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima City, Hiroshima, 734 8553, Japan
    Interact Cardiovasc Thorac Surg 7:102-6. 2008
    ..Although P/D appears to be acceptable in early stages, we encourage EPP, en bloc resection without entering the pleural cavity with intent for curability, which provides oncologically complete resection of all disease...
  49. ncbi request reprint [Current status and future direction of Japan's clinical trial for malignant pleural mesothelioma]
    Seiki Hasegawa
    Department of Thoracic Surgery, Hyogo College of Medicine, Mukogawa cho, Nishinomiya, Japan
    Nihon Eiseigaku Zasshi 66:558-61. 2011
    ..Primary endpoints are macroscopic complete resection rate by EPP and treatment-related mortality for trimodality therapy. The study was initiated in May 2008 and patient enrollment was finished in November 2010...
  50. pmc Increased ectodomain shedding of lung epithelial cell adhesion molecule 1 as a cause of increased alveolar cell apoptosis in emphysema
    Takahiro Mimae
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Thorax 69:223-31. 2014
    ..It generates two membrane associated C terminal fragments (CTFs), αCTF and βCTF, through protease mediated ectodomain shedding...
  51. doi request reprint Involvement of ribonucleotide reductase-M1 in 5-fluorouracil‑induced DNA damage in esophageal cancer cell lines
    Yoshiro Aoki
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Minami Ku, Hiroshima, Japan
    Int J Oncol 42:1951-60. 2013
    ..These results suggest that RRM-1 is involved not only in the induction of DNA damage by 5-FU but also in the synergistic cytotoxic effect in the combination therapy of 5-FU and CDDP...
  52. ncbi request reprint Airway stenting for tracheal obstruction due to lymph node metastasis of hepatocellular carcinoma
    Yoichi Hamai
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
    Anticancer Res 33:1761-4. 2013
    ..Tracheal obstruction in this patient was successfully treated by airway stenting...
  53. doi request reprint Upregulation of notch2 and six1 is associated with progression of early-stage lung adenocarcinoma and a more aggressive phenotype at advanced stages
    Takahiro Mimae
    Surgical Oncology, Division of Genome Radiobiology and Medicine, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Clin Cancer Res 18:945-55. 2012
    ..This study investigates how transcriptional aberrations in adenocarcinoma cells at the early stage define the clinical phenotypes of adenocarcinoma tumors at the advanced stage...
  54. pmc Radical hybrid video-assisted thoracic segmentectomy: long-term results of minimally invasive anatomical sublobar resection for treating lung cancer
    Morihito Okada
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan
    Interact Cardiovasc Thorac Surg 14:5-11. 2012
    ..The exact identification of anatomical intersegmental plane followed by dissection using electrocautery is critical from oncological and functional perspectives...
  55. doi request reprint Value of integrated positron emission tomography revised using a phantom study to evaluate malignancy grade of lung adenocarcinoma: a multicenter study
    Haruhiko Nakayama
    Department of Thoracic Surgery, Kanagawa Cancer Center, Yokohama, Japan
    Cancer 116:3170-7. 2010
    ....
  56. ncbi request reprint Decreased orotate phosphoribosyltransferase activity produces 5-fluorouracil resistance in a human gastric cancer cell line
    Yasuhiro Tsutani
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
    Oncol Rep 20:1545-51. 2008
    ..Further studies are now underway to identify genes related to crossresistance to these chemotherapeutic agents...
  57. ncbi request reprint Expression of orotate phosphoribosyltransferase in colorectal carcinoma: an immunohistochemical analysis in several components of neoplastic lesions
    Yuichi Sanada
    Department of Surgical Oncology, Research Institution for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
    Oncol Rep 20:1005-11. 2008
    ..1, 69.8, 88.2 and 88.8%, respectively. In addition, nuclear staining of OPRT was observed in metastatic lymph nodes and lymphovascularly invasive lesions. Our results suggest that OPRT is involved in the invasion and metastasis of CRC...
  58. doi request reprint Successful management of multiple esophagorespiratory fistulas using two types of stent: report of a case
    Yoichi Hamai
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8551, Japan
    Surg Today 41:560-2. 2011
    ..These secondary ERFs were subsequently closed using two silicone stents, together with one SEMS in the airway. This experience suggests that appropriate stenting can control multiple and large ERFs...
  59. ncbi request reprint Resection of chest wall invasion in patients with non-small cell lung cancer
    Hidehito Matsuoka
    Department of Surgery, Hyogo Prefectural Kaibara Hospital, Kaibara, Hyogo, Japan
    Eur J Cardiothorac Surg 26:1200-4. 2004
    ..It is unsolved whether the depth of chest wall involvement or the type of resection (extrapleural or en bloc) affects long-term survival...
  60. doi request reprint Use of high-resolution computed tomography and positron emission tomography/computed tomography in the management of stage IA adenocarcinoma
    Yoshihiro Miyata
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
    Semin Thorac Cardiovasc Surg 24:267-74. 2012
    ..The aim of present review was to evaluate high-resolution computed tomography and fluorodeoxyglucose-positron emission tomography/computed tomography as tools for management of clinical stage IA adenocarcinoma...
  61. doi request reprint Methylation of breast cancer susceptibility gene 1 (BRCA1) predicts recurrence in patients with curatively resected stage I non-small cell lung cancer
    Hiroaki Harada
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Cancer 119:792-8. 2013
    ..Molecular biomarkers that can predict the risk of recurrence thus need to be identified to improve clinical outcomes...
  62. doi request reprint Esophageal reconstruction using the terminal ileum and right colon in esophageal cancer surgery
    Yoichi Hamai
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8551, Japan
    Surg Today 42:342-50. 2012
    ..To evaluate the outcomes of colon interposition based on our surgical experience...
  63. ncbi request reprint Airway stenting for malignant respiratory complications in esophageal cancer
    Yoichi Hamai
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Anticancer Res 32:1785-90. 2012
    ..Airway stenting could play a role in the multidisciplinary management of advanced esophageal cancer...
  64. ncbi request reprint Functional advantage after radical segmentectomy versus lobectomy for lung cancer
    Hiroaki Harada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi, Japan
    Ann Thorac Surg 80:2041-5. 2005
    ..The purpose of this study was to evaluate the degree of postoperative functional loss in patients undergoing segmentectomy or lobectomy for lung cancer...
  65. ncbi request reprint Clinical implication and prognostic significance of the tumor suppressor TSLC1 gene detected in adenocarcinoma of the lung
    Kazuya Uchino
    Department of Cardiothoracic Surgery, Kobe University Medical School, Kobe, Hyogo, Japan
    Cancer 98:1002-7. 2003
    ..The current study was designed to evaluate whether the TSLC1 gene can serve as a target for the prognostic determination of patients with pulmonary adenocarcinoma...
  66. ncbi request reprint Bronchoplasty for bronchial carcinoid tumor without removing lung parenchyma
    Kazuya Uchino
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi, Japan
    Jpn J Thorac Cardiovasc Surg 54:345-7. 2006
    ..We performed bronchial resection with atypical bronchoplasty, which preserves lung parenchyma in cases of s-T1N0M0 disease. The patient has had no evidence of recurrence 7 years after surgery...
  67. ncbi request reprint A feasibility study of induction pemetrexed plus cisplatin followed by extrapleural pneumonectomy and postoperative hemithoracic radiation for malignant pleural mesothelioma
    Takeharu Yamanaka
    Division of Respiratory Medicine, Department of Internal Medicine, Hyogo College of Medicine, 1 1 Mukogawa, Nishinomiya, Hyogo, Japan
    Jpn J Clin Oncol 39:186-8. 2009
    ..Secondary endpoints include treatment completion rate, adverse events, response rate by chemotherapy and 2-year overall and relapse-free survival...
  68. doi request reprint Interferon (alpha, beta and omega) receptor 2 is a prognostic biomarker for lung cancer
    Sonosuke Tanaka
    Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Pathobiology 79:24-33. 2012
    ....
  69. ncbi request reprint Advanced esophageal cancer with situs inversus totalis successfully treated with chemoradiotherapy followed by esophagectomy: case report
    Yoshiro Aoki
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Hiroshima J Med Sci 60:21-4. 2011
    ..The patient has been followed up periodically on an outpatient basis and has remained free of recurrence for longer than 2 years 5 months after surgery...
  70. ncbi request reprint Management of air leak after pulmonary resection
    Toshihiko Sakamoto
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi, Hyogo, Japan
    Jpn J Thorac Cardiovasc Surg 52:292-5. 2004
    ..We prospectively evaluated the efficacy of water seal in the management of air leak after pulmonary resection...
  71. doi request reprint A phase III randomized trial of lobectomy versus limited resection for small-sized peripheral non-small cell lung cancer (JCOG0802/WJOG4607L)
    Kenichi Nakamura
    Department of Thoracic Surgery, Kanagawa Cancer Center, 1 1 2, Nakao, Asahi ku, Yokohama 241 0815, Japan
    Jpn J Clin Oncol 40:271-4. 2010
    ..This study is one of the first intergroup studies in Japan between the Japan Clinical Oncology Group and the West Japan Oncology Group...
  72. pmc A case of HER-2-positive recurrent breast cancer showing a clinically complete response to trastuzumab-containing chemotherapy after primary treatment of triple-negative breast cancer
    Hideo Shigematsu
    Department of Breast Surgery, Hiroshima University Hospital, Hiroshima, Japan
    World J Surg Oncol 9:146. 2011
    ..This report suggests the benefit of routine evaluation of HER-2 status in recurrent breast cancer with the introduction of HER-2-targeting agents...
  73. doi request reprint Dihydropyrimidine dehydrogenase and orotate phosphoribosyltransferase in esophageal cancer patients: Correlation with clinicopathological factors and prognosis
    Yasuhiro Tsutani
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
    Mol Med Report 1:713-9. 2008
    ..006, P=0.003, respectively). To conclude, in esophageal cancer DPD expression was associated with tumor progression and prognosis, and OPRT expression was correlated with carcinogenesis and tumor progression...
  74. ncbi request reprint [Radical sublobar resection via hybrid video-assisted thoracic surgery (VATS) for small-sized non-small cell lung cancer]
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi, Japan
    Kyobu Geka 59:724-9. 2006
    ..The combination of sublobar resection and hybrid VATS might be an alternative as a much less invasive standard operation for patients with small peripheral lung cancers...
  75. ncbi request reprint Induction of gamma delta T cells using zoledronate plus interleukin-2 in patients with metastatic cancer
    Ichiro Nagamine
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Kasumi 1 2 3, Minami Ku, Hiroshima 734 8553, Japan
    Hiroshima J Med Sci 58:37-44. 2009
    ..The use of zoledronate-activated killer (ZAK) cells should be encouraged in possible adoptive immunotherapy trials for patients with incurable cancer...
  76. doi request reprint A feasibility study of postoperative adjuvant therapy of carboplatin and weekly paclitaxel for completely resected non-small cell lung cancer
    Yoshinori Yamashita
    Department of Surgery, Hiroshima City Asa Hospital, Hiroshima, Japan
    J Thorac Oncol 3:612-6. 2008
    ..The purpose of the study was to test the feasibility of adjuvant chemotherapy with carboplatin and separate weekly paclitaxel after complete resection of pStage IB, II, IIIA NSCLC in a multicenter study...
  77. ncbi request reprint [Extended segmentectomy for small-sized peripheral CN0 non-small cell lung cancer]
    Morihito Okada
    Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi, Japan
    Nihon Geka Gakkai Zasshi 106:395-9. 2005
    ..However, patient selection with intraoperative pathologic examination and accurate technique with wide lesion margins must be strictly adhered to...
  78. doi request reprint Hybrid video-assisted thoracic surgery basilar (S9-10) segmentectomy
    Yoshihiro Miyata
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
    Semin Thorac Cardiovasc Surg 23:73-7. 2011
    ....
  79. doi request reprint Possible involvement of regulatory T cells in tumor onset and progression in primary breast cancer
    Masahiro Ohara
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Minami Ku, Hiroshima, Japan
    Cancer Immunol Immunother 58:441-7. 2009
    ..The FOXP3 mRNA expression and the other regulatory T cell-related molecules were investigated and compared with clinicopathological parameters in human primary breast cancer...
  80. doi request reprint Advantage of absorbable suture material for pulmonary artery ligation
    Takahiro Mimae
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan
    Gen Thorac Cardiovasc Surg 58:511-5. 2010
    ..The present study compares tissue reactions around sites of pulmonary arteries ligated with absorbable material (Vicryl) and with nonabsorbable material (silk)...
  81. ncbi request reprint Invasive ductal carcinoma of the pancreas showing exophytic growth
    Yuichi Sanada
    Department of Surgical Oncology, Research Institution for Radiation Biology and Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8551, Japan
    Hepatobiliary Pancreat Dis Int 8:97-102. 2009
    ..We aimed to identify the histological and immunohistochemical features in a rare case of pancreatic carcinoma showing exophytic growth...
  82. ncbi request reprint Dose-finding study of anti-CD25 antibody for targeting regulatory T cells in locoregional immunotherapy of malignant effusion
    Makoto Okawaki
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Kasumi 1 2 3, Minami hu, Hiroshima 734 8551, Japan
    Hiroshima J Med Sci 57:37-46. 2008
    ....
  83. doi request reprint Krebs von den Lungen-6 (KL-6) is a prognostic biomarker in patients with surgically resected nonsmall cell lung cancer
    Sonosuke Tanaka
    Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734 8551, Japan
    Int J Cancer 130:377-87. 2012
    ..041 and 0.023, respectively). Our data suggest that preoperative serum KL-6 level reflects KL-6 expression patterns in NSCLC tissue, and can serve as a useful prognostic biomarker in NSCLC patients who undergo curative surgery...
  84. doi request reprint Skin tube reconstruction for esophageal defect due to postoperative complication
    Yoichi Hamai
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
    Ann Thorac Surg 87:1605-7. 2009
    ..Four years after skin tube reconstruction, the patient remains free of cancer recurrence with good oral intake and has resumed routine activities. Thus, the skin tube is considered very useful for salvage esophageal reconstruction...
  85. ncbi request reprint Increased expression of connexin 26 in the invasive component of lung squamous cell carcinoma: significant correlation with poor prognosis
    Akihiko Ito
    Department of Surgical Pathology, Kobe University Medical School, Kobe, Hyogo 650 0017, Japan
    Cancer Lett 234:239-48. 2006
    ..0338) and vascular invasion (P=0.0191) were independent, significant prognostic predictors. These results suggest that C x 26 may represent an essential effector for controlling the biological aggressiveness of lung SCC tumor...
  86. ncbi request reprint Complications and outcomes after pulmonary resection for cancer in patients 80 to 89 years of age
    Hidehito Matsuoka
    Department of Surgery, Hyogo Prefectural Kaibara Hospital, Kaibara 5208 1, Kaibara cho, Tanba city, Hyogo 669 3395, Japan
    Eur J Cardiothorac Surg 28:380-3. 2005
    ..Patients 80 years or older often present with potentially resectable cases of non-small cell lung cancer. Whether such patients should undergo surgical treatment is becoming increasingly important in this rapidly aging society...
  87. ncbi request reprint Expression of the TSLC1 adhesion molecule in pulmonary epithelium and its down-regulation in pulmonary adenocarcinoma other than bronchioloalveolar carcinoma
    Akihiko Ito
    Department of Pathology, Osaka University Medical School, Suita, Osaka, Japan
    Lab Invest 83:1175-83. 2003
    ..Thus, the present results not only support the hypothesis that TSLC1 is a tumor suppressor of NSCLC but also suggest that preserved integrity of TSLC1 may contribute to less invasive phenotypes of lepidic growth tumor cells...
  88. pmc PKCbeta regulates ischemia/reperfusion injury in the lung
    Tomoyuki Fujita
    Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Clin Invest 113:1615-23. 2004
    ..These findings elucidate key roles for PKCbetaII activation in I/R by coordinated activation of MAPKs (ERK1/2, JNK) and Egr-1...
  89. ncbi request reprint Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activation suppresses ischemic induction of Egr-1 and its inflammatory gene targets
    Morihito Okada
    College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    FASEB J 16:1861-8. 2002
    ..These data reveal a new mechanism whereby PPAR-gamma activation may decrease tissue inflammation in response to an ischemic insult...