Laurence O'Dwyer

Summary

Publications

  1. pmc Reduced hippocampal volume in healthy young ApoE4 carriers: an MRI study
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    PLoS ONE 7:e48895. 2012
  2. pmc White matter differences between healthy young ApoE4 carriers and non-carriers identified with tractography and support vector machines
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    PLoS ONE 7:e36024. 2012
  3. pmc Sexual dimorphism in healthy aging and mild cognitive impairment: a DTI study
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    PLoS ONE 7:e37021. 2012
  4. pmc Using support vector machines with multiple indices of diffusion for automated classification of mild cognitive impairment
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    PLoS ONE 7:e32441. 2012
  5. doi request reprint Using diffusion tensor imaging and mixed-effects models to investigate primary and secondary white matter degeneration in Alzheimer's disease and mild cognitive impairment
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    J Alzheimers Dis 26:667-82. 2011
  6. pmc Multiple indices of diffusion identifies white matter damage in mild cognitive impairment and Alzheimer's disease
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    PLoS ONE 6:e21745. 2011
  7. doi request reprint Association of microstructural white matter abnormalities with cognitive dysfunction in geriatric patients with major depression
    Gilberto Sousa Alves
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    Psychiatry Res 203:194-200. 2012
  8. doi request reprint Association between white matter fiber integrity and subclinical psychotic symptoms in schizophrenia patients and unaffected relatives
    Christian Knöchel
    Laboratory of Neuroscience, Dept of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe Univ, Frankfurt Main, Germany
    Schizophr Res 140:129-35. 2012
  9. doi request reprint Patterns of autobiographical memory in bipolar disorder examined by psychometric and functional neuroimaging methods
    Viola Oertel-Knöchel
    Laboratory of Neuroscience, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt Main, Germany
    J Nerv Ment Dis 200:296-304. 2012
  10. pmc Different patterns of white matter degeneration using multiple diffusion indices and volumetric data in mild cognitive impairment and Alzheimer patients
    Gilberto Sousa Alves
    Alzheimer s Disease Center Institute of Psychiatry, Universidade Federal do Rio de Janeiro, Brazil
    PLoS ONE 7:e52859. 2012

Collaborators

Detail Information

Publications11

  1. pmc Reduced hippocampal volume in healthy young ApoE4 carriers: an MRI study
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    PLoS ONE 7:e48895. 2012
    ..Possession of the ApoE4 allele may lead to greater predilection for right hemisphere atrophy even in healthy young subjects in their twenties...
  2. pmc White matter differences between healthy young ApoE4 carriers and non-carriers identified with tractography and support vector machines
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    PLoS ONE 7:e36024. 2012
    ....
  3. pmc Sexual dimorphism in healthy aging and mild cognitive impairment: a DTI study
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    PLoS ONE 7:e37021. 2012
    ..Overall, these data suggest that the same degree of cognitive impairment is associated with greater structural damage in men compared with women...
  4. pmc Using support vector machines with multiple indices of diffusion for automated classification of mild cognitive impairment
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    PLoS ONE 7:e32441. 2012
    ..Such tools may be useful for large scale drug trials in Alzheimer's disease where the early identification of subjects with MCI is critical...
  5. doi request reprint Using diffusion tensor imaging and mixed-effects models to investigate primary and secondary white matter degeneration in Alzheimer's disease and mild cognitive impairment
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    J Alzheimers Dis 26:667-82. 2011
    ..A greater understanding of the pattern of WM changes in AD may prove useful for the early detection of AD...
  6. pmc Multiple indices of diffusion identifies white matter damage in mild cognitive impairment and Alzheimer's disease
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    PLoS ONE 6:e21745. 2011
    ..DA and MD indices were most sensitive at detecting early changes in MCIa...
  7. doi request reprint Association of microstructural white matter abnormalities with cognitive dysfunction in geriatric patients with major depression
    Gilberto Sousa Alves
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    Psychiatry Res 203:194-200. 2012
    ..Results provide additional evidence supporting the neuronal disconnection hypothesis in MDD and suggest that cognitive deficits are related to the loss of integrity in WM tracts associated with the disorder...
  8. doi request reprint Association between white matter fiber integrity and subclinical psychotic symptoms in schizophrenia patients and unaffected relatives
    Christian Knöchel
    Laboratory of Neuroscience, Dept of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe Univ, Frankfurt Main, Germany
    Schizophr Res 140:129-35. 2012
    ..Such endophenotypes may serve as quantitative traits for future genetic studies and as candidate markers for early and preclinical identification of subjects at risk...
  9. doi request reprint Patterns of autobiographical memory in bipolar disorder examined by psychometric and functional neuroimaging methods
    Viola Oertel-Knöchel
    Laboratory of Neuroscience, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt Main, Germany
    J Nerv Ment Dis 200:296-304. 2012
    ..More frequent intrusions from a person's past, which had a neural correlate in the lack of deactivation in some default mode network areas in BD patients, may contribute to manic or depressive symptoms...
  10. pmc Different patterns of white matter degeneration using multiple diffusion indices and volumetric data in mild cognitive impairment and Alzheimer patients
    Gilberto Sousa Alves
    Alzheimer s Disease Center Institute of Psychiatry, Universidade Federal do Rio de Janeiro, Brazil
    PLoS ONE 7:e52859. 2012
    ....
  11. doi request reprint Cognitive and behavioural effects of physical exercise in psychiatric patients
    Christian Knöchel
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Frankfurt Main, Heinrich Hoffmann Str 12, 60528 Frankfurt, Germany
    Prog Neurobiol 96:46-68. 2012
    ..Furthermore, exercise might have the potential to be a preventative treatment within the context of multi-modal therapeutic programs...