Elizabeth O'Day

Summary

Publications

  1. pmc MicroRNAs and their target gene networks in breast cancer
    Elizabeth O'Day
    Immune Disease Institute, Program in Cellular and Molecular Medicine, Children s Hospital Boston and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Breast Cancer Res 12:201. 2010
  2. pmc Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling
    Ashish Lal
    Immune Disease Institute, Program in Cellular and Molecular Medicine, Children s Hospital Boston, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1002363. 2011
  3. pmc HIV DNA is heavily uracilated, which protects it from autointegration
    Nan Yan
    Children s Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:9244-9. 2011
  4. pmc miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements
    Ashish Lal
    Immune Disease Institute, Children s Hospital Boston, Department of Pediatrics, Harvard Medical School, MA 02115, USA
    Mol Cell 35:610-25. 2009
  5. pmc miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells
    Ashish Lal
    Immune Disease Institute and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    Nat Struct Mol Biol 16:492-8. 2009
  6. pmc miR-200 enhances mouse breast cancer cell colonization to form distant metastases
    Derek M Dykxhoorn
    Department of Pediatrics, Immune Disease Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 4:e7181. 2009
  7. pmc Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression
    Mun Chun Chan
    Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA 02111, USA
    EMBO J 29:559-73. 2010
  8. doi Desperately seeking microRNA targets
    Marshall Thomas
    Immune Disease Institute and Program in Cellular and Molecular Medicine, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Nat Struct Mol Biol 17:1169-74. 2010

Collaborators

Detail Information

Publications8

  1. pmc MicroRNAs and their target gene networks in breast cancer
    Elizabeth O'Day
    Immune Disease Institute, Program in Cellular and Molecular Medicine, Children s Hospital Boston and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Breast Cancer Res 12:201. 2010
    ..Here we report how the observed perturbations in miRNA expression profiles may lead to disruption of key pathways involved in breast cancer...
  2. pmc Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling
    Ashish Lal
    Immune Disease Institute, Program in Cellular and Molecular Medicine, Children s Hospital Boston, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1002363. 2011
    ..Thus miR-34a tempers the proliferative and pro-survival effect of growth factor stimulation by interfering with growth factor signal transduction and downstream pathways required for cell division...
  3. pmc HIV DNA is heavily uracilated, which protects it from autointegration
    Nan Yan
    Children s Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:9244-9. 2011
    ..Thus, HIV tolerates, or even benefits from, nonmutagenic uracil incorporation during reverse transcription in human immune cells...
  4. pmc miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements
    Ashish Lal
    Immune Disease Institute, Children s Hospital Boston, Department of Pediatrics, Harvard Medical School, MA 02115, USA
    Mol Cell 35:610-25. 2009
    ..The E2F2 3'UTR lacks a predicted miR-24 recognition element. In fact, miR-24 regulates expression of E2F2, MYC, AURKB, CCNA2, CDC2, CDK4, and FEN1 by recognizing seedless but highly complementary sequences...
  5. pmc miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells
    Ashish Lal
    Immune Disease Institute and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    Nat Struct Mol Biol 16:492-8. 2009
    ..Therefore, miR-24 upregulation in postreplicative cells reduces H2AX and makes them vulnerable to DNA damage...
  6. pmc miR-200 enhances mouse breast cancer cell colonization to form distant metastases
    Derek M Dykxhoorn
    Department of Pediatrics, Immune Disease Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 4:e7181. 2009
    ..Because some miRNAs are dysregulated in cancer and affect cellular transformation, tumor formation, and metastasis, we examined whether changes in miRNA expression might explain the differences in metastasis of these cells...
  7. pmc Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression
    Mun Chun Chan
    Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA 02111, USA
    EMBO J 29:559-73. 2010
    ..Thus, this study provides a molecular basis for the antagonism between the PDGF and TGFbeta pathways, and its effect on the control of the vSMC phenotype...
  8. doi Desperately seeking microRNA targets
    Marshall Thomas
    Immune Disease Institute and Program in Cellular and Molecular Medicine, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Nat Struct Mol Biol 17:1169-74. 2010
    ..Bioinformatic analysis of over-represented pathways and nodes in protein-DNA interactomes formed from experimental candidate miRNA gene target lists can focus attention on biologically significant target genes...