Lisa O'Brien

Summary

Publications

  1. doi request reprint Changes in antidepressant metabolism in pregnancy evidenced by metabolic ratios in hair: a novel approach
    Lisa O'Brien
    Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada
    Forensic Sci Int 196:93-6. 2010
  2. doi request reprint Hair as a novel noninvasive method to study the impact of pregnancy on CYP2D6 metabolizing capacity
    Lisa O'Brien
    Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada
    Ther Drug Monit 31:531-2. 2009
  3. ncbi request reprint Estimating the economic costs of antidepressant discontinuation during pregnancy
    Lisa O'Brien
    Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario
    Can J Psychiatry 54:399-408. 2009
  4. ncbi request reprint Topical 4% amethocaine gel reduces the pain of subcutaneous measles-mumps-rubella vaccination
    Lisa O'Brien
    Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatrics 114:e720-4. 2004
  5. doi request reprint The safety of quinolones--a meta-analysis of pregnancy outcomes
    Benjamin Bar-Oz
    The Motherisk Program, Hospital for Sick Children, Toronto, Canada
    Eur J Obstet Gynecol Reprod Biol 143:75-8. 2009
  6. ncbi request reprint A critical review of the topical local anesthetic amethocaine (Ametop) for pediatric pain
    Lisa O'Brien
    Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada
    Paediatr Drugs 7:41-54. 2005
  7. doi request reprint The safety of proton pump inhibitors (PPIs) in pregnancy: a meta-analysis
    Simerpal K Gill
    The Motherisk Program, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    Am J Gastroenterol 104:1541-5; quiz 1540, 1546. 2009
  8. doi request reprint The safety of histamine 2 (H2) blockers in pregnancy: a meta-analysis
    Simerpal Kaur Gill
    The Motherisk Program, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Dig Dis Sci 54:1835-8. 2009
  9. ncbi request reprint Paroxetine and congenital malformations: meta-Analysis and consideration of potential confounding factors
    Benjamin Bar-Oz
    Motherisk Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    Clin Ther 29:918-26. 2007
  10. doi request reprint Reliability and validity of observer ratings of pain using the visual analog scale (VAS) in infants undergoing immunization injections
    Anna Taddio
    Leslie Dan Faculty of Pharmacy, University of Toronto, and Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ont, Canada
    Pain 147:141-6. 2009

Collaborators

Detail Information

Publications10

  1. doi request reprint Changes in antidepressant metabolism in pregnancy evidenced by metabolic ratios in hair: a novel approach
    Lisa O'Brien
    Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada
    Forensic Sci Int 196:93-6. 2010
    ..Human hair offers a safe, non-invasive way to monitor long term systemic exposures to medications...
  2. doi request reprint Hair as a novel noninvasive method to study the impact of pregnancy on CYP2D6 metabolizing capacity
    Lisa O'Brien
    Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada
    Ther Drug Monit 31:531-2. 2009
    ..A novel method is described to investigate changes in the drug metabolizing capacity of CYP2D6 during pregnancy using hair analysis...
  3. ncbi request reprint Estimating the economic costs of antidepressant discontinuation during pregnancy
    Lisa O'Brien
    Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario
    Can J Psychiatry 54:399-408. 2009
    ..Our study sought to determine the direct medical costs incurred by the Ontario government owing to cessation of antidepressant therapy during pregnancy...
  4. ncbi request reprint Topical 4% amethocaine gel reduces the pain of subcutaneous measles-mumps-rubella vaccination
    Lisa O'Brien
    Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatrics 114:e720-4. 2004
    ..The objective of this study was to assess the efficacy and safety of 4% amethocaine in reducing the pain of subcutaneous measles-mumps-rubella vaccination in 1-year-old infants...
  5. doi request reprint The safety of quinolones--a meta-analysis of pregnancy outcomes
    Benjamin Bar-Oz
    The Motherisk Program, Hospital for Sick Children, Toronto, Canada
    Eur J Obstet Gynecol Reprod Biol 143:75-8. 2009
    ..We conducted a meta-analysis of all published data in order to evaluate the risk for birth defects, stillbirths, preterm births and low birth weight following exposure to quinolones in the first trimester of pregnancy...
  6. ncbi request reprint A critical review of the topical local anesthetic amethocaine (Ametop) for pediatric pain
    Lisa O'Brien
    Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada
    Paediatr Drugs 7:41-54. 2005
    ....
  7. doi request reprint The safety of proton pump inhibitors (PPIs) in pregnancy: a meta-analysis
    Simerpal K Gill
    The Motherisk Program, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    Am J Gastroenterol 104:1541-5; quiz 1540, 1546. 2009
    ..The aim of this study is to determine the fetal safety of PPIs during early pregnancy through systematic literature review...
  8. doi request reprint The safety of histamine 2 (H2) blockers in pregnancy: a meta-analysis
    Simerpal Kaur Gill
    The Motherisk Program, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Dig Dis Sci 54:1835-8. 2009
    ..62 [0.36-1.05], 1.17 [0.94, 1.147], and 0.28 [0.06, 1.22], respectively. H2 blockers can be used safely in pregnancy...
  9. ncbi request reprint Paroxetine and congenital malformations: meta-Analysis and consideration of potential confounding factors
    Benjamin Bar-Oz
    Motherisk Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    Clin Ther 29:918-26. 2007
    ..Antidepressants have been commonly used by women of childbearing age. Recent studies suggest that paroxetine, a selective serotonin reuptake inhibitor (SSRI), might specifically increase teratogenic risk...
  10. doi request reprint Reliability and validity of observer ratings of pain using the visual analog scale (VAS) in infants undergoing immunization injections
    Anna Taddio
    Leslie Dan Faculty of Pharmacy, University of Toronto, and Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ont, Canada
    Pain 147:141-6. 2009
    ..However, different conclusions may be reached about the effectiveness of analgesic interventions depending on the rater. Sources of variability include use of multiple raters, rater focus (procedure vs. child) and experience level...