Estimating the economic costs of antidepressant discontinuation during pregnancyLisa O'Brien
Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario
Can J Psychiatry 54:399-408. 2009
..Our study sought to determine the direct medical costs incurred by the Ontario government owing to cessation of antidepressant therapy during pregnancy...
Hair as a novel noninvasive method to study the impact of pregnancy on CYP2D6 metabolizing capacityLisa O'Brien
Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada
Ther Drug Monit 31:531-2. 2009
..A novel method is described to investigate changes in the drug metabolizing capacity of CYP2D6 during pregnancy using hair analysis...
- Changes in antidepressant metabolism in pregnancy evidenced by metabolic ratios in hair: a novel approach
Lisa O'Brien
Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada
Forensic Sci Int 196:93-6. 2010
..Human hair offers a safe, non-invasive way to monitor long term systemic exposures to medications...
- The safety of quinolones--a meta-analysis of pregnancy outcomes
Benjamin Bar-Oz
The Motherisk Program, Hospital for Sick Children, Toronto, Canada
Eur J Obstet Gynecol Reprod Biol 143:75-8. 2009
..We conducted a meta-analysis of all published data in order to evaluate the risk for birth defects, stillbirths, preterm births and low birth weight following exposure to quinolones in the first trimester of pregnancy...
- The safety of proton pump inhibitors (PPIs) in pregnancy: a meta-analysis
Simerpal K Gill
The Motherisk Program, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
Am J Gastroenterol 104:1541-5; quiz 1540, 1546. 2009
..The aim of this study is to determine the fetal safety of PPIs during early pregnancy through systematic literature review...
- The safety of histamine 2 (H2) blockers in pregnancy: a meta-analysis
Simerpal Kaur Gill
The Motherisk Program, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
Dig Dis Sci 54:1835-8. 2009
..62 [0.36-1.05], 1.17 [0.94, 1.147], and 0.28 [0.06, 1.22], respectively. H2 blockers can be used safely in pregnancy...
- Reliability and validity of observer ratings of pain using the visual analog scale (VAS) in infants undergoing immunization injections
Anna Taddio
Leslie Dan Faculty of Pharmacy, University of Toronto, and Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ont, Canada
Pain 147:141-6. 2009
..However, different conclusions may be reached about the effectiveness of analgesic interventions depending on the rater. Sources of variability include use of multiple raters, rater focus (procedure vs. child) and experience level...
