Daniel P O'Brien

Summary

Publications

  1. ncbi request reprint In resource-limited settings good early outcomes can be achieved in children using adult fixed-dose combination antiretroviral therapy
    Daniel P O'Brien
    AIDS Working Group, Medecins Sans Frontieres, Plantage Middenlaan 14, 1001 EA Amsterdam, The Netherlands
    AIDS 20:1955-60. 2006
  2. ncbi request reprint Treatment outcomes stratified by baseline immunological status among young children receiving nonnucleoside reverse-transcriptase inhibitor-based antiretroviral therapy in resource-limited settings
    Daniel P O'Brien
    AIDS Working Group, Medecins Sans Frontieres, Paris, France
    Clin Infect Dis 44:1245-8. 2007
  3. pmc Incidence of WHO stage 3 and 4 conditions following initiation of anti-retroviral therapy in resource limited settings
    Andrea J Curtis
    Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
    PLoS ONE 7:e52019. 2012
  4. ncbi request reprint The urgent need for clinical, diagnostic, and operational research for management of Buruli ulcer in Africa
    Daniel P O'Brien
    Manson Unit, Medecins Sans Frontieres, London, UK Department of Infectious Diseases, Geelong Hospital, Geelong, Vic, Australia Department of Medicine and Infectious Diseases, Royal Melbourne Hospital, University of Melbourne, Melbourne, Vic, Australia Electronic address
    Lancet Infect Dis 14:435-40. 2014
  5. pmc Incidence, clinical spectrum, diagnostic features, treatment and predictors of paradoxical reactions during antibiotic treatment of Mycobacterium ulcerans infections
    Daniel P O'Brien
    Department of Infectious Diseases, Barwon Health, Geelong, Australia
    BMC Infect Dis 13:416. 2013
  6. pmc Successful outcomes with oral fluoroquinolones combined with rifampicin in the treatment of Mycobacterium ulcerans: an observational cohort study
    Daniel P O'Brien
    Department of Infectious Diseases, Barwon Health, Geelong, Australia
    PLoS Negl Trop Dis 6:e1473. 2012
  7. ncbi request reprint "Paradoxical" immune-mediated reactions to Mycobacterium ulcerans during antibiotic treatment: a result of treatment success, not failure
    Daniel P O'Brien
    Barwon Health, Geelong, Vic, Australia
    Med J Aust 191:564-6. 2009
  8. ncbi request reprint Outcomes for Mycobacterium ulcerans infection with combined surgery and antibiotic therapy: findings from a south-eastern Australian case series
    Daniel P O'Brien
    Barwon Health, Geelong, Victoria, Australia
    Med J Aust 186:58-61. 2007
  9. pmc Provision of antiretroviral treatment in conflict settings: the experience of Médecins Sans Frontières
    Daniel P O'Brien
    Public Health Department, Medecins Sans Frontieres, Amsterdam, Netherlands
    Confl Health 4:12. 2010
  10. doi request reprint Antiretroviral therapy outcomes in resource-limited settings for HIV-infected children <5 years of age
    Delphine Sauvageot
    Epicentre, Paris, France
    Pediatrics 125:e1039-47. 2010

Collaborators

Detail Information

Publications35

  1. ncbi request reprint In resource-limited settings good early outcomes can be achieved in children using adult fixed-dose combination antiretroviral therapy
    Daniel P O'Brien
    AIDS Working Group, Medecins Sans Frontieres, Plantage Middenlaan 14, 1001 EA Amsterdam, The Netherlands
    AIDS 20:1955-60. 2006
    ..To (a) determine early treatment outcomes and (b) assess safety in children treated with adult fixed-dose combination (FDC) antiretroviral tablets...
  2. ncbi request reprint Treatment outcomes stratified by baseline immunological status among young children receiving nonnucleoside reverse-transcriptase inhibitor-based antiretroviral therapy in resource-limited settings
    Daniel P O'Brien
    AIDS Working Group, Medecins Sans Frontieres, Paris, France
    Clin Infect Dis 44:1245-8. 2007
    ..86-0.92), with no significant difference among children stratified on the basis of baseline immunological levels; 62% attained a CD4 cell percentage >25%, and 7% continued to have a CD4 cell percentage <15%...
  3. pmc Incidence of WHO stage 3 and 4 conditions following initiation of anti-retroviral therapy in resource limited settings
    Andrea J Curtis
    Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
    PLoS ONE 7:e52019. 2012
    ..To determine the incidence of WHO clinical stage 3 and 4 conditions during early anti-retroviral therapy (ART) in resource limited settings (RLS)...
  4. ncbi request reprint The urgent need for clinical, diagnostic, and operational research for management of Buruli ulcer in Africa
    Daniel P O'Brien
    Manson Unit, Medecins Sans Frontieres, London, UK Department of Infectious Diseases, Geelong Hospital, Geelong, Vic, Australia Department of Medicine and Infectious Diseases, Royal Melbourne Hospital, University of Melbourne, Melbourne, Vic, Australia Electronic address
    Lancet Infect Dis 14:435-40. 2014
    ..A critical next step is to build consensus for a research agenda with WHO and relevant groups experienced in Buruli ulcer care or related diseases, and we call on on them to help to turn this agenda into reality. ..
  5. pmc Incidence, clinical spectrum, diagnostic features, treatment and predictors of paradoxical reactions during antibiotic treatment of Mycobacterium ulcerans infections
    Daniel P O'Brien
    Department of Infectious Diseases, Barwon Health, Geelong, Australia
    BMC Infect Dis 13:416. 2013
    ..Data is lacking regarding their incidence, clinical and diagnostic features, treatment, outcomes and risk factors in an Australian population...
  6. pmc Successful outcomes with oral fluoroquinolones combined with rifampicin in the treatment of Mycobacterium ulcerans: an observational cohort study
    Daniel P O'Brien
    Department of Infectious Diseases, Barwon Health, Geelong, Australia
    PLoS Negl Trop Dis 6:e1473. 2012
    ..We describe outcomes and tolerability of fluoroquinolone-containing antibiotic regimens for Mycobacterium ulcerans in south-eastern Australia...
  7. ncbi request reprint "Paradoxical" immune-mediated reactions to Mycobacterium ulcerans during antibiotic treatment: a result of treatment success, not failure
    Daniel P O'Brien
    Barwon Health, Geelong, Vic, Australia
    Med J Aust 191:564-6. 2009
    ..Recognition of this phenomenon could prevent unnecessary changes to antibiotic regimens, and might obviate the need for, or reduce the extent of, further surgery...
  8. ncbi request reprint Outcomes for Mycobacterium ulcerans infection with combined surgery and antibiotic therapy: findings from a south-eastern Australian case series
    Daniel P O'Brien
    Barwon Health, Geelong, Victoria, Australia
    Med J Aust 186:58-61. 2007
    ..To describe the effect of antibiotics on outcomes of treatment for Buruli or Bairnsdale ulcer (BU) in patients on the Bellarine Peninsula in south-eastern Australia...
  9. pmc Provision of antiretroviral treatment in conflict settings: the experience of Médecins Sans Frontières
    Daniel P O'Brien
    Public Health Department, Medecins Sans Frontieres, Amsterdam, Netherlands
    Confl Health 4:12. 2010
    ..Universal access to HIV care cannot be achieved unless the needs of populations in conflict-affected areas are addressed...
  10. doi request reprint Antiretroviral therapy outcomes in resource-limited settings for HIV-infected children <5 years of age
    Delphine Sauvageot
    Epicentre, Paris, France
    Pediatrics 125:e1039-47. 2010
    ..We describe medium-term outcomes for young children receiving antiretroviral therapy (ART) in resource-limited countries...
  11. pmc Impact of HIV-associated conditions on mortality in people commencing anti-retroviral therapy in resource limited settings
    Catherine S Marshall
    Infectious Diseases Unit, Alfred Hospital, Melbourne, Australia
    PLoS ONE 8:e68445. 2013
    ..To identify associations between specific WHO stage 3 and 4 conditions diagnosed after ART initiation and all cause mortality for patients in resource-limited settings (RLS)...
  12. pmc Mycobacterium ulcerans disease: experience with primary oral medical therapy in an Australian cohort
    N Deborah Friedman
    Department of Infectious Diseases, Barwon Health, Geelong, Australia
    PLoS Negl Trop Dis 7:e2315. 2013
    ..Antibiotics have been shown to be highly effective in sterilizing lesions and preventing disease recurrences when used alone or in combination with surgery. Our practice has evolved to using primarily oral medical therapy...
  13. ncbi request reprint Treatment and prevention of Mycobacterium ulcerans infection (Buruli ulcer) in Australia: guideline update
    Daniel P O'Brien
    Barwon Health, Geelong, Vic, Australia
    Med J Aust 200:267-70. 2014
    ....
  14. ncbi request reprint Risk factors for recurrent Mycobacterium ulcerans disease after exclusive surgical treatment in an Australian cohort
    Daniel P O'Brien
    Barwon Health, Geelong, Vic, Australia
    Med J Aust 198:436-9. 2013
    ..To describe risk factors for recurrence after exclusive surgical treatment of Mycobacterium ulcerans infection...
  15. ncbi request reprint Epidemiology, clinical features and diagnosis of Mycobacterium ulcerans in an Australian population
    Sarah C Boyd
    Barwon Health, Geelong, Vic, Australia
    Med J Aust 196:341-4. 2012
    ..To describe the epidemiology, clinical features and diagnosis of Mycobacterium ulcerans infection occurring on the Bellarine Peninsula in Victoria...
  16. pmc HIV treatment in a conflict setting: outcomes and experiences from Bukavu, Democratic Republic of the Congo
    Heather Culbert
    Medecins Sans Frontieres Holland, Amsterdam, The Netherlands
    PLoS Med 4:e129. 2007
  17. pmc Viral load testing in a resource-limited setting: quality control is critical
    Jane Greig
    Manson Unit, Medecins Sans Frontieres, London, UK
    J Int AIDS Soc 14:23. 2011
    ..We describe the issues encountered by Médecins Sans Frontières (MSF) when using routine viral load testing in a large HIV programme in sub-Saharan Africa...
  18. ncbi request reprint Association between older age and adverse outcomes on antiretroviral therapy: a cohort analysis of programme data from nine countries
    Jane Greig
    Medecins Sans Frontieres, London, UK
    AIDS 26:S31-7. 2012
    ..We report on the associations between older age and adverse outcomes in HIV/AIDS antiretroviral programmes across 17 programmes in sub-Saharan Africa...
  19. doi request reprint Similar mortality and reduced loss to follow-up in integrated compared with vertical programs providing antiretroviral treatment in sub-saharan Africa
    Jane Greig
    Manson Unit, Medecins Sans Frontieres, Saffron Hill, London, UK
    J Acquir Immune Defic Syndr 59:e92-8. 2012
    ..We analyzed the survival probability among patients receiving antiretroviral therapy (ART) from 2003 to 2010 in integrated versus vertical programs in 9 countries in sub-Saharan Africa...
  20. pmc Predictors of raised viral load during antiretroviral therapy in patients with and without prior antiretroviral use: a cross-sectional study
    Jane E Greig
    Manson Unit, Medecins Sans Frontieres, London, United Kingdom
    PLoS ONE 8:e71407. 2013
    ..We also examined factors influencing ARV adherence in experienced patients prior to clinic entry...
  21. pmc False positive HIV diagnoses in resource limited settings: operational lessons learned for HIV programmes
    Leslie Shanks
    Medecins Sans Frontieres, Amsterdam, The Netherlands
    PLoS ONE 8:e59906. 2013
    ..This paper describes the result of an audit of three sites to review testing practices, implement improved testing algorithms and offer re-testing to clients enrolled in the HIV clinic...
  22. pmc Clinical Features and Risk Factors of Oedematous Mycobacterium ulcerans Lesions in an Australian Population: Beware Cellulitis in an Endemic Area
    Daniel P O'Brien
    Department of Infectious Diseases, Barwon Health, Geelong, Australia Department of Medicine and Infectious Diseases, Royal Melbourne Hospital, University of Melbourne, Australia Manson Unit, Medecins Sans Frontieres, London, United Kingdom
    PLoS Negl Trop Dis 8:e2612. 2014
    ..We report the first comprehensive descriptions of the clinical features and risk factors of patients with oedematous disease from the Bellarine Peninsula of south-eastern Victoria, Australia...
  23. doi request reprint Cost-effectiveness of routine and low-cost CD4 T-cell count compared with WHO clinical staging of HIV to guide initiation of antiretroviral therapy in resource-limited settings
    Eugene Athan
    Department of Infectious Diseases, Barwon Health, Geelong, Australia
    AIDS 24:1887-95. 2010
    ..Low-cost CD4 cell count tests are comparable to conventional methods. We compared the direct healthcare costs and benefits using routine and low-cost CD4 cell count versus WHO staging to initiate ART...
  24. ncbi request reprint Mycobacterium ulcerans infection: factors influencing diagnostic delay
    Tricia Y J Quek
    Department of Clinical and Biomedical Sciences, Barwon Health, University of Melbourne, Geelong, Vic
    Med J Aust 187:561-3. 2007
    ....
  25. ncbi request reprint Dengue Fever in travelers returning from southeast Asia
    Valerie Sung
    Victorian Infectious Disease Service, Royal Melbourne Hospital, The University of Melbourne, Melbourne, Australia
    J Travel Med 10:208-13. 2003
    ..Dengue fever is an important illness facing travelers from nonendemic to endemic countries...
  26. pmc The evaluation of a rapid in situ HIV confirmation test in a programme with a high failure rate of the WHO HIV two-test diagnostic algorithm
    Derryck B Klarkowski
    Public Health Department, Medecins Sans Frontieres, Amsterdam, The Netherlands
    PLoS ONE 4:e4351. 2009
    ....
  27. doi request reprint Outcomes of a remote, decentralized health center-based HIV/AIDS antiretroviral program in Zambia, 2003 to 2007
    Riekje Elema
    Medecins Sans Frontieres Holland, Amsterdam, The Netherlands
    J Int Assoc Physicians AIDS Care (Chic) 8:60-7. 2009
    ..In a remote, resource-limited setting in decentralized health centers, virological and immunological assessments of patients on antiretroviral therapy >12 months showed that positive health outcomes are achievable...
  28. ncbi request reprint Treatment of AIDS in conflict-affected settings: a failure of imagination
    Tom Ellman
    Medecins Sans Frontieres, London WC1R 5DJ, UK
    Lancet 365:278-80. 2005
  29. ncbi request reprint Acute rheumatic fever: an unusual cause of fever in a returned traveler
    Andrei Catanchin
    Department of Infectious Diseases, Geelong Hospital, Geelong, Victoria, Australia
    J Travel Med 12:353-5. 2005
    ..Acute rheumatic fever presenting as fever in a returned traveler has not previously been described. We report one such case...
  30. pmc Screening practices for infectious diseases among Burmese refugees in Australia
    Nadia J Chaves
    Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Emerg Infect Dis 15:1769-72. 2009
    ..Of those tested, Helicobacter pylori infection affected 80%, latent tuberculosis 70%, vitamin D deficiency 37%, and strongyloidiasis 26%. Treating these diseases can prevent long-term illness...
  31. doi request reprint Mycobacterium ulcerans infection: evolution in clinical management
    Candice Simpson
    Department of Plastic Surgery, Barwon Health, Geelong, Victoria, Australia
    ANZ J Surg 83:523-6. 2013
    ..This paper will present the evolution in clinical management of M. ulcerans cases on the Bellarine Peninsula, Victoria, Australia...
  32. doi request reprint Long-term follow-up of schistosomiasis serology post-treatment in Australian travelers and immigrants
    Michelle K Yong
    Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Australia
    J Travel Med 17:89-93. 2010
    ....
  33. doi request reprint Treatment costs of Mycobacterium ulcerans in the antibiotic era
    Jason Pak
    Barwon Health, Geelong Hospital, Ryrie Street, Geelong, Victoria 3220, Australia
    Int Health 4:123-7. 2012
    ..Therefore, earlier diagnosis and treatment of M. ulcerans, including the use of outpatient-based oral antibiotic regimens, has the potential to reduce the cost of treatment. ..