Long-term opioid blockade and hedonic response: preliminary data from two open-label extension studies with extended-release naltrexoneCHARLES P O'BRIEN
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Am J Addict 20:106-12. 2011
..The differential hedonic ratings suggest that, in patients who persist with long-term continuous therapy, XR-NTX may selectively inhibit the pleasure associated with drinking alcohol, compared to a variety of other activities. ..
Dopamine transporter genotype modulation of neural responses to smoking cues: confirmation in a new cohortTeresa R Franklin
Research Assistant Professor of Neuroscience, Addiction Treatment Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA
Addict Biol 16:308-22. 2011
..Despite heterogeneity introduced by a host of factors, including variance in other genes involved in smoking behavior, we confirm that DAT genotype predicts the direction and location of neural responses to SCs...
- Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence
Falk W Lohoff
Department of Psychiatry, Translational Research Laboratories, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Neuropsychopharmacology 33:3078-84. 2008
..Additional studies are required to elucidate the role of COMT in the pathophysiology of substance use disorders...
- Initiating acamprosate within-detoxification versus post-detoxification in the treatment of alcohol dependence
Kyle M Kampman
Department of Psychiatry, University of Pennsylvania School of Medicine, 3900, Chestnut Street, Philadelphia, PA 19104, USA
Addict Behav 34:581-6. 2009
..This trial compared the efficacy of acamprosate, started at the beginning of detoxification, to acamprosate started at the completion of detoxification, in the treatment of alcohol dependence...
- Effects of varenicline on smoking cue–triggered neural and craving responses
Teresa Franklin
Department of Psychiatry, University of Pennsylvania and Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
Arch Gen Psychiatry 68:516-26. 2011
....
- Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence
Falk W Lohoff
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Neurosci Lett 453:199-203. 2009
..However, additional studies using larger sample sizes, comprehensive SNP coverage, and clinically homogenous populations are necessary before confidently excluding CDNF as a significant genetic risk factor for cocaine dependence...
No association between polymorphisms in the prostate apoptosis factor-4 gene and cocaine dependenceAndrew E Weller
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Psychiatr Genet 16:193-6. 2006
..The aim of this study is to investigate whether polymorphisms in the human Par-4 gene contribute to the etiology of cocaine dependence...
- Gender differences with high-dose naltrexone in patients with co-occurring cocaine and alcohol dependence
Helen M Pettinati
Department of Psychiatry, Center for the Study of Addictions, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Subst Abuse Treat 34:378-90. 2008
..Thus, 150 mg/day naltrexone added to a psychosocial treatment resulted in reductions in cocaine and alcohol use and drug severity in men, compared to higher rates of cocaine and alcohol use and drug severity in women...
- A double blind, placebo-controlled trial that combines disulfiram and naltrexone for treating co-occurring cocaine and alcohol dependence
Helen M Pettinati
Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Addict Behav 33:651-67. 2008
..This is a double blind, placebo-controlled trial that evaluated the efficacy of disulfiram, naltrexone and their combination in patients with co-occurring cocaine and alcohol dependence...
- DAT genotype modulates brain and behavioral responses elicited by cigarette cues
Teresa R Franklin
Department of Psychiatry, Addiction Treatment Research Center, University of Pennsylvania and Philadelphia VA Medical Center, Philadelphia, PA 19104, USA
Neuropsychopharmacology 34:717-28. 2009
..These results provide evidence that genetic variation in the DAT gene contributes to the neural and behavioral responses elicited by smoking cues...
- A double-blind, placebo-controlled trial of modafinil for cocaine dependence
Charles A Dackis
University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Subst Abuse Treat 43:303-12. 2012
..06). Our negative findings might be explained by gender differences and/or inadequate psychosocial treatment intensity in patients with severe cocaine dependence...
- Modulation of resting brain cerebral blood flow by the GABA B agonist, baclofen: a longitudinal perfusion fMRI study
Teresa R Franklin
Department of Psychiatry, University of Pennsylvania, Center for Studies of Addiction and VA Medical Center, Philadelphia, PA, USA franklin
Drug Alcohol Depend 117:176-83. 2011
..Its mechanism in humans is unknown. Here, we used continuous arterial spin labeled (CASL) perfusion fMRI to examine baclofen's effects on blood flow in the human brain...
- Genetic variants in the cocaine- and amphetamine-regulated transcript gene (CARTPT) and cocaine dependence
Falk W Lohoff
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Neurosci Lett 440:280-3. 2008
....
- Association analysis between polymorphisms in the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes with cocaine dependence
Falk W Lohoff
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Neurosci Lett 473:87-91. 2010
..However, additional studies using larger sample sizes and clinically homogenous populations are necessary before confidently excluding these variants as contributing genetic risk factors for CD...
- Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence
John P Dahl
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, USA
Addict Biol 11:76-83. 2006
..This work suggests that variations in the TPH2 gene are not a risk factor for the development of cocaine dependence, but these findings require confirmation in larger, independent samples of cocaine-dependent and control subjects...
- A functional prodynorphin promoter polymorphism and opioid dependence
Riju Ray
Department of Pharmacology, University of Pennsylvania, Philadelphia, 19104, USA
Psychiatr Genet 15:295-8. 2005
..We examined this polymorphism for association in our sample of 168 opioid-dependent patients and 122 ethnically and geographically matched controls...
- Acute baclofen diminishes resting baseline blood flow to limbic structures: a perfusion fMRI study
Teresa R Franklin
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA franklin
Drug Alcohol Depend 125:60-6. 2012
..In the present study, we hypothesized that a single dose of baclofen would have effects similar to repeated dosing...
- Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population
John P Dahl
Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Clinical Research Building, Philadelphia, 19104, USA
Psychiatr Genet 15:277-83. 2005
..The purpose of this study is to determine whether single-nucleotide polymorphisms in the Homer1 and Homer2 genes associate with the cocaine-dependent phenotype in an African American population...
- Low prefrontal perfusion linked to depression symptoms in methadone-maintained opiate-dependent patients
Jesse J Suh
Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, United States
Drug Alcohol Depend 99:11-7. 2009
..In this study, we examined the link between resting rCBF in the PFC and current depressive symptoms in methadone-maintained opiate-dependent (MM) patients with or without major depression...
- Current status of co-occurring mood and substance use disorders: a new therapeutic target
Helen M Pettinati
Penn VA Center for Studies of Addiction, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
Am J Psychiatry 170:23-30. 2013
..With new data becoming available, it appears that we need to revisit current practice in the pharmacological management of co-occurring mood and substance use disorders...
- The status of naltrexone in the treatment of alcohol dependence: specific effects on heavy drinking
Helen M Pettinati
Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6178, USA
J Clin Psychopharmacol 26:610-25. 2006
..Clinical trial results in this article are evaluated by the type of outcome measure used to determine naltrexone's treatment advantage, that is, measures related to reducing heavy drinking versus those related to increasing abstinence...
- A double-blind, placebo-controlled pilot trial of quetiapine for the treatment of Type A and Type B alcoholism
Kyle M Kampman
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Clin Psychopharmacol 27:344-51. 2007
..Quetiapine is an atypical antipsychotic with a favorable side effect profile, and may be a promising medication for the treatment of alcohol dependence, particularly Type B alcoholism...
- Gender differences in predictors of treatment attrition with high dose naltrexone in cocaine and alcohol dependence
Jesse J Suh
Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA Suh
Am J Addict 17:463-8. 2008
..Further research on the impact of pre-treatment and in-treatment gender differences with naltrexone is warranted...
- A placebo-controlled randomized clinical trial of naltrexone in the context of different levels of psychosocial intervention
David W Oslin
Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Alcohol Clin Exp Res 32:1299-308. 2008
....
- A double-blind, placebo-controlled trial of amantadine, propranolol, and their combination for the treatment of cocaine dependence in patients with severe cocaine withdrawal symptoms
Kyle M Kampman
Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA
Drug Alcohol Depend 85:129-37. 2006
..This trial evaluated the efficacy of amantadine, propranolol and their combination in cocaine dependent patients with severe cocaine withdrawal symptoms...
- Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependence
Rachel J Smith
Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Am J Med Genet B Neuropsychiatr Genet 133:105-9. 2005
..The results indicate that polymorphisms in the novel splice variant are not associated with opioid dependence, but are in LD with other polymorphisms in OPRM1...
- Neuronal calcium sensor-1 and cocaine addiction: a genetic association study in African-Americans and European Americans
Pushpinder K Multani
Psychiatric Pharmacogenetics Laboratory, Center for Neurobiology and Behavior, Department of Psychiatry, Philadelphia, PA, USA
Neurosci Lett 531:46-51. 2012
..0001, allelic p = 0.002) with a gender specific effect for males (allelic p = 0.005, genotypic p = 0.0003). Our data suggest that genetic variants in the NCS-1 gene contribute to susceptibility of CA in individuals of African descent...
- Menstrual cycle phase at quit date predicts smoking status in an NRT treatment trial: a retrospective analysis
Teresa R Franklin
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6178, USA
J Womens Health (Larchmt) 17:287-92. 2008
..However, no experimental data have been published to support this claim. Our objective was to determine whether MC phase affected smoking status in premenopausal female smokers participating in a smoking cessation treatment trial...
- The GABA B agonist baclofen reduces cigarette consumption in a preliminary double-blind placebo-controlled smoking reduction study
Teresa R Franklin
Department of Psychiatry, University of Pennsylvania, Philadelphia School of Medicine, PA 19104, USA
Drug Alcohol Depend 103:30-6. 2009
..These preliminary results demonstrate provisional evidence of the utility of baclofen to aid in smoking cessation and indicate further investigation...
- A double-blind, placebo-controlled pilot trial of acamprosate for the treatment of cocaine dependence
Kyle M Kampman
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
Addict Behav 36:217-21. 2011
..Therefore, we conducted a double-blind placebo-controlled pilot trial of acamprosate for the treatment of cocaine dependence...
- Clinical pharmacokinetics of lofexidine, the alpha 2-adrenergic receptor agonist, in opiate addicts plasma using a highly sensitive liquid chromatography tandem mass spectrometric analysis
Elmer Yu
University of Pennsylvania and Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA
Am J Drug Alcohol Abuse 34:611-6. 2008
..Lofexidine is an orally bioavailable alpha 2-adrenergic receptor agonist analogue of clonidine that acts centrally to suppress opiate withdrawal symptoms...
- A double-blind, placebo-controlled trial combining sertraline and naltrexone for treating co-occurring depression and alcohol dependence
Helen M Pettinati
Center for the Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA
Am J Psychiatry 167:668-75. 2010
....
- Low frequency genetic variants in the μ-opioid receptor (OPRM1) affect risk for addiction to heroin and cocaine
Toni Kim Clarke
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA Electronic address
Neurosci Lett 542:71-5. 2013
..02; 95% C.I. 0.47 [0.24-0.92]). This study suggests a potential role for rare OPRM1 variants in addiction disorders and highlights an area worthy of future study...
- Depot naltrexone decreases rewarding properties of sugar in patients with opioid dependence
Daniel D Langleben
Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Psychopharmacology (Berl) 220:559-64. 2012
..05 to 0.83 m...
- A pilot trial of topiramate for the treatment of cocaine dependence
Kyle M Kampman
Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA
Drug Alcohol Depend 75:233-40. 2004
..Topiramate, an anticonvulsant, raises cerebral GABA levels, facilitates GABAergic neurotransmission and inhibits glutametergic activity at AMPA/kainite receptors. Thus, it may be useful for treating cocaine dependence...
- A VBM study demonstrating 'apparent' effects of a single dose of medication on T1-weighted MRIs
Teresa R Franklin
Department of Psychiatry, Center for Studies of Addiction, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA
Brain Struct Funct 218:97-104. 2013
....
- The status of disulfiram: a half of a century later
Jesse J Suh
Treatment Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
J Clin Psychopharmacol 26:290-302. 2006
..Preliminary evidence also suggests that disulfiram treatment could be a viable treatment for cocaine dependence because it was shown to reduce cocaine use among nonalcoholic, cocaine-dependent patients...
- Covariates of craving in actively drinking alcoholics
Subhajit Chakravorty
Veterans Integrated Service Network, Mental Illness Research, Education and Clinical Center, Philadelphia V A Medical Center, Philadelphia, Pennsylvania 19104, USA
Am J Addict 19:450-7. 2010
..The results from this study suggest that alcohol craving is a complex phenomenon influenced by multiple factors...
- Results of an initial clinical trial of varenicline for the treatment of cocaine dependence
Jennifer G Plebani
University of Pennsylvania, Department of Psychiatry, Treatment Research Center, 3900 Chestnut Street, Philadelphia, PA 19104, United States plebani
Drug Alcohol Depend 121:163-6. 2012
..Cocaine use, abuse and dependence remains a pressing public health problem. Based on its mechanism of action, varenicline, an alpha4beta2 partial agonist seemed to be a likely candidate for treating cocaine dependence...
- Cocaine dependence severity predicts outcome in outpatient detoxification from cocaine and alcohol
Kyle M Kampman
Department of Psychiatry, University of Pennsylvania School of Medicine, Treatment Research Center, 3900 Chestnut Street, Philadelphia, PA 19104, USA
Am J Addict 13:74-82. 2004
..Among cocaine- and alcohol-dependent subjects, cocaine dependence severity appears to be a more important predictor of detoxification success than alcohol dependence severity...
- A randomized trial of oral naltrexone for treating opioid-dependent offenders
Donna M Coviello
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA coviello
Am J Addict 19:422-32. 2010
..The study provides limited support for the use of oral naltrexone for offenders who are not closely monitored by the criminal justice system...
- Anticraving medications for relapse prevention: a possible new class of psychoactive medications
CHARLES P O'BRIEN
University of Pennsylvania Philadelphia VA Medical Center, Philadelphia, PA 19104 6178, USA
Am J Psychiatry 162:1423-31. 2005
..Recent developments in pharmacogenetics may result in improved selection of medications based on genotype...
- Identifying risk factors for marijuana use among veterans affairs patients
Marina Goldman
Department of Psychiatry MG, JJS, KL, RS, HX, CPO, DWO, University of Pennsylvania School of Medicine, Philadelphia, PA and Philadelphia Veterans Affairs Medical Center VAMC Philadelphia JJS, Jr, CPO, DWO and VISN 4 Mental Illness Research, Education and Clinical Center MIRECC, Philadelphia, PA
J Addict Med 4:47-51. 2010
..If data commonly collected in the primary care setting (eg, use of alcohol, smoking status, and depression symptoms) could predict cannabis use, then providers can implement targeted marijuana screening in high-risk groups...
- A double-blind, placebo-controlled trial of modafinil for cocaine dependence
Charles A Dackis
University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Neuropsychopharmacology 30:205-11. 2005
..This study provides preliminary evidence, which should be confirmed by a larger study, that modafinil improves clinical outcome when combined with psychosocial treatment for cocaine dependence...
- Confirmation of the association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence
John P Dahl
Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Clinical Research Building, Philadelphia, PA 19104, USA
Am J Med Genet B Neuropsychiatr Genet 139:106-8. 2005
....
- A Phase 3 placebo-controlled, double-blind, multi-site trial of the alpha-2-adrenergic agonist, lofexidine, for opioid withdrawal
Elmer Yu
University of Pennsylvania and Philadelphia Veterans Affairs Medical Center, Philadelphia VAMC 116, University and Woodland Avenues, Philadelphia, PA 19104, USA
Drug Alcohol Depend 97:158-68. 2008
..Lofexidine has been reported to have more significant effects on decreasing opioid withdrawal symptoms with less hypotension than clonidine...
- Long-acting injectable versus oral naltrexone maintenance therapy with psychosocial intervention for heroin dependence: a quasi-experiment
Adam C Brooks
Treatment Research Institute, 600 Public Ledger Bldg, 150 S Independence Mall West, Philadelphia, PA 19106, USA
J Clin Psychiatry 71:1371-8. 2010
..To conduct a quasi-experimental comparison of early clinical outcomes between injectable, sustained-release, depot naltrexone formulation versus oral naltrexone maintenance therapy in individuals with opiate dependence...
- Prelude to passion: limbic activation by "unseen" drug and sexual cues
Anna Rose Childress
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
PLoS ONE 3:e1506. 2008
..recognition? Can the brain response to "unseen" reward cues predict the future affective response to recognizable versions of such cues, revealing a link between affective/motivational processes inside and outside awareness?..
- The impact of sex on brain responses to smoking cues: a perfusion fMRI study
Reagan R Wetherill
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Biol Sex Differ 4:9. 2013
..The current study examines the impact of sex on brain responses to smoking cues...
- Acute effect of methadone maintenance dose on brain FMRI response to heroin-related cues
Daniel D Langleben
Department of Psychiatry, University of Pennsylvania, Treatment Research Center, Philadelphia, PA 19104, USA
Am J Psychiatry 165:390-4. 2008
..The authors sought to identify the functional neuroanatomy of the brain response to visual heroin-related stimuli in methadone maintenance patients...
- Benzodiazepine use, abuse, and dependence
CHARLES P O'BRIEN
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
J Clin Psychiatry 66:28-33. 2005
..Due to the chronic nature of anxiety, long-term low-dose benzodiazepine treatment may be necessary for some patients; this continuation of treatment should not be considered abuse or addiction...
- Limbic activation to cigarette smoking cues independent of nicotine withdrawal: a perfusion fMRI study
Teresa R Franklin
Department of Psychiatry, Addiction Treatment Research Center, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
Neuropsychopharmacology 32:2301-9. 2007
....
- Drug treatment as HIV prevention: a research update
David S Metzger
HIV AIDS Prevention Research Division, University of Pennsylvania, Philadelphia, PA 19104, USA
J Acquir Immune Defic Syndr 55:S32-6. 2010
..Although there are challenges to implementing drug treatment programs for maximum impact, the scientific literature leaves no doubt about the effectiveness of drug treatment as an HIV prevention strategy...
- Opioid therapy in patients with chronic noncancer pain: diagnostic and clinical challenges
Martin D Cheatle
Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Adv Psychosom Med 30:61-91. 2011
..Pharmacologic and nonpharmacologic treatment strategies for the patient with pain and opioid addiction are reviewed...
- A genetic association study of the mu opioid receptor and severe opioid dependence
James J Crowley
Department of Pharmacology, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA
Psychiatr Genet 13:169-73. 2003
..A recent report (Hoehe et al., 2000) found a significant association between a specific combination of OPRM1 single nucleotide polymorphisms (SNPs) and substance dependence...
- Penn/VA center for studies of addiction
CHARLES P O'BRIEN
University of Pennsylvania, Treatment Research Center, 3900 Chestnut Street, Philadelphia, PA 19104 6178, USA
Neuropharmacology 56:44-7. 2009
..Some of the findings that came out of both the Penn/VA laboratory and clinical studies are now widely accepted and form the basis of standard clinical practice. These concepts and evidence will be briefly reviewed below...
- Review. Evidence-based treatments of addiction
CHARLES P O'BRIEN
Department of Psychiatry, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104 6178, USA
Philos Trans R Soc Lond B Biol Sci 363:3277-86. 2008
..Addiction is a chronic disease that tends to recur when treatment is stopped; thus, long-term treatment is recommended...
- Neuroplasticity in addictive disorders
CHARLES P O'BRIEN
Department of Psychiatry, University of Pennsylvania, Treatment Research Center, Philadelphia, PA 19104 6178, USA
Dialogues Clin Neurosci 11:350-3. 2009
..It therefore requires chronic treatment with medications and behavioral therapies based on an understanding of the fundamental nature of these changes in the brain...
- A pilot trial of olanzapine for the treatment of cocaine dependence
Kyle M Kampman
Department of Psychiatry, School of Medicine, Treatment Research Center, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
Drug Alcohol Depend 70:265-73. 2003
....
- Research advances in the understanding and treatment of addiction
CHARLES P O'BRIEN
University of Pennsylvania, VA Medical Center, Philadelphia, PA 19104 6178, USA
Am J Addict 12:S36-47. 2003
..In this paper, strategies for effective treatment of addiction, including long-term relapse management and new pharmacological therapies such as naltrexone and acamprosate, are discussed...
- A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients
David W Oslin
Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Room 3002, Philadelphia, PA 19104, USA
Neuropsychopharmacology 28:1546-52. 2003
..If replicated, these results would help to identify alcohol-dependent individuals who may be most likely to respond to treatment with naltrexone...
- Retrospective study: influence of menstrual cycle on cue-induced cigarette craving
Teresa R Franklin
Addiction Treatment Research Center, Department of Psychiatry, University of Pennsylvania, Veteran s Administration Hospital of Philadelphia, USA
Nicotine Tob Res 6:171-5. 2004
..05). The suppressed craving response in FFemales suggests an influence of cycle phase on cue-induced craving...
