CHARLES P O'BRIEN

Summary

Publications

  1. pmc Long-term opioid blockade and hedonic response: preliminary data from two open-label extension studies with extended-release naltrexone
    CHARLES P O'BRIEN
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Addict 20:106-12. 2011
  2. pmc Dopamine transporter genotype modulation of neural responses to smoking cues: confirmation in a new cohort
    Teresa R Franklin
    Research Assistant Professor of Neuroscience, Addiction Treatment Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Addict Biol 16:308-22. 2011
  3. pmc Further evidence for association of polymorphisms in the CNR1 gene with cocaine addiction: confirmation in an independent sample and meta-analysis
    Toni Kim Clarke
    Psychiatric Pharmacogenetics Laboratory Center for Neurobiology and Behavior Treatment Research Center Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Addict Biol 18:702-8. 2013
  4. pmc Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence
    Falk W Lohoff
    Department of Psychiatry, Translational Research Laboratories, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 33:3078-84. 2008
  5. pmc Initiating acamprosate within-detoxification versus post-detoxification in the treatment of alcohol dependence
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900, Chestnut Street, Philadelphia, PA 19104, USA
    Addict Behav 34:581-6. 2009
  6. pmc Reward-related brain response and craving correlates of marijuana cue exposure: a preliminary study in treatment-seeking marijuana-dependent subjects
    Marina Goldman
    Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
    J Addict Med 7:8-16. 2013
  7. pmc Effects of varenicline on smoking cue–triggered neural and craving responses
    Teresa Franklin
    Department of Psychiatry, University of Pennsylvania and Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    Arch Gen Psychiatry 68:516-26. 2011
  8. pmc Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence
    Falk W Lohoff
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Neurosci Lett 453:199-203. 2009
  9. pmc Low frequency genetic variants in the μ-opioid receptor (OPRM1) affect risk for addiction to heroin and cocaine
    Toni Kim Clarke
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA
    Neurosci Lett 542:71-5. 2013
  10. pmc DAT genotype modulates brain and behavioral responses elicited by cigarette cues
    Teresa R Franklin
    Department of Psychiatry, Addiction Treatment Research Center, University of Pennsylvania and Philadelphia VA Medical Center, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 34:717-28. 2009

Detail Information

Publications80

  1. pmc Long-term opioid blockade and hedonic response: preliminary data from two open-label extension studies with extended-release naltrexone
    CHARLES P O'BRIEN
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Addict 20:106-12. 2011
    ..The differential hedonic ratings suggest that, in patients who persist with long-term continuous therapy, XR-NTX may selectively inhibit the pleasure associated with drinking alcohol, compared to a variety of other activities. ..
  2. pmc Dopamine transporter genotype modulation of neural responses to smoking cues: confirmation in a new cohort
    Teresa R Franklin
    Research Assistant Professor of Neuroscience, Addiction Treatment Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Addict Biol 16:308-22. 2011
    ..Despite heterogeneity introduced by a host of factors, including variance in other genes involved in smoking behavior, we confirm that DAT genotype predicts the direction and location of neural responses to SCs...
  3. pmc Further evidence for association of polymorphisms in the CNR1 gene with cocaine addiction: confirmation in an independent sample and meta-analysis
    Toni Kim Clarke
    Psychiatric Pharmacogenetics Laboratory Center for Neurobiology and Behavior Treatment Research Center Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Addict Biol 18:702-8. 2013
    ..Furthermore, as this population consists of American individuals of African descent, the possibility of population stratification should not be excluded...
  4. pmc Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence
    Falk W Lohoff
    Department of Psychiatry, Translational Research Laboratories, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 33:3078-84. 2008
    ..Additional studies are required to elucidate the role of COMT in the pathophysiology of substance use disorders...
  5. pmc Initiating acamprosate within-detoxification versus post-detoxification in the treatment of alcohol dependence
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900, Chestnut Street, Philadelphia, PA 19104, USA
    Addict Behav 34:581-6. 2009
    ..This trial compared the efficacy of acamprosate, started at the beginning of detoxification, to acamprosate started at the completion of detoxification, in the treatment of alcohol dependence...
  6. pmc Reward-related brain response and craving correlates of marijuana cue exposure: a preliminary study in treatment-seeking marijuana-dependent subjects
    Marina Goldman
    Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
    J Addict Med 7:8-16. 2013
    ....
  7. pmc Effects of varenicline on smoking cue–triggered neural and craving responses
    Teresa Franklin
    Department of Psychiatry, University of Pennsylvania and Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    Arch Gen Psychiatry 68:516-26. 2011
    ....
  8. pmc Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence
    Falk W Lohoff
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Neurosci Lett 453:199-203. 2009
    ..However, additional studies using larger sample sizes, comprehensive SNP coverage, and clinically homogenous populations are necessary before confidently excluding CDNF as a significant genetic risk factor for cocaine dependence...
  9. pmc Low frequency genetic variants in the μ-opioid receptor (OPRM1) affect risk for addiction to heroin and cocaine
    Toni Kim Clarke
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA
    Neurosci Lett 542:71-5. 2013
    ..02; 95% C.I. 0.47 [0.24-0.92]). This study suggests a potential role for rare OPRM1 variants in addiction disorders and highlights an area worthy of future study...
  10. pmc DAT genotype modulates brain and behavioral responses elicited by cigarette cues
    Teresa R Franklin
    Department of Psychiatry, Addiction Treatment Research Center, University of Pennsylvania and Philadelphia VA Medical Center, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 34:717-28. 2009
    ..These results provide evidence that genetic variation in the DAT gene contributes to the neural and behavioral responses elicited by smoking cues...
  11. ncbi No association between polymorphisms in the prostate apoptosis factor-4 gene and cocaine dependence
    Andrew E Weller
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Psychiatr Genet 16:193-6. 2006
    ..The aim of this study is to investigate whether polymorphisms in the human Par-4 gene contribute to the etiology of cocaine dependence...
  12. pmc A double blind, placebo-controlled trial that combines disulfiram and naltrexone for treating co-occurring cocaine and alcohol dependence
    Helen M Pettinati
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Addict Behav 33:651-67. 2008
    ..This is a double blind, placebo-controlled trial that evaluated the efficacy of disulfiram, naltrexone and their combination in patients with co-occurring cocaine and alcohol dependence...
  13. pmc Gender differences with high-dose naltrexone in patients with co-occurring cocaine and alcohol dependence
    Helen M Pettinati
    Department of Psychiatry, Center for the Study of Addictions, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Subst Abuse Treat 34:378-90. 2008
    ..Thus, 150 mg/day naltrexone added to a psychosocial treatment resulted in reductions in cocaine and alcohol use and drug severity in men, compared to higher rates of cocaine and alcohol use and drug severity in women...
  14. pmc Nipping cue reactivity in the bud: baclofen prevents limbic activation elicited by subliminal drug cues
    Kimberly A Young
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, Department of Physiology and Pharmacology, School of Medicine, Wake Forest University, Winston Salem, North Carolina 27157, and Philadelphia VA Medical Center, Philadelphia, Pennsylvania 19104
    J Neurosci 34:5038-43. 2014
    ..005; cluster corrected at p < 0.05). These results suggest that baclofen may inhibit the earliest type of drug cue-induced motivational processing-that which occurs outside of awareness-before it evolves into a less manageable state. ..
  15. pmc A double-blind, placebo-controlled trial of modafinil for cocaine dependence
    Charles A Dackis
    University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Subst Abuse Treat 43:303-12. 2012
    ..06). Our negative findings might be explained by gender differences and/or inadequate psychosocial treatment intensity in patients with severe cocaine dependence...
  16. pmc Modulation of resting brain cerebral blood flow by the GABA B agonist, baclofen: a longitudinal perfusion fMRI study
    Teresa R Franklin
    Department of Psychiatry, University of Pennsylvania, Center for Studies of Addiction and VA Medical Center, Philadelphia, PA, USA franklin
    Drug Alcohol Depend 117:176-83. 2011
    ..Its mechanism in humans is unknown. Here, we used continuous arterial spin labeled (CASL) perfusion fMRI to examine baclofen's effects on blood flow in the human brain...
  17. ncbi Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence
    John P Dahl
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, USA
    Addict Biol 11:76-83. 2006
    ..This work suggests that variations in the TPH2 gene are not a risk factor for the development of cocaine dependence, but these findings require confirmation in larger, independent samples of cocaine-dependent and control subjects...
  18. pmc Genetic variants in the cocaine- and amphetamine-regulated transcript gene (CARTPT) and cocaine dependence
    Falk W Lohoff
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neurosci Lett 440:280-3. 2008
    ....
  19. doi Association analysis between polymorphisms in the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes with cocaine dependence
    Falk W Lohoff
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Neurosci Lett 473:87-91. 2010
    ..However, additional studies using larger sample sizes and clinically homogenous populations are necessary before confidently excluding these variants as contributing genetic risk factors for CD...
  20. ncbi A functional prodynorphin promoter polymorphism and opioid dependence
    Riju Ray
    Department of Pharmacology, University of Pennsylvania, Philadelphia, 19104, USA
    Psychiatr Genet 15:295-8. 2005
    ..We examined this polymorphism for association in our sample of 168 opioid-dependent patients and 122 ethnically and geographically matched controls...
  21. pmc A VBM study demonstrating 'apparent' effects of a single dose of medication on T1-weighted MRIs
    Teresa R Franklin
    Department of Psychiatry, Center for Studies of Addiction, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Brain Struct Funct 218:97-104. 2013
    ....
  22. pmc Acute baclofen diminishes resting baseline blood flow to limbic structures: a perfusion fMRI study
    Teresa R Franklin
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA franklin
    Drug Alcohol Depend 125:60-6. 2012
    ..In the present study, we hypothesized that a single dose of baclofen would have effects similar to repeated dosing...
  23. ncbi Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population
    John P Dahl
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Clinical Research Building, Philadelphia, 19104, USA
    Psychiatr Genet 15:277-83. 2005
    ..The purpose of this study is to determine whether single-nucleotide polymorphisms in the Homer1 and Homer2 genes associate with the cocaine-dependent phenotype in an African American population...
  24. pmc Low prefrontal perfusion linked to depression symptoms in methadone-maintained opiate-dependent patients
    Jesse J Suh
    Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, United States
    Drug Alcohol Depend 99:11-7. 2009
    ..In this study, we examined the link between resting rCBF in the PFC and current depressive symptoms in methadone-maintained opiate-dependent (MM) patients with or without major depression...
  25. pmc A double-blind, placebo-controlled trial of topiramate for the treatment of comorbid cocaine and alcohol dependence
    Kyle M Kampman
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA Electronic address
    Drug Alcohol Depend 133:94-9. 2013
    ..The current trial was intended to test the ability of topiramate to promote cocaine and alcohol abstinence among patients addicted to both drugs...
  26. ncbi Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients
    Teresa R Franklin
    Addiction Treatment Research Center, Department of Psychiatry, University of Pennsylvania and Philadelphia VA Medical Center, Philadelphia, PA 19104 6178, USA
    Biol Psychiatry 51:134-42. 2002
    ..To date, a focal structural analysis of the brains of cocaine patients has not been undertaken...
  27. pmc Current status of co-occurring mood and substance use disorders: a new therapeutic target
    Helen M Pettinati
    Penn VA Center for Studies of Addiction, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
    Am J Psychiatry 170:23-30. 2013
    ..With new data becoming available, it appears that we need to revisit current practice in the pharmacological management of co-occurring mood and substance use disorders...
  28. ncbi The status of naltrexone in the treatment of alcohol dependence: specific effects on heavy drinking
    Helen M Pettinati
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6178, USA
    J Clin Psychopharmacol 26:610-25. 2006
    ..Clinical trial results in this article are evaluated by the type of outcome measure used to determine naltrexone's treatment advantage, that is, measures related to reducing heavy drinking versus those related to increasing abstinence...
  29. pmc A double-blind, placebo-controlled pilot trial of quetiapine for the treatment of Type A and Type B alcoholism
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Psychopharmacol 27:344-51. 2007
    ..Quetiapine is an atypical antipsychotic with a favorable side effect profile, and may be a promising medication for the treatment of alcohol dependence, particularly Type B alcoholism...
  30. pmc Case-control association study of WLS variants in opioid and cocaine addicted populations
    Richard C Crist
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA
    Psychiatry Res 208:62-6. 2013
    ..However, this study does not exclude the possibilities that rare variants in WLS may affect susceptibility to drug addiction, or that common variants with small effect size may fall below the detection level of our analysis...
  31. ncbi A double-blind, placebo-controlled trial of amantadine, propranolol, and their combination for the treatment of cocaine dependence in patients with severe cocaine withdrawal symptoms
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 85:129-37. 2006
    ..This trial evaluated the efficacy of amantadine, propranolol and their combination in cocaine dependent patients with severe cocaine withdrawal symptoms...
  32. pmc Gender differences in predictors of treatment attrition with high dose naltrexone in cocaine and alcohol dependence
    Jesse J Suh
    Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA Suh
    Am J Addict 17:463-8. 2008
    ..Further research on the impact of pre-treatment and in-treatment gender differences with naltrexone is warranted...
  33. pmc A placebo-controlled randomized clinical trial of naltrexone in the context of different levels of psychosocial intervention
    David W Oslin
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Alcohol Clin Exp Res 32:1299-308. 2008
    ....
  34. ncbi Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependence
    Rachel J Smith
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 133:105-9. 2005
    ..The results indicate that polymorphisms in the novel splice variant are not associated with opioid dependence, but are in LD with other polymorphisms in OPRM1...
  35. pmc Neuronal calcium sensor-1 and cocaine addiction: a genetic association study in African-Americans and European Americans
    Pushpinder K Multani
    Psychiatric Pharmacogenetics Laboratory, Center for Neurobiology and Behavior, Department of Psychiatry, Philadelphia, PA, USA
    Neurosci Lett 531:46-51. 2012
    ..0001, allelic p = 0.002) with a gender specific effect for males (allelic p = 0.005, genotypic p = 0.0003). Our data suggest that genetic variants in the NCS-1 gene contribute to susceptibility of CA in individuals of African descent...
  36. pmc The GABA B agonist baclofen reduces cigarette consumption in a preliminary double-blind placebo-controlled smoking reduction study
    Teresa R Franklin
    Department of Psychiatry, University of Pennsylvania, Philadelphia School of Medicine, PA 19104, USA
    Drug Alcohol Depend 103:30-6. 2009
    ..These preliminary results demonstrate provisional evidence of the utility of baclofen to aid in smoking cessation and indicate further investigation...
  37. doi Clinical pharmacokinetics of lofexidine, the alpha 2-adrenergic receptor agonist, in opiate addicts plasma using a highly sensitive liquid chromatography tandem mass spectrometric analysis
    Elmer Yu
    University of Pennsylvania and Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA
    Am J Drug Alcohol Abuse 34:611-6. 2008
    ..Lofexidine is an orally bioavailable alpha 2-adrenergic receptor agonist analogue of clonidine that acts centrally to suppress opiate withdrawal symptoms...
  38. pmc A double-blind, placebo-controlled pilot trial of acamprosate for the treatment of cocaine dependence
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Addict Behav 36:217-21. 2011
    ..Therefore, we conducted a double-blind placebo-controlled pilot trial of acamprosate for the treatment of cocaine dependence...
  39. pmc A double-blind, placebo-controlled trial combining sertraline and naltrexone for treating co-occurring depression and alcohol dependence
    Helen M Pettinati
    Center for the Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA
    Am J Psychiatry 167:668-75. 2010
    ....
  40. pmc Menstrual cycle phase at quit date predicts smoking status in an NRT treatment trial: a retrospective analysis
    Teresa R Franklin
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6178, USA
    J Womens Health (Larchmt) 17:287-92. 2008
    ..However, no experimental data have been published to support this claim. Our objective was to determine whether MC phase affected smoking status in premenopausal female smokers participating in a smoking cessation treatment trial...
  41. ncbi Alcohol potentiates hepatitis C virus replicon expression
    Ting Zhang
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hepatology 38:57-65. 2003
    ..Thus, alcohol may play an important role in vivo as a cofactor in HCV disease progression and compromise IFN-alpha-based therapy against HCV infection...
  42. pmc Depot naltrexone decreases rewarding properties of sugar in patients with opioid dependence
    Daniel D Langleben
    Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
    Psychopharmacology (Berl) 220:559-64. 2012
    ..05 to 0.83 m...
  43. ncbi A pilot trial of topiramate for the treatment of cocaine dependence
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 75:233-40. 2004
    ..Topiramate, an anticonvulsant, raises cerebral GABA levels, facilitates GABAergic neurotransmission and inhibits glutametergic activity at AMPA/kainite receptors. Thus, it may be useful for treating cocaine dependence...
  44. ncbi Targeting treatments for alcohol dependence: the pharmacogenetics of naltrexone
    David W Oslin
    University of Pennsylvania, Geriartric and Addiction Psychiatry, Philadelphia, PA 19104, USA
    Addict Biol 11:397-403. 2006
    ..This article reviews the biological correlates and outlines a scientific agenda for better understanding the role of opioid neurotransmission in the etiology, maintenance and treatment of alcohol dependence...
  45. pmc The dopamine receptor D2 (DRD2) SNP rs1076560 is associated with opioid addiction
    Toni Kim Clarke
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA
    Ann Hum Genet 78:33-9. 2014
    ..No association was found with cocaine dependence. These data demonstrate the importance of dopamine gene variants in the risk for opioid dependence and highlight a functional polymorphism that warrants further study. ..
  46. pmc Alcohol suppresses IL-2-induced CC chemokine production by natural killer cells
    Ting Zhang
    Department of Pediatrics, Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, PA 19104, USA
    Alcohol Clin Exp Res 29:1559-67. 2005
    ..We investigated whether alcohol impairs NK cell function, particularly production of CC chemokines induced by interleukin (IL)-2, the natural ligands for CCR5 receptor...
  47. ncbi The status of disulfiram: a half of a century later
    Jesse J Suh
    Treatment Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Clin Psychopharmacol 26:290-302. 2006
    ..Preliminary evidence also suggests that disulfiram treatment could be a viable treatment for cocaine dependence because it was shown to reduce cocaine use among nonalcoholic, cocaine-dependent patients...
  48. pmc Covariates of craving in actively drinking alcoholics
    Subhajit Chakravorty
    Veterans Integrated Service Network, Mental Illness Research, Education and Clinical Center, Philadelphia V A Medical Center, Philadelphia, Pennsylvania 19104, USA
    Am J Addict 19:450-7. 2010
    ..The results from this study suggest that alcohol craving is a complex phenomenon influenced by multiple factors...
  49. doi Extended-release naltrexone modulates brain response to drug cues in abstinent heroin-dependent patients
    Daniel D Langleben
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA Veterans Administration Health Care System, Philadelphia, PA, USA Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Addict Biol 19:262-71. 2014
    ..Our findings call for further evaluation of the brain fMRI response to drug-related cues and of the 6-beta-naltrexol levels as potential biomarkers of XRNTX therapeutic effects in patients with opioid dependence. ..
  50. pmc Neural correlates of attentional bias for smoking cues: modulation by variance in the dopamine transporter gene
    Reagan R Wetherill
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Addict Biol 19:294-304. 2014
    ..Findings suggest that genetic variation in the DAT gene influences brain responses associated with attentional bias; thus, providing additional support for a SC-vulnerable endophenotype. ..
  51. doi Neural responses to subliminally presented cannabis and other emotionally evocative cues in cannabis-dependent individuals
    Reagan R Wetherill
    Department of Psychiatry, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA, 19104, USA
    Psychopharmacology (Berl) 231:1397-407. 2014
    ..Activation of reward neurocircuitry may provoke craving and perhaps prime an individual for subsequent drug-seeking behaviors...
  52. ncbi Priority actions to improve the care of persons with co-occurring substance abuse and other mental disorders: a call to action
    CHARLES P O'BRIEN
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104 6178, USA
    Biol Psychiatry 56:703-13. 2004
  53. doi Concurrent naltrexone and prolonged exposure therapy for patients with comorbid alcohol dependence and PTSD: a randomized clinical trial
    Edna B Foa
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    JAMA 310:488-95. 2013
    ..Alcohol dependence comorbid with posttraumatic stress disorder (PTSD) has been found to be resistant to treatment. In addition, there is a concern that prolonged exposure therapy for PTSD may exacerbate alcohol use...
  54. pmc Results of an initial clinical trial of varenicline for the treatment of cocaine dependence
    Jennifer G Plebani
    University of Pennsylvania, Department of Psychiatry, Treatment Research Center, 3900 Chestnut Street, Philadelphia, PA 19104, United States plebani
    Drug Alcohol Depend 121:163-6. 2012
    ..Cocaine use, abuse and dependence remains a pressing public health problem. Based on its mechanism of action, varenicline, an alpha4beta2 partial agonist seemed to be a likely candidate for treating cocaine dependence...
  55. ncbi Anticraving medications for relapse prevention: a possible new class of psychoactive medications
    CHARLES P O'BRIEN
    University of Pennsylvania Philadelphia VA Medical Center, Philadelphia, PA 19104 6178, USA
    Am J Psychiatry 162:1423-31. 2005
    ..Recent developments in pharmacogenetics may result in improved selection of medications based on genotype...
  56. ncbi Cocaine dependence severity predicts outcome in outpatient detoxification from cocaine and alcohol
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, Treatment Research Center, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Am J Addict 13:74-82. 2004
    ..Among cocaine- and alcohol-dependent subjects, cocaine dependence severity appears to be a more important predictor of detoxification success than alcohol dependence severity...
  57. pmc A randomized trial of oral naltrexone for treating opioid-dependent offenders
    Donna M Coviello
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA coviello
    Am J Addict 19:422-32. 2010
    ..The study provides limited support for the use of oral naltrexone for offenders who are not closely monitored by the criminal justice system...
  58. ncbi Naltrexone inhibits alcohol-mediated enhancement of HIV infection of T lymphocytes
    Xu Wang
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Leukoc Biol 79:1166-72. 2006
    ..These findings suggest a biological mechanism for the potential therapeutic benefit of naltrexone in treating HIV-infected alcoholics...
  59. pmc Rational development of addiction pharmacotherapies: successes, failures, and prospects
    R Christopher Pierce
    Center for Neurobiology and Behavior Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Cold Spring Harb Perspect Med 2:a012880. 2012
    ..In addition, the development of promising cocaine addiction therapeutics derived from animal research will be reviewed...
  60. pmc Identifying risk factors for marijuana use among veterans affairs patients
    Marina Goldman
    Department of Psychiatry MG, JJS, KL, RS, HX, CPO, DWO, University of Pennsylvania School of Medicine, Philadelphia, PA and Philadelphia Veterans Affairs Medical Center VAMC Philadelphia JJS, Jr, CPO, DWO and VISN 4 Mental Illness Research, Education and Clinical Center MIRECC, Philadelphia, PA
    J Addict Med 4:47-51. 2010
    ..If data commonly collected in the primary care setting (eg, use of alcohol, smoking status, and depression symptoms) could predict cannabis use, then providers can implement targeted marijuana screening in high-risk groups...
  61. ncbi A double-blind, placebo-controlled trial of modafinil for cocaine dependence
    Charles A Dackis
    University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neuropsychopharmacology 30:205-11. 2005
    ..This study provides preliminary evidence, which should be confirmed by a larger study, that modafinil improves clinical outcome when combined with psychosocial treatment for cocaine dependence...
  62. pmc Prelude to passion: limbic activation by "unseen" drug and sexual cues
    Anna Rose Childress
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    PLoS ONE 3:e1506. 2008
    ..conscious recognition? Can the brain response to "unseen" reward cues predict the future affective response to recognizable versions of such cues, revealing a link between affective/motivational processes inside and outside awareness?..
  63. pmc Long-acting injectable versus oral naltrexone maintenance therapy with psychosocial intervention for heroin dependence: a quasi-experiment
    Adam C Brooks
    Treatment Research Institute, 600 Public Ledger Bldg, 150 S Independence Mall West, Philadelphia, PA 19106, USA
    J Clin Psychiatry 71:1371-8. 2010
    ..To conduct a quasi-experimental comparison of early clinical outcomes between injectable, sustained-release, depot naltrexone formulation versus oral naltrexone maintenance therapy in individuals with opiate dependence...
  64. pmc A Phase 3 placebo-controlled, double-blind, multi-site trial of the alpha-2-adrenergic agonist, lofexidine, for opioid withdrawal
    Elmer Yu
    University of Pennsylvania and Philadelphia Veterans Affairs Medical Center, Philadelphia VAMC 116, University and Woodland Avenues, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 97:158-68. 2008
    ..Lofexidine has been reported to have more significant effects on decreasing opioid withdrawal symptoms with less hypotension than clonidine...
  65. ncbi Confirmation of the association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence
    John P Dahl
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Clinical Research Building, Philadelphia, PA 19104, USA
    Am J Med Genet B Neuropsychiatr Genet 139:106-8. 2005
    ....
  66. ncbi A case report of naltrexone for alcoholism in a liver transplant recipient: side effects and safety
    Robert M Weinrieb
    Department of Psychiatry, Treatment and Evaluation Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Addict 13:495-7. 2004
  67. pmc The impact of sex on brain responses to smoking cues: a perfusion fMRI study
    Reagan R Wetherill
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Biol Sex Differ 4:9. 2013
    ..The current study examines the impact of sex on brain responses to smoking cues...
  68. ncbi Benzodiazepine use, abuse, and dependence
    CHARLES P O'BRIEN
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Clin Psychiatry 66:28-33. 2005
    ..Due to the chronic nature of anxiety, long-term low-dose benzodiazepine treatment may be necessary for some patients; this continuation of treatment should not be considered abuse or addiction...
  69. ncbi Limbic activation to cigarette smoking cues independent of nicotine withdrawal: a perfusion fMRI study
    Teresa R Franklin
    Department of Psychiatry, Addiction Treatment Research Center, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 32:2301-9. 2007
    ....
  70. ncbi Acute effect of methadone maintenance dose on brain FMRI response to heroin-related cues
    Daniel D Langleben
    Department of Psychiatry, University of Pennsylvania, Treatment Research Center, Philadelphia, PA 19104, USA
    Am J Psychiatry 165:390-4. 2008
    ..The authors sought to identify the functional neuroanatomy of the brain response to visual heroin-related stimuli in methadone maintenance patients...
  71. pmc Drug treatment as HIV prevention: a research update
    David S Metzger
    HIV AIDS Prevention Research Division, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Acquir Immune Defic Syndr 55:S32-6. 2010
    ..Although there are challenges to implementing drug treatment programs for maximum impact, the scientific literature leaves no doubt about the effectiveness of drug treatment as an HIV prevention strategy...
  72. doi Opioid therapy in patients with chronic noncancer pain: diagnostic and clinical challenges
    Martin D Cheatle
    Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Adv Psychosom Med 30:61-91. 2011
    ..Pharmacologic and nonpharmacologic treatment strategies for the patient with pain and opioid addiction are reviewed...
  73. pmc Penn/VA center for studies of addiction
    CHARLES P O'BRIEN
    University of Pennsylvania, Treatment Research Center, 3900 Chestnut Street, Philadelphia, PA 19104 6178, USA
    Neuropharmacology 56:44-7. 2009
    ..Some of the findings that came out of both the Penn/VA laboratory and clinical studies are now widely accepted and form the basis of standard clinical practice. These concepts and evidence will be briefly reviewed below...
  74. ncbi A genetic association study of the mu opioid receptor and severe opioid dependence
    James J Crowley
    Department of Pharmacology, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Psychiatr Genet 13:169-73. 2003
    ..A recent report (Hoehe et al., 2000) found a significant association between a specific combination of OPRM1 single nucleotide polymorphisms (SNPs) and substance dependence...
  75. pmc Review. Evidence-based treatments of addiction
    CHARLES P O'BRIEN
    Department of Psychiatry, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104 6178, USA
    Philos Trans R Soc Lond B Biol Sci 363:3277-86. 2008
    ..Addiction is a chronic disease that tends to recur when treatment is stopped; thus, long-term treatment is recommended...
  76. pmc Neuroplasticity in addictive disorders
    CHARLES P O'BRIEN
    Department of Psychiatry, University of Pennsylvania, Treatment Research Center, Philadelphia, PA 19104 6178, USA
    Dialogues Clin Neurosci 11:350-3. 2009
    ..It therefore requires chronic treatment with medications and behavioral therapies based on an understanding of the fundamental nature of these changes in the brain...
  77. ncbi Research advances in the understanding and treatment of addiction
    CHARLES P O'BRIEN
    University of Pennsylvania, VA Medical Center, Philadelphia, PA 19104 6178, USA
    Am J Addict 12:S36-47. 2003
    ..In this paper, strategies for effective treatment of addiction, including long-term relapse management and new pharmacological therapies such as naltrexone and acamprosate, are discussed...
  78. ncbi A pilot trial of olanzapine for the treatment of cocaine dependence
    Kyle M Kampman
    Department of Psychiatry, School of Medicine, Treatment Research Center, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 70:265-73. 2003
    ....
  79. ncbi Retrospective study: influence of menstrual cycle on cue-induced cigarette craving
    Teresa R Franklin
    Addiction Treatment Research Center, Department of Psychiatry, University of Pennsylvania, Veteran s Administration Hospital of Philadelphia, USA
    Nicotine Tob Res 6:171-5. 2004
    ..05). The suppressed craving response in FFemales suggests an influence of cycle phase on cue-induced craving...
  80. ncbi A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients
    David W Oslin
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Room 3002, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 28:1546-52. 2003
    ..If replicated, these results would help to identify alcohol-dependent individuals who may be most likely to respond to treatment with naltrexone...