Research Topics

Daniel Obrecht



  1. Cigana C, Bernardini F, Facchini M, Alcalá Franco B, Riva C, De Fino I, et al. Efficacy of the Novel Antibiotic POL7001 in Preclinical Models of Pseudomonas aeruginosa Pneumonia. Antimicrob Agents Chemother. 2016;60:4991-5000 pubmed publisher
    ..These results support the further evaluation of POL7001 as a novel therapeutic agent for the treatment of P. aeruginosa pulmonary infections. ..
  2. request reprint
    Obrecht D, Robinson J, Bernardini F, Bisang C, DeMarco S, Moehle K, et al. Recent progress in the discovery of macrocyclic compounds as potential anti-infective therapeutics. Curr Med Chem. 2009;16:42-65 pubmed
    ..Several recent examples highlight the great potential of the PEM approach in the discovery of new anti-infective agents. ..
  3. Luther A, Moehle K, Chevalier E, Dale G, Obrecht D. Protein epitope mimetic macrocycles as biopharmaceuticals. Curr Opin Chem Biol. 2017;38:45-51 pubmed publisher
    ..Finally, this review describes some of the most advanced protein epitope mimetic (PEM) macrocycles in clinical development. ..
  4. Luther A, Bisang C, Obrecht D. Advances in macrocyclic peptide-based antibiotics. Bioorg Med Chem. 2018;26:2850-2858 pubmed publisher
    ..This mini-review gives an up-date on recent developments. ..