Hans Oberleithner

Summary

Publications

  1. doi request reprint Pathogenesis of hypertension: interactions among sodium, potassium, and aldosterone
    Eckhart Büssemaker
    Medizinische Klinik und Poliklinik D, Universitatsklinikum Munster, Munster, Germany
    Am J Kidney Dis 55:1111-20. 2010
  2. doi request reprint Role of rho-kinase in the regulation of vascular tone in hypertensive renal transplant recipients
    E Büssemaker
    Medizinische Klinik und Poliklinik D, Universitatsklinikum Munster, Munster, Germany
    Atherosclerosis 207:567-72. 2009
  3. pmc Nanomechanics and sodium permeability of endothelial surface layer modulated by hawthorn extract WS 1442
    Wladimir Peters
    Institute of Physiology II, University of Munster, Munster, Germany
    PLoS ONE 7:e29972. 2012
  4. doi request reprint Firewall function of the endothelial glycocalyx in the regulation of sodium homeostasis
    Stefanie Korte
    Institute of Physiology II, University of Muenster, Robert Koch Strasse 27 b, 48149, Munster, Germany
    Pflugers Arch 463:269-78. 2012
  5. doi request reprint Long-term application of the aldosterone antagonist spironolactone prevents stiff endothelial cell syndrome
    Verena Drüppel
    Institute of Physiology II, University of Munster, Munster, Germany
    FASEB J 27:3652-9. 2013
  6. ncbi request reprint Ethanol alters access to the cell nucleus
    Claudia Schafer
    Institute of Physiology II, University of Munster, Munster, Germany
    Pflugers Arch 453:809-18. 2007
  7. doi request reprint Caspase-9-dependent decrease of nuclear pore channel hydrophobicity is accompanied by nuclear envelope leakiness
    Armin Kramer
    Institute of Physiology II, University of Munster, Munster, Germany
    Nanomedicine 6:605-11. 2010
  8. doi request reprint High phosphate directly affects endothelial function by downregulating annexin II
    Giovana Seno Di Marco
    Department of Internal Medicine D, University of Munster, Munster, Germany
    Kidney Int 83:213-22. 2013
  9. doi request reprint Role of cellular mechanics in the function and life span of vascular endothelium
    Katrin Kliche
    Institute of Physiology II, University of Munster, Robert Koch Strasse 27b, Munster, Germany
    Pflugers Arch 462:209-17. 2011
  10. doi request reprint Investigation of nuclear envelope structure and passive permeability
    Victor Shahin
    Institute of Physiology II, University of Munster, Munster, Germany
    Methods Mol Biol 464:161-80. 2009

Collaborators

Detail Information

Publications24

  1. doi request reprint Pathogenesis of hypertension: interactions among sodium, potassium, and aldosterone
    Eckhart Büssemaker
    Medizinische Klinik und Poliklinik D, Universitatsklinikum Munster, Munster, Germany
    Am J Kidney Dis 55:1111-20. 2010
    ..A restriction in sodium intake that is accompanied by increased intake of potassium can profoundly improve the prevalence of hypertension and cardiovascular disease...
  2. doi request reprint Role of rho-kinase in the regulation of vascular tone in hypertensive renal transplant recipients
    E Büssemaker
    Medizinische Klinik und Poliklinik D, Universitatsklinikum Munster, Munster, Germany
    Atherosclerosis 207:567-72. 2009
    ..The greater NO-insensitive fasudil-induced increase in FBF in NTX suggests an increased ROK-mediated VSMC constrictor tone in these patients. Basal NO-mediated tone is attenuated in hypertensive NTX...
  3. pmc Nanomechanics and sodium permeability of endothelial surface layer modulated by hawthorn extract WS 1442
    Wladimir Peters
    Institute of Physiology II, University of Munster, Munster, Germany
    PLoS ONE 7:e29972. 2012
    ..This mechanism may explain some of the vasoprotective actions of this herbal therapeutic...
  4. doi request reprint Firewall function of the endothelial glycocalyx in the regulation of sodium homeostasis
    Stefanie Korte
    Institute of Physiology II, University of Muenster, Robert Koch Strasse 27 b, 48149, Munster, Germany
    Pflugers Arch 463:269-78. 2012
    ..After eGC removal, sodium access to the system is facilitated. Thus the pump-leak system could be regulated by ambient sodium and control vascular permeability in pathophysiological conditions...
  5. doi request reprint Long-term application of the aldosterone antagonist spironolactone prevents stiff endothelial cell syndrome
    Verena Drüppel
    Institute of Physiology II, University of Munster, Munster, Germany
    FASEB J 27:3652-9. 2013
    ..This emphasizes the key role of vascular endothelium as a therapeutical target in cardiovascular disorders and might explain blood pressure independent actions of MR antagonism...
  6. ncbi request reprint Ethanol alters access to the cell nucleus
    Claudia Schafer
    Institute of Physiology II, University of Munster, Munster, Germany
    Pflugers Arch 453:809-18. 2007
    ..Within hours, the NE becomes less permeable for diffusible ions and macromolecules. This could explain altered signaling to and communication with the cell nucleus in the pathophysiology of alcohol abuse...
  7. doi request reprint Caspase-9-dependent decrease of nuclear pore channel hydrophobicity is accompanied by nuclear envelope leakiness
    Armin Kramer
    Institute of Physiology II, University of Munster, Munster, Germany
    Nanomedicine 6:605-11. 2010
    ..We conclude that caspase 9 gives rise to NE leakiness by perturbing the hydrophobicity-based barrier inside the NPC channel. This explains the high passive NE permeability in early apoptosis...
  8. doi request reprint High phosphate directly affects endothelial function by downregulating annexin II
    Giovana Seno Di Marco
    Department of Internal Medicine D, University of Munster, Munster, Germany
    Kidney Int 83:213-22. 2013
    ..In addition, high phosphate stiffened endothelial cells in vitro and in rats in vivo. Thus, our results link phosphate and adverse clinical outcomes involving the endothelium in both healthy individuals and patients with renal disease...
  9. doi request reprint Role of cellular mechanics in the function and life span of vascular endothelium
    Katrin Kliche
    Institute of Physiology II, University of Munster, Robert Koch Strasse 27b, Munster, Germany
    Pflugers Arch 462:209-17. 2011
    ..This may explain the recently observed beneficial effects of spironolactone on the cardiovascular system. Taken together, the review highlights the importance of elasticity for normal endothelial function...
  10. doi request reprint Investigation of nuclear envelope structure and passive permeability
    Victor Shahin
    Institute of Physiology II, University of Munster, Munster, Germany
    Methods Mol Biol 464:161-80. 2009
    ..This chapter describes in detail the protocols for performing such investigations...
  11. ncbi request reprint Plugs in nuclear pores: transcripts in early oocyte development identified with nanotechniques
    Andrea Schlune
    Institute of Physiology II, University of Munster, Munster, Germany
    J Cell Biochem 98:567-76. 2006
    ....
  12. pmc The soluble VEGF receptor sFlt1 contributes to endothelial dysfunction in CKD
    Giovana S Di Marco
    Department of Internal Medicine D, University Clinics Münster, Munster, Germany
    J Am Soc Nephrol 20:2235-45. 2009
    ..Our findings show that excess sFlt-1 associates with endothelial dysfunction in CKD and suggest that increased sFlt-1 may predict cardiovascular risk in CKD...
  13. ncbi request reprint Direct aldosterone action on mouse cardiomyocytes detected with atomic force microscopy
    Katrin Kliche
    Institute of Physiology II, University of Munster, Munster, Germany
    Cell Physiol Biochem 18:265-74. 2006
    ..These nanometer changes, detectable only with AFM in cells scanned in fluid after fixation under physiological conditions, indicate plasma membrane remodeling of cardiomyocytes by mineralocorticoids...
  14. doi request reprint Exceptional mechanical and structural stability of HSV-1 unveiled with fluid atomic force microscopy
    Ivan Liashkovich
    Institute of Physiology II, University of Munster, Munster, Germany
    J Cell Sci 121:2287-92. 2008
    ..This stability might be the key determinant for capsid survival over long distances in the axonal cytoplasm where it is exposed to mechanical forces by molecular motors before it reaches the nuclear pore for crucial genome uncoating...
  15. pmc Two barriers for sodium in vascular endothelium?
    Hans Oberleithner
    Institute of Physiology II, University of Munster, Munster, Germany
    Ann Med 44:S143-8. 2012
    ..Gradually, the sodium overload damages the organism...
  16. pmc Salt overload damages the glycocalyx sodium barrier of vascular endothelium
    Hans Oberleithner
    Institute of Physiology II, University of Munster, Robert Koch Str 27b, 48149, Munster, Germany
    Pflugers Arch 462:519-28. 2011
    ..Damaged eGC facilitates sodium entry into the endothelial cells. This could explain endothelial dysfunction and arterial hypertension observed in sodium abuse...
  17. doi request reprint Paracellular permeability of bronchial epithelium is controlled by CFTR
    Nelly Weiser
    Institute of Physiology II, University of Munster, Munster, Germany
    Cell Physiol Biochem 28:289-96. 2011
    ..Taken together, our results link CFTR dysfunction to an improper regulation of the paracellular transport route...
  18. doi request reprint Sodium: a wolf in sheep's clothing
    Hans Oberleithner
    Institute of Physiology II, Medical Faculty, University Munster, Robert Koch Strasse 27b, Munster, Germany
    Blood Purif 31:82-5. 2011
    ..It becomes pathogenic, however, when the concentration of plasma sodium or potassium changes towards and beyond the upper limits of the normal range...
  19. pmc Real-time monitoring of cell elasticity reveals oscillating myosin activity
    Hermann Schillers
    Institute of Physiology II, University of Munster, Munster, Germany
    Biophys J 99:3639-46. 2010
    ..In conclusion, the collective activities of the myosin motor proteins define overall mechanical cell dynamics, reflecting specific changes of the chemical and mechanical environment...
  20. ncbi request reprint Vacuolar structures can be identified by AFM elasticity mapping
    Christoph Riethmuller
    Institute of Physiology II, University of Muenster, Munster, Germany
    Ultramicroscopy 107:895-901. 2007
    ..This AFM application opens up a mechanical dimension for the investigation of intracellular organelles...
  21. ncbi request reprint Shape and volume of living aldosterone-sensitive cells imaged with the atomic force microscope
    Stefan W Schneider
    Department of Dermatology, Westfalische Wilhelms Universitat, Munster, Germany
    Methods Mol Biol 242:255-79. 2004
  22. ncbi request reprint IADS, a decomposition product of DIDS activates a cation conductance in Xenopus oocytes and human erythrocytes: new compound for the diagnosis of cystic fibrosis
    Astrid Stumpf
    Institute of Physiology II, University of Munster, Munster, Germany
    Cell Physiol Biochem 18:243-52. 2006
    ..Thus, IADS stimulated activation of a cation conductance could form the basis for a novel diagnostic test of cystic fibrosis...
  23. ncbi request reprint Steroids dilate nuclear pores imaged with atomic force microscopy
    Victor Shahin
    Nanolab, Institute of Physiology II, University of Munster, Munster, Germany
    J Cell Physiol 202:591-601. 2005
    ..The NPC dilation signal is most likely transmitted through NPC associated filaments or yet unknown structures in the NE outer membrane. NPC dilation could have significant impact on nuclear targeting of therapeutic macromolecules...
  24. doi request reprint Dynamics of single potassium channel proteins in the plasma membrane of migrating cells
    Volodymyr Nechyporuk-Zloy
    Institute of Physiology II, University of Munster, Munster, Germany
    Am J Physiol Cell Physiol 294:C1096-102. 2008
    ..Thus tracking fluorescent particles within the glycocalyx opens up a possibility to characterize the pericellular nanoenvironment...