Role of rho-kinase in the regulation of vascular tone in hypertensive renal transplant recipientsE Büssemaker
Medizinische Klinik und Poliklinik D, Universitatsklinikum Munster, Munster, Germany
Atherosclerosis 207:567-72. 2009
..The greater NO-insensitive fasudil-induced increase in FBF in NTX suggests an increased ROK-mediated VSMC constrictor tone in these patients. Basal NO-mediated tone is attenuated in hypertensive NTX...
- Pathogenesis of hypertension: interactions among sodium, potassium, and aldosterone
Eckhart Büssemaker
Medizinische Klinik und Poliklinik D, Universitatsklinikum Munster, Munster, Germany
Am J Kidney Dis 55:1111-20. 2010
..A restriction in sodium intake that is accompanied by increased intake of potassium can profoundly improve the prevalence of hypertension and cardiovascular disease...
Nanomechanics and sodium permeability of endothelial surface layer modulated by hawthorn extract WS 1442Wladimir Peters
Institute of Physiology II, University of Munster, Munster, Germany
PLoS ONE 7:e29972. 2012
..This mechanism may explain some of the vasoprotective actions of this herbal therapeutic...
- Firewall function of the endothelial glycocalyx in the regulation of sodium homeostasis
Stefanie Korte
Institute of Physiology II, University of Muenster, Robert Koch Strasse 27 b, 48149, Munster, Germany
Pflugers Arch 463:269-78. 2012
..After eGC removal, sodium access to the system is facilitated. Thus the pump-leak system could be regulated by ambient sodium and control vascular permeability in pathophysiological conditions...
- High phosphate directly affects endothelial function by downregulating annexin II
Giovana Seno Di Marco
Department of Internal Medicine D, University of Munster, Munster, Germany
Kidney Int 83:213-22. 2013
..In addition, high phosphate stiffened endothelial cells in vitro and in rats in vivo. Thus, our results link phosphate and adverse clinical outcomes involving the endothelium in both healthy individuals and patients with renal disease...
- Sodium: a wolf in sheep's clothing
Hans Oberleithner
Institute of Physiology II, Medical Faculty, University Munster, Robert Koch Strasse 27b, Munster, Germany
Blood Purif 31:82-5. 2011
..It becomes pathogenic, however, when the concentration of plasma sodium or potassium changes towards and beyond the upper limits of the normal range...
- Role of cellular mechanics in the function and life span of vascular endothelium
Katrin Kliche
Institute of Physiology II, University of Munster, Robert Koch Strasse 27b, Munster, Germany
Pflugers Arch 462:209-17. 2011
..This may explain the recently observed beneficial effects of spironolactone on the cardiovascular system. Taken together, the review highlights the importance of elasticity for normal endothelial function...
- Paracellular permeability of bronchial epithelium is controlled by CFTR
Nelly Weiser
Institute of Physiology II, University of Munster, Munster, Germany
Cell Physiol Biochem 28:289-96. 2011
..Taken together, our results link CFTR dysfunction to an improper regulation of the paracellular transport route...
- Two barriers for sodium in vascular endothelium?
Hans Oberleithner
Institute of Physiology II, University of Munster, Munster, Germany
Ann Med 44:S143-8. 2012
..Gradually, the sodium overload damages the organism...
- Salt overload damages the glycocalyx sodium barrier of vascular endothelium
Hans Oberleithner
Institute of Physiology II, University of Munster, Robert Koch Str 27b, 48149, Munster, Germany
Pflugers Arch 462:519-28. 2011
..Damaged eGC facilitates sodium entry into the endothelial cells. This could explain endothelial dysfunction and arterial hypertension observed in sodium abuse...
- The soluble VEGF receptor sFlt1 contributes to endothelial dysfunction in CKD
Giovana S Di Marco
Department of Internal Medicine D, University Clinics Münster, Munster, Germany
J Am Soc Nephrol 20:2235-45. 2009
..Our findings show that excess sFlt-1 associates with endothelial dysfunction in CKD and suggest that increased sFlt-1 may predict cardiovascular risk in CKD...
- Real-time monitoring of cell elasticity reveals oscillating myosin activity
Hermann Schillers
Institute of Physiology II, University of Munster, Munster, Germany
Biophys J 99:3639-46. 2010
..In conclusion, the collective activities of the myosin motor proteins define overall mechanical cell dynamics, reflecting specific changes of the chemical and mechanical environment...
