Andrew Oberst

Summary

Publications

  1. Daniels B, Kofman S, Smith J, Norris G, Snyder A, Kolb J, et al. The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons. Immunity. 2019;50:64-76.e4 pubmed publisher
    ..These findings demonstrate an immunometabolic mechanism of viral restriction during neuroinvasive infection. ..
  2. Messmer M, Snyder A, Oberst A. Comparing the effects of different cell death programs in tumor progression and immunotherapy. Cell Death Differ. 2019;26:115-129 pubmed publisher
  3. Gutierrez K, Davis M, Daniels B, Olsen T, Ralli Jain P, Tait S, et al. MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1β Independently of Gasdermin-D. J Immunol. 2017;198:2156-2164 pubmed publisher
    ..Taken together, our findings indicate that MLKL is an endogenous activator of the NLRP3 inflammasome, and that MLKL activation provides a mechanism for concurrent processing and release of IL-1β independently of gasdermin-D. ..
  4. Daniels B, Snyder A, Olsen T, Orozco S, Oguin T, Tait S, et al. RIPK3 Restricts Viral Pathogenesis via Cell Death-Independent Neuroinflammation. Cell. 2017;169:301-313.e11 pubmed publisher
    ..These data identify pleiotropic functions for RIPK3 in the restriction of viral pathogenesis and implicate RIPK3 as a key coordinator of immune responses within the CNS. ..

Collaborators