- Mutations in calmodulin cause ventricular tachycardia and sudden cardiac death
Department of Biomedicine, Aarhus University, DK 8000 Aarhus, Denmark
Am J Hum Genet 91:703-12. 2012
- No association of polymorphisms in human endogenous retrovirus K18 and CD48 with schizophrenia
Department of Haematology, Aalborg Hospital Science and Innovation Center, Aarhus University Hospital, Aalborg, Denmark
Psychiatr Genet 22:146-8. 2012
..However, one HERV-K18 SNP showed a tendency toward an association with T2D in younger SZ patients, in agreement with previous findings, but due to a very low sample size, this result needs to be further investigated...
- Validation and implementation of a method for microarray gene expression profiling of minor B-cell subpopulations in man
Kim Steve Bergkvist
Department of Haematology, Aalborg University Hospital Science and Innovation Center, Sdr Skovvej 15, DK 9000 Aalborg, Denmark
BMC Immunol 15:3. 2014
..However, some of the differentiating compartments involve a low number of cells and therefore it is important to optimize and validate each step in the procedure...
- Exposure time independent summary statistics for assessment of drug dependent cell line growth inhibition
Department of Haematology, Aalborg University Hospital, Aalborg, Denmark
BMC Bioinformatics 15:168. 2014
..This may lead to suboptimal exploitation of data and biased conclusions on the potential of the drug in question. Therefore we set out to improve the dose-response assessments by eliminating the impact of time dependency...
- The Schizophrenia and Bipolar Disorder associated BRD1 gene is regulated upon chronic restraint stress
Jane H Christensen
Department of Biomedicine, Aarhus University, Denmark
Eur Neuropsychopharmacol 22:651-6. 2012
- Association of GRIN1 and GRIN2A-D with schizophrenia and genetic interaction with maternal herpes simplex virus-2 infection affecting disease risk
Department of Human Genetics, Aarhus University, Aarhus, Denmark
Am J Med Genet B Neuropsychiatr Genet 156:913-22. 2011
..0008). The significant associations and interactions were located at the 3' region of GRIN2B suggesting that genetic variation in this part of the gene may be involved in the pathophysiology of schizophrenia...
- The gene encoding the melanin-concentrating hormone receptor 1 is associated with schizophrenia in a Danish case-control sample
Department of Human Genetics, Aarhus University, Arhus, Denmark
Psychiatr Genet 22:62-9. 2012
..Herein we report an association between variations in the MCHR1 gene and schizophrenia, based on analyses of a larger sample and an increased number of single nucleotide polymorphisms (SNPs) than used in the previous study...
- A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene
Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Aarhus, Denmark
Eur J Hum Genet 20:84-90. 2012
..This suggests that the possible risk alleles associated in the isolated population are not those involved in the development of PD in a larger outbred population...
- A major imprinted gene involved in hydatidiform mole is not located in 2q31.2-qter or 5q34-qter
Aarhus University Hospital, Aalborg, Denmark
Gene 497:280-4. 2012
..However it remains yet to be specified which gene(s) in the molar genome actually causes the molar phenotype when present in a state of "paternal excess" or "maternal deficiency"...
- A genome-wide search for linkage to allergic rhinitis in Danish sib-pair families
Lisbeth Venø Kruse
Department of Biomedicine, Aarhus University, Aarhus, Denmark
Eur J Hum Genet 20:965-72. 2012
..Likely maternal imprinting was observed at 2q23, and possible maternal imprinting at 3q28...
- Promoter polymorphisms in the chitinase 3-like 1 gene influence the serum concentration of YKL-40 in Danish patients with rheumatoid arthritis and in healthy subjects
Kaspar R Nielsen
Department of Clinical Immunology, Aalborg Hospital, Aarhus University Hospital, Reberbansgade, Pobox 561, 9000, Aalborg, Denmark
Arthritis Res Ther 13:R109. 2011
..YKL-40 concentrations are elevated in the serum of patients with RA compared to healthy subjects, and YKL-40 has been suggested to be an auto-antigen and may play a role in development of RA and in inflammation...
- Multiparametric flow cytometry for identification and fluorescence activated cell sorting of five distinct B-cell subpopulations in normal tonsil tissue
Malene Krag Kjeldsen
Department of Haematology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
Am J Clin Pathol 136:960-9. 2011
..This study has established a detailed and fast procedure for simultaneous sorting of up to 5 distinct maturation-associated B-cell subpopulations from human tonsils...
- Clinical impact of leukemic blast heterogeneity at diagnosis in cytogenetic intermediate-risk acute myeloid leukemia
Marianne Hutchings Hoffmann
Department of Haematology, Herlev University Hospital, Copenhagen, Denmark
Cytometry B Clin Cytom 82:123-31. 2012
- The Hypercholesterolemia-Risk Gene SORT1 Facilitates PCSK9 Secretion
The Lundbeck Foundation Research Center, Mind, Department of Biomedicine, Aarhus University, Vennelyst Boulevard 4, DK 8000 C Aarhus, Denmark
Cell Metab 19:310-8. 2014
..Taken together, our findings establish sortilin as a critical regulator of PCSK9 activity. ..
- A model system for assessing and comparing the ability of exon microarray and tag sequencing to detect genes specific for malignant B-cells
Maria Bro Kloster
Department of Haematology, Aalborg Hospital, Aarhus University Hospital, Sdr Skovvej 15, 9000 Aalborg, Denmark
BMC Genomics 13:596. 2012
..A model system was established by eight serial dilutions of the malignant B-cell lymphoma cell line, OCI-Ly8, into the embryonic kidney cell line, HEK293, prior to parallel analysis by exon microarrays and tag-seq...
- Support for a bipolar affective disorder susceptibility locus on chromosome 12q24.3
Henriette Nørmølle Buttenschøn
Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Denmark
Psychiatr Genet 20:93-101. 2010
..Linkage and association studies of bipolar affective disorder (BAD) point out chromosome 12q24 as a region of interest...