M Numasaki

Summary

Publications

  1. ncbi request reprint Nucleotide sequence analysis of a human monoclonal antibody TONO-1 with cytotoxic potential for T-leukemia/lymphoma cells
    M Numasaki
    Cancer Cell Repository, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai, 980 8575, Miyagi, Japan
    Immunol Lett 75:167-77. 2001
  2. ncbi request reprint IL-28 elicits antitumor responses against murine fibrosarcoma
    Muneo Numasaki
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan
    J Immunol 178:5086-98. 2007
  3. ncbi request reprint IL-17 and IL-17F modulate GM-CSF production by lung microvascular endothelial cells stimulated with IL-1beta and/or TNF-alpha
    Muneo Numasaki
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Immunol Lett 95:175-84. 2004
  4. ncbi request reprint Regulatory roles of IL-17 and IL-17F in G-CSF production by lung microvascular endothelial cells stimulated with IL-1beta and/or TNF-alpha
    Muneo Numasaki
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Immunol Lett 95:97-104. 2004
  5. ncbi request reprint Interleukin-17 augments tumor necrosis factor-alpha-induced elaboration of proangiogenic factors from fibroblasts
    Muneo Numasaki
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Immunol Lett 93:39-43. 2004
  6. ncbi request reprint Interleukin-17 promotes angiogenesis and tumor growth
    Muneo Numasaki
    Department of Surgery, School of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh, PA, USA
    Blood 101:2620-7. 2003
  7. ncbi request reprint Interleukin-17 enhances bFGF-, HGF- and VEGF-induced growth of vascular endothelial cells
    Hidenori Takahashi
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Immunol Lett 98:189-93. 2005
  8. ncbi request reprint IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis
    Muneo Numasaki
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan
    J Immunol 175:6177-89. 2005
  9. ncbi request reprint Bone marrow-derived cells contribute to lung regeneration after elastase-induced pulmonary emphysema
    Kota Ishizawa
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, 980 8574, Miyagi, Japan
    FEBS Lett 556:249-52. 2004
  10. ncbi request reprint Bone marrow-derived progenitor cells are important for lung repair after lipopolysaccharide-induced lung injury
    Mitsuhiro Yamada
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryou Machi, Aobaku, Sendai 980 8574, Japan
    J Immunol 172:1266-72. 2004

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Nucleotide sequence analysis of a human monoclonal antibody TONO-1 with cytotoxic potential for T-leukemia/lymphoma cells
    M Numasaki
    Cancer Cell Repository, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai, 980 8575, Miyagi, Japan
    Immunol Lett 75:167-77. 2001
    ....
  2. ncbi request reprint IL-28 elicits antitumor responses against murine fibrosarcoma
    Muneo Numasaki
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan
    J Immunol 178:5086-98. 2007
    ..Moreover, IL-12 augmented IL-28-mediated antitumor activity in the presence or absence of IFN-gamma. These findings indicate that IL-28 has bioactivities that induce innate and adaptive immune responses against tumors...
  3. ncbi request reprint IL-17 and IL-17F modulate GM-CSF production by lung microvascular endothelial cells stimulated with IL-1beta and/or TNF-alpha
    Muneo Numasaki
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Immunol Lett 95:175-84. 2004
    ..Our findings indicate that IL-17 and IL-17F play a differential regulatory role in GM-CSF production by LMVECs stimulated with IL-1beta and/or TNF-alpha, which is sensitive to Th1 and Th2 cytokine modulation...
  4. ncbi request reprint Regulatory roles of IL-17 and IL-17F in G-CSF production by lung microvascular endothelial cells stimulated with IL-1beta and/or TNF-alpha
    Muneo Numasaki
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Immunol Lett 95:97-104. 2004
    ..Our findings indicate that CD4 T cell cytokines IL-17 and IL-17F play a differential regulatory role in G-CSF production by LMVECs stimulated with IL-1beta and/or TNF-alpha, which is also sensitive to Th1 and Th2 cytokine modulation...
  5. ncbi request reprint Interleukin-17 augments tumor necrosis factor-alpha-induced elaboration of proangiogenic factors from fibroblasts
    Muneo Numasaki
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Immunol Lett 93:39-43. 2004
    ..Our findings also demonstrate that IL-17 might be a potential contributor to the inflammatory angiogenesis via induction of proangiogenic factors by stromal fibroblasts...
  6. ncbi request reprint Interleukin-17 promotes angiogenesis and tumor growth
    Muneo Numasaki
    Department of Surgery, School of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh, PA, USA
    Blood 101:2620-7. 2003
    ..Furthermore, they suggest that inhibition of biologic action of IL-17 may have therapeutic benefits when applied to angiogenesis-related disorders...
  7. ncbi request reprint Interleukin-17 enhances bFGF-, HGF- and VEGF-induced growth of vascular endothelial cells
    Hidenori Takahashi
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Immunol Lett 98:189-93. 2005
    ..Our findings also suggest that IL-17 may promote bFGF-, HGF- and VEGF-mediated angiogenesis through enhancing bFGF-, HGF- and VEGF-induced growth of vascular endothelial cells...
  8. ncbi request reprint IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis
    Muneo Numasaki
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan
    J Immunol 175:6177-89. 2005
    ....
  9. ncbi request reprint Bone marrow-derived cells contribute to lung regeneration after elastase-induced pulmonary emphysema
    Kota Ishizawa
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, 980 8574, Miyagi, Japan
    FEBS Lett 556:249-52. 2004
    ..ATRA or G-CSF promoted lung regeneration and increased bone marrow-derived cell (BMC) numbers in alveoli. Combined treatment of both had an additive effect, which indicated that BMC mobilization might be important in lung regeneration...
  10. ncbi request reprint Bone marrow-derived progenitor cells are important for lung repair after lipopolysaccharide-induced lung injury
    Mitsuhiro Yamada
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryou Machi, Aobaku, Sendai 980 8574, Japan
    J Immunol 172:1266-72. 2004
    ..Reconstitution of the bone marrow prevents these changes. These data suggest that BMPCs are important and required for lung repair after LPS-induced lung injury...
  11. ncbi request reprint IL-17A promotes the growth of airway epithelial cells through ERK-dependent signaling pathway
    Daisuke Inoue
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Biochem Biophys Res Commun 347:852-8. 2006
    ..These findings provide the first evidence that IL-17A stimulates the growth of airway epithelial cells through the ERK MAP kinase pathway...
  12. ncbi request reprint Mechanisms of mucin production by rhinovirus infection in cultured human airway epithelial cells
    Daisuke Inoue
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Respir Physiol Neurobiol 154:484-99. 2006
    ..Src-related p44/42 mitogen-activated protein kinase pathway may be associated with RV-induced mucin hypersecretion in human airways...
  13. doi request reprint Submucosal gland cells in human lower airways produce MUC5AC protein
    Daisuke Inoue
    Department of Geriatrics and Gerontology, Tohoku University Hospital, Seiryoumachi, Sendai 980 8574, Japan
    Respirology 13:285-7. 2008
    ..The aim of this study was to clarify whether human submucosal glands produce MUC5AC...
  14. ncbi request reprint [Criteria of impairment of pulmonary function using Japanese standard values]
    Masao Nakamura
    Department of Pulmonary Medicine, Keihai Rosai Hospital, 1632 Takatoku, Fujiharamachi, Shioyagun, Tochigi 321 2523, Japan
    Nihon Kokyuki Gakkai Zasshi 40:925-8. 2002
    ..We suggest that Japanese standard values should be used in order to judge the impairment of these patients...