Nucleotide sequence analysis of a human monoclonal antibody TONO-1 with cytotoxic potential for T-leukemia/lymphoma cellsM Numasaki
Cancer Cell Repository, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai, 980 8575, Miyagi, Japan
Immunol Lett 75:167-77. 2001
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- IL-28 elicits antitumor responses against murine fibrosarcoma
Muneo Numasaki
Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan
J Immunol 178:5086-98. 2007
..Moreover, IL-12 augmented IL-28-mediated antitumor activity in the presence or absence of IFN-gamma. These findings indicate that IL-28 has bioactivities that induce innate and adaptive immune responses against tumors...
- IL-17 and IL-17F modulate GM-CSF production by lung microvascular endothelial cells stimulated with IL-1beta and/or TNF-alpha
Muneo Numasaki
Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
Immunol Lett 95:175-84. 2004
..Our findings indicate that IL-17 and IL-17F play a differential regulatory role in GM-CSF production by LMVECs stimulated with IL-1beta and/or TNF-alpha, which is sensitive to Th1 and Th2 cytokine modulation...
- Regulatory roles of IL-17 and IL-17F in G-CSF production by lung microvascular endothelial cells stimulated with IL-1beta and/or TNF-alpha
Muneo Numasaki
Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
Immunol Lett 95:97-104. 2004
..Our findings indicate that CD4 T cell cytokines IL-17 and IL-17F play a differential regulatory role in G-CSF production by LMVECs stimulated with IL-1beta and/or TNF-alpha, which is also sensitive to Th1 and Th2 cytokine modulation...
- Interleukin-17 augments tumor necrosis factor-alpha-induced elaboration of proangiogenic factors from fibroblasts
Muneo Numasaki
Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
Immunol Lett 93:39-43. 2004
..Our findings also demonstrate that IL-17 might be a potential contributor to the inflammatory angiogenesis via induction of proangiogenic factors by stromal fibroblasts...
- Interleukin-17 promotes angiogenesis and tumor growth
Muneo Numasaki
Department of Surgery, School of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh, PA, USA
Blood 101:2620-7. 2003
..Furthermore, they suggest that inhibition of biologic action of IL-17 may have therapeutic benefits when applied to angiogenesis-related disorders...
- Interleukin-17 enhances bFGF-, HGF- and VEGF-induced growth of vascular endothelial cells
Hidenori Takahashi
Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan
Immunol Lett 98:189-93. 2005
..Our findings also suggest that IL-17 may promote bFGF-, HGF- and VEGF-mediated angiogenesis through enhancing bFGF-, HGF- and VEGF-induced growth of vascular endothelial cells...
- IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis
Muneo Numasaki
Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan
J Immunol 175:6177-89. 2005
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- Bone marrow-derived cells contribute to lung regeneration after elastase-induced pulmonary emphysema
Kota Ishizawa
Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, 980-8574, Miyagi, Japan
FEBS Lett 556:249-52. 2004
..ATRA or G-CSF promoted lung regeneration and increased bone marrow-derived cell (BMC) numbers in alveoli. Combined treatment of both had an additive effect, which indicated that BMC mobilization might be important in lung regeneration...
- Bone marrow-derived progenitor cells are important for lung repair after lipopolysaccharide-induced lung injury
Mitsuhiro Yamada
Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1-1 Seiryou-machi, Aobaku, Sendai 980-8574, Japan
J Immunol 172:1266-72. 2004
..Reconstitution of the bone marrow prevents these changes. These data suggest that BMPCs are important and required for lung repair after LPS-induced lung injury...
- IL-17A promotes the growth of airway epithelial cells through ERK-dependent signaling pathway
Daisuke Inoue
Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
Biochem Biophys Res Commun 347:852-8. 2006
..These findings provide the first evidence that IL-17A stimulates the growth of airway epithelial cells through the ERK MAP kinase pathway...
- Mechanisms of mucin production by rhinovirus infection in cultured human airway epithelial cells
Daisuke Inoue
Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan
Respir Physiol Neurobiol 154:484-99. 2006
..Src-related p44/42 mitogen-activated protein kinase pathway may be associated with RV-induced mucin hypersecretion in human airways...
Submucosal gland cells in human lower airways produce MUC5AC proteinDaisuke Inoue
Department of Geriatrics and Gerontology, Tohoku University Hospital, Seiryoumachi, Sendai 980 8574, Japan
Respirology 13:285-7. 2008
..The aim of this study was to clarify whether human submucosal glands produce MUC5AC...
- [Criteria of impairment of pulmonary function using Japanese standard values]
Masao Nakamura
Department of Pulmonary Medicine, Keihai Rosai Hospital, 1632 Takatoku, Fujiharamachi, Shioyagun, Tochigi 321 2523, Japan
Nihon Kokyuki Gakkai Zasshi 40:925-8. 2002
..We suggest that Japanese standard values should be used in order to judge the impairment of these patients...
