F Ntoumi

..This may have possible implication for the clearance of malaria parasites and for protection against severe malaria...

..vivax malaria after visiting this region. An attempt was made, therefore, to detect the presence of P. vivax parasites in blood samples collected from the indigenous populations of west and central Africa...

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..falciparum strains were investigated...

..01 clones/child with asymptomatic infections). We observed also a reduction of the complexity of infection beyond the age of 10 years. These results are discussed in regard to studies conducted in other areas in Africa...

..Could it be rightly stated today that the MIM concept reflects the africanization of malaria research?..

..The role of the high multiclonal carriage associated with high family-specific antibodies reactive to MSP2 in HbAS children with asymptomatic P. falciparum parasitism is discussed...

..This could be considered a watershed in the development of health research capacity in Central Africa and rejuvenation in regional collaborations...

..Data are interpreted in the context of malaria epidemiology in both settings...

..falciparum malaria, and that the TNFalpha(-238A) allele confers protection against clinical malaria...

..Below microscopy level, the placenta remains the most infected organ and this submicroscopic carriage of parasites may contribute to the development and maintenance of immunity to malaria during pregnancy...

..Only codons 436 and 437 of the 38 analysed sequences of the DHPS gene revealed point mutations. These results have been compared with those reported from different sites in Africa, Asia or South-America...

..This corresponded to the age reported for the acquisition of anti-parasite immunity under high malaria endemicity. The contribution of variant-specific immunity in asymptomatic malaria infections is discussed...

..It therefore appears that msp2 genotypes are associated with asymptomatic carriage and that children with mono-infections are more likely to develop severe malaria than children with polyinfection...

..These findings are not consistent with those of previous in vitro studies and suggest that further evaluation of pfmdr1 gene polymorphism and in vivo mefloquine sensitivity are needed...

..These findings suggest that the multiplicity of falciparum infection may be a potentially useful parameter in the evaluation of malaria control interventions...

..029). These results suggest that humoral immune responses play a supportive role in the efficacy of amodiaquine treatment...

..These results suggest that, in malaria, a specific dysregulation of the cytokine balance may lead to complications such as severe anemia...

..However, genomics studies of human populations raise important ethical issues, such as the disposition of data related to disease susceptibility or paternity, and the ability of communities to understand the nature of the research...

..5% of isolates. This study confirms the high level of in vivo resistance to CQ and shows the high prevalence of pfcrt K76T mutation in the Republic of Congo...

..05). With a similar level of malaria transmission in both urban sites, these results suggest an impact of malaria control interventions on the dynamics of concurrent P. falciparum infections...

..falciparum isolates collected in 1996 and 2002, and the severity of the disease was not associated with specific mutations neither in the Pfcrt nor in the Pfmdr1 genes in the study site...

..Our findings support the WHO recommendation of PCR genotyping in malaria clinical trials and suggest that stepwise genotyping of only two loci (msp2 and msp1 or glurp) can reliably discriminate recrudescences from new infections...

..Based on our results, the implementation of artemisinin-based combination therapy appears to be urgent in the country...

..To test the efficacy of sulfadoxine-pyremethamine (SP) monotherapy and establish the prevalence of mutations in dhfr and dhps in Brazzaville, Congo...