F Ntoumi

Summary

Publications

  1. ncbi request reprint Distribution of IgG subclass antibodies specific for Plasmodium falciparum glutamate-rich-protein molecule in sickle cell trait children with asymptomatic infections
    Davy W Matondo Maya
    Unite de Recherches Medicales, Hopital Albert Schweitzer, Lambarene, Gabon
    Exp Parasitol 112:92-8. 2006
  2. pmc Genetic evidence of regulatory gene variants of the STAT6, IL10R and FOXP3 locus as a susceptibility factor in uncomplicated malaria and parasitaemia in Congolese children
    Felix Koukouikila-Koussounda
    Institute of Tropical Medicine, University of Tubingen, Tubingen, Germany
    Malar J 12:9. 2013
  3. pmc Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing
    Richard L Culleton
    Laboratory of Malariology, International Research Centre of Infectious Diseases, Research Institute of Microbial Diseases, Osaka University, Osaka, Japan
    Malar J 7:174. 2008
  4. pmc Fine specificity of anti-MSP119 antibodies and multiplicity of Plasmodium falciparum merozoite surface protein 1 types in individuals in Nigeria with sub-microscopic infection
    Josiane Ngoundou-Landji
    1Université des Sciences et Techniques de Masuku, Franceville, Gabon
    Malar J 9:287. 2010
  5. ncbi request reprint The importance and future of malaria research in Africa
    Francine Ntoumi
    Unite de Recherches Medicales, Hopital Albert Schweitzer, Lambarene, Gabon
    Am J Trop Med Hyg 71:IV. 2004
  6. ncbi request reprint [Allelic polymorphism of Plasmodium falciparum MSP-2 gene in blood samples from Gabonese children]
    F Ntoumi
    Centre International de Recherches Medicales, B P 769, Franceville, Gabon
    Bull Soc Pathol Exot 94:183-7. 2001
  7. doi request reprint Networking and capacity building for health research in Central Africa
    Francine Ntoumi
    Institute for Tropical Medicine, University of Tubingen, Tubingen, Germany
    Wien Klin Wochenschr 122:23-6. 2010
  8. ncbi request reprint Sickle cell trait carriage: imbalanced distribution of IgG subclass antibodies reactive to Plasmodium falciparum family-specific MSP2 peptides in serum samples from Gabonese children
    Francine Ntoumi
    Centre International de Recherches Medicales de Franceville CIRMF, Franceville, Gabon
    Immunol Lett 84:9-16. 2002
  9. pmc Africanizing scientific knowledge: the Multilateral Initiative on Malaria as a model?
    Francine Ntoumi
    Multilateral Initiative on Malaria, AMANET Secretariat, P O 33207, Dar es Salaam, Tanzania
    Malar J 9:S7. 2010
  10. ncbi request reprint Site-based study on polymorphism of Plasmodium falciparum MSP-1 and MSP-2 genes in isolates from two villages in Central Africa
    F Ntoumi
    Centre International de Recherches Medicales de Franceville CIRMF, BP 769, Franceville, Gabon
    Parassitologia 42:197-203. 2000

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Distribution of IgG subclass antibodies specific for Plasmodium falciparum glutamate-rich-protein molecule in sickle cell trait children with asymptomatic infections
    Davy W Matondo Maya
    Unite de Recherches Medicales, Hopital Albert Schweitzer, Lambarene, Gabon
    Exp Parasitol 112:92-8. 2006
    ..This may have possible implication for the clearance of malaria parasites and for protection against severe malaria...
  2. pmc Genetic evidence of regulatory gene variants of the STAT6, IL10R and FOXP3 locus as a susceptibility factor in uncomplicated malaria and parasitaemia in Congolese children
    Felix Koukouikila-Koussounda
    Institute of Tropical Medicine, University of Tubingen, Tubingen, Germany
    Malar J 12:9. 2013
    ..The aim of this study was to evaluate possible associations between regulatory gene polymorphisms and the risk of uncomplicated malaria and the control of Plasmodium falciparum parasite density levels...
  3. pmc Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing
    Richard L Culleton
    Laboratory of Malariology, International Research Centre of Infectious Diseases, Research Institute of Microbial Diseases, Osaka University, Osaka, Japan
    Malar J 7:174. 2008
    ..vivax malaria after visiting this region. An attempt was made, therefore, to detect the presence of P. vivax parasites in blood samples collected from the indigenous populations of west and central Africa...
  4. pmc Fine specificity of anti-MSP119 antibodies and multiplicity of Plasmodium falciparum merozoite surface protein 1 types in individuals in Nigeria with sub-microscopic infection
    Josiane Ngoundou-Landji
    1Université des Sciences et Techniques de Masuku, Franceville, Gabon
    Malar J 9:287. 2010
    ....
  5. ncbi request reprint The importance and future of malaria research in Africa
    Francine Ntoumi
    Unite de Recherches Medicales, Hopital Albert Schweitzer, Lambarene, Gabon
    Am J Trop Med Hyg 71:IV. 2004
  6. ncbi request reprint [Allelic polymorphism of Plasmodium falciparum MSP-2 gene in blood samples from Gabonese children]
    F Ntoumi
    Centre International de Recherches Medicales, B P 769, Franceville, Gabon
    Bull Soc Pathol Exot 94:183-7. 2001
    ..01 clones/child with asymptomatic infections). We observed also a reduction of the complexity of infection beyond the age of 10 years. These results are discussed in regard to studies conducted in other areas in Africa...
  7. doi request reprint Networking and capacity building for health research in Central Africa
    Francine Ntoumi
    Institute for Tropical Medicine, University of Tubingen, Tubingen, Germany
    Wien Klin Wochenschr 122:23-6. 2010
    ..This could be considered a watershed in the development of health research capacity in Central Africa and rejuvenation in regional collaborations...
  8. ncbi request reprint Sickle cell trait carriage: imbalanced distribution of IgG subclass antibodies reactive to Plasmodium falciparum family-specific MSP2 peptides in serum samples from Gabonese children
    Francine Ntoumi
    Centre International de Recherches Medicales de Franceville CIRMF, Franceville, Gabon
    Immunol Lett 84:9-16. 2002
    ..The role of the high multiclonal carriage associated with high family-specific antibodies reactive to MSP2 in HbAS children with asymptomatic P. falciparum parasitism is discussed...
  9. pmc Africanizing scientific knowledge: the Multilateral Initiative on Malaria as a model?
    Francine Ntoumi
    Multilateral Initiative on Malaria, AMANET Secretariat, P O 33207, Dar es Salaam, Tanzania
    Malar J 9:S7. 2010
    ..Could it be rightly stated today that the MIM concept reflects the africanization of malaria research?..
  10. ncbi request reprint Site-based study on polymorphism of Plasmodium falciparum MSP-1 and MSP-2 genes in isolates from two villages in Central Africa
    F Ntoumi
    Centre International de Recherches Medicales de Franceville CIRMF, BP 769, Franceville, Gabon
    Parassitologia 42:197-203. 2000
    ..Data are interpreted in the context of malaria epidemiology in both settings...
  11. ncbi request reprint Influence of carriage of hemoglobin AS and the Fc gamma receptor IIa-R131 allele on levels of immunoglobulin G2 antibodies to Plasmodium falciparum merozoite antigens in Gabonese children
    Francine Ntoumi
    Unite de Recherches Medicales, Hopital Albert Schweitzer, Lambarene, Gabon
    J Infect Dis 192:1975-80. 2005
    ..falciparum strains were investigated...
  12. ncbi request reprint Human genetic polymorphisms and asymptomatic Plasmodium falciparum malaria in Gabonese schoolchildren
    Landry Erik Mombo
    Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    Am J Trop Med Hyg 68:186-90. 2003
    ..falciparum malaria, and that the TNFalpha(-238A) allele confers protection against clinical malaria...
  13. ncbi request reprint Submicroscopic Plasmodium falciparum infections and multiplicity of infection in matched peripheral, placental and umbilical cord blood samples from Gabonese women
    Pembe Issamou Mayengue
    Unite de Recherches Medicales, Hopital Albert Schweitzer, Lambarene, Gabon
    Trop Med Int Health 9:949-58. 2004
    ..Below microscopy level, the placenta remains the most infected organ and this submicroscopic carriage of parasites may contribute to the development and maintenance of immunity to malaria during pregnancy...
  14. ncbi request reprint Molecular analysis of DHFR and DHPS genes in P. falciparum clinical isolates from the Haut--Ogooué region in Gabon
    D P Mawili-Mboumba
    , BP 769, Franceville, Gabon
    Acta Trop 78:231-40. 2001
    ..Only codons 436 and 437 of the 38 analysed sequences of the DHPS gene revealed point mutations. These results have been compared with those reported from different sites in Africa, Asia or South-America...
  15. ncbi request reprint Plasmodium falciparum merozoite surface protein 1 (MSP1): genotyping and humoral responses to allele-specific variants
    Marie Therese Ekala
    Centre International de Recherches Medicales, Franceville CIRMF B P 769, Franceville, Gabon
    Acta Trop 81:33-46. 2002
    ..This corresponded to the age reported for the acquisition of anti-parasite immunity under high malaria endemicity. The contribution of variant-specific immunity in asymptomatic malaria infections is discussed...
  16. doi request reprint Complexity of the msp2 locus and the severity of childhood malaria, in south-western Nigeria
    O K Amodu
    Institute of Child Health, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria
    Ann Trop Med Parasitol 102:95-102. 2008
    ..It therefore appears that msp2 genotypes are associated with asymptomatic carriage and that children with mono-infections are more likely to develop severe malaria than children with polyinfection...
  17. pmc Pfmdr1 alleles and response to ultralow-dose mefloquine treatment in Gabonese patients
    Denise P Mawili-Mboumba
    Unité de Recherche Médicale, Hopital Albert Schweitzer, Lambarene, Gabon
    Antimicrob Agents Chemother 46:166-70. 2002
    ..These findings are not consistent with those of previous in vitro studies and suggest that further evaluation of pfmdr1 gene polymorphism and in vivo mefloquine sensitivity are needed...
  18. doi request reprint The multiplicity of Plasmodium falciparum infections is associated with acquired immunity to asexual blood stage antigens
    Pembe Issamou Mayengue
    Unite de Recherches Medicales, Hopital Albert Schweitzer, Lambarene, Gabon
    Microbes Infect 11:108-14. 2009
    ..These findings suggest that the multiplicity of falciparum infection may be a potentially useful parameter in the evaluation of malaria control interventions...
  19. ncbi request reprint Antibody responses to Plasmodium falciparum merozoite surface protein-1 and efficacy of amodiaquine in Gabonese children with P. falciparum malaria
    Denise P Mawili-Mboumba
    Unité de Recherche Médicale, Hopital Albert Schweitzer, Lambarene, Gabon
    J Infect Dis 187:1137-41. 2003
    ..029). These results suggest that humoral immune responses play a supportive role in the efficacy of amodiaquine treatment...
  20. ncbi request reprint Severe malarial anemia associated with increased soluble Fas ligand (sFasL) concentrations in Gabonese children
    Saadou Issifou
    Unite de Recherches Medicales, Hopital Albert Schweitzer, Lambarene, Gabon
    Eur Cytokine Netw 14:238-41. 2003
    ..These results suggest that, in malaria, a specific dysregulation of the cytokine balance may lead to complications such as severe anemia...
  21. ncbi request reprint New interventions for malaria: mining the human and parasite genomes
    Francine Ntoumi
    Research Unit, Hopital Albert Schweitzer, Lambarene, Gabon
    Am J Trop Med Hyg 77:270-5. 2007
    ..However, genomics studies of human populations raise important ethical issues, such as the disposition of data related to disease susceptibility or paternity, and the ability of communities to understand the nature of the research...
  22. ncbi request reprint No variation in the prevalence of point mutations in the Pfcrt and Pfmdr1 genes in isolates from Gabonese patients with uncomplicated or severe Plasmodium falciparum malaria
    Pembe Issamou Mayengue
    Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
    Parasitol Res 100:487-93. 2007
    ..falciparum isolates collected in 1996 and 2002, and the severity of the disease was not associated with specific mutations neither in the Pfcrt nor in the Pfmdr1 genes in the study site...
  23. ncbi request reprint Molecular genotyping to distinguish between recrudescents and new infections in treatment trials of Plasmodium falciparum malaria conducted in Sub-Saharan Africa: adjustment of parasitological outcomes and assessment of genotyping effectiveness
    Kefas Mugittu
    Ifakara Health Research and Development Centre, Ifakara, Tanzania
    Trop Med Int Health 11:1350-9. 2006
    ..Our findings support the WHO recommendation of PCR genotyping in malaria clinical trials and suggest that stepwise genotyping of only two loci (msp2 and msp1 or glurp) can reliably discriminate recrudescences from new infections...
  24. ncbi request reprint Complexity and genetic diversity of Plasmodium falciparum infections in young children living in urban areas of Central and West Africa
    Saadou Issifou
    Centre Régional pour le Développement et la Santé CREDESA SSP, Cotonou, Benin
    Parasitol Res 90:423-8. 2003
    ..05). With a similar level of malaria transmission in both urban sites, these results suggest an impact of malaria control interventions on the dynamics of concurrent P. falciparum infections...
  25. ncbi request reprint In vivo chloroquine resistance and prevalence of the pfcrt codon 76 mutation in Plasmodium falciparum isolates from the Republic of Congo
    Pembe Issamou Mayengue
    Albert Schweitzer Hospital, BP 118, Lambarene, Gabon
    Acta Trop 95:219-25. 2005
    ..5% of isolates. This study confirms the high level of in vivo resistance to CQ and shows the high prevalence of pfcrt K76T mutation in the Republic of Congo...
  26. ncbi request reprint Therapeutic efficacy of sulfadoxine-pyrimethamine and the prevalence of molecular markers of resistance in under 5-year olds in Brazzaville, Congo
    Mathieu Ndounga
    Laboratoire de Pharmacologie, Centre d études sur les ressources végétales, Brazzaville, Congo
    Trop Med Int Health 12:1164-71. 2007
    ..To test the efficacy of sulfadoxine-pyremethamine (SP) monotherapy and establish the prevalence of mutations in dhfr and dhps in Brazzaville, Congo...
  27. ncbi request reprint Efficacy of sulfadoxine-pyrimethamine, amodiaquine, and sulfadoxine-pyrimethamine-amodiaquine combination for the treatment of uncomplicated falciparum malaria in the urban and suburban areas of Brazzaville (Congo)
    Mathieu Ndounga
    Laboratoire de Pharmacologie, Centre d études sur les ressources végétales, Brazzaville, Congo
    Acta Trop 103:163-71. 2007
    ..Based on our results, the implementation of artemisinin-based combination therapy appears to be urgent in the country...