J Fox

Summary

Affiliation: NPS Pharmaceuticals

Publications

  1. ncbi request reprint Developments in parathyroid hormone and related peptides as bone-formation agents
    John Fox
    NPS Pharmaceuticals, Inc, 420 Chipeta Way, Salt Lake City, UT 84108, USA
    Curr Opin Pharmacol 2:338-44. 2002
  2. ncbi request reprint Plasma levels of parathyroid hormone that induce anabolic effects in bone of ovariectomized rats can be achieved by stimulation of endogenous hormone secretion
    J Fox
    Department of Pharmacology, NPS Pharmaceuticals, Inc, Salt Lake City, UT 84108, USA
    Bone 21:163-9. 1997
  3. ncbi request reprint Treatment of postmenopausal osteoporotic women with parathyroid hormone 1-84 for 18 months increases cancellous bone formation and improves cancellous architecture: a study of iliac crest biopsies using histomorphometry and micro computed tomography
    J Fox
    NPS Pharmaceuticals, Salt Lake City, UT 84108, USA
    J Musculoskelet Neuronal Interact 5:356-7. 2005
  4. doi request reprint Effects of treatment with parathyroid hormone 1-84 on quantity and biomechanical properties of thoracic vertebral trabecular bone in ovariectomized rhesus monkeys
    J Fox
    NPS Pharmaceuticals, 550 Hills Drive, Bedminster, NJ 07921, USA
    Calcif Tissue Int 82:212-20. 2008
  5. ncbi request reprint Daily treatment of aged ovariectomized rats with human parathyroid hormone (1-84) for 12 months reverses bone loss and enhances trabecular and cortical bone strength
    J Fox
    NPS Pharmaceuticals, 383 Colorow Drive, Salt Lake City, UT 84108, USA
    Calcif Tissue Int 79:262-72. 2006
  6. ncbi request reprint Effects of daily treatment with parathyroid hormone 1-84 for 16 months on density, architecture and biomechanical properties of cortical bone in adult ovariectomized rhesus monkeys
    J Fox
    NPS Pharmaceuticals, Inc, 383 Colorow Drive, Salt Lake City, UT 84108, USA
    Bone 41:321-30. 2007
  7. ncbi request reprint Treatment of skeletally mature ovariectomized rhesus monkeys with PTH(1-84) for 16 months increases bone formation and density and improves trabecular architecture and biomechanical properties at the lumbar spine
    John Fox
    NPS Pharmaceuticals, Salt Lake City, Utah 84108, USA
    J Bone Miner Res 22:260-73. 2007
  8. ncbi request reprint Calcimimetic compound NPS R-568 stimulates calcitonin secretion but selectively targets parathyroid gland Ca(2+) receptor in rats
    J Fox
    NPS Pharmaceuticals, Inc, Salt Lake City, Utah, USA
    J Pharmacol Exp Ther 290:480-6. 1999
  9. ncbi request reprint NPS R-568: a type II calcimimetic compound that acts on parathyroid cell calcium receptor of rats to reduce plasma levels of parathyroid hormone and calcium
    J Fox
    NPS Pharmaceuticals, Inc, Salt Lake City, Utah
    J Pharmacol Exp Ther 290:473-9. 1999
  10. ncbi request reprint Effects of treatment of ovariectomized adult rhesus monkeys with parathyroid hormone 1-84 for 16 months on trabecular and cortical bone structure and biomechanical properties of the proximal femur
    J Fox
    NPS Pharmaceuticals, 383 Colorow Drive, Salt Lake City, UT 84108, USA
    Calcif Tissue Int 81:53-63. 2007

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Developments in parathyroid hormone and related peptides as bone-formation agents
    John Fox
    NPS Pharmaceuticals, Inc, 420 Chipeta Way, Salt Lake City, UT 84108, USA
    Curr Opin Pharmacol 2:338-44. 2002
    ..Because of these differences, care must be taken to consider the effects of native PTH and N-terminal PTH fragments and analogs separately...
  2. ncbi request reprint Plasma levels of parathyroid hormone that induce anabolic effects in bone of ovariectomized rats can be achieved by stimulation of endogenous hormone secretion
    J Fox
    Department of Pharmacology, NPS Pharmaceuticals, Inc, Salt Lake City, UT 84108, USA
    Bone 21:163-9. 1997
    ..These data suggest that agents that transiently increase endogenous PTH secretion may represent a novel means to promote anabolic effects in skeletal tissues...
  3. ncbi request reprint Treatment of postmenopausal osteoporotic women with parathyroid hormone 1-84 for 18 months increases cancellous bone formation and improves cancellous architecture: a study of iliac crest biopsies using histomorphometry and micro computed tomography
    J Fox
    NPS Pharmaceuticals, Salt Lake City, UT 84108, USA
    J Musculoskelet Neuronal Interact 5:356-7. 2005
  4. doi request reprint Effects of treatment with parathyroid hormone 1-84 on quantity and biomechanical properties of thoracic vertebral trabecular bone in ovariectomized rhesus monkeys
    J Fox
    NPS Pharmaceuticals, 550 Hills Drive, Bedminster, NJ 07921, USA
    Calcif Tissue Int 82:212-20. 2008
    ..Importantly, the changes observed were similar to those in lumbar vertebrae, thereby validating extrapolation of results from the lumbar to the thoracic spine...
  5. ncbi request reprint Daily treatment of aged ovariectomized rats with human parathyroid hormone (1-84) for 12 months reverses bone loss and enhances trabecular and cortical bone strength
    J Fox
    NPS Pharmaceuticals, 383 Colorow Drive, Salt Lake City, UT 84108, USA
    Calcif Tissue Int 79:262-72. 2006
    ..Thus, long-term PTH therapy normalized bone strength in the aged OVX rat, a model of postmenopausal osteoporosis, through increased bone turnover and enhanced formation of both trabecular and cortical bone...
  6. ncbi request reprint Effects of daily treatment with parathyroid hormone 1-84 for 16 months on density, architecture and biomechanical properties of cortical bone in adult ovariectomized rhesus monkeys
    J Fox
    NPS Pharmaceuticals, Inc, 383 Colorow Drive, Salt Lake City, UT 84108, USA
    Bone 41:321-30. 2007
    ..However, PTH treatment increased the energy required to break the femur making it more resistant to fracture...
  7. ncbi request reprint Treatment of skeletally mature ovariectomized rhesus monkeys with PTH(1-84) for 16 months increases bone formation and density and improves trabecular architecture and biomechanical properties at the lumbar spine
    John Fox
    NPS Pharmaceuticals, Salt Lake City, Utah 84108, USA
    J Bone Miner Res 22:260-73. 2007
    ..PTH increased bone turnover, rapidly normalized BMD, and increased vertebral compressive strength. PTH increased trabecular bone volume primarily by increasing trabecular number by markedly increasing intratrabecular tunneling...
  8. ncbi request reprint Calcimimetic compound NPS R-568 stimulates calcitonin secretion but selectively targets parathyroid gland Ca(2+) receptor in rats
    J Fox
    NPS Pharmaceuticals, Inc, Salt Lake City, Utah, USA
    J Pharmacol Exp Ther 290:480-6. 1999
    ..Thus, NPS R-568 causes hypocalcemia by activating Ca(2+) receptors on C cells and parathyroid cells; however, NPS R-568 is about 40 times more potent in reducing PTH levels than in increasing calcitonin levels...
  9. ncbi request reprint NPS R-568: a type II calcimimetic compound that acts on parathyroid cell calcium receptor of rats to reduce plasma levels of parathyroid hormone and calcium
    J Fox
    NPS Pharmaceuticals, Inc, Salt Lake City, Utah
    J Pharmacol Exp Ther 290:473-9. 1999
    ..Moreover, the data add pharmacological support to the view that the Ca(2+) receptor is the primary molecular entity regulating systemic Ca(2+) homeostasis...
  10. ncbi request reprint Effects of treatment of ovariectomized adult rhesus monkeys with parathyroid hormone 1-84 for 16 months on trabecular and cortical bone structure and biomechanical properties of the proximal femur
    J Fox
    NPS Pharmaceuticals, 383 Colorow Drive, Salt Lake City, UT 84108, USA
    Calcif Tissue Int 81:53-63. 2007
    ..Together, the changes had no effect on stiffness or peak load but increased the energy required to break the proximal femur, thereby making it more resistant to fracture...
  11. doi request reprint Intratrabecular tunneling increases trabecular number throughout the skeleton of ovariectomized rhesus monkeys treated with parathyroid hormone 1-84
    M A Miller
    NPS Pharmaceuticals, Bedminster, New Jersey, USA
    Bone 42:1175-83. 2008
    ..N observed in OVX monkeys. Moreover, these analyses allowed a comparison of the effects PTH(1-84) treatment on trabecular bone at multiple locations...
  12. ncbi request reprint Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone
    E F Nemeth
    NPS Pharmaceuticals, Inc, Salt Lake City, Utah, USA
    J Pharmacol Exp Ther 299:323-31. 2001
    ....
  13. ncbi request reprint 3H-Quinazolin-4-ones as a new calcilytic template for the potential treatment of osteoporosis
    Irina Shcherbakova
    Drug Discovery, NPS Pharmaceuticals, Inc, 383 Colorow Drive, Salt Lake City, UT 84108, USA
    Bioorg Med Chem Lett 15:1557-60. 2005
    ....
  14. ncbi request reprint Design, new synthesis, and calcilytic activity of substituted 3H-pyrimidin-4-ones
    Irina Shcherbakova
    Drug Discovery, NPS Pharmaceuticals, Inc, 383 Colorow Drive, Salt Lake City, UT 84108, USA
    Bioorg Med Chem Lett 15:2537-40. 2005
    ..Design, new synthesis, structure-activity relationship studies and calcium receptor antagonist (calcilytic) properties of novel 3H-pyrimidin-4-ones are described...
  15. ncbi request reprint Comparison of hypotensive response following intravenous injection of parathyroid hormone 1-84 and 1-34 in conscious rats
    K R Scott
    NPS Pharmaceuticals, 383 Colorow Drive, Salt Lake City, UT 84108, USA
    Calcif Tissue Int 79:389-94. 2006
    ..We found no evidence to support the concept that the C-terminal region of PTH is responsible for this difference in potency...
  16. ncbi request reprint Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl
    Edward F Nemeth
    Amgen, Inc, Thousand Oaks, CA 91320 1799, USA
    J Pharmacol Exp Ther 308:627-35. 2004
    ..The present findings provide compelling evidence that cinacalcet HCl is a potent and stereoselective activator of the parathyroid CaR and, as such, might be beneficial in the treatment of hyperparathyroidism...
  17. ncbi request reprint Efficacy and safety of human parathyroid hormone-(1-84) in increasing bone mineral density in postmenopausal osteoporosis
    Anthony B Hodsman
    Department of Medicine, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada N6A 4V2
    J Clin Endocrinol Metab 88:5212-20. 2003
    ..Dose-related incidences of transient hypercalcemia occurred, but only one patient (100-microg group) was withdrawn because of repeated hypercalcemia. Thus, full-length PTH was efficacious and safe over 12 months...
  18. ncbi request reprint Defining a noncarcinogenic dose of recombinant human parathyroid hormone 1-84 in a 2-year study in Fischer 344 rats
    Jacquelin Jolette
    Charles River Laboratories, Senneville, Quebec H9X 3R3, Canada
    Toxicol Pathol 34:929-40. 2006
    ..The ability of PTH to interact with and balance the effects of both the PTH-1 receptor and the putative C-terminal PTH receptor, may lead to the lower carcinogenic potential observed with PTH than reported previously for teriparatide...
  19. ncbi request reprint Skeletal effects of exemestane on bone-mineral density, bone biomarkers, and fracture incidence in postmenopausal women with early breast cancer participating in the Intergroup Exemestane Study (IES): a randomised controlled study
    Robert E Coleman
    Academic Unit of Clinical Oncology, Weston Park Hospital, Sheffield, UK
    Lancet Oncol 8:119-27. 2007
    ....
  20. ncbi request reprint Sensitivity to reward and body mass index (BMI): evidence for a non-linear relationship
    Caroline Davis
    Kinesiology and Health Sciences, York University, 343 Bethune College, 4700 Keele Street, Toronto Ont, Canada, M3J 1P3
    Appetite 50:43-9. 2008
    ....
  21. doi request reprint Response to letter of Vahle et al
    Jacquelin Jolette
    Toxicol Pathol 36:520-1. 2008
  22. ncbi request reprint Interaction dynamics of neuronal oscillations analysed using wavelet transforms
    Xiaoli Li
    Cercia, School of Computer Science, The University of Birmingham, Birmingham B15 2TT, UK
    J Neurosci Methods 160:178-85. 2007
    ..The results of this real case study show that the computational tool can successfully analyse and quantify the temporal interactions between neuronal oscillators and could be employed to investigate the mechanisms underlying epilepsy...
  23. ncbi request reprint Quantification of recombinant human parathyroid hormone (rhPTH(1-84)) in human plasma by immunoassay: commercial kit evaluation and validation to support pharmacokinetic studies
    Richard L Sukovaty
    MDS Pharma Services, Lincoln, NE, USA
    J Pharm Biomed Anal 42:261-71. 2006
    ....
  24. ncbi request reprint Capturing expert knowledge with argumentation: a case study in bioinformatics
    Benjamin R Jefferys
    Division of Molecular Biosciences, Imperial College, London SW7 2AZ, UK
    Bioinformatics 22:924-33. 2006
    ..Often the process is laborious, goes unrecorded and may be biased. Argumentation is an established technique for reasoning about situations where absolute truth or precise probability is impossible to determine...
  25. ncbi request reprint Effect of the calcimimetic NPS R-467 on furosemide-induced nephrocalcinosis in the young rat
    Anirut Pattaragarn
    Section of Pediatric Nephrology, Children s Mercy Hospital, University of Missouri Kansas City, Kansas City, Missouri 64108, USA
    Kidney Int 65:1684-9. 2004
    ..Calcimimetic agents such as NPS R-467 are potent and selective agonists at the calcium-sensing receptor in parathyroid glands and inhibit PTH secretion...
  26. ncbi request reprint Looking good-family focus on appearance and the risk for eating disorders
    Caroline Davis
    Department of Kinesiology and Health Sciences, York University, Toronto, Ontario, Canada
    Int J Eat Disord 35:136-44. 2004
    ..We tested this hypothesis by predicting that proneness to anxiety (neuroticism) and a family appearance focus would relate interactively (after controlling for body size) to a measure of weight preoccupation...
  27. pmc Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents
    Martti Vaara
    Northern Antibiotics Ltd, Helsinki, Finland
    Antimicrob Agents Chemother 52:3229-36. 2008
    ..The affinities of the NAB compounds for isolated rat kidney brush border membrane were significantly lower than that of polymyxin B...