Affiliation: Novartis Institutes for BioMedical Research
- Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic painK Walker
Nervous System Research, Novartis Pharma AG, CH 4002, Basle, Switzerland
Neuropharmacology 40:1-9. 2001..In contrast to its effects in models of inflammatory pain, MPEP did not produce significant reversal of mechanical hyperalgesia in a rat model of neuropathic pain...
- mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesiaK Walker
Novartis Pharma AG, Nervous System Research, CH 4002, Basle, Switzerland
Neuropharmacology 40:10-9. 2001..These results suggest that mGlu5 receptors expressed on the peripheral terminals of sensory neurones are involved in nociceptive processes and contribute to the hyperalgesia associated with inflammation...