Fabrizio C Serluca

Summary

Affiliation: Novartis Institutes for BioMedical Research

Publications

  1. pmc Zebrafish mutations affecting cilia motility share similar cystic phenotypes and suggest a mechanism of cyst formation that differs from pkd2 morphants
    Jessica Sullivan-Brown
    Department of Molecular Biology, Princeton University, Washington Road, Mof 433, Princeton, NJ 08544, USA
    Dev Biol 314:261-75. 2008
  2. doi request reprint Development of the proepicardial organ in the zebrafish
    Fabrizio C Serluca
    Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, USA
    Dev Biol 315:18-27. 2008
  3. pmc Mutations in zebrafish leucine-rich repeat-containing six-like affect cilia motility and result in pronephric cysts, but have variable effects on left-right patterning
    Fabrizio C Serluca
    Massachusetts General Hospital, Charlestown, MA 02129, USA
    Development 136:1621-31. 2009
  4. ncbi request reprint santa and valentine pattern concentric growth of cardiac myocardium in the zebrafish
    John D Mably
    Cardiovascular Research Center, Massachusetts General Hospital and the Department of Medicine, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Development 133:3139-46. 2006
  5. doi request reprint olig1 Expression identifies developing oligodendrocytes in zebrafish and requires hedgehog and notch signaling
    Michael Schebesta
    Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, USA
    Dev Dyn 238:887-98. 2009
  6. doi request reprint Identification of a BMP7 homolog in zebrafish expressed in developing organ systems
    May Shawi
    Developmental and Molecular Pathways, The Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, USA
    Gene Expr Patterns 8:369-75. 2008
  7. doi request reprint Integrated compound profiling screens identify the mitochondrial electron transport chain as the molecular target of the natural products manassantin, sesquicillin, and arctigenin
    Kevin Lai
    Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States
    ACS Chem Biol 8:257-67. 2013
  8. doi request reprint ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
    Huai Xiang Hao
    Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nature 485:195-200. 2012
  9. ncbi request reprint Notch1b and neuregulin are required for specification of central cardiac conduction tissue
    David J Milan
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Development 133:1125-32. 2006
  10. pmc A betaPix Pak2a signaling pathway regulates cerebral vascular stability in zebrafish
    Jing Liu
    Department of Biochemistry and Molecular Biology, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, Canada T2N 4N1
    Proc Natl Acad Sci U S A 104:13990-5. 2007

Collaborators

Detail Information

Publications12

  1. pmc Zebrafish mutations affecting cilia motility share similar cystic phenotypes and suggest a mechanism of cyst formation that differs from pkd2 morphants
    Jessica Sullivan-Brown
    Department of Molecular Biology, Princeton University, Washington Road, Mof 433, Princeton, NJ 08544, USA
    Dev Biol 314:261-75. 2008
    ..Finally, we show that knock-down of polycystic kidney disease 2 (pkd2) specifically causes glomerular cysts and does not affect cilia motility, suggesting multiple mechanisms exist for cyst formation...
  2. doi request reprint Development of the proepicardial organ in the zebrafish
    Fabrizio C Serluca
    Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, USA
    Dev Biol 315:18-27. 2008
    ....
  3. pmc Mutations in zebrafish leucine-rich repeat-containing six-like affect cilia motility and result in pronephric cysts, but have variable effects on left-right patterning
    Fabrizio C Serluca
    Massachusetts General Hospital, Charlestown, MA 02129, USA
    Development 136:1621-31. 2009
    ..Combined with recently published results, our alleles suggest that the function of seahorse in cilia motility is separable from its function in other cilia-related phenotypes...
  4. ncbi request reprint santa and valentine pattern concentric growth of cardiac myocardium in the zebrafish
    John D Mably
    Cardiovascular Research Center, Massachusetts General Hospital and the Department of Medicine, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Development 133:3139-46. 2006
    ..This suggests that concentric growth of the myocardium, crucial for blood pressure generation, is dictated by a heg-san-vtn signaling pathway...
  5. doi request reprint olig1 Expression identifies developing oligodendrocytes in zebrafish and requires hedgehog and notch signaling
    Michael Schebesta
    Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, USA
    Dev Dyn 238:887-98. 2009
    ..Lastly, knockdown of Olig1 in an Olig2-sensitized background did result in defects in CNS myelination, indicating a functional overlap between Olig1 and Olig2 proteins...
  6. doi request reprint Identification of a BMP7 homolog in zebrafish expressed in developing organ systems
    May Shawi
    Developmental and Molecular Pathways, The Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, USA
    Gene Expr Patterns 8:369-75. 2008
    ..We further show that bmp7b is strongly expressed in developing organ systems such as the eyes, the ears, the pronephric kidney and the gastrointestinal system...
  7. doi request reprint Integrated compound profiling screens identify the mitochondrial electron transport chain as the molecular target of the natural products manassantin, sesquicillin, and arctigenin
    Kevin Lai
    Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States
    ACS Chem Biol 8:257-67. 2013
    ..Together, zebrafish screening and transcriptional profiling represent sensitive and scalable approaches for identifying bioactive compounds and elucidating their mechanism of action...
  8. doi request reprint ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
    Huai Xiang Hao
    Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nature 485:195-200. 2012
    ..These data suggest that R-spondin enhances Wnt signalling by inhibiting ZNRF3. Our study provides new mechanistic insights into the regulation of Wnt receptor turnover, and reveals ZNRF3 as a tractable target for therapeutic exploration...
  9. ncbi request reprint Notch1b and neuregulin are required for specification of central cardiac conduction tissue
    David J Milan
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Development 133:1125-32. 2006
    ....
  10. pmc A betaPix Pak2a signaling pathway regulates cerebral vascular stability in zebrafish
    Jing Liu
    Department of Biochemistry and Molecular Biology, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, Canada T2N 4N1
    Proc Natl Acad Sci U S A 104:13990-5. 2007
    ..These data identify an essential in vivo role for betaPix and Pak2a during embryonic development and illuminate a previously unrecognized pathway specifically involved in cerebrovascular stabilization...
  11. ncbi request reprint Chemical approaches to angiogenesis
    Joanne Chan
    Vascular Biology Program, Children s Hospital of Boston, Boston, Massachusetts 02115, USA
    Methods Cell Biol 76:475-87. 2004
  12. ncbi request reprint Endothelial signaling in kidney morphogenesis: a role for hemodynamic forces
    Fabrizio C Serluca
    Cardiovascular Research Center and Developmental Biology Laboratory, Boston, MA 02119, USA
    Curr Biol 12:492-7. 2002
    ..Thus, vascular flow is required for glomerular assembly, most probably acting via a stretch-responsive signaling system in the vessel wall...