R E Pratley

Summary

Affiliation: Novartis Institutes for BioMedical Research

Publications

  1. ncbi request reprint Rapid acting insulinotropic agents: restoration of early insulin secretion as a physiologic approach to improve glucose control
    R E Pratley
    Novartis Pharmaceuticals Corporation, 59 Route 10, East Hanover, New Jersey 07936, USA
    Curr Pharm Des 7:1375-97. 2001
  2. ncbi request reprint Progression from IGT to type 2 diabetes mellitus: the central role of impaired early insulin secretion
    Richard E Pratley
    Novartis Pharmaceuticals Corporation, Clinical Research and Development, Diabetes and Obesity Section, One Health Plaza, East Hanover, NJ 07936, USA
    Curr Diab Rep 2:242-8. 2002
  3. ncbi request reprint Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 51:1884-8. 2002
  4. ncbi request reprint Management of type 2 diabetes in treatment-naive elderly patients: benefits and risks of vildagliptin monotherapy
    Richard E Pratley
    Vermont College of Medicine, Burlington, USA
    Diabetes Care 30:3017-22. 2007
  5. ncbi request reprint Inhibition of DPP-4: a new therapeutic approach for the treatment of type 2 diabetes
    Richard E Pratley
    University of Vermont College of Medicine, Burlington, VT 05405, USA
    Curr Med Res Opin 23:919-31. 2007
  6. ncbi request reprint The PROactive Study: pioglitazone in the secondary prevention of macrovascular events in patients with type 2 diabetes
    Richard E Pratley
    Curr Diab Rep 6:45-6. 2006
  7. ncbi request reprint Beta-cell function in mild type 2 diabetic patients: effects of 6-month glucose lowering with nateglinide
    Andrea Mari
    Institute of Biomedical Engineering, National Research Council, Corso Stati Uniti 4, 35127 Padua, Italy
    Diabetes Care 28:1132-8. 2005
  8. ncbi request reprint The evolving role of inflammation in obesity and the metabolic syndrome
    Yong Ho Lee
    Diabetes and Metabolism Translational Medicine Unit, Division of Endocrinology and Metabolism, Department of Medicine, University of Vermont College of Medicine, FAHC UHC Arnold 3412, One South Prospect Street, Burlington, VT 05401, USA
    Curr Diab Rep 5:70-5. 2005
  9. ncbi request reprint Endogenous glucose production, insulin sensitivity, and insulin secretion in normal glucose-tolerant Pima Indians with low birth weight
    Norbert Stefan
    The Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
    Metabolism 53:904-11. 2004
  10. ncbi request reprint UCP5/BMCP1 transcript isoforms in human skeletal muscle: relationship of the short-insert isoform with lipid oxidation and resting metabolic rates
    Xiaolin Yang
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Mol Genet Metab 75:369-73. 2002

Detail Information

Publications13

  1. ncbi request reprint Rapid acting insulinotropic agents: restoration of early insulin secretion as a physiologic approach to improve glucose control
    R E Pratley
    Novartis Pharmaceuticals Corporation, 59 Route 10, East Hanover, New Jersey 07936, USA
    Curr Pharm Des 7:1375-97. 2001
    ..g., metformin and thiazolidinediones). Because these new agents can potentially bring patients to near normoglycemia without an undue risk of hypoglycemia, they are important additions to the therapeutic armamentarium...
  2. ncbi request reprint Progression from IGT to type 2 diabetes mellitus: the central role of impaired early insulin secretion
    Richard E Pratley
    Novartis Pharmaceuticals Corporation, Clinical Research and Development, Diabetes and Obesity Section, One Health Plaza, East Hanover, NJ 07936, USA
    Curr Diab Rep 2:242-8. 2002
    ..Other trials using pharmacologic agents to decrease insulin resistance and increase early insulin secretion are underway. Prevention remains the best hope for a long-term solutions to the worldwide epidemic of diabetes...
  3. ncbi request reprint Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 51:1884-8. 2002
    ..Prospectively, low plasma adiponectin concentration at baseline precedes a decrease in insulin sensitivity. Our data indicate that adiponectin plays an important role in regulation of insulin sensitivity in humans...
  4. ncbi request reprint Management of type 2 diabetes in treatment-naive elderly patients: benefits and risks of vildagliptin monotherapy
    Richard E Pratley
    Vermont College of Medicine, Burlington, USA
    Diabetes Care 30:3017-22. 2007
    ..The purpose of this study was to evaluate the efficacy and safety of vildagliptin in elderly patients with type 2 diabetes...
  5. ncbi request reprint Inhibition of DPP-4: a new therapeutic approach for the treatment of type 2 diabetes
    Richard E Pratley
    University of Vermont College of Medicine, Burlington, VT 05405, USA
    Curr Med Res Opin 23:919-31. 2007
    ..Drugs that inhibit dipeptidyl peptidase-4 (DPP-4), a ubiquitous enzyme that rapidly inactivates both GLP-1 and GIP, increase active levels of these hormones and, in doing so, improve islet function and glycemic control in T2DM...
  6. ncbi request reprint The PROactive Study: pioglitazone in the secondary prevention of macrovascular events in patients with type 2 diabetes
    Richard E Pratley
    Curr Diab Rep 6:45-6. 2006
  7. ncbi request reprint Beta-cell function in mild type 2 diabetic patients: effects of 6-month glucose lowering with nateglinide
    Andrea Mari
    Institute of Biomedical Engineering, National Research Council, Corso Stati Uniti 4, 35127 Padua, Italy
    Diabetes Care 28:1132-8. 2005
    ....
  8. ncbi request reprint The evolving role of inflammation in obesity and the metabolic syndrome
    Yong Ho Lee
    Diabetes and Metabolism Translational Medicine Unit, Division of Endocrinology and Metabolism, Department of Medicine, University of Vermont College of Medicine, FAHC UHC Arnold 3412, One South Prospect Street, Burlington, VT 05401, USA
    Curr Diab Rep 5:70-5. 2005
    ..An improved understanding of the role of adipose tissue in the activation of inflammatory pathways may suggest novel treatment and prevention strategies aimed at reducing obesity-associated morbidities and mortality...
  9. ncbi request reprint Endogenous glucose production, insulin sensitivity, and insulin secretion in normal glucose-tolerant Pima Indians with low birth weight
    Norbert Stefan
    The Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
    Metabolism 53:904-11. 2004
    ..We conclude that interaction of multiple defects may contribute to increased susceptibility to type 2 diabetes among individuals with LBW...
  10. ncbi request reprint UCP5/BMCP1 transcript isoforms in human skeletal muscle: relationship of the short-insert isoform with lipid oxidation and resting metabolic rates
    Xiaolin Yang
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Mol Genet Metab 75:369-73. 2002
    ..38, P=0.02, adjusted for age, sex, fat mass, and fat-free mass) and lipid oxidation rate (adjusted for age, sex, and percent body fat) during a euglycemic clamp with infusion of insulin at a physiologic concentration (r=0.42, P=0.01)...
  11. ncbi request reprint High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes
    Barbora Vozarova
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 51:1889-95. 2002
    ..Our findings indicate that high ALT is a marker of risk for type 2 diabetes and suggest a potential role of the liver in the pathogenesis of type 2 diabetes...
  12. ncbi request reprint High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes
    Barbora Vozarova
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 51:455-61. 2002
    ..These findings are consistent with the hypothesis that a chronic activation of the immune system may play a role in the pathogenesis of type 2 diabetes...
  13. pmc Effect of ovarian suppression with gonadotropin-releasing hormone agonist on glucose disposal and insulin secretion
    Michael J Toth
    Department of Medicine and Obstetrics and Gynecology, University of Vermont, Burlington, VT 05405, USA
    Am J Physiol Endocrinol Metab 294:E1035-45. 2008
    ..Our data do, however, support a role for ovarian hormones in the regulation of plasma adiponectin levels...