- Rapid acting insulinotropic agents: restoration of early insulin secretion as a physiologic approach to improve glucose control
R E Pratley
Novartis Pharmaceuticals Corporation, 59 Route 10, East Hanover, New Jersey 07936, USA
Curr Pharm Des 7:1375-97. 2001
..g., metformin and thiazolidinediones). Because these new agents can potentially bring patients to near normoglycemia without an undue risk of hypoglycemia, they are important additions to the therapeutic armamentarium...
- Progression from IGT to type 2 diabetes mellitus: the central role of impaired early insulin secretion
Richard E Pratley
Novartis Pharmaceuticals Corporation, Clinical Research and Development, Diabetes and Obesity Section, One Health Plaza, East Hanover, NJ 07936, USA
Curr Diab Rep 2:242-8. 2002
..Other trials using pharmacologic agents to decrease insulin resistance and increase early insulin secretion are underway. Prevention remains the best hope for a long-term solutions to the worldwide epidemic of diabetes...
- Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans
Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
Diabetes 51:1884-8. 2002
..Prospectively, low plasma adiponectin concentration at baseline precedes a decrease in insulin sensitivity. Our data indicate that adiponectin plays an important role in regulation of insulin sensitivity in humans...
- Management of type 2 diabetes in treatment-naive elderly patients: benefits and risks of vildagliptin monotherapy
Richard E Pratley
Vermont College of Medicine, Burlington, USA
Diabetes Care 30:3017-22. 2007
..The purpose of this study was to evaluate the efficacy and safety of vildagliptin in elderly patients with type 2 diabetes...
- Inhibition of DPP-4: a new therapeutic approach for the treatment of type 2 diabetes
Richard E Pratley
University of Vermont College of Medicine, Burlington, VT 05405, USA
Curr Med Res Opin 23:919-31. 2007
..Drugs that inhibit dipeptidyl peptidase-4 (DPP-4), a ubiquitous enzyme that rapidly inactivates both GLP-1 and GIP, increase active levels of these hormones and, in doing so, improve islet function and glycemic control in T2DM...
- The PROactive Study: pioglitazone in the secondary prevention of macrovascular events in patients with type 2 diabetes
Richard E Pratley
Curr Diab Rep 6:45-6. 2006
- Beta-cell function in mild type 2 diabetic patients: effects of 6-month glucose lowering with nateglinide
Institute of Biomedical Engineering, National Research Council, Corso Stati Uniti 4, 35127 Padua, Italy
Diabetes Care 28:1132-8. 2005
- The evolving role of inflammation in obesity and the metabolic syndrome
Yong Ho Lee
Diabetes and Metabolism Translational Medicine Unit, Division of Endocrinology and Metabolism, Department of Medicine, University of Vermont College of Medicine, FAHC UHC Arnold 3412, One South Prospect Street, Burlington, VT 05401, USA
Curr Diab Rep 5:70-5. 2005
..An improved understanding of the role of adipose tissue in the activation of inflammatory pathways may suggest novel treatment and prevention strategies aimed at reducing obesity-associated morbidities and mortality...
- Endogenous glucose production, insulin sensitivity, and insulin secretion in normal glucose-tolerant Pima Indians with low birth weight
The Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
Metabolism 53:904-11. 2004
..We conclude that interaction of multiple defects may contribute to increased susceptibility to type 2 diabetes among individuals with LBW...
- UCP5/BMCP1 transcript isoforms in human skeletal muscle: relationship of the short-insert isoform with lipid oxidation and resting metabolic rates
Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
Mol Genet Metab 75:369-73. 2002
..38, P=0.02, adjusted for age, sex, fat mass, and fat-free mass) and lipid oxidation rate (adjusted for age, sex, and percent body fat) during a euglycemic clamp with infusion of insulin at a physiologic concentration (r=0.42, P=0.01)...
- High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
Diabetes 51:1889-95. 2002
..Our findings indicate that high ALT is a marker of risk for type 2 diabetes and suggest a potential role of the liver in the pathogenesis of type 2 diabetes...
- High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
Diabetes 51:455-61. 2002
..These findings are consistent with the hypothesis that a chronic activation of the immune system may play a role in the pathogenesis of type 2 diabetes...
- Effect of ovarian suppression with gonadotropin-releasing hormone agonist on glucose disposal and insulin secretion
Michael J Toth
Department of Medicine and Obstetrics and Gynecology, University of Vermont, Burlington, VT 05405, USA
Am J Physiol Endocrinol Metab 294:E1035-45. 2008
..Our data do, however, support a role for ovarian hormones in the regulation of plasma adiponectin levels...