Calman A MacLennan

Summary

Affiliation: Novartis Institutes for BioMedical Research

Publications

  1. pmc The stability of complement-mediated bactericidal activity in human serum against Salmonella
    Colette M O'Shaughnessy
    Medical Research Council Centre for Immune Regulation and Clinical Immunology Service, Institute of Biomedical Research, School of Immunity and Infection, College of Medicine and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 7:e49147. 2012
  2. doi request reprint Vaccines for low-income countries
    Calman A MacLennan
    Novartis Vaccines Institute for Global Health, Siena, Italy
    Semin Immunol 25:114-23. 2013
  3. ncbi request reprint Differential timing of antibody-mediated phagocytosis and cell-free killing of invasive African Salmonella allows immune evasion
    Matthew K Siggins
    Medical Research Council Centre for Immune Regulation and Clinical Immunology Service, Institute of Biomedical Research, School of Immunity and Infection, College of Medicine and Dental Sciences, University of Birmingham, Birmingham, UK Novartis Vaccines Institute for Global Health, Siena, Italy
    Eur J Immunol 44:1093-8. 2014
  4. doi request reprint Invasive African Salmonella Typhimurium induces bactericidal antibodies against O-antigens
    Simona Rondini
    Novartis Vaccines Institute for Global Health, Via Fiorentina 1, 53100 Siena, Italy
    Microb Pathog 63:19-23. 2013
  5. doi request reprint Purification of antibodies to O antigen of Salmonella Typhimurium from human serum by affinity chromatography
    Colette M O'Shaughnessy
    Novartis Vaccines Institute for Global Health, Via Fiorentina 1, 53100 Siena, Italy
    J Immunol Methods 387:199-210. 2013
  6. doi request reprint Absent bactericidal activity of mouse serum against invasive African nontyphoidal Salmonella results from impaired complement function but not a lack of antibody
    Matthew K Siggins
    Medical Research Council Centre for Immune Regulation and Clinical Immunology Service, Institute of Biomedical Research, School of Immunity and Infection, College of Medicine and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Immunol 186:2365-71. 2011
  7. doi request reprint Invasive African nontyphoidal Salmonella requires high levels of complement for cell-free antibody-dependent killing
    Yun Shan Goh
    Novartis Vaccines Institute for Global Health, Via Fiorentina 1, 53100 Siena, Italy
    J Immunol Methods 387:121-9. 2013
  8. pmc Development of a glycoconjugate vaccine to prevent meningitis in Africa caused by meningococcal serogroup X
    Francesca Micoli
    Novartis Vaccines Institute for Global Health, and Research, Novartis Vaccines and Diagnostics, I 53100 Siena, Italy
    Proc Natl Acad Sci U S A 110:19077-82. 2013
  9. pmc The capsular polysaccharide Vi from Salmonella typhi is a B1b antigen
    Jennifer L Marshall
    Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, Institute for Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Immunol 189:5527-32. 2012
  10. pmc Early interferon-γ production in human lymphocyte subsets in response to nontyphoidal Salmonella demonstrates inherent capacity in innate cells
    Tonney S Nyirenda
    Medical Research Council Centre for Immune Regulation and Clinical Immunology Service, Institute of Biomedical Research, School of Immunity and Infection, College of Medicine and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 5:e13667. 2010

Collaborators

  • Adam F Cunningham
  • Gerd Pluschke
  • Simona Rondini
  • Robert A Kingsley
  • Gordon Dougan
  • Melita A Gordon
  • Laura B Martin
  • Rino Rappuoli
  • Mark A Webber
  • Douglas F Browning
  • Dominique A Caugant
  • Rainer Doffinger
  • James E Turner
  • Malcolm E Molyneux
  • Colette M O'Shaughnessy
  • Matthew K Siggins
  • Ian R Henderson
  • Allan Saul
  • Francesca Micoli
  • Mark T Drayson
  • Jennifer L Marshall
  • Oliver Koeberling
  • Yun Shan Goh
  • Massimiliano Gavini
  • Mark Cobbold
  • John Pravin
  • Alison M E Whitelegg
  • Jessica R Hitchcock
  • Adriana Flores-Langarica
  • Dhaarini Raghunathan
  • Tonney S Nyirenda
  • Emma Ispasanie
  • Julia Hauser
  • Omar Rossi
  • Maria Rosaria Romano
  • Sara Filippini
  • Margaret Goodall
  • Paolo Costantino
  • Roberto Adamo
  • Francesco Berti
  • Marta Tontini
  • Gunnstein Norheim
  • Emilia Cappelletti
  • Andrew Pollard
  • Laura Santini
  • Daniela Proietti
  • Cristiana Balocchi
  • Erwin Swennen
  • Jane Birtwistle
  • Alastair J Ferraro
  • Ewan A Ross
  • Ian C Maclennan
  • Mark Fellows
  • John P Campbell
  • Alex Richter
  • Tim Plant
  • Tarana M Ahmed
  • Kai Michael Toellner
  • Jeremy Lakey
  • Constantino López-Macías
  • Lynda J Giles
  • Saeeda Bobat
  • Gavin K Paterson
  • Claudia T P Moraes
  • Karina Tveen Jensen
  • Duncan J Maskell
  • Robin C May
  • Timothy J Wells
  • Jessica M A Blair
  • Laura J Piddock
  • Denisse L Leyton
  • Sarah E Peters
  • Jayne L Chamberlain
  • Robert K Shaw
  • Faye C Morris
  • Roxane M F Piazza
  • Anna E Seeley
  • Wilson L Mandala

Detail Information

Publications15

  1. pmc The stability of complement-mediated bactericidal activity in human serum against Salmonella
    Colette M O'Shaughnessy
    Medical Research Council Centre for Immune Regulation and Clinical Immunology Service, Institute of Biomedical Research, School of Immunity and Infection, College of Medicine and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 7:e49147. 2012
    ..The study provides a scheme for determining the requirements for serum handling in relation to functional activity of complement in other systems...
  2. doi request reprint Vaccines for low-income countries
    Calman A MacLennan
    Novartis Vaccines Institute for Global Health, Siena, Italy
    Semin Immunol 25:114-23. 2013
    ....
  3. ncbi request reprint Differential timing of antibody-mediated phagocytosis and cell-free killing of invasive African Salmonella allows immune evasion
    Matthew K Siggins
    Medical Research Council Centre for Immune Regulation and Clinical Immunology Service, Institute of Biomedical Research, School of Immunity and Infection, College of Medicine and Dental Sciences, University of Birmingham, Birmingham, UK Novartis Vaccines Institute for Global Health, Siena, Italy
    Eur J Immunol 44:1093-8. 2014
    ....
  4. doi request reprint Invasive African Salmonella Typhimurium induces bactericidal antibodies against O-antigens
    Simona Rondini
    Novartis Vaccines Institute for Global Health, Via Fiorentina 1, 53100 Siena, Italy
    Microb Pathog 63:19-23. 2013
    ..The current findings support the development of an O-antigen conjugate vaccine against invasive nontyphoidal Salmonellae for Africa. ..
  5. doi request reprint Purification of antibodies to O antigen of Salmonella Typhimurium from human serum by affinity chromatography
    Colette M O'Shaughnessy
    Novartis Vaccines Institute for Global Health, Via Fiorentina 1, 53100 Siena, Italy
    J Immunol Methods 387:199-210. 2013
    ..This method offers the potential to purify antibodies to Salmonella OAg from polyclonal serum following vaccination or natural exposure to Salmonella and so investigate the functionality and diversity of the antibody response to OAg...
  6. doi request reprint Absent bactericidal activity of mouse serum against invasive African nontyphoidal Salmonella results from impaired complement function but not a lack of antibody
    Matthew K Siggins
    Medical Research Council Centre for Immune Regulation and Clinical Immunology Service, Institute of Biomedical Research, School of Immunity and Infection, College of Medicine and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Immunol 186:2365-71. 2011
    ..This difference in Ab-dependent immunity to Salmonella in mice and men must be considered when applying findings from the mouse model of Salmonella disease and vaccination response to man...
  7. doi request reprint Invasive African nontyphoidal Salmonella requires high levels of complement for cell-free antibody-dependent killing
    Yun Shan Goh
    Novartis Vaccines Institute for Global Health, Via Fiorentina 1, 53100 Siena, Italy
    J Immunol Methods 387:121-9. 2013
    ..To develop SBA to assess the in vivo efficacy of Salmonella vaccines, it is necessary to optimize the assay for the Salmonella isolates against which the vaccine is targeted...
  8. pmc Development of a glycoconjugate vaccine to prevent meningitis in Africa caused by meningococcal serogroup X
    Francesca Micoli
    Novartis Vaccines Institute for Global Health, and Research, Novartis Vaccines and Diagnostics, I 53100 Siena, Italy
    Proc Natl Acad Sci U S A 110:19077-82. 2013
    ....
  9. pmc The capsular polysaccharide Vi from Salmonella typhi is a B1b antigen
    Jennifer L Marshall
    Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, Institute for Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Immunol 189:5527-32. 2012
    ..This work therefore suggests that, in mice, B1b cells contribute to the protection induced by Vi Ag, and targeting non-Vi Ags as subunit vaccines may offer an attractive strategy to augment current Vi-based vaccine strategies...
  10. pmc Early interferon-γ production in human lymphocyte subsets in response to nontyphoidal Salmonella demonstrates inherent capacity in innate cells
    Tonney S Nyirenda
    Medical Research Council Centre for Immune Regulation and Clinical Immunology Service, Institute of Biomedical Research, School of Immunity and Infection, College of Medicine and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 5:e13667. 2010
    ..This report identifies the lymphocyte subsets that produce IFNγ early in Salmonella infection...
  11. pmc Dysregulated humoral immunity to nontyphoidal Salmonella in HIV-infected African adults
    Calman A MacLennan
    Medical Research Council Centre for Immune Regulation and Clinical Immunology Service, Institute of Biomedical Research, School of Immunity and Infection, University of Birmingham, Birmingham, UK
    Science 328:508-12. 2010
    ....
  12. doi request reprint Measurement of antibodies to pneumococcal, meningococcal and haemophilus polysaccharides, and tetanus and diphtheria toxoids using a 19-plexed assay
    Alison M E Whitelegg
    Medical Research Council Centre for Immune Regulation and Clinical Immunology Service, Institute of Biomedical Research, School of Immunity and Infection, College of Medicine and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK
    J Immunol Methods 377:37-46. 2012
    ..It is suitable for use in standard clinical practice to assess the in vivo immune response to test vaccinations and measure absolute antibody levels to these antigens...
  13. pmc SadA, a trimeric autotransporter from Salmonella enterica serovar Typhimurium, can promote biofilm formation and provides limited protection against infection
    Dhaarini Raghunathan
    School of Immunity and Infection, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Infect Immun 79:4342-52. 2011
    ..Therefore, despite SadA having pleiotropic functions, it is not a dominant, protective antigen for antibody-mediated protection against Salmonella...
  14. ncbi request reprint A broadly-protective vaccine against meningococcal disease in sub-Saharan Africa based on Generalized Modules for Membrane Antigens (GMMA)
    Oliver Koeberling
    Novartis Vaccines Institute for Global Health, Siena, Italy
    Vaccine 32:2688-95. 2014
    ..Therefore, an affordable vaccine that provides broad protection against meningococcal disease in sub-Saharan Africa is required...