Affiliation: Novartis Institutes for BioMedical Research
- Matrix metalloproteinase inhibitor, MMI270 (CGS27023A) inhibited hematogenic metastasis of B16 melanoma cells in both experimental and spontaneous metastasis modelsTatsuhiko Kasaoka
Tsukuba Research Institute, Novartis Pharma K K, Ohkubo 8, Tsukuba shi, Ibaraki 300 2611, Japan
Clin Exp Metastasis 25:827-34. 2008....
- Silencing of focal adhesion kinase by tumor direct injection of small interfering RNA decreases in vivo tumor growthKae Tsutsumi
Tsukuba Research Institute, Novartis Pharma, KK, Tsukuba shi, Ibaraki, Japan
Cancer Biol Ther 8:1292-9. 2009..In addition, we showed that ERK is the critical MAP kinase in the signaling pathway down stream of FAK in in vivo proliferation of 4T1 tumor cells...
- Tumor growth inhibition by synthetic and expressed siRNA targeting focal adhesion kinaseKae Tsutsumi
Tsukuba Research Institute, Novartis Pharma K K, Tsukuba shi, Ibaraki 300 2611, Japan
Int J Oncol 33:215-24. 2008..These results support our hypothesis that FAK plays a crucial role in tumor formation and growth in vivo by regulation of cell adhesion and proliferation by FAK-dependent signals...