Hans O Kalkman

Summary

Affiliation: Novartis Institutes for BioMedical Research

Publications

  1. doi request reprint Potential opposite roles of the extracellular signal-regulated kinase (ERK) pathway in autism spectrum and bipolar disorders
    Hans O Kalkman
    Neuroscience Department, Novartis Institute of Biomedical Research, Building 386 14 22 15, CH 4002 Basel, Switzerland
    Neurosci Biobehav Rev 36:2206-13. 2012
  2. pmc A review of the evidence for the canonical Wnt pathway in autism spectrum disorders
    Hans Otto Kalkman
    Neuroscience Department, Novartis Institute of Biomedical Research, Building 386 14, 22, 15, Basel, CH 4002, Switzerland
    Mol Autism 3:10. 2012
  3. doi request reprint Circumstantial evidence for a role of glutamine-synthetase in suicide
    Hans O Kalkman
    Novartis Pharma AG, Novartis Institutes of Biomedical Research Basel, WSJ386 11 40, Postfach, CH4002 Basel, Switzerland
    Med Hypotheses 76:905-7. 2011
  4. doi request reprint Alterations in the expression of neuronal chloride transporters may contribute to schizophrenia
    Hans O Kalkman
    Novartis Pharma AG, Novartis Institutes of Biomedical Research Basel, WSJ 386 11 40, Postfach, CH 4002 Basel, Switzerland
    Prog Neuropsychopharmacol Biol Psychiatry 35:410-4. 2011
  5. doi request reprint Altered growth factor signaling pathways as the basis of aberrant stem cell maturation in schizophrenia
    Hans O Kalkman
    Novartis Pharma AG, Novartis Institutes of Biomedical Research Basel, WSJ 386 11 40, Postfach, CH 4002 Basel, Switzerland
    Pharmacol Ther 121:115-22. 2009
  6. ncbi request reprint The role of the phosphatidylinositide 3-kinase-protein kinase B pathway in schizophrenia
    Hans O Kalkman
    Neuroscience Research, Novartis Institutes of Biomedical Research Basel, Building WSJ 360 4 05, Novartis Pharma AG, CH4002 Basel, Switzerland
    Pharmacol Ther 110:117-34. 2006
  7. ncbi request reprint Functional characterization of the novel antipsychotic iloperidone at human D2, D3, alpha 2C, 5-HT6, and 5-HT1A receptors
    Hans O Kalkman
    Novartis Pharma AG, Research Nervous System, Building S 360 405 CH 4002 Basel, Switzerland
    Life Sci 73:1151-9. 2003
  8. ncbi request reprint alpha2C-Adrenoceptor blockade by clozapine and other antipsychotic drugs
    Hans O Kalkman
    Novartis Pharma AG, Research Nervous System, Building WSJ 360 405, CH 4002 Basel, Switzerland
    Eur J Pharmacol 462:33-40. 2003
  9. ncbi request reprint Antischizophrenic activity independent of dopamine D2 blockade
    Hans O Kalkman
    Novartis Pharma AG, Research Nervous System, Building WSJ 360 405, CH 4002 Basel, Switzerland
    Expert Opin Ther Targets 6:571-82. 2002
  10. ncbi request reprint Receptor profile of P88-8991 and P95-12113, metabolites of the novel antipsychotic iloperidone
    Natarajan Subramanian
    Novartis Pharma AG, Research Nervous System, Basel, Switzerland
    Prog Neuropsychopharmacol Biol Psychiatry 26:553-60. 2002

Collaborators

Detail Information

Publications10

  1. doi request reprint Potential opposite roles of the extracellular signal-regulated kinase (ERK) pathway in autism spectrum and bipolar disorders
    Hans O Kalkman
    Neuroscience Department, Novartis Institute of Biomedical Research, Building 386 14 22 15, CH 4002 Basel, Switzerland
    Neurosci Biobehav Rev 36:2206-13. 2012
    ..Thus, with respect to the ERK pathway, autism and bipolar disorder seem each other's counter pole...
  2. pmc A review of the evidence for the canonical Wnt pathway in autism spectrum disorders
    Hans Otto Kalkman
    Neuroscience Department, Novartis Institute of Biomedical Research, Building 386 14, 22, 15, Basel, CH 4002, Switzerland
    Mol Autism 3:10. 2012
    ..However, without a validated biomarker to stratify for deviant canonical Wnt pathway activity, it is probably too dangerous to treat patients with compounds that modify pathway activity...
  3. doi request reprint Circumstantial evidence for a role of glutamine-synthetase in suicide
    Hans O Kalkman
    Novartis Pharma AG, Novartis Institutes of Biomedical Research Basel, WSJ386 11 40, Postfach, CH4002 Basel, Switzerland
    Med Hypotheses 76:905-7. 2011
    ..However, since inhibition of glutamine synthetase may lead to a deficit in glutamine and as consequence a GABA and glutamate deficit, even simple food supplementation with glutamine might help to reduce suicide...
  4. doi request reprint Alterations in the expression of neuronal chloride transporters may contribute to schizophrenia
    Hans O Kalkman
    Novartis Pharma AG, Novartis Institutes of Biomedical Research Basel, WSJ 386 11 40, Postfach, CH 4002 Basel, Switzerland
    Prog Neuropsychopharmacol Biol Psychiatry 35:410-4. 2011
    ....
  5. doi request reprint Altered growth factor signaling pathways as the basis of aberrant stem cell maturation in schizophrenia
    Hans O Kalkman
    Novartis Pharma AG, Novartis Institutes of Biomedical Research Basel, WSJ 386 11 40, Postfach, CH 4002 Basel, Switzerland
    Pharmacol Ther 121:115-22. 2009
    ....
  6. ncbi request reprint The role of the phosphatidylinositide 3-kinase-protein kinase B pathway in schizophrenia
    Hans O Kalkman
    Neuroscience Research, Novartis Institutes of Biomedical Research Basel, Building WSJ 360 4 05, Novartis Pharma AG, CH4002 Basel, Switzerland
    Pharmacol Ther 110:117-34. 2006
    ..However, a major challenge that remains to be solved is how the PI3K-PKB pathway can be activated without increasing the risk of cancer...
  7. ncbi request reprint Functional characterization of the novel antipsychotic iloperidone at human D2, D3, alpha 2C, 5-HT6, and 5-HT1A receptors
    Hans O Kalkman
    Novartis Pharma AG, Research Nervous System, Building S 360 405 CH 4002 Basel, Switzerland
    Life Sci 73:1151-9. 2003
    ..59 +/- 0.20; n = 6), followed by alpha(2C) (pK(B) 7.83 +/- 0.06; n = 15), 5-HT(1A) (pK(B) 7.69 +/- 0.18; n = 10), D(2A) (pK(B) 7.53 +/- 0.04; n = 11) and 5-HT(6) (pK(B) 7.11 +/- 0.08; n = 11) receptors...
  8. ncbi request reprint alpha2C-Adrenoceptor blockade by clozapine and other antipsychotic drugs
    Hans O Kalkman
    Novartis Pharma AG, Research Nervous System, Building WSJ 360 405, CH 4002 Basel, Switzerland
    Eur J Pharmacol 462:33-40. 2003
    ..Clozapine had the highest alpha(2C)/D(2) selectivity, and iloperidone the highest alpha(2C)/alpha(2A) ratio. It is hypothesised that alpha(2C)-adrenoceptor blockade contributes to improvement of cognitive function...
  9. ncbi request reprint Antischizophrenic activity independent of dopamine D2 blockade
    Hans O Kalkman
    Novartis Pharma AG, Research Nervous System, Building WSJ 360 405, CH 4002 Basel, Switzerland
    Expert Opin Ther Targets 6:571-82. 2002
    ..In this review, the possible pharmacological approaches and their respective advantages and disadvantages are discussed...
  10. ncbi request reprint Receptor profile of P88-8991 and P95-12113, metabolites of the novel antipsychotic iloperidone
    Natarajan Subramanian
    Novartis Pharma AG, Research Nervous System, Basel, Switzerland
    Prog Neuropsychopharmacol Biol Psychiatry 26:553-60. 2002
    ..However, the comparable receptor binding profile of P88-8991 indicates that it is likely to contribute to the clinical profile of iloperidone...