Robert Janulczyk

Summary

Affiliation: Novartis Institutes for BioMedical Research

Publications

  1. pmc Simple sequence repeats and genome plasticity in Streptococcus agalactiae
    Robert Janulczyk
    Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy
    J Bacteriol 192:3990-4000. 2010
  2. pmc Targeted amino acid substitutions impair streptolysin O toxicity and group A Streptococcus virulence
    Emiliano Chiarot
    Novartis Vaccines and Diagnostics, Siena, Italy
    MBio 4:e00387-12. 2013
  3. pmc Analysis of two-component systems in group B Streptococcus shows that RgfAC and the novel FspSR modulate virulence and bacterial fitness
    Cristina Faralla
    Novartis Vaccines, Siena, Italy
    MBio 5:e00870-14. 2014
  4. pmc The regulator PerR is involved in oxidative stress response and iron homeostasis and is necessary for full virulence of Streptococcus pyogenes
    Susanna Ricci
    Laboratory of Molecular Microbiology and Biotechnology, Section of Microbiology, Department of Molecular Biology, University of Siena, Siena, Italy
    Infect Immun 70:4968-76. 2002
  5. pmc Streptococcus agalactiae capsule polymer length and attachment is determined by the proteins CpsABCD
    Chiara Toniolo
    From Novartis Vaccines and Diagnostics, Research Center, Via Fiorentina 1, 53100 Siena, Italy
    J Biol Chem 290:9521-32. 2015
  6. pmc Streptococcus pyogenes SpyCEP influences host-pathogen interactions during infection in a murine air pouch model
    Nico Chiappini
    Research Centre, Novartis Vaccines and Diagnostics, Siena, Italy
    PLoS ONE 7:e40411. 2012
  7. pmc Multi high-throughput approach for highly selective identification of vaccine candidates: the Group A Streptococcus case
    Giuliano Bensi
    Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy
    Mol Cell Proteomics 11:M111.015693. 2012

Collaborators

  • John L Telford
  • Alessandro Muzzi
  • Susanna Ricci
  • Kelly S Doran
  • Vega Masignani
  • Anja Seubert
  • Domenico Maione
  • James M Musser
  • Davide Serruto
  • HERVE S TETTELIN
  • Guido Grandi
  • Immaculada Margarit
  • Nico Chiappini
  • Cristina Faralla
  • Emiliano Chiarot
  • Giuliano Bensi
  • Chiara Toniolo
  • Giovanna Tuscano
  • Maria Scarselli
  • Fabiana Falugi
  • Sabrina Capo
  • Francesco Berti
  • Evita Balducci
  • Maria Rosaria Romano
  • Immaculada Margarit Y Ros
  • Ilaria Ferlenghi
  • Daniela Proietti
  • Matteo De Chiara
  • Rong Mu
  • Matteo M Metruccio
  • Kathryn A Patras
  • Annarita Taddei
  • Simona Tavarini
  • Alessia Corrado
  • Elena Cartocci
  • Daniele Veggi
  • Gabriella Gambellini
  • Simona Mangiavacchi
  • Vittoria Pinto
  • Massimiliano Biagini
  • Erwin Swennen
  • Andrea G O Manetti
  • Marirosa Mora
  • Massimo Mariani
  • Marilena Gallotta
  • Renata Grifantini
  • Mauro Bombaci
  • Paolo Donato
  • Nathalie Norais
  • Manuela Garibaldi

Detail Information

Publications7

  1. pmc Simple sequence repeats and genome plasticity in Streptococcus agalactiae
    Robert Janulczyk
    Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy
    J Bacteriol 192:3990-4000. 2010
    ..The data suggest that SSRs contributes to genome plasticity in S. agalactiae but that the bet-hedging strategy is different from Gram-negative organisms...
  2. pmc Targeted amino acid substitutions impair streptolysin O toxicity and group A Streptococcus virulence
    Emiliano Chiarot
    Novartis Vaccines and Diagnostics, Siena, Italy
    MBio 4:e00387-12. 2013
    ..We conclude that protection occurs by antibody-mediated neutralization of active toxin...
  3. pmc Analysis of two-component systems in group B Streptococcus shows that RgfAC and the novel FspSR modulate virulence and bacterial fitness
    Cristina Faralla
    Novartis Vaccines, Siena, Italy
    MBio 5:e00870-14. 2014
    ..Our data suggest a role for the previously unknown TCS-16, here named FspSR, in bacterial fitness and carbon metabolism during host colonization, and the data also provide experimental evidence for TCS-17/RgfAC involvement in virulence...
  4. pmc The regulator PerR is involved in oxidative stress response and iron homeostasis and is necessary for full virulence of Streptococcus pyogenes
    Susanna Ricci
    Laboratory of Molecular Microbiology and Biotechnology, Section of Microbiology, Department of Molecular Biology, University of Siena, Siena, Italy
    Infect Immun 70:4968-76. 2002
    ..05). These results demonstrate that PerR is involved in the regulation of iron homeostasis and oxidative stress responses and that it contributes to the virulence of S. pyogenes...
  5. pmc Streptococcus agalactiae capsule polymer length and attachment is determined by the proteins CpsABCD
    Chiara Toniolo
    From Novartis Vaccines and Diagnostics, Research Center, Via Fiorentina 1, 53100 Siena, Italy
    J Biol Chem 290:9521-32. 2015
    ..e. the balance between polymerization and attachment to the cell wall). ..
  6. pmc Streptococcus pyogenes SpyCEP influences host-pathogen interactions during infection in a murine air pouch model
    Nico Chiappini
    Research Centre, Novartis Vaccines and Diagnostics, Siena, Italy
    PLoS ONE 7:e40411. 2012
    ..The animal model we employed shows promise for broad application in the study of bacterial pathogenesis...
  7. pmc Multi high-throughput approach for highly selective identification of vaccine candidates: the Group A Streptococcus case
    Giuliano Bensi
    Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy
    Mol Cell Proteomics 11:M111.015693. 2012
    ..This approach may find general application as an accelerated and highly accurate path to bacterial vaccine discovery...