Robert Janulczyk

Summary

Affiliation: Novartis Institutes for BioMedical Research

Publications

  1. pmc Streptococcus pyogenes SpyCEP influences host-pathogen interactions during infection in a murine air pouch model
    Nico Chiappini
    Research Centre, Novartis Vaccines and Diagnostics, Siena, Italy
    PLoS ONE 7:e40411. 2012
  2. pmc Simple sequence repeats and genome plasticity in Streptococcus agalactiae
    Robert Janulczyk
    Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy
    J Bacteriol 192:3990-4000. 2010
  3. pmc Targeted amino acid substitutions impair streptolysin O toxicity and group A Streptococcus virulence
    Emiliano Chiarot
    Novartis Vaccines and Diagnostics, Siena, Italy
    MBio 4:e00387-12. 2013
  4. pmc Analysis of two-component systems in group B Streptococcus shows that RgfAC and the novel FspSR modulate virulence and bacterial fitness
    Cristina Faralla
    Novartis Vaccines, Siena, Italy
    MBio 5:e00870-14. 2014
  5. pmc The regulator PerR is involved in oxidative stress response and iron homeostasis and is necessary for full virulence of Streptococcus pyogenes
    Susanna Ricci
    Laboratory of Molecular Microbiology and Biotechnology, Section of Microbiology, Department of Molecular Biology, University of Siena, Siena, Italy
    Infect Immun 70:4968-76. 2002
  6. pmc Multi high-throughput approach for highly selective identification of vaccine candidates: the Group A Streptococcus case
    Giuliano Bensi
    Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy
    Mol Cell Proteomics 11:M111.015693. 2012

Collaborators

Detail Information

Publications6

  1. pmc Streptococcus pyogenes SpyCEP influences host-pathogen interactions during infection in a murine air pouch model
    Nico Chiappini
    Research Centre, Novartis Vaccines and Diagnostics, Siena, Italy
    PLoS ONE 7:e40411. 2012
    ..The animal model we employed shows promise for broad application in the study of bacterial pathogenesis...
  2. pmc Simple sequence repeats and genome plasticity in Streptococcus agalactiae
    Robert Janulczyk
    Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy
    J Bacteriol 192:3990-4000. 2010
    ..The data suggest that SSRs contributes to genome plasticity in S. agalactiae but that the bet-hedging strategy is different from Gram-negative organisms...
  3. pmc Targeted amino acid substitutions impair streptolysin O toxicity and group A Streptococcus virulence
    Emiliano Chiarot
    Novartis Vaccines and Diagnostics, Siena, Italy
    MBio 4:e00387-12. 2013
    ..We conclude that protection occurs by antibody-mediated neutralization of active toxin...
  4. pmc Analysis of two-component systems in group B Streptococcus shows that RgfAC and the novel FspSR modulate virulence and bacterial fitness
    Cristina Faralla
    Novartis Vaccines, Siena, Italy
    MBio 5:e00870-14. 2014
    ..Our data suggest a role for the previously unknown TCS-16, here named FspSR, in bacterial fitness and carbon metabolism during host colonization, and the data also provide experimental evidence for TCS-17/RgfAC involvement in virulence...
  5. pmc The regulator PerR is involved in oxidative stress response and iron homeostasis and is necessary for full virulence of Streptococcus pyogenes
    Susanna Ricci
    Laboratory of Molecular Microbiology and Biotechnology, Section of Microbiology, Department of Molecular Biology, University of Siena, Siena, Italy
    Infect Immun 70:4968-76. 2002
    ..05). These results demonstrate that PerR is involved in the regulation of iron homeostasis and oxidative stress responses and that it contributes to the virulence of S. pyogenes...
  6. pmc Multi high-throughput approach for highly selective identification of vaccine candidates: the Group A Streptococcus case
    Giuliano Bensi
    Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy
    Mol Cell Proteomics 11:M111.015693. 2012
    ..This approach may find general application as an accelerated and highly accurate path to bacterial vaccine discovery...