Affiliation: Novartis Institutes for BioMedical Research
- An integrated approach for identification and target validation of antifungal compounds active against Erg11pDominic Hoepfner
Novartis Institutes for BioMedical Research, Novartis Campus, Basel, Switzerland
Antimicrob Agents Chemother 56:4233-40. 2012..Thus, we have identified non-azole Erg11p inhibitors, using a systematic approach for ligand and target characterization...
- Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporinDominic Hoepfner
Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1 Novartis Campus, Basel, Switzerland
Cell Host Microbe 11:654-63. 2012..Our data indicate that lysyl-tRNA synthetase is an attractive, druggable, antimalarial target that can be selectively inhibited...
- MHO1, an evolutionarily conserved gene, is synthetic lethal with PLC1; Mho1p has a role in invasive growthIvan D Schlatter
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
PLoS ONE 7:e32501. 2012..Moreover, a role for Memo in cell motility/invasion appears to be conserved across species...