Dominic Hoepfner

Summary

Affiliation: Novartis Institutes for BioMedical Research

Publications

  1. doi request reprint High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions
    Dominic Hoepfner
    Novartis Institutes for BioMedical Research, Novartis Campus, CH 4056 Basel, Switzerland Electronic address
    Microbiol Res 169:107-20. 2014
  2. pmc An integrated approach for identification and target validation of antifungal compounds active against Erg11p
    Dominic Hoepfner
    Novartis Institutes for BioMedical Research, Novartis Campus, Basel, Switzerland
    Antimicrob Agents Chemother 56:4233-40. 2012
  3. pmc Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin
    Dominic Hoepfner
    Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1 Novartis Campus, Basel, Switzerland
    Cell Host Microbe 11:654-63. 2012
  4. pmc Evidence for a functionally relevant rocaglamide binding site on the eIF4A-RNA complex
    Heather Sadlish
    Novartis Institutes for BioMedical Research, Novartis Campus, CH 4056 Basel, Switzerland
    ACS Chem Biol 8:1519-27. 2013
  5. pmc MHO1, an evolutionarily conserved gene, is synthetic lethal with PLC1; Mho1p has a role in invasive growth
    Ivan D Schlatter
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    PLoS ONE 7:e32501. 2012
  6. pmc Reorientation of mispositioned spindles in short astral microtubule mutant spc72Delta is dependent on spindle pole body outer plaque and Kar3 motor protein
    Dominic Hoepfner
    Lehrstuhl für Angewandte Mikrobiologie, Biozentrum, Universitat Basel, CH 4056 Basel, Switzerland
    Mol Biol Cell 13:1366-80. 2002

Collaborators

Detail Information

Publications6

  1. doi request reprint High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions
    Dominic Hoepfner
    Novartis Institutes for BioMedical Research, Novartis Campus, CH 4056 Basel, Switzerland Electronic address
    Microbiol Res 169:107-20. 2014
    ..This comprehensive resource of cellular responses enables the expansion of our understanding of eukaryotic pathway biology. ..
  2. pmc An integrated approach for identification and target validation of antifungal compounds active against Erg11p
    Dominic Hoepfner
    Novartis Institutes for BioMedical Research, Novartis Campus, Basel, Switzerland
    Antimicrob Agents Chemother 56:4233-40. 2012
    ..Thus, we have identified non-azole Erg11p inhibitors, using a systematic approach for ligand and target characterization...
  3. pmc Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin
    Dominic Hoepfner
    Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1 Novartis Campus, Basel, Switzerland
    Cell Host Microbe 11:654-63. 2012
    ..Our data indicate that lysyl-tRNA synthetase is an attractive, druggable, antimalarial target that can be selectively inhibited...
  4. pmc Evidence for a functionally relevant rocaglamide binding site on the eIF4A-RNA complex
    Heather Sadlish
    Novartis Institutes for BioMedical Research, Novartis Campus, CH 4056 Basel, Switzerland
    ACS Chem Biol 8:1519-27. 2013
    ..Finally, these data confirm the value of the rocaglamide scaffold for exploring the impact of translational modulation on disease...
  5. pmc MHO1, an evolutionarily conserved gene, is synthetic lethal with PLC1; Mho1p has a role in invasive growth
    Ivan D Schlatter
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    PLoS ONE 7:e32501. 2012
    ..Moreover, a role for Memo in cell motility/invasion appears to be conserved across species...
  6. pmc Reorientation of mispositioned spindles in short astral microtubule mutant spc72Delta is dependent on spindle pole body outer plaque and Kar3 motor protein
    Dominic Hoepfner
    Lehrstuhl für Angewandte Mikrobiologie, Biozentrum, Universitat Basel, CH 4056 Basel, Switzerland
    Mol Biol Cell 13:1366-80. 2002
    ..In addition, our data exclude involvement of Spc72 in spindle formation and elongation functions...