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Publications
Combination of non-hypotensive doses of valsartan and enalapril improves survival of spontaneously hypertensive rats with endothelial dysfunctionM De Gasparo
Novartis Pharma AG, Basel, 2842, Switzerland
J Renin Angiotensin Aldosterone Syst 1:151-8. 2000..The results suggest a beneficial role for endothelium in hypertension. Reduced renal perfusion pressure probably underlies the beneficial renal effects of high-dose valsartan...- International union of pharmacology. XXIII. The angiotensin II receptorsM De Gasparo
Novartis Pharma AG, Metabolic and Cardiovascular Diseases, Basel, Switzerland
Pharmacol Rev 52:415-72. 2000..The development of specific nonpeptide receptor antagonists has led to major advances in the physiology, pharmacology, and therapy of the renin-angiotensin system... - The AT2 receptor: fact, fancy and fantasyM De Gasparo
Novartis Pharma AG, Basel, Switzerland
Regul Pept 81:11-24. 1999..A more extensive knowledge of the AT2 receptor could therefore contribute to the understanding of the clincial beneficial effects of the AT1 receptor antagonists... - Identification of two subtypes in the rat type I angiotensin II receptorN Iwai
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232
FEBS Lett 298:257-60. 1992..The existence of two subtypes in the rat type I angiotensin II receptor might explain the diverse actions of angiotensin II in various tissues... - Cloning, expression and regulation of angiotensin II receptorsT Inagami
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232 0146
Eur Heart J 15:104-7. 1994..Thus, AT2 belongs to a new class of angiotensin receptors with unique signalling and regulatory mechanisms... - Vascular response to angiotensin II is exaggerated through an upregulation of AT1 receptor in AT2 knockout miceM Tanaka
Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women s Medical University, 8 1 Kawadacho, Tokyo, Shinjuku ku, 162 8666, Japan
Biochem Biophys Res Commun 258:194-8. 1999.... - Inhibition of pressure natriuresis in mice lacking the AT2 receptorV Gross
Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
Kidney Int 57:191-202. 2000..Inhibition of pressure natriuresis in mice lacking the AT2 receptor... 
Effects of targeted disruption of the mouse angiotensin II type 2 receptor gene on stress-induced hyperthermiaT Watanabe
Department of Physiology Yamaguchi University School of Medicine, Ube, Yamaguchi 755, Japan
J Physiol 515:881-5. 1999..4. These results suggest that AT2, presumably in the brain, plays important roles in stress-induced hyperthermia in mice...- Potent antihypertrophic effect of the bradykinin B2 receptor system on the renal vasculatureS Tsuchida
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2584, USA
Kidney Int 56:509-16. 1999..In the present study, we explored the possible involvement of the kinin-kallikrein system in the development of this renal vascular hypertrophy... - Increased renal vasodilator prostanoids prevent hypertension in mice lacking the angiotensin subtype-2 receptorH M Siragy
Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
J Clin Invest 104:181-8. 1999..These results demonstrate that in the absence of the AT(2) receptor, increased vasodilator prostanoids protect against the development of hypertension... - Sustained hypersensitivity to angiotensin II and its mechanism in mice lacking the subtype-2 (AT2) angiotensin receptorH M Siragy
Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
Proc Natl Acad Sci U S A 96:6506-10. 1999..These results strongly suggest that the AT2 receptor plays a counterregulatory protective role mediated via BK and nitric oxide against the antinatriuretic and pressor actions of ANG II... - Communication between myocytes and fibroblasts in cardiac remodeling in angiotensin chimeric miceT Matsusaka
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2584, USA
J Clin Invest 103:1451-8. 1999..Importantly, the former is determined by the Ang II receptor of neighboring cardiomyocytes, indicating that a communication between myocytes and fibroblasts plays an important role during Ang II-dependent cardiac remodeling... - Role of the angiotensin II type-2 receptor in the mouse central nervous systemS Okuyama
Medicinal Research Laboratories, Taisho Pharmaceutical Co, Ltd, Ohmiya, Saitama, Japan
Jpn J Pharmacol 81:259-63. 1999..We discuss here evidence regarding the function of the AT2 receptor in the brain, determined using mice lacking the AT2 receptor... - The angiotensin type II receptor tonically inhibits angiotensin- converting enzyme in AT2 null mutant miceT E Hunley
Division of Pediatric Nephrology, Department of Biochemistry, and Department of Urology, Vanderbilt University Medical Center, Nashville, TN, USA
Kidney Int 57:570-7. 2000..There is emerging evidence that some of the beneficial effects of ACE inhibitors may be endogenously available through the angiotensin receptor type 2 (AT2)... - Long-term blood pressure telemetry in AT2 receptor-disrupted miceV Gross
Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
J Hypertens 18:955-61. 2000..Therefore, we investigated the influence of dietary salt loading and deoxycorticosterone (DOCA)-salt treatment on blood pressure and diurnal patterns of blood pressure in these mice by radiotelemetry... - Overexpression of the human angiotensin II type 1 receptor in the rat heart augments load induced cardiac hypertrophyS Hoffmann
Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
J Mol Med (Berl) 79:601-8. 2001.... - Increased AT(1) receptors in adrenal gland of AT(2) receptor gene-disrupted miceJ M Saavedra
Section on Pharmacology, National Institute of Mental Health, 10 Center Drive MSC 1514, Building 10, Room 2D 57, Bethesda, MD 20892, USA
Regul Pept 102:41-7. 2001.... - Angiotensin II type 2 receptor is essential for left ventricular hypertrophy and cardiac fibrosis in chronic angiotensin II-induced hypertensionS Ichihara
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Circulation 104:346-51. 2001..In the present study, we examined the hypothesis that signaling by AT(2) is important to the development of left ventricular hypertrophy and cardiac fibrosis by Ang II infusion in mice lacking the AT(2) gene (Agtr2-/Y)... - Changes of AT(2) receptor levels in the rat adrenal cortex and medulla induced by bilateral nephrectomy and its modulation by circulating ANG IIB Peters
Department of Pharmacology, University of Heidelberg, INF 366, 69120 Heidelberg, Germany
J Histochem Cytochem 49:649-56. 2001..J Histochem Cytochem 49:649-656, 2001).. - 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors block calcium-dependent tyrosine kinase Pyk2 activation by angiotensin II in vascular endothelial cells. involvement of geranylgeranylation of small G protein Rap1K Satoh
Departments of Biochemistry and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Biol Chem 276:15761-7. 2001..In addition, our results indicate that 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, a class of cholesterol-lowering drugs, could interrupt Ang II signaling independent of cholesterol lowering in endothelial cells... - Association of a polymorphism at the 5'-region of the angiotensin II type 1 receptor with hypertensionN Takahashi
Department of Genetics, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ku, Hiroshima, 732 0815, Japan
Ann Hum Genet 64:197-205. 2000..Evidence was obtained that the AT 1 (-535)*T allele showed a synergistic effect on risk of hypertension with angiotensin I converting enzyme D allele (ACE*D)... - Increased AT(1) receptor expression and mRNA in kidney glomeruli of AT(2) receptor gene-disrupted miceJ M Saavedra
Section on Pharmacology, National Institute of Mental Health, Bethesda, Maryland 20892, USA
Am J Physiol Renal Physiol 280:F71-8. 2001..The indirect AT(1)/AT(2) receptor feedback could have clinical significance because AT(1) antagonists are widely used in medical practice... - Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overloadT Senbonmatsu
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
J Clin Invest 106:R25-9. 2000..This article may have been published online in advance of the print edition. The date of publication is available from the JCI website, http://www.jci.org... - Anxiety-like behavior in mice lacking the angiotensin II type-2 receptorS Okuyama
1st Laboratory, Medicinal Research Laboratories, Taisho Pharmaceutical, 1 403, Yoshinocho, Ohmiya 330 8530, Japan
Brain Res 821:150-9. 1999..These findings indicate that the noradrenergic system is involved in mediating the anxiety-like behavior in AT2-deficient mice... - Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and menH Nishimura
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2584, USA
Mol Cell 3:1-10. 1999.... - Expression, genomic organization, and transcription of the mouse angiotensin II type 2 receptor geneT Ichiki
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tenn 37232, USA
Circ Res 76:693-700. 1995..A DNA segment of about 1.5 kb of the promoter region (-1497 to +56 bp) of the mouse AT2 gene was fused to a luciferase reporter gene.(ABSTRACT TRUNCATED AT 250 WORDS).. - Transcriptional regulation of the mouse angiotensin II type 2 receptor geneT Ichiki
Dept of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Hypertension 25:720-5. 1995..Two other DNA binding proteins were not observed in nuclear extracts from vascular smooth muscle cells.(ABSTRACT TRUNCATED AT 250 WORDS).. - Localization of the genes encoding the three rat angiotensin II receptors, Agtr1a, Agtr1b, Agtr2, and the human AGTR2 receptor respectively to rat chromosomes 17q12, 2q24 and Xq34, and the human Xq22F Tissir
Universite Libre de Bruxelles, Departement de Biologie Moleculaire, Rhode St Genese, Belgium
Cytogenet Cell Genet 71:77-80. 1995..In parallel, we showed that the type 2 human gene, AGTR2, also maps on the X chromosome, at band Xq22... - Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptorT Ichiki
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville 37232, USA
Nature 377:748-50. 1995..Our results show that angiotensin II activates AT1 and AT2, which have mutually counteracting haemodynamic effects, and that AT2 regulates central nervous system functions, including behaviour... - Rat angiotensin II receptor: cDNA sequence and regulation of the gene expressionN Iwai
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232
Biochem Biophys Res Commun 177:299-304. 1991..Interestingly the expression of this receptor gene was developmentally regulated... - Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptorK Sasaki
Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232
Nature 351:230-3. 1991..Northern blot analysis revealed that the messenger RNA for this receptor is expressed in bovine adrenal medulla, cortex and kidney... - Roles of renal and vascular renin in spontaneous hypertension and switching of the mechanism upon nephrectomy. Lack of hypotensive effects of inhibition of renin, converting enzyme, and angiotensin II receptor blocker after bilateral nephrectomyT Inagami
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee
Am J Hypertens 4:15S-22S. 1991.... - Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptorR Takayanagi
Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
Biochem Biophys Res Commun 183:910-6. 1992..The expression of the Ang II receptor mRNA was detected in human liver, lung, adrenal and adrenocortical adenomas but not in adrenomedullary tumor, pheochromocytoma, by Northern blot analysis... - Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptorH Furuta
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232
Biochem Biophys Res Commun 183:8-13. 1992..Amino acid substitutions specific to the human AT1 receptor were mostly confined to the carboxy terminal half of the molecule. The seven-transmembrane domains are well-conserved in those sequences... - Developmental expression of renal angiotensin II receptor genes in the mouseJ Kakuchi
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Kidney Int 47:140-7. 1995..Thus, contrary to current belief, the activation of AT1 and AT2 genes takes place in different cell types of the kidney during embryonic development, and thereby conceivably contributes to the ontogeny of those specific renal cells... - Cloning of a rabbit kidney cortex AT1 angiotensin II receptor that is present in proximal tubule epitheliumK D Burns
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee
Am J Physiol 264:F645-54. 1993..The clone isolated in the present study should provide a useful tool with which to study the regulation of the PT renin-angiotensin system... - Angiotensin induces the urinary peristaltic machinery during the perinatal periodY Miyazaki
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
J Clin Invest 102:1489-97. 1998..These results reveal a new role for angiotensin in the unique cellular adaptations of the mammalian kidney to the physiological stresses of postnatal life... - Accelerated fibrosis and collagen deposition develop in the renal interstitium of angiotensin type 2 receptor null mutant mice during ureteral obstructionJ Ma
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Kidney Int 53:937-44. 1998..Thus, the AT2 receptor significantly impacts the remodeling process within renal interstitium, potentially by regulating the population of collagen-producing cells... - Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotesS Tsuchida
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2584, USA
J Clin Invest 101:755-60. 1998..Also, unlike Agt-/- mice, some Agtr1a-/-; Agtr1b-/- mice have a large ventricular septum defect, suggesting that another receptor such as AT2 is functionally activated in Agtr1a-/-, Agtr1b-/- mice... - Chimeric mice carrying 'regional' targeted deletion of the angiotensin type 1A receptor gene. Evidence against the role for local angiotensin in the in vivo feedback regulation of renin synthesis in juxtaglomerular cellsT Matsusaka
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Clin Invest 98:1867-77. 1996..Thus, in the in vivo condition tested, the local interaction between angiotensin and the AT1 receptor on the JG cells has little functional contribution to the feedback regulation of JG renin synthesis... - Cloning of the cDNA and the genomic DNA of the mouse angiotensin II type 2 receptorT Ichiki
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232
Biochim Biophys Acta 1189:247-50. 1994..Amino acid identity of the mouse AT2 with mouse AT1 is 37%, and 98% with rat AT2. The genomic DNA (4.4 kb) contained three exons and two introns and the entire coding region was contained in the third exon... - Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibitionY Kambayashi
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
J Biol Chem 268:24543-6. 1993.... - The genomic organization of the rat angiotensin II receptor AT1BD F Guo
Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, TN 37232
Biochim Biophys Acta 1218:91-4. 1994..The transcription initiation site was located at -8 bp upstream the 5' end of the cDNA in the 5'-flanking region... - Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptorS Tsuzuki
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232
Biochem Biophys Res Commun 200:1449-54. 1994..Scatchard analysis and ligand displacement profile were typical of the AT2 receptor. Reverse transcription-polymerase chain reaction analysis showed that AT2 receptor mRNA was expressed in adult uterus and pheochromocytoma... - The genomic organization of human angiotensin II type 1 receptorD F Guo
Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, TN 37232
Biochem Biophys Res Commun 200:313-9. 1994..Multiple transcription initiation sites were observed by primer extension experiment. The promoter function was examined by using luciferase as a report gene in transfected human vascular smooth muscle cells... - Analysis of the evolution of angiotensin II type 1 receptor gene in mammals (mouse, rat, bovine and human)H Yoshida
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232
Biochem Biophys Res Commun 186:1042-9. 1992..This conclusion was consistent with the results of genomic Southern blot analyses, which revealed that the mouse and rat possess 2 similar but separate genes, whereas the bovine and human have only a single class gene...