P Hess

Summary

Affiliation: Novartis Institutes for BioMedical Research

Publications

  1. ncbi Combination of non-hypotensive doses of valsartan and enalapril improves survival of spontaneously hypertensive rats with endothelial dysfunction
    M De Gasparo
    Novartis Pharma AG, Basel, 2842, Switzerland
    J Renin Angiotensin Aldosterone Syst 1:151-8. 2000
  2. ncbi International union of pharmacology. XXIII. The angiotensin II receptors
    M De Gasparo
    Novartis Pharma AG, Metabolic and Cardiovascular Diseases, Basel, Switzerland
    Pharmacol Rev 52:415-72. 2000
  3. ncbi The AT2 receptor: fact, fancy and fantasy
    M De Gasparo
    Novartis Pharma AG, Basel, Switzerland
    Regul Pept 81:11-24. 1999
  4. ncbi Identification of two subtypes in the rat type I angiotensin II receptor
    N Iwai
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232
    FEBS Lett 298:257-60. 1992
  5. ncbi Cloning, expression and regulation of angiotensin II receptors
    T Inagami
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232 0146
    Eur Heart J 15:104-7. 1994
  6. ncbi Vascular response to angiotensin II is exaggerated through an upregulation of AT1 receptor in AT2 knockout mice
    M Tanaka
    Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women s Medical University, 8 1 Kawadacho, Tokyo, Shinjuku ku, 162 8666, Japan
    Biochem Biophys Res Commun 258:194-8. 1999
  7. ncbi Inhibition of pressure natriuresis in mice lacking the AT2 receptor
    V Gross
    Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Kidney Int 57:191-202. 2000
  8. pmc Effects of targeted disruption of the mouse angiotensin II type 2 receptor gene on stress-induced hyperthermia
    T Watanabe
    Department of Physiology Yamaguchi University School of Medicine, Ube, Yamaguchi 755, Japan
    J Physiol 515:881-5. 1999
  9. ncbi Potent antihypertrophic effect of the bradykinin B2 receptor system on the renal vasculature
    S Tsuchida
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2584, USA
    Kidney Int 56:509-16. 1999
  10. pmc Increased renal vasodilator prostanoids prevent hypertension in mice lacking the angiotensin subtype-2 receptor
    H M Siragy
    Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Clin Invest 104:181-8. 1999

Collaborators

  • J P Clozel
  • T Unger
  • T Inagami
  • T Ichiki
  • J M Saavedra
  • Ines Armando
  • Helmy Siragy
  • Deng Fu Guo
  • I Ichikawa
  • A Fogo
  • M De Gasparo
  • H Nishimura
  • S Tsuchida
  • T Matsusaka
  • S Okuyama
  • V Gross
  • T E Hunley
  • Y Miyazaki
  • S Ichihara
  • T Senbonmatsu
  • J Ma
  • K Satoh
  • S Hoffmann
  • B Peters
  • F A Gaffney
  • E Price
  • N Takahashi
  • F C Luft
  • A F Milia
  • T Watanabe
  • M Tanaka
  • V Kon
  • T Sakagawa
  • J Kakuchi
  • S Tsuzuki
  • F Niimura
  • H Utsunomiya
  • H Yoshida
  • B L Hogan
  • J Peters
  • H Urata
  • Y M Pinto
  • D Ganten
  • N Gretz
  • H Buikema
  • C Lindschau
  • P Teubner
  • K Ichihara
  • H Tang
  • R C Harris
  • E J Landon
  • S Clausmeyer
  • R Willenbrock
  • P P van Geel
  • I Pagel
  • M Paul
  • T Krause
  • W H van Gilst
  • P Bruneval
  • E Kärgel
  • K Kodama
  • B J Stoneking
  • H Murakami
  • K J Catt
  • T Walther
  • T Nishishita
  • M Yamada
  • F Tissir
  • J W Wright
  • W Schneider
  • F Kasagi
  • W H Schunck
  • M Bader
  • R Plehm
  • M Tamura
  • B Nuesslein-Hildesheim
  • S Chaki
  • H Honeck
  • S Nakamura
  • Y Imagawa
  • N Fujii
  • E Yerkes
  • J W Brock
  • H Katori
  • H Miyazaki
  • K Hohenfellner
  • M Naruse
  • J A Phillips
  • T Imai
  • M Hashimoto

Detail Information

Publications46

  1. ncbi Combination of non-hypotensive doses of valsartan and enalapril improves survival of spontaneously hypertensive rats with endothelial dysfunction
    M De Gasparo
    Novartis Pharma AG, Basel, 2842, Switzerland
    J Renin Angiotensin Aldosterone Syst 1:151-8. 2000
    ..The results suggest a beneficial role for endothelium in hypertension. Reduced renal perfusion pressure probably underlies the beneficial renal effects of high-dose valsartan...
  2. ncbi International union of pharmacology. XXIII. The angiotensin II receptors
    M De Gasparo
    Novartis Pharma AG, Metabolic and Cardiovascular Diseases, Basel, Switzerland
    Pharmacol Rev 52:415-72. 2000
    ..The development of specific nonpeptide receptor antagonists has led to major advances in the physiology, pharmacology, and therapy of the renin-angiotensin system...
  3. ncbi The AT2 receptor: fact, fancy and fantasy
    M De Gasparo
    Novartis Pharma AG, Basel, Switzerland
    Regul Pept 81:11-24. 1999
    ..A more extensive knowledge of the AT2 receptor could therefore contribute to the understanding of the clincial beneficial effects of the AT1 receptor antagonists...
  4. ncbi Identification of two subtypes in the rat type I angiotensin II receptor
    N Iwai
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232
    FEBS Lett 298:257-60. 1992
    ..The existence of two subtypes in the rat type I angiotensin II receptor might explain the diverse actions of angiotensin II in various tissues...
  5. ncbi Cloning, expression and regulation of angiotensin II receptors
    T Inagami
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232 0146
    Eur Heart J 15:104-7. 1994
    ..Thus, AT2 belongs to a new class of angiotensin receptors with unique signalling and regulatory mechanisms...
  6. ncbi Vascular response to angiotensin II is exaggerated through an upregulation of AT1 receptor in AT2 knockout mice
    M Tanaka
    Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women s Medical University, 8 1 Kawadacho, Tokyo, Shinjuku ku, 162 8666, Japan
    Biochem Biophys Res Commun 258:194-8. 1999
    ....
  7. ncbi Inhibition of pressure natriuresis in mice lacking the AT2 receptor
    V Gross
    Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Kidney Int 57:191-202. 2000
    ..Inhibition of pressure natriuresis in mice lacking the AT2 receptor...
  8. pmc Effects of targeted disruption of the mouse angiotensin II type 2 receptor gene on stress-induced hyperthermia
    T Watanabe
    Department of Physiology Yamaguchi University School of Medicine, Ube, Yamaguchi 755, Japan
    J Physiol 515:881-5. 1999
    ..4. These results suggest that AT2, presumably in the brain, plays important roles in stress-induced hyperthermia in mice...
  9. ncbi Potent antihypertrophic effect of the bradykinin B2 receptor system on the renal vasculature
    S Tsuchida
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2584, USA
    Kidney Int 56:509-16. 1999
    ..In the present study, we explored the possible involvement of the kinin-kallikrein system in the development of this renal vascular hypertrophy...
  10. pmc Increased renal vasodilator prostanoids prevent hypertension in mice lacking the angiotensin subtype-2 receptor
    H M Siragy
    Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Clin Invest 104:181-8. 1999
    ..These results demonstrate that in the absence of the AT(2) receptor, increased vasodilator prostanoids protect against the development of hypertension...
  11. pmc Sustained hypersensitivity to angiotensin II and its mechanism in mice lacking the subtype-2 (AT2) angiotensin receptor
    H M Siragy
    Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 96:6506-10. 1999
    ..These results strongly suggest that the AT2 receptor plays a counterregulatory protective role mediated via BK and nitric oxide against the antinatriuretic and pressor actions of ANG II...
  12. pmc Communication between myocytes and fibroblasts in cardiac remodeling in angiotensin chimeric mice
    T Matsusaka
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2584, USA
    J Clin Invest 103:1451-8. 1999
    ..Importantly, the former is determined by the Ang II receptor of neighboring cardiomyocytes, indicating that a communication between myocytes and fibroblasts plays an important role during Ang II-dependent cardiac remodeling...
  13. ncbi Role of the angiotensin II type-2 receptor in the mouse central nervous system
    S Okuyama
    Medicinal Research Laboratories, Taisho Pharmaceutical Co, Ltd, Ohmiya, Saitama, Japan
    Jpn J Pharmacol 81:259-63. 1999
    ..We discuss here evidence regarding the function of the AT2 receptor in the brain, determined using mice lacking the AT2 receptor...
  14. ncbi The angiotensin type II receptor tonically inhibits angiotensin- converting enzyme in AT2 null mutant mice
    T E Hunley
    Division of Pediatric Nephrology, Department of Biochemistry, and Department of Urology, Vanderbilt University Medical Center, Nashville, TN, USA
    Kidney Int 57:570-7. 2000
    ..There is emerging evidence that some of the beneficial effects of ACE inhibitors may be endogenously available through the angiotensin receptor type 2 (AT2)...
  15. ncbi Long-term blood pressure telemetry in AT2 receptor-disrupted mice
    V Gross
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    J Hypertens 18:955-61. 2000
    ..Therefore, we investigated the influence of dietary salt loading and deoxycorticosterone (DOCA)-salt treatment on blood pressure and diurnal patterns of blood pressure in these mice by radiotelemetry...
  16. ncbi Overexpression of the human angiotensin II type 1 receptor in the rat heart augments load induced cardiac hypertrophy
    S Hoffmann
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    J Mol Med (Berl) 79:601-8. 2001
    ....
  17. ncbi Increased AT(1) receptors in adrenal gland of AT(2) receptor gene-disrupted mice
    J M Saavedra
    Section on Pharmacology, National Institute of Mental Health, 10 Center Drive MSC 1514, Building 10, Room 2D 57, Bethesda, MD 20892, USA
    Regul Pept 102:41-7. 2001
    ....
  18. ncbi Angiotensin II type 2 receptor is essential for left ventricular hypertrophy and cardiac fibrosis in chronic angiotensin II-induced hypertension
    S Ichihara
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Circulation 104:346-51. 2001
    ..In the present study, we examined the hypothesis that signaling by AT(2) is important to the development of left ventricular hypertrophy and cardiac fibrosis by Ang II infusion in mice lacking the AT(2) gene (Agtr2-/Y)...
  19. ncbi Changes of AT(2) receptor levels in the rat adrenal cortex and medulla induced by bilateral nephrectomy and its modulation by circulating ANG II
    B Peters
    Department of Pharmacology, University of Heidelberg, INF 366, 69120 Heidelberg, Germany
    J Histochem Cytochem 49:649-56. 2001
    ..J Histochem Cytochem 49:649-656, 2001)..
  20. ncbi 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors block calcium-dependent tyrosine kinase Pyk2 activation by angiotensin II in vascular endothelial cells. involvement of geranylgeranylation of small G protein Rap1
    K Satoh
    Departments of Biochemistry and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 276:15761-7. 2001
    ..In addition, our results indicate that 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, a class of cholesterol-lowering drugs, could interrupt Ang II signaling independent of cholesterol lowering in endothelial cells...
  21. ncbi Association of a polymorphism at the 5'-region of the angiotensin II type 1 receptor with hypertension
    N Takahashi
    Department of Genetics, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ku, Hiroshima, 732 0815, Japan
    Ann Hum Genet 64:197-205. 2000
    ..Evidence was obtained that the AT 1 (-535)*T allele showed a synergistic effect on risk of hypertension with angiotensin I converting enzyme D allele (ACE*D)...
  22. ncbi Increased AT(1) receptor expression and mRNA in kidney glomeruli of AT(2) receptor gene-disrupted mice
    J M Saavedra
    Section on Pharmacology, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Am J Physiol Renal Physiol 280:F71-8. 2001
    ..The indirect AT(1)/AT(2) receptor feedback could have clinical significance because AT(1) antagonists are widely used in medical practice...
  23. pmc Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overload
    T Senbonmatsu
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Clin Invest 106:R25-9. 2000
    ..This article may have been published online in advance of the print edition. The date of publication is available from the JCI website, http://www.jci.org...
  24. ncbi Anxiety-like behavior in mice lacking the angiotensin II type-2 receptor
    S Okuyama
    1st Laboratory, Medicinal Research Laboratories, Taisho Pharmaceutical, 1 403, Yoshinocho, Ohmiya 330 8530, Japan
    Brain Res 821:150-9. 1999
    ..These findings indicate that the noradrenergic system is involved in mediating the anxiety-like behavior in AT2-deficient mice...
  25. ncbi Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men
    H Nishimura
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2584, USA
    Mol Cell 3:1-10. 1999
    ....
  26. ncbi Expression, genomic organization, and transcription of the mouse angiotensin II type 2 receptor gene
    T Ichiki
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tenn 37232, USA
    Circ Res 76:693-700. 1995
    ..A DNA segment of about 1.5 kb of the promoter region (-1497 to +56 bp) of the mouse AT2 gene was fused to a luciferase reporter gene.(ABSTRACT TRUNCATED AT 250 WORDS)..
  27. ncbi Transcriptional regulation of the mouse angiotensin II type 2 receptor gene
    T Ichiki
    Dept of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Hypertension 25:720-5. 1995
    ..Two other DNA binding proteins were not observed in nuclear extracts from vascular smooth muscle cells.(ABSTRACT TRUNCATED AT 250 WORDS)..
  28. ncbi Localization of the genes encoding the three rat angiotensin II receptors, Agtr1a, Agtr1b, Agtr2, and the human AGTR2 receptor respectively to rat chromosomes 17q12, 2q24 and Xq34, and the human Xq22
    F Tissir
    Universite Libre de Bruxelles, Departement de Biologie Moleculaire, Rhode St Genese, Belgium
    Cytogenet Cell Genet 71:77-80. 1995
    ..In parallel, we showed that the type 2 human gene, AGTR2, also maps on the X chromosome, at band Xq22...
  29. ncbi Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor
    T Ichiki
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville 37232, USA
    Nature 377:748-50. 1995
    ..Our results show that angiotensin II activates AT1 and AT2, which have mutually counteracting haemodynamic effects, and that AT2 regulates central nervous system functions, including behaviour...
  30. ncbi Rat angiotensin II receptor: cDNA sequence and regulation of the gene expression
    N Iwai
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232
    Biochem Biophys Res Commun 177:299-304. 1991
    ..Interestingly the expression of this receptor gene was developmentally regulated...
  31. ncbi Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor
    K Sasaki
    Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232
    Nature 351:230-3. 1991
    ..Northern blot analysis revealed that the messenger RNA for this receptor is expressed in bovine adrenal medulla, cortex and kidney...
  32. ncbi Roles of renal and vascular renin in spontaneous hypertension and switching of the mechanism upon nephrectomy. Lack of hypotensive effects of inhibition of renin, converting enzyme, and angiotensin II receptor blocker after bilateral nephrectomy
    T Inagami
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee
    Am J Hypertens 4:15S-22S. 1991
    ....
  33. ncbi Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor
    R Takayanagi
    Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Biochem Biophys Res Commun 183:910-6. 1992
    ..The expression of the Ang II receptor mRNA was detected in human liver, lung, adrenal and adrenocortical adenomas but not in adrenomedullary tumor, pheochromocytoma, by Northern blot analysis...
  34. ncbi Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor
    H Furuta
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232
    Biochem Biophys Res Commun 183:8-13. 1992
    ..Amino acid substitutions specific to the human AT1 receptor were mostly confined to the carboxy terminal half of the molecule. The seven-transmembrane domains are well-conserved in those sequences...
  35. ncbi Developmental expression of renal angiotensin II receptor genes in the mouse
    J Kakuchi
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Kidney Int 47:140-7. 1995
    ..Thus, contrary to current belief, the activation of AT1 and AT2 genes takes place in different cell types of the kidney during embryonic development, and thereby conceivably contributes to the ontogeny of those specific renal cells...
  36. ncbi Cloning of a rabbit kidney cortex AT1 angiotensin II receptor that is present in proximal tubule epithelium
    K D Burns
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee
    Am J Physiol 264:F645-54. 1993
    ..The clone isolated in the present study should provide a useful tool with which to study the regulation of the PT renin-angiotensin system...
  37. pmc Angiotensin induces the urinary peristaltic machinery during the perinatal period
    Y Miyazaki
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Clin Invest 102:1489-97. 1998
    ..These results reveal a new role for angiotensin in the unique cellular adaptations of the mammalian kidney to the physiological stresses of postnatal life...
  38. ncbi Accelerated fibrosis and collagen deposition develop in the renal interstitium of angiotensin type 2 receptor null mutant mice during ureteral obstruction
    J Ma
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Kidney Int 53:937-44. 1998
    ..Thus, the AT2 receptor significantly impacts the remodeling process within renal interstitium, potentially by regulating the population of collagen-producing cells...
  39. pmc Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes
    S Tsuchida
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2584, USA
    J Clin Invest 101:755-60. 1998
    ..Also, unlike Agt-/- mice, some Agtr1a-/-; Agtr1b-/- mice have a large ventricular septum defect, suggesting that another receptor such as AT2 is functionally activated in Agtr1a-/-, Agtr1b-/- mice...
  40. pmc Chimeric mice carrying 'regional' targeted deletion of the angiotensin type 1A receptor gene. Evidence against the role for local angiotensin in the in vivo feedback regulation of renin synthesis in juxtaglomerular cells
    T Matsusaka
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Clin Invest 98:1867-77. 1996
    ..Thus, in the in vivo condition tested, the local interaction between angiotensin and the AT1 receptor on the JG cells has little functional contribution to the feedback regulation of JG renin synthesis...
  41. ncbi Cloning of the cDNA and the genomic DNA of the mouse angiotensin II type 2 receptor
    T Ichiki
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232
    Biochim Biophys Acta 1189:247-50. 1994
    ..Amino acid identity of the mouse AT2 with mouse AT1 is 37%, and 98% with rat AT2. The genomic DNA (4.4 kb) contained three exons and two introns and the entire coding region was contained in the third exon...
  42. ncbi Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition
    Y Kambayashi
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
    J Biol Chem 268:24543-6. 1993
    ....
  43. ncbi The genomic organization of the rat angiotensin II receptor AT1B
    D F Guo
    Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, TN 37232
    Biochim Biophys Acta 1218:91-4. 1994
    ..The transcription initiation site was located at -8 bp upstream the 5' end of the cDNA in the 5'-flanking region...
  44. ncbi Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor
    S Tsuzuki
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232
    Biochem Biophys Res Commun 200:1449-54. 1994
    ..Scatchard analysis and ligand displacement profile were typical of the AT2 receptor. Reverse transcription-polymerase chain reaction analysis showed that AT2 receptor mRNA was expressed in adult uterus and pheochromocytoma...
  45. ncbi The genomic organization of human angiotensin II type 1 receptor
    D F Guo
    Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, TN 37232
    Biochem Biophys Res Commun 200:313-9. 1994
    ..Multiple transcription initiation sites were observed by primer extension experiment. The promoter function was examined by using luciferase as a report gene in transfected human vascular smooth muscle cells...
  46. ncbi Analysis of the evolution of angiotensin II type 1 receptor gene in mammals (mouse, rat, bovine and human)
    H Yoshida
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232
    Biochem Biophys Res Commun 186:1042-9. 1992
    ..This conclusion was consistent with the results of genomic Southern blot analyses, which revealed that the mouse and rat possess 2 similar but separate genes, whereas the bovine and human have only a single class gene...