Ekkehard Glimm

Summary

Affiliation: Novartis Institutes for BioMedical Research

Publications

  1. doi request reprint Hierarchical testing of multiple endpoints in group-sequential trials
    Ekkehard Glimm
    Novartis Pharma AG, Statistical Methodology, Novartis Campus, CH 4056 Basel, Switzerland
    Stat Med 29:219-28. 2010
  2. doi request reprint Directional multivariate tests rejecting null and negative effects in all variables
    Ekkehard Glimm
    Novartis Pharma AG, Basel, Switzerland
    Biom J 52:757-70. 2010
  3. pmc Graphical approaches for multiple comparison procedures using weighted Bonferroni, Simes, or parametric tests
    Frank Bretz
    Statistical Methodology, Novartis Pharma AG, Basel, Switzerland
    Biom J 53:894-913. 2011
  4. doi request reprint Adaptive designs for confirmatory clinical trials
    Frank Bretz
    Novartis Pharma AG, Lichtstrasse 35, 4002 Basel, Switzerland
    Stat Med 28:1181-217. 2009

Detail Information

Publications4

  1. doi request reprint Hierarchical testing of multiple endpoints in group-sequential trials
    Ekkehard Glimm
    Novartis Pharma AG, Statistical Methodology, Novartis Campus, CH 4056 Basel, Switzerland
    Stat Med 29:219-28. 2010
    ..We use a numerical example based on a real case study to illustrate the results of different hierarchical test strategies...
  2. doi request reprint Directional multivariate tests rejecting null and negative effects in all variables
    Ekkehard Glimm
    Novartis Pharma AG, Basel, Switzerland
    Biom J 52:757-70. 2010
    ..The derivation of the tests is supplemented by simulations investigating their performance and by the application in an osteoporosis trial...
  3. pmc Graphical approaches for multiple comparison procedures using weighted Bonferroni, Simes, or parametric tests
    Frank Bretz
    Statistical Methodology, Novartis Pharma AG, Basel, Switzerland
    Biom J 53:894-913. 2011
    ..We illustrate the extended graphical approaches with several examples. In addition, we describe briefly the gMCP package in R, which implements some of the methods described in this paper...
  4. doi request reprint Adaptive designs for confirmatory clinical trials
    Frank Bretz
    Novartis Pharma AG, Lichtstrasse 35, 4002 Basel, Switzerland
    Stat Med 28:1181-217. 2009
    ..A case study and related numerical examples are used to illustrate the key results. In addition we provide a detailed discussion of current methods to calculate point estimates and confidence intervals for relevant parameters...