Affiliation: Novartis Institutes for BioMedical Research
- Hierarchical testing of multiple endpoints in group-sequential trialsEkkehard Glimm
Novartis Pharma AG, Statistical Methodology, Novartis Campus, CH 4056 Basel, Switzerland
Stat Med 29:219-28. 2010..We use a numerical example based on a real case study to illustrate the results of different hierarchical test strategies...
- Directional multivariate tests rejecting null and negative effects in all variablesEkkehard Glimm
Novartis Pharma AG, Basel, Switzerland
Biom J 52:757-70. 2010..The derivation of the tests is supplemented by simulations investigating their performance and by the application in an osteoporosis trial...
- Graphical approaches for multiple comparison procedures using weighted Bonferroni, Simes, or parametric testsFrank Bretz
Statistical Methodology, Novartis Pharma AG, Basel, Switzerland
Biom J 53:894-913. 2011..We illustrate the extended graphical approaches with several examples. In addition, we describe briefly the gMCP package in R, which implements some of the methods described in this paper...
- Adaptive designs for confirmatory clinical trialsFrank Bretz
Novartis Pharma AG, Lichtstrasse 35, 4002 Basel, Switzerland
Stat Med 28:1181-217. 2009..A case study and related numerical examples are used to illustrate the key results. In addition we provide a detailed discussion of current methods to calculate point estimates and confidence intervals for relevant parameters...