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Genomes and Genes | David J GlassSummaryAffiliation: Novartis Institutes for BioMedical Research Publications
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Publications
Two tales concerning skeletal muscleDavid J Glass
Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, USA
J Clin Invest 117:2388-91. 2007..Here it is shown that nNOS is similarly perturbed in a setting of skeletal muscle atrophy. Both of these studies suggest new avenues for the treatment of skeletal muscle disease...
Skeletal muscle hypertrophy and atrophy signaling pathwaysDavid J Glass
Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591 6707, USA
Int J Biochem Cell Biol 37:1974-84. 2005..This review will focus on the recent progress in the understanding of molecular signalling, which governs skeletal muscle atrophy and hypertrophy, and the known instances of cross-regulation between the two systems...
A brief history of the hypothesisDavid J Glass
Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA
Cell 134:378-81. 2008..Two terms used as frameworks for scientific experimentation--the "hypothesis" and the "model"--carry distinct philosophical assumptions, with important consequences for the practicing scientist...- The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factorsTrevor N Stitt
Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
Mol Cell 14:395-403. 2004.... - A signaling role for dystrophin: inhibiting skeletal muscle atrophy pathwaysDavid J Glass
Novartis Institutes for BioMedical Research, 400 Technology Square, Cambridge, Massachusetts 02139, USA
Cancer Cell 8:351-2. 2005..These data reposition dystrophin as a signaling protein and connect an important cellular complex required for the structural integrity of muscle to the pathways that modulate muscle size... - Se-Jin Lee, myostatin discoverer, elected to the National Academy of ScienceDavid J Glass
Novartis Institutes for BioMedical Research, 100 Technology Square, RM4210, Cambridge, MA 02139, USA
Skelet Muscle 2:11. 2012..He also determined the primary binding receptor for myostatin, and has characterized additional transforming growth factor-β family members acting in this pathway... - TAK-1/p38/nNFκB signaling inhibits myoblast differentiation by increasing levels of Activin AAnne Ulrike Trendelenburg
Novartis Institutes for BioMedical Research, Forum 1, Novartis Campus, 4056 Basel, Switzerland
Skelet Muscle 2:3. 2012..abstract:.. - Treating cancer cachexia to treat cancerSe Jin Lee
Johns Hopkins University School of Medicine, Department of Molecular Biology and Genetics, 725 N, Wolfe St, PCTB 803, Baltimore, Maryland 21205, USA
Skelet Muscle 1:2. 2011.... - Signaling pathways perturbing muscle massDavid J Glass
Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA
Curr Opin Clin Nutr Metab Care 13:225-9. 2010..To discuss the mechanisms of muscle loss during cachexia... - A critique of the hypothesis, and a defense of the question, as a framework for experimentationDavid J Glass
Novartis Institutes for BioMedical Research, Cambridge, MA, USA
Clin Chem 56:1080-5. 2010..Presented is an alternative framework-the query/model approach-which many scientists may discover is the framework they are actually using, despite being required to give lip service to the hypothesis... - PI3 kinase regulation of skeletal muscle hypertrophy and atrophyDavid J Glass
Novartis Institute for Biomedical Research, Cambridge, MA 02139, USA
Curr Top Microbiol Immunol 346:267-78. 2010..These findings show that myostatin signaling acts by blocking genes induced during differentiation, even in a myotube, as opposed to activating the distinct "atrophy program.".. - Genomic and proteomic profiling reveals reduced mitochondrial function and disruption of the neuromuscular junction driving rat sarcopeniaChikwendu Ibebunjo
Muscle Diseases Group, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA
Mol Cell Biol 33:194-212. 2013..Together, these findings suggest that therapeutic approaches that simultaneously stimulate mitochondrogenesis and reduce muscle proteolysis and inflammation have potential for treating sarcopenia... - MNK2 inhibits eIF4G activation through a pathway involving serine-arginine-rich protein kinase in skeletal muscleShou Ih Hu
Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, USA
Sci Signal 5:ra14. 2012..These data indicate that MNK2 plays a unique role, not shared by its closest paralog MNK1, in limiting protein translation through its negative effect on eIF4G Ser¹¹⁰⁸ phosphorylation and p70S6K activation... - The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscleBrian A Clarke
Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, USA
Cell Metab 6:376-85. 2007..These data identify the mechanism by which MYH is depleted under atrophy conditions and demonstrate that inhibition of a single E3 ligase, MuRF1, is sufficient to maintain this important sarcomeric protein... - An HMGA2-IGF2BP2 axis regulates myoblast proliferation and myogenesisZhizhong Li
Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA
Dev Cell 23:1176-88. 2012..These data demonstrate that the HMGA2-IGF2BP2 axis functions as a key regulator of satellite cell activation and therefore skeletal muscle development... - Electrical impedance as a novel biomarker of myotube atrophy and hypertrophySergey Rakhilin
Novartis Institute for Biomedical Research, Cambridge, MA, USA
J Biomol Screen 16:565-74. 2011..Application of this technique to drug screening might be beneficial in finding novel treatments preventing muscle atrophy and other diseases associated with any morphological change in cell shape... - The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signalingJun Shi
Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, USA
Dev Cell 21:835-47. 2011..These findings establish an important means of restraining IGF1's effects on skeletal muscle... - Voluntary running, skeletal muscle gene expression, and signaling inversely regulated by orchidectomy and testosterone replacementChikwendu Ibebunjo
Department of Musculoskeletal Diseases, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA
Am J Physiol Endocrinol Metab 300:E327-40. 2011..These data demonstrate the necessity of testosterone for both speed and endurance of voluntary wheel running in mice and suggest a potential mechanism for declined activity in humans where androgens are deficient... - IKKbeta/NF-kappaB activation causes severe muscle wasting in miceDongsheng Cai
Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
Cell 119:285-98. 2004.... - Signalling pathways that mediate skeletal muscle hypertrophy and atrophyDavid J Glass
Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591 6707, USA
Nat Cell Biol 5:87-90. 2003.... - Molecular mechanisms modulating muscle massDavid J Glass
Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591 6707, USA
Trends Mol Med 9:344-50. 2003..The pathways modulating hypertrophy and atrophy will be further discussed, to highlight potential targets for clinical intervention... - Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3Jens Fielitz
Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9148, USA
J Clin Invest 117:2486-95. 2007..These findings identify MuRF1 and MuRF3 as key E3 ubiquitin ligases for the UPS-dependent turnover of sarcomeric proteins and reveal a potential basis for myosin storage myopathies... - Conditional activation of akt in adult skeletal muscle induces rapid hypertrophyKa Man V Lai
Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 6707, USA
Mol Cell Biol 24:9295-304. 2004..These findings suggest that pharmacologic approaches directed toward activating Akt will be useful in inducing skeletal muscle hypertrophy and that an increase in lean muscle mass is sufficient to decrease fat storage... - Conditional activation of MET in differentiated skeletal muscle induces atrophyTiziana Crepaldi
Center for Experimental Research and Medical Studies, University of Turin, 10126 Turin, Italy
J Biol Chem 282:6812-22. 2007.... - Mapping sites responsible for interactions of agrin with neuronsRobert W Burgess
Department of Anatomy and Neurobiology, Washington University Medical School, St Louis, Missouri 63110, USA
J Neurochem 83:271-84. 2002..Together, these studies define sites that contribute to the subcellular localization of and signaling by neuronal agrin...