Sonya G Fonseca

Summary

Affiliation: Novartis Institutes for BioMedical Research

Publications

  1. pmc Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion
    Sonya G Fonseca
    Cardiovascular and Metabolism Disease Area, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, USA
    Nat Cell Biol 14:1105-12. 2012
  2. doi request reprint Stress hypERactivation in the β-cell
    Sonya G Fonseca
    Novartis Institutes for BioMedical Research, Cambridge, MA USA
    Islets 2:1-9. 2010
  3. pmc Endoplasmic reticulum stress in beta-cells and development of diabetes
    Sonya G Fonseca
    Cardiovascular and Metabolism Division, Novartis Institutes for BioMedical Research, Inc, Cambridge, MA 02139, USA
    Curr Opin Pharmacol 9:763-70. 2009
  4. pmc Endoplasmic reticulum stress and pancreatic β-cell death
    Sonya G Fonseca
    Cardiovascular and Metabolism Disease Area, Novartis Institutes for BioMedical Research, Cambridge, MA, USA
    Trends Endocrinol Metab 22:266-74. 2011

Detail Information

Publications4

  1. pmc Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion
    Sonya G Fonseca
    Cardiovascular and Metabolism Disease Area, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, USA
    Nat Cell Biol 14:1105-12. 2012
    ..The reduction of WFS1 protein on the plasma membrane during ER stress is a contributing factor for β-cell dysfunction and progression of type 2 diabetes...
  2. doi request reprint Stress hypERactivation in the β-cell
    Sonya G Fonseca
    Novartis Institutes for BioMedical Research, Cambridge, MA USA
    Islets 2:1-9. 2010
    ..In this review, we outline the mechanisms of ER stress-mediated β-cell death and focus on the role of ER stress in various forms of diabetes, particularly a genetic form of diabetes called Wolfram syndrome...
  3. pmc Endoplasmic reticulum stress in beta-cells and development of diabetes
    Sonya G Fonseca
    Cardiovascular and Metabolism Division, Novartis Institutes for BioMedical Research, Inc, Cambridge, MA 02139, USA
    Curr Opin Pharmacol 9:763-70. 2009
    ..There are several models of ER-stress-mediated diabetes. In this review, we outline the underlying molecular mechanisms of ER-stress-mediated beta-cell dysfunction and death during the progression of diabetes...
  4. pmc Endoplasmic reticulum stress and pancreatic β-cell death
    Sonya G Fonseca
    Cardiovascular and Metabolism Disease Area, Novartis Institutes for BioMedical Research, Cambridge, MA, USA
    Trends Endocrinol Metab 22:266-74. 2011
    ..In this review, we address the transition from the physiological ER stress response to the pathological response, and explore the mechanisms of ER stress-mediated β-cell loss during the progression of diabetes...