Research Topics
Species | J F CryanSummaryAffiliation: Novartis Institutes for BioMedical Research Publications
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Publications
In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified miceJ F Cryan
Neuroscience Research, The Novartis Institutes for BioMedical Research, Basel, Switzerland
Mol Psychiatry 9:326-57. 2004....- Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepinesJohn F Cryan
Psychiatry Program, Neuroscience Research, The Novartis Institutes for BioMedical Research WSJ 386 344, Novartis Pharma AG, Basel CH 4002, Switzerland
J Pharmacol Exp Ther 310:952-63. 2004..Overall, the data obtained here suggest that positive modulation of GABAB receptors may serve as a novel therapeutic strategy for the development of anxiolytics, with a superior side effect profile to both baclofen and benzodiazepines... - Don't worry 'B' happy!: a role for GABA(B) receptors in anxiety and depressionJohn F Cryan
Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
Trends Pharmacol Sci 26:36-43. 2005..These include mice that lack functional GABA(B) receptors, and novel positive modulators of the GABA(B) receptor. In this review, we discuss evidence that points to a role of GABA(B) receptors in anxiety and depression... - Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7John F Cryan
Nervous System Research, Novartis Institutes for BioMedical Sciences, Novartis Pharma AG, Basel, Switzerland
Eur J Neurosci 17:2409-17. 2003..Therefore, drugs acting at mGluR7 may provide novel treatments for psychiatric disorders such as depression and anxiety... - The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in miceJohn F Cryan
Psychiatry Program, Neuroscience Research, The Novartis Institutes for BioMedical Research WSJ 386 344, Novartis Pharma AG, CH 4002 Basel, Switzerland
Neurosci Biobehav Rev 29:571-625. 2005..Taken together, we conclude that the tail suspension test is a useful test for assessing the behavioural effects of antidepressant compounds and other pharmacological and genetic manipulations relevant to depression... - Assessing antidepressant activity in rodents: recent developments and future needsJohn F Cryan
Neuromodulation Unit, Nervous System Research, Novartis Pharma AG, WSJ 386 344, CH 4002 Basel, Switzerland
Trends Pharmacol Sci 23:238-45. 2002.... - mGluR7 facilitates extinction of aversive memories and controls amygdala plasticityM Fendt
Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
Mol Psychiatry 13:970-9. 2008..The finding that mGluR7 critically regulates extinction, in addition to acquisition of aversive memories, demonstrates that this receptor may be relevant for the manifestation and treatment of anxiety disorders... - Feeling strained? Influence of genetic background on depression-related behavior in mice: a reviewL H Jacobson
Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH 4002, Basel, Switzerland
Behav Genet 37:171-213. 2007..Neurochemical differences that may underlie strain differences are examined, and some caveats and cautions associated with the use of inbred strains are highlighted... - siRNA-mediated knockdown of the serotonin transporter in the adult mouse brainD R Thakker
Psychiatry Program, Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
Mol Psychiatry 10:782-9, 714. 2005..Further, these data demonstrate that siRNA-induced widespread knockdown of gene expression serves as a powerful tool for assessing the function of endogenous genes in the adult brain... - GABAB1 receptor subunit isoforms exert a differential influence on baseline but not GABAB receptor agonist-induced changes in miceLaura H Jacobson
Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
J Pharmacol Exp Ther 319:1317-26. 2006..Therefore, GABA(B(1a)) and GABA(B(1b)) isoforms are functionally relevant molecular variants of the GABA(B(1)) receptor subunit, which are differentially involved in specific neurophysiological processes and behaviors... - GABA(B(1)) receptor isoforms differentially mediate the acquisition and extinction of aversive taste memoriesLaura H Jacobson
Novartis Institutes for BioMedical Research, Novartis Pharma, CH 4002 Basel, Switzerland
J Neurosci 26:8800-3. 2006.... - Concomitant deficits in working memory and fear extinction are functionally dissociated from reduced anxiety in metabotropic glutamate receptor 7-deficient miceZsuzsanna Callaerts-Vegh
Laboratory of Biological Psychology, Department of Psychology, University of Leuven, B 3000 Leuven, Belgium
J Neurosci 26:6573-82. 2006..It appears to depend on glutamatergic and higher-level brain functions similar to those involved in spatial working memory but functionally dissociated from those that mediate constitutional responses in anxiety tests... 
GABA(B) receptor-positive modulation decreases selective molecular and behavioral effects of cocaineLoic Lhuillier
Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
Neuropsychopharmacology 32:388-98. 2007..Further investigation of GABA(B) receptor-positive modulation as a novel therapeutic strategy for the treatment of cocaine dependence and possibly other drugs of abuse is therefore warranted...- Metabotropic glutamate receptor subtype 7 ablation causes dysregulation of the HPA axis and increases hippocampal BDNF protein levels: implications for stress-related psychiatric disordersKayo Mitsukawa
Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
Neuropsychopharmacology 31:1112-22. 2006..We conclude that genetic ablation of mGluR7 in mice interferes at multiple sites in the neuronal circuitry and molecular pathways implicated in affective disorders... 
Evaluation of the anxiolytic-like profile of the GABAB receptor positive modulator CGP7930 in rodentsLaura H Jacobson
Novartis Institutes for BioMedical Research, CH 4002 Basel, Switzerland
Neuropharmacology 54:854-62. 2008..The generation of more potent compounds is now warranted...- The rostral anterior cingulate cortex modulates depression but not anxiety-related behaviour in the ratStephanie Bissiere
Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
Behav Brain Res 175:195-9. 2006..On the contrary, none of the parameters measured in the EPM was affected by the lesion. These data point to an involvement of the rCG1/rCG2 in depression-related coping behaviours... - Global down-regulation of gene expression in the brain using RNA interference, with emphasis on monoamine transporters and GPCRs: implications for target characterization in psychiatric and neurological disordersDaniel Hoyer
Psychiatry Program, Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
J Recept Signal Transduct Res 26:527-47. 2006..Application of this non-viral RNAi approach may accelerate target validation for neuropsychiatric disorders that involve a complex interplay of gene(s) from various brain regions... - Animal models of mood disorders: Recent developmentsJohn F Cryan
Department of Pharmacology and Therapeutics, School of Pharmacy, University College Cork, Cork, Ireland
Curr Opin Psychiatry 20:1-7. 2007..This review focuses on the attempts to improve current paradigms and also illustrates examples where current paradigms are used to uncover novel molecular targets of antidepressants... - Behavioral evaluation of mice deficient in GABA(B(1)) receptor isoforms in tests of unconditioned anxietyLaura H Jacobson
Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4002 Basel, Switzerland
Psychopharmacology (Berl) 190:541-53. 2007..Recent findings indicate specific roles for these isoforms in conditioned fear responses, although their influence on behavior in tests of unconditioned anxiety is unknown... - Evaluation of reward processes in an animal model of depressionDavid A Slattery
Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
Psychopharmacology (Berl) 190:555-68. 2007..Deficits in reward function, which underlie anhedonia, can be readily assessed in animals. Therefore, anhedonia may serve as an endophenotype for understanding the neural circuitry and molecular pathways underlying depression... - GABAB receptor-positive modulation-induced blockade of the rewarding properties of nicotine is associated with a reduction in nucleus accumbens DeltaFosB accumulationCedric Mombereau
Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
J Pharmacol Exp Ther 321:172-7. 2007..Taken together, the behavioral and molecular changes induced by nicotine occur in concert and are concomitantly amenable to reversal by GABAB receptor-positive modulators... - Antidepressant-like effects of the novel, selective, 5-HT2C receptor agonist WAY-163909 in rodentsSharon Rosenzweig-Lipson
Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
Psychopharmacology (Berl) 192:159-70. 2007..Activation of one or more of the serotonin (5-HT) receptors may play a role in mediating the antidepressant effects of SSRIs... - Specific roles of GABA(B(1)) receptor isoforms in cognitionLaura H Jacobson
Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH 4002 Basel, Switzerland
Behav Brain Res 181:158-62. 2007..On the other hand, GABA(B(1a))(-/-) mice were impaired in familiar and novel object recognition. We conclude that GABA(B(1)) isoforms contribute differentially to GABA(B) receptor-mediated cognitive processes... - Amyloid precursor protein knockdown by siRNA impairs spontaneous alternation in adult miceYann Senechal
Department of Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Lichtstrasse, Basel, Switzerland
J Neurochem 102:1928-40. 2007..These data suggest that acute knockdown of APP in adult mouse brain impairs hippocampus-dependent spatial working memory... - Interfering with the brain: use of RNA interference for understanding the pathophysiology of psychiatric and neurological disordersDeepak R Thakker
Psychiatry Program, Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
Pharmacol Ther 109:413-38. 2006.... - Differential behavioral effects of the antidepressants reboxetine, fluoxetine, and moclobemide in a modified forced swim test following chronic treatmentJohn F Cryan
Department of Psychiatry, University of Pennsylvania, 538A Clinical Research Building, Philadelphia, PA 19104, USA
Psychopharmacology (Berl) 182:335-44. 2005..This suggests that modifications of the FST can be used to examine the onset of action of antidepressant agents produced by long-term administration... - Noradrenergic lesions differentially alter the antidepressant-like effects of reboxetine in a modified forced swim testJohn F Cryan
Department of Psychiatry, University of Pennsylvania, 538A Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104, USA
Eur J Pharmacol 436:197-205. 2002..Taken together, these data suggest that forebrain regions innervated by these two distinct noradrenergic pathways exert opposing influences on the behavioral response to reboxetine in the rat forced swim test... - cAMP response element-binding protein is essential for the upregulation of brain-derived neurotrophic factor transcription, but not the behavioral or endocrine responses to antidepressant drugsAlana C Conti
Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6084, USA
J Neurosci 22:3262-8. 2002.... - Withdrawal from chronic amphetamine induces depressive-like behavioral effects in rodentsJohn F Cryan
Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
Biol Psychiatry 54:49-58. 2003..e., elevations in brain reward thresholds) and behaviors opposite to those seen after treatment with antidepressant drugs, such as decreased immobility in the forced swim test and the tail suspension test... - Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient miceKlemens Kaupmann
Novartis Institutes for BioMedical Research, WKL 125 7 42, Novartis Pharma AG, CH 4002 Basel, Switzerland
Eur J Neurosci 18:2722-30. 2003..It, therefore, appears that all studied GHB effects are GABAB receptor dependent. The molecular nature and the signalling properties of the specific [3H]GHB-binding sites remain elusive... - Genetic and pharmacological evidence of a role for GABA(B) receptors in the modulation of anxiety- and antidepressant-like behaviorCedric Mombereau
Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
Neuropsychopharmacology 29:1050-62. 2004.... - Redistribution of GABAB(1) protein and atypical GABAB responses in GABAB(2)-deficient miceMartin Gassmann
Pharmazentrum, Department of Clinical Biological Sciences, University of Basel, CH 4056 Basel, Switzerland
J Neurosci 24:6086-97. 2004..It is therefore possible that functional GABAB receptors exist in neurons that naturally lack GABAB(2) subunits... - Altered response to benzodiazepine anxiolytics in mice lacking GABA B(1) receptorsCedric Mombereau
Neuroscience Research, Novartis Institutes for BioMedical Research WSJ 386 344, Novartis Pharma AG, Basel CH 4002, Switzerland
Eur J Pharmacol 497:119-20. 2004..These data suggest that targeted deletion of GABA(B(1)) subunit alters GABA(A) receptor function in vivo... - GABAB receptor antagonist-mediated antidepressant-like behavior is serotonin-dependentDavid A Slattery
Neuroscience Research, Novartis Institutes for BioMedical Research WSJ 386.344, Novartis, Basel, CH-4002, Switzerland
J Pharmacol Exp Ther 312:290-6. 2005..Together, these data demonstrate that GABA(B) receptor antagonists via an interaction with the serotonergic system display antidepressant-like properties and therefore represent a novel approach for the treatment of depression... - Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interferenceDeepak R Thakker
Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4002 Basel, Switzerland
Proc Natl Acad Sci U S A 101:17270-5. 2004..Application of this nonviral RNAi approach may accelerate target validation for neuropsychiatric disorders that involve a complex interplay of gene(s) from various brain regions... - Altered anxiety and depression-related behaviour in mice lacking GABAB(2) receptor subunitsCedric Mombereau
Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
Neuroreport 16:307-10. 2005..In contrast, these mice exhibited an antidepressant-like behaviour in the forced swim test. Taken together, these data suggest that heterodimeric GABAB(1,2) receptors are required for the normal regulation of emotional behaviour... - The GABAB receptor-positive modulator GS39783 and the GABAB receptor agonist baclofen attenuate the reward-facilitating effects of cocaine: intracranial self-stimulation studies in the ratDavid A Slattery
Psychiatry Program, Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
Neuropsychopharmacology 30:2065-72. 2005..Therefore, GABAB-positive modulation may represent a novel therapeutic strategy for the treatment of cocaine dependence and possibly other drugs of abuse without the side effects of full GABAB receptor agonists... - Differential sensitivity to the motor and hypothermic effects of the GABA B receptor agonist baclofen in various mouse strainsLaura H Jacobson
Novartis Institutes for BioMedical Research, Neuroscience Research, WSJ-386.344, 4002, Basel, Switzerland
Psychopharmacology (Berl) 179:688-99. 2005..Further, these studies demonstrate that background strain is an important determinant of GABA B receptor mediated responses, and that hypothermic and ataxic responses may be influenced by independent genetic loci... - Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming testJohn F Cryan
Department of Psychiatry and Pharmacology, University of Pennsylvania, 538A Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104, USA
Neurosci Biobehav Rev 29:547-69. 2005..Finally, a physiological model of performance in the rat FST has been proposed involving the regulation of 5-HT transmission by corticotropin releasing factor (CRF)... - The rostral anterior cingulate cortex modulates the efficiency of amygdala-dependent fear learningStephanie Bissiere
Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
Biol Psychiatry 63:821-31. 2008..The aim of this study is to investigate a possible top-down control of a specific rACC sub-region over amygdala activation during pavlovian fear acquisition... - Behavioral and neurochemical effects of 5-(4-[4-(5-Cyano-3-indolyl)-butyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide (EMD 68843): a combined selective inhibitor of serotonin reuptake and 5-hydroxytryptamine(1A) receptor partial agonistMichelle E Page
Department of Psychiatry, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104-6140, USA
J Pharmacol Exp Ther 302:1220-7. 2002..At higher doses, however, weak efficacy of EMD 68843 at postsynaptic 5-HT(1A) receptors may inhibit the expression of rodent antidepressant-like behaviors... - Bupropion enhances brain reward function and reverses the affective and somatic aspects of nicotine withdrawal in the ratJohn F Cryan
Department of Neuropharmacology, CVN-7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Psychopharmacology (Berl) 168:347-58. 2003..Third, bupropion reverses the negative affective aspects of nicotine withdrawal. Such actions are likely to act in concert to mediate the unique anti-smoking properties of bupropion... - A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivoKayo Mitsukawa
Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4002 Basel, Switzerland
Proc Natl Acad Sci U S A 102:18712-7. 2005..Therefore, AMN082 is a valuable tool for unraveling the role of mGluR7 in stress-related CNS disorders... - Non-nicotinic neuropharmacological strategies for nicotine dependence: beyond bupropionJohn F Cryan
Neuroscience Disease Area, The Novartis Institutes for BioMedical Research, WSJ 386 344Novartis Pharma AG CH 4002, Basel, Switzerland
Drug Discov Today 8:1025-34. 2003.... - Differential compartmentalization and distinct functions of GABAB receptor variantsRejan Vigot
Department of Clinical Biological Sciences, Institute of Physiology, Pharmazentrum, University of Basel, CH 4056 Basel, Switzerland
Neuron 50:589-601. 2006..The constitutive absence of GABAB1a but not GABAB1b results in impaired synaptic plasticity and hippocampus-dependent memory, emphasizing molecular differences in synaptic GABAB functions... - Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitorsJohn F Cryan
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 101:8186-91. 2004..These data show that NE plays an important role in mediating acute behavioral and neurochemical actions of many antidepressants, including most SSRIs... - Blockade of the mGlu5 receptor decreases basal and stress-induced cortical norepinephrine in rodentsMichelle E Page
Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
Psychopharmacology (Berl) 179:240-6. 2005..The noradrenergic nucleus locus coeruleus (LC) is an important mediator of stress responses and dysfunction of this system is implicated in affective disorders such as anxiety and depression... - The ascent of mouse: advances in modelling human depression and anxietyJohn F Cryan
Neuroscience Research, Novartis Institutes for BioMedical Research, Basel CH 4055, Switzerland
Nat Rev Drug Discov 4:775-90. 2005..Here, we assess the current status of research into developing appropriate tests for assessing such behaviours...