Affiliation: Novartis Institutes for BioMedical Research
Cryan J, Mombereau C. In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice. Mol Psychiatry. 2004;9:326-57 pubmed
Cryan J, Kaupmann K. Don't worry 'B' happy!: a role for GABA(B) receptors in anxiety and depression. Trends Pharmacol Sci. 2005;26:36-43 pubmed
..These include mice that lack functional GABA(B) receptors, and novel positive modulators of the GABA(B) receptor. In this review, we discuss evidence that points to a role of GABA(B) receptors in anxiety and depression. ..
Cryan J, Kelly P, Neijt H, Sansig G, Flor P, van der Putten H. Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7. Eur J Neurosci. 2003;17:2409-17 pubmed
..Therefore, drugs acting at mGluR7 may provide novel treatments for psychiatric disorders such as depression and anxiety. ..