Volker Brinkmann

Summary

Affiliation: Novartis Institutes for BioMedical Research

Publications

  1. ncbi request reprint Pulmonary and vascular pharmacology of sphingosine 1-phosphate
    Volker Brinkmann
    Autoimmunity and Transplantation, Novartis Institutes for BioMedical Research, WSJ 386 101, Lichtstrasse 35, CH 4002 Basel, Switzerland
    Curr Opin Pharmacol 6:244-50. 2006
  2. ncbi request reprint The sphingosine-1-phosphate receptor agonist FTY720 modulates dendritic cell trafficking in vivo
    Yuk Yuen Lan
    Thomas E Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Transplant 5:2649-59. 2005
  3. pmc Transgenic, fluorescent Leishmania mexicana allow direct analysis of the proteome of intracellular amastigotes
    Daniel Paape
    Institute of Immunology and Infection Research, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Mol Cell Proteomics 7:1688-701. 2008
  4. pmc FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system
    Volker Brinkmann
    Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research, Basel, Switzerland
    Br J Pharmacol 158:1173-82. 2009
  5. ncbi request reprint Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology
    Volker Brinkmann
    Autoimmunity and Transplantation, Novartis Institutes for BioMedical Research, Lichtstrasse 35, CH 4002 Basel, Switzerland
    Pharmacol Ther 115:84-105. 2007
  6. doi request reprint Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis
    Volker Brinkmann
    Department of Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research, Novartis Campus Forum 1, WSJ 386, CH 4056 Basel, Switzerland
    Nat Rev Drug Discov 9:883-97. 2010
  7. doi request reprint Modulation of T cell homeostasis and alloreactivity under continuous FTY720 exposure
    Barbara Metzler
    Department of Autoimmunity and Transplantation, Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland
    Int Immunol 20:633-44. 2008
  8. ncbi request reprint FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function
    Volker Brinkmann
    Transplantation and Immunology, Novartis Institutes for BioMedical Research, Basel, Switzerland
    Am J Transplant 4:1019-25. 2004
  9. ncbi request reprint FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis
    Thomas Baumruker
    Novartis Institutes for BioMedical Research, Autoimmunity and Transplantation, Brunner Strasse 59, A 1235 Vienna, Austria
    Expert Opin Investig Drugs 16:283-9. 2007
  10. ncbi request reprint FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity
    Volker Brinkmann
    Novartis Pharma AG Transplantation Research WSJ 386 101, CH 4002 Basel, Switzerland
    Curr Opin Immunol 14:569-75. 2002

Detail Information

Publications58

  1. ncbi request reprint Pulmonary and vascular pharmacology of sphingosine 1-phosphate
    Volker Brinkmann
    Autoimmunity and Transplantation, Novartis Institutes for BioMedical Research, WSJ 386 101, Lichtstrasse 35, CH 4002 Basel, Switzerland
    Curr Opin Pharmacol 6:244-50. 2006
    ....
  2. ncbi request reprint The sphingosine-1-phosphate receptor agonist FTY720 modulates dendritic cell trafficking in vivo
    Yuk Yuen Lan
    Thomas E Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Transplant 5:2649-59. 2005
    ..Transendothelial migration of FTY720-P-treated immature DCs to the CCR7 ligand CCL19 was reduced. These novel data suggest that modulation of DC trafficking by FTY720 may contribute to its immunosuppressive effects...
  3. pmc Transgenic, fluorescent Leishmania mexicana allow direct analysis of the proteome of intracellular amastigotes
    Daniel Paape
    Institute of Immunology and Infection Research, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Mol Cell Proteomics 7:1688-701. 2008
    ..Last but not least, at 6% coverage the proteome identified all vaccine antigens tested to date. Thus, the present data set provides a valuable resource for selection of candidate vaccine antigens...
  4. pmc FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system
    Volker Brinkmann
    Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research, Basel, Switzerland
    Br J Pharmacol 158:1173-82. 2009
    ..Differential effects of the drug on the trafficking of naïve, central memory and effector memory T cell subsets are discussed...
  5. ncbi request reprint Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology
    Volker Brinkmann
    Autoimmunity and Transplantation, Novartis Institutes for BioMedical Research, Lichtstrasse 35, CH 4002 Basel, Switzerland
    Pharmacol Ther 115:84-105. 2007
    ..This review provides an overview on S1P activities and S1P receptor function in health and disease, and summarizes the clinical experience with FTY720 in transplantation and multiple sclerosis...
  6. doi request reprint Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis
    Volker Brinkmann
    Department of Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research, Novartis Campus Forum 1, WSJ 386, CH 4056 Basel, Switzerland
    Nat Rev Drug Discov 9:883-97. 2010
    ....
  7. doi request reprint Modulation of T cell homeostasis and alloreactivity under continuous FTY720 exposure
    Barbara Metzler
    Department of Autoimmunity and Transplantation, Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland
    Int Immunol 20:633-44. 2008
    ....
  8. ncbi request reprint FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function
    Volker Brinkmann
    Transplantation and Immunology, Novartis Institutes for BioMedical Research, Basel, Switzerland
    Am J Transplant 4:1019-25. 2004
    ..The available data establish S1P(1) as a key target for FTY720, and further point to therapeutically relevant effects of the drug on lymphocytes and vascular endothelium...
  9. ncbi request reprint FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis
    Thomas Baumruker
    Novartis Institutes for BioMedical Research, Autoimmunity and Transplantation, Brunner Strasse 59, A 1235 Vienna, Austria
    Expert Opin Investig Drugs 16:283-9. 2007
    ....
  10. ncbi request reprint FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity
    Volker Brinkmann
    Novartis Pharma AG Transplantation Research WSJ 386 101, CH 4002 Basel, Switzerland
    Curr Opin Immunol 14:569-75. 2002
    ..Stimulation of sphingosine 1-phosphate receptors leads to sequestration of lymphocytes in secondary lymphatic tissues and thus away from inflammatory lesions and graft sites...
  11. ncbi request reprint FTY720: mechanism of action and potential benefit in organ transplantation
    Volker Brinkmann
    Novartis Institutes for BioMedical Research, Auto Immunity and Transplantation, WSJ 386 101, CH 4002 Basel, Switzerland
    Yonsei Med J 45:991-7. 2004
    ..This review summarises the mechanism of action of FTY720, its effects in models of transplantation and autoimmunity, and results from clinical trials in humans...
  12. ncbi request reprint FTY720 preferentially depletes naive T cells from peripheral and lymphoid organs
    Matthias Hofmann
    Novartis Institutes for BioMedical Research, Transplantation Research, Autoimmunity Transplantation Disease Area, Novartis Pharma AG, Basel, Switzerland
    Int Immunopharmacol 6:1902-10. 2006
    ..This suggests that treatment with FTY720 may not interfere with immune functions mediated locally by tissue-resident peripheral effector/memory T cells...
  13. ncbi request reprint Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer
    Rainer Albert
    Novartis Institutes for BioMedical Research, Lichtstrasse 35, WSJ 507 3 02, CH 4056 Basel, Switzerland
    J Med Chem 48:5373-7. 2005
    ..Pure enantiomers were obtained after purification of a partially protected key intermediate on an enantioselective support. The absolute stereochemistry was determined by X-ray diffraction...
  14. doi request reprint Impact of sphingosine 1-phosphate modulation on immune outcomes
    Daniel D Pinschewer
    Department of Pathology and Immunology, University of Geneva, Geneva
    Neurology 76:S15-9. 2011
    ..However, in patients, long-term observation is important as both the risk of cancer and infection is potentially increased by the use of any immunomodulatory agent...
  15. ncbi request reprint T-cell depletion and graft survival induced by anti-human CD3 immunotoxins in human CD3epsilon transgenic mice
    Marla Weetall
    Novartis Pharmaceuticals, Summit, New Jersey 07901, USA
    Transplantation 73:1658-66. 2002
    ..However, the anti-CD3 immunotoxins used in animal studies do not cross-react with human T cells, limiting extrapolation to humans and hindering clinical development...
  16. doi request reprint The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activation
    Jean Pierre Evenou
    Novartis Institute for Biomedical Research, WSJ 386 5 27, CH 4002 Basel, Switzerland
    J Pharmacol Exp Ther 330:792-801. 2009
    ..The mode of action of AEB071 is different from that of calcineurin inhibitors, and AEB071 and cyclosporine A seem to have complementary effects on T-cell signaling pathways...
  17. ncbi request reprint Long-term islet graft survival in streptozotocin- and autoimmune-induced diabetes models by immunosuppressive and potential insulinotropic agent FTY720
    Fumin Fu
    Novartis Institute for Biomedical Research, Summit, New Jersey Novartis Pharma AG, Basel, Switzerland
    Transplantation 73:1425-30. 2002
    ..This study was designed to assess the efficacy of FTY720, a novel immunomodulator with a unique mechanism of action, on islet graft survival and function in streptozotocin (STZ)- and autoimmune-induced diabetic recipients...
  18. ncbi request reprint The immune modulator FTY720 targets sphingosine 1-phosphate receptors
    Volker Brinkmann
    Department of Transplantation, Novartis Pharma AG, Lichtstrasse 35, CH 4002 Basel, Switzerland
    J Biol Chem 277:21453-7. 2002
    ..Our results suggest that FTY720, after phosphorylation, acts through sphingosine 1-phosphate signaling pathways to modulate chemotactic responses and lymphocyte trafficking...
  19. ncbi request reprint Efficacy and safety of ABI793, a novel human anti-human CD154 monoclonal antibody, in cynomolgus monkey renal allotransplantation
    Walter Schuler
    Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
    Transplantation 77:717-26. 2004
    ..This is the first report on the efficacy and safety of ABI793, a novel human anti-human CD154 mAb, in Cynomolgus renal transplant recipients...
  20. doi request reprint A potent and selective S1P(1) antagonist with efficacy in experimental autoimmune encephalomyelitis
    Jean Quancard
    Novartis Institutes for BioMedical Research, CH 4056 Basel, Switzerland
    Chem Biol 19:1142-51. 2012
    ..In addition, the profile of NIBR-0213 makes it an attractive candidate to further study the consequences of S1P(1) receptor antagonism and to differentiate the effects from those of S1P(1) agonists...
  21. pmc Angiogenesis is present in experimental autoimmune encephalomyelitis and pro-angiogenic factors are increased in multiple sclerosis lesions
    Timothy J Seabrook
    Department of Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research, Basel, Switzerland
    J Neuroinflammation 7:95. 2010
    ..Therefore we examined angiogenic promoting factors in MS and EAE lesions to determine if there were changes in blood vessel density at different stages of EAE...
  22. ncbi request reprint The sphingosine 1-phosphate receptor agonist FTY720 supports CXCR4-dependent migration and bone marrow homing of human CD34+ progenitor cells
    Takafumi Kimura
    Department of Medicine II, University of Tubingen, Otfried Muller Strasse 10, 72076 Tubingen, Germany
    Blood 103:4478-86. 2004
    ..In the hematopoietic microenvironment, S1PRs are involved in migration and maintenance of HPCs by modulating the effects of SDF-1...
  23. ncbi request reprint A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model
    Shifeng Pan
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, USA
    Chem Biol 13:1227-34. 2006
    ..This demonstrates that a selective agonist of the S1P(1) receptor is sufficient to achieve efficacy in an animal model of transplantation...
  24. ncbi request reprint Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor
    Dirk H Walter
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Arterioscler Thromb Vasc Biol 27:275-82. 2007
    ....
  25. ncbi request reprint FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat Munster, Albert Schweizer Str 33, D 48129 Munster, Germany
    Circulation 115:501-8. 2007
    ..The present study was undertaken to investigate whether modulation of S1P signaling would affect atherosclerosis in a murine model of disease...
  26. ncbi request reprint Increased resistance of LFA-1-deficient mice to lipopolysaccharide-induced shock/liver injury in the presence of TNF-alpha and IL-12 is mediated by IL-10: a novel role for LFA-1 in the regulation of the proinflammatory and anti-inflammatory cytokine balan
    Masashi Emoto
    Department of Immunology and Central Core Facility Microscopy, Max Planck Institute for Infection Biology, Berlin, Germany
    J Immunol 171:584-93. 2003
    ..Our data point to a novel role of LFA-1 in control of the proinflammatory/anti-inflammatory cytokine network...
  27. ncbi request reprint The immune modulator FYT720 prevents autoimmune diabetes in nonobese diabetic mice small star, filled
    Zandong Yang
    Department of Internal Medicine, P O Box 801413, University of Virginia, Charlottesville, VA 22908, USA
    Clin Immunol 107:30-5. 2003
    ..These results suggest that FTY720 may be effective in prevention of autoimmune diabetes or in slowing its progression...
  28. pmc Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD)
    Patricia A Taylor
    Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota Cancer Center, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Blood 110:3480-8. 2007
    ..Our data further define the mechanisms of action and provide insight as to the potential clinical uses of FTY in allogeneic bone marrow transplant recipients...
  29. ncbi request reprint Requirement of secondary lymphoid tissues for the induction of primary and secondary T cell responses against Listeria monocytogenes
    Mischo Kursar
    Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany
    Eur J Immunol 38:127-38. 2008
    ..Overall, these results indicate that not only primary T cell responses, but also secondary T cell responses, highly depend on the lymphoid environment for effective activation...
  30. ncbi request reprint Neutrophilia in LFA-1-deficient mice confers resistance to listeriosis: possible contribution of granulocyte-colony-stimulating factor and IL-17
    Mamiko Miyamoto
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    J Immunol 170:5228-34. 2003
    ..Consequently, we conclude that increased resistance of LFA-1(-/-) mice to listeriosis is due to neutrophilia facilitating liver infiltration by granulocytes promptly after L. monocytogenes infection, although it is LFA-1 independent...
  31. doi request reprint Delay of phagosome maturation by a mycobacterial lipid is reversed by nitric oxide
    Sofia Axelrod
    Department of Immunology, Max Planck Institute for Infection Biology, D 10117 Berlin, Germany
    Cell Microbiol 10:1530-45. 2008
    ..Thus, specific host defence effectors of activated macrophages directly target a specific virulence function of mycobacteria...
  32. ncbi request reprint FTY720 pretreatment reduces warm hepatic ischemia reperfusion injury through inhibition of T-lymphocyte infiltration
    Dean M Anselmo
    Dumont UCLA Transplant Center, UCLA School of Medicine, Los Angeles, CA 90095 7054, USA
    Am J Transplant 2:843-9. 2002
    ..Myeloperoxidase data suggest this mechanism is independent of neutrophil activation. These results indicate that T lymphocytes are pivotal mediators in hepatic IR and may have important implications in liver transplantation...
  33. ncbi request reprint Oral efficacy of the new immunomodulator FTY720 in cynomolgus monkey kidney allotransplantation, given alone or in combination with cyclosporine or RAD
    Henk Jan Schuurman
    Transplantation Research, Novartis Pharma AG, Basel, Switzerland Presently, Immerge BioTherapeutics, Charlestown, MA 02129, USA
    Transplantation 74:951-60. 2002
    ..We investigated its efficacy, either FTY720 alone or together with cyclosporine or the rapamycin derivative rapamycin derivative (RAD), in cynomolgus monkey kidney allotransplantation...
  34. ncbi request reprint Argyrins, immunosuppressive cyclic peptides from myxobacteria. I. Production, isolation, physico-chemical and biological properties
    Florenz Sasse
    GBF, Gesellschaft fur Biotechnologische Forschung mbH, Abteilung Naturstoffbiologie, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    J Antibiot (Tokyo) 55:543-51. 2002
    ..All argyrins had slight antibiotic activity, especially against Pseudomonas sp., and inhibited growth of mammalian cell cultures. The growth inhibition was often incomplete and varied highly with different cell lines...
  35. ncbi request reprint The IFN-inducible Golgi- and endoplasmic reticulum- associated 47-kDa GTPase IIGP is transiently expressed during listeriosis
    Jens Zerrahn
    Department of Immunology and Core Facility Microscopy, Max Planck Institute for Infectionbiology, Berlin, Germany
    J Immunol 168:3428-36. 2002
    ..We conclude that IIGP exerts a distinct role in IFN-induced intracellular membrane trafficking or processing...
  36. pmc Neisserial immunoglobulin A1 protease induces specific T-cell responses in humans
    Anastasios Tsirpouchtsidis
    Abteilung Molekulare Biologie Zentralbereich Mikroskopie, Max Planck Institut für Infektionsbiologie, D 10117 Berlin, Germany
    Infect Immun 70:335-44. 2002
    ..These findings support the significance of IgA1 protease as a virulence determinant of bacterial meningitis and its function as a dominant proinflammatory T-cell antigen...
  37. pmc Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D
    Laurens A van Meeteren
    Division of Cellular Biochemistry and Center for Biomedical Genetics, The Netherlands Cancer Institute, 1066 Amsterdam, The Netherlands
    Cancer Lett 266:203-8. 2008
    ..After oral administration in mice, FTY720 (3mg/kg) significantly reduced plasma LPA levels. These results suggest that FTY720 may exert its anticancer effects, at least in part, by targeting the ATX-LPA axis...
  38. ncbi request reprint Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
    Mehrdad Matloubian
    Howard Hughes Medical Institute and Department of Microbiology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0414, USA
    Nature 427:355-60. 2004
    ..These findings establish that S1P1 is essential for lymphocyte recirculation and that it regulates egress from both thymus and peripheral lymphoid organs...
  39. ncbi request reprint Saposin C is required for lipid presentation by human CD1b
    Florian Winau
    Max Planck Institute for Infection Biology, Department of Immunology, Schumannstrasse 21 22, D 10117 Berlin, Germany
    Nat Immunol 5:169-74. 2004
    ..We propose a model in which SAP-C exposes lipid antigens from intralysosomal membranes for loading onto CD1b. Thus, SAP-C represents a missing link in antigen presentation of lipids through CD1b to human T cells...
  40. ncbi request reprint Inhibition of Th1- and Th2-mediated airway inflammation by the sphingosine 1-phosphate receptor agonist FTY720
    Elzbieta Sawicka
    Novartis Horsham Research Centre, Horsham, U K
    J Immunol 171:6206-14. 2003
    ....
  41. ncbi request reprint The heart rate decrease caused by acute FTY720 administration is mediated by the G protein-gated potassium channel I
    Lev Koyrakh
    Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
    Am J Transplant 5:529-36. 2005
    ..In contrast, the HR reduction induced by FTY720 in I(KACh)-deficient mice was blunted. We conclude that the effect of acute FTY720 administration on HR is mediated primarily by I(KACh) activation...
  42. ncbi request reprint Immunomodulator FTY720 Induces eNOS-dependent arterial vasodilatation via the lysophospholipid receptor S1P3
    Markus Tölle
    Med Klinik IV, Charite Campus Benjamin Franklin, Berlin, Germany
    Circ Res 96:913-20. 2005
    ....
  43. ncbi request reprint Protection of mouse small bowel allografts by FTY720 and costimulation blockade
    Sheng Yan
    Department of Surgery, The 1st Affiliated Hospital of Zhejiang University, Zhejiang, China
    Transplantation 79:1703-10. 2005
    ..We aimed to test the hypothesis that prolonged sequestration of lymphocytes in secondary lymphoid organs may enhance the alloprotective effect of costimulation blockade...
  44. ncbi request reprint Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration
    Krishnaraj Rajalingam
    Department of Molecular Biology, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, D 10117 Berlin, Germany
    Nat Cell Biol 7:837-43. 2005
    ..Our data show an unexpected role of prohibitin in the activation of the Ras-Raf signalling pathway and in modulating epithelial cell adhesion and migration...
  45. ncbi request reprint Highly biased type 1 immune responses in mice deficient in LFA-1 in Listeria monocytogenes infection are caused by elevated IL-12 production by granulocytes
    Masashi Emoto
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    J Immunol 171:3970-6. 2003
    ..In conclusion, LFA-1 regulates type 1 immune responses by controlling prompt infiltration of IL-12-producing granulocytes into sites of inflammation...
  46. ncbi request reprint FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance
    Hiroshi Yasui
    Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 65:7478-84. 2005
    ..These results suggest that FTY720 overcomes drug resistance in multiple myeloma cells and provide the rationale for its clinical evaluation to improve patient outcome in multiple myeloma...
  47. ncbi request reprint Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability
    Teresa Sanchez
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3501, USA
    J Biol Chem 278:47281-90. 2003
    ....
  48. ncbi request reprint A novel low molecular weight inhibitor of dendritic cells and B cells blocks allergic inflammation
    Peter Ettmayer
    Novartis Institutes for Biomedical Research Vienna, Brunnerstrasse 59, A 1230 Vienna, Austria
    Am J Respir Crit Care Med 173:599-606. 2006
    ..Thus, inhibitors of DC function should have therapeutic benefits in patients with allergies...
  49. ncbi request reprint Transient T cell accumulation in lymph nodes and sustained lymphopenia in mice treated with FTY720
    Margaret A Morris
    Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    Eur J Immunol 35:3570-80. 2005
    ..Our data indicate that the commonly held belief that FTY720 blocks lymphocyte egress from lymph nodes cannot fully explain the lymphocyte dynamics observed with prolonged treatment...
  50. ncbi request reprint Novel insights into the mechanism of action of FTY720 in a transgenic model of allograft rejection: implications for therapy of chronic rejection
    Antje Habicht
    Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital, Boston, MA 02115, USA
    J Immunol 176:36-42. 2006
    ..These data have important implications for targeting the sphingosine 1-phosphate receptor 1 in solid organ transplantation...
  51. ncbi request reprint The sphingosine 1-phosphate receptor agonist FTY720 differentially affects the sequestration of CD4+/CD25+ T-regulatory cells and enhances their functional activity
    Elzbieta Sawicka
    Novartis Institutes for BioMedical Research, Horsham, West Sussex, United Kingdom
    J Immunol 175:7973-80. 2005
    ..Thus, FTY720 differentially affects the sequestration of T-regulatory cells and importantly, increases the functional activity of T-regulatory cells, suggesting that it may have disease-modifying potential in inflammatory disorders...
  52. ncbi request reprint A small non-coding RNA of the invasion gene island (SPI-1) represses outer membrane protein synthesis from the Salmonella core genome
    Verena Pfeiffer
    Max Planck Institute for Infection Biology, Chariteplatz 1, D 10117 Berlin, Germany
    Mol Microbiol 66:1174-91. 2007
    ..This study identifies the first regulatory RNA of an enterobacterial pathogenicity island, and new roles for Hfq and HilD in SPI-1 gene expression...
  53. pmc Helicobacter pylori induces AGS cell motility and elongation via independent signaling pathways
    Stefan Moese
    Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany
    Infect Immun 72:3646-9. 2004
    ..The cag pathogenicity island appears to be nonessential for induction of motility, whereas the elongation phenotype depends on translocation and phosphorylation of CagA...
  54. ncbi request reprint Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis
    Ulrich E Schaible
    Max Planck Institute for Infection Biology, Department of Immunology, Schumannstrasse 21 22, D 10117 Berlin, Germany
    Nat Med 9:1039-46. 2003
    ....
  55. ncbi request reprint The Helicobacter pylori CagA protein disrupts matrix adhesion of gastric epithelial cells by dephosphorylation of vinculin
    Stefan Moese
    Department of Molecular Biology, Max Planck Institute for Infection Biology, Chariteplatz 1, 10117 Berlin, Germany
    Cell Microbiol 9:1148-61. 2007
    ..We hypothesize that CagA-mediated inactivation of vinculin is a key step in the mechanism by which H. pylori induces damage to the gastric epithelium and represents an important step in disease development...
  56. pmc Human neutrophils kill Bacillus anthracis
    Anne Mayer-Scholl
    Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany
    PLoS Pathog 1:e23. 2005
    ..anthracis infections, and that alpha-defensins play an important role in the potent anti-B. anthracis activity of neutrophils...
  57. doi request reprint Role of interleukin-12 in determining differential kinetics of invariant natural killer T cells in response to differential burden of Listeria monocytogenes
    Yoshiko Emoto
    Laboratory of Immunology, Department of Laboratory Sciences, Gunma University School of Health Sciences, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Microbes Infect 10:224-32. 2008
    ..Our results indicate that NK1.1 surface expression on iNKT cells is differentially modulated by the burden of infection, and suggest that a high bacterial load probably causes loss of IL-12 production...
  58. ncbi request reprint Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosis
    Florian Winau
    Department of Immunology, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Immunity 24:105-17. 2006
    ..tuberculosis infection. Taken together, we propose the detour pathway to represent a genuine immunological mechanism mediating crosspriming of CD8 T cells in vivo and protection against tuberculosis...