N Beckmann

Summary

Affiliation: Novartis Institutes for BioMedical Research

Publications

  1. ncbi request reprint Magnetic resonance imaging in drug discovery: lessons from disease areas
    Nicolau Beckmann
    Novartis Institutes for BioMedical Research, Discovery Technologies, Analytics and Imaging Sciences Unit, Lichstr 35, WSJ 386 209, CH 4002 Basel Switzerland
    Drug Discov Today 9:35-42. 2004
  2. ncbi request reprint MRI of lung parenchyma in rats and mice using a gradient-echo sequence
    N Beckmann
    Core Technologies Area, Novartis Pharma AG, Analytics and Imaging Sciences Unit, CH 4002 Basel, Switzerland
    NMR Biomed 14:297-306. 2001
  3. ncbi request reprint Macrophage labeling by SPIO as an early marker of allograft chronic rejection in a rat model of kidney transplantation
    N Beckmann
    Central Technologies, Novartis Institutes for BioMedical Research, CH 4002 Basel, Switzerland
    Magn Reson Med 49:459-67. 2003
  4. ncbi request reprint Non-invasive, quantitative assessment of the anatomical phenotype of corticotropin-releasing factor-overexpressing mice by MRI
    N Beckmann
    Core Technologies Area, Novartis Pharma AG, CH 4002 Basel, Switzerland
    NMR Biomed 14:210-6. 2001
  5. ncbi request reprint From anatomy to the target: contributions of magnetic resonance imaging to preclinical pharmaceutical research
    N Beckmann
    Novartis Pharma Ltd, Core Technologies Area, Basel, Switzerland
    Anat Rec 265:85-100. 2001
  6. ncbi request reprint Macrophage infiltration into the rat knee detected by MRI in a model of antigen-induced arthritis
    Nicolau Beckmann
    Central Technologies, Novartis Institutes for BioMedical Research, Basel, Switzerland
    Magn Reson Med 49:1047-55. 2003
  7. ncbi request reprint Pulmonary edema induced by allergen challenge in the rat: noninvasive assessment by magnetic resonance imaging
    N Beckmann
    Core Technologies Area, Novartis Pharma AG, Basel, Switzerland
    Magn Reson Med 45:88-95. 2001
  8. ncbi request reprint The role of magnetic resonance imaging and spectroscopy in transplantation: from animal models to man
    N Beckmann
    Core Technologies Area, Novartis Pharma AG, CH 4002 Basel, Switzerland
    NMR Biomed 13:329-48. 2000
  9. ncbi request reprint High resolution magnetic resonance angiography non-invasively reveals mouse strain differences in the cerebrovascular anatomy in vivo
    N Beckmann
    Novartis Pharma Inc, Basel, Switzerland
    Magn Reson Med 44:252-8. 2000
  10. ncbi request reprint Age-dependent cerebrovascular abnormalities and blood flow disturbances in APP23 mice modeling Alzheimer's disease
    Nicolau Beckmann
    Discovery Technologies Center, Novartis Institutes for BioMedical Research, CH 4002 Basel, Switzerland
    J Neurosci 23:8453-9. 2003

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Magnetic resonance imaging in drug discovery: lessons from disease areas
    Nicolau Beckmann
    Novartis Institutes for BioMedical Research, Discovery Technologies, Analytics and Imaging Sciences Unit, Lichstr 35, WSJ 386 209, CH 4002 Basel Switzerland
    Drug Discov Today 9:35-42. 2004
    ..The non-invasiveness of MRI strengthens the link between pre-clinical and clinical drug studies, making the technique attractive for pharmaceutical research...
  2. ncbi request reprint MRI of lung parenchyma in rats and mice using a gradient-echo sequence
    N Beckmann
    Core Technologies Area, Novartis Pharma AG, Analytics and Imaging Sciences Unit, CH 4002 Basel, Switzerland
    NMR Biomed 14:297-306. 2001
    ..g. in pharmacological studies concerning asthma models in small rodents. The method was applied to lung inflammation models involving challenge with ovalbumin or lipopolysaccharide...
  3. ncbi request reprint Macrophage labeling by SPIO as an early marker of allograft chronic rejection in a rat model of kidney transplantation
    N Beckmann
    Central Technologies, Novartis Institutes for BioMedical Research, CH 4002 Basel, Switzerland
    Magn Reson Med 49:459-67. 2003
    ....
  4. ncbi request reprint Non-invasive, quantitative assessment of the anatomical phenotype of corticotropin-releasing factor-overexpressing mice by MRI
    N Beckmann
    Core Technologies Area, Novartis Pharma AG, CH 4002 Basel, Switzerland
    NMR Biomed 14:210-6. 2001
    ..This makes MRI an attractive, non-terminal tool to monitor in laboratory animals, including transgenic mice, the consequence of continuous stress on relevant organs...
  5. ncbi request reprint From anatomy to the target: contributions of magnetic resonance imaging to preclinical pharmaceutical research
    N Beckmann
    Novartis Pharma Ltd, Core Technologies Area, Basel, Switzerland
    Anat Rec 265:85-100. 2001
    ..Successful applications in drug discovery exploit one or several of these aspects. Additionally, MRI is contributing to strengthen the link between preclinical and clinical drug research...
  6. ncbi request reprint Macrophage infiltration into the rat knee detected by MRI in a model of antigen-induced arthritis
    Nicolau Beckmann
    Central Technologies, Novartis Institutes for BioMedical Research, Basel, Switzerland
    Magn Reson Med 49:1047-55. 2003
    ..Also, the approach can be potentially adapted to clinical studies...
  7. ncbi request reprint Pulmonary edema induced by allergen challenge in the rat: noninvasive assessment by magnetic resonance imaging
    N Beckmann
    Core Technologies Area, Novartis Pharma AG, Basel, Switzerland
    Magn Reson Med 45:88-95. 2001
    ..MRI could be of importance for the noninvasive profiling of anti-inflammatory drugs in animal models of asthma and in the clinic. Magn Reson Med 45:88-95, 2001...
  8. ncbi request reprint The role of magnetic resonance imaging and spectroscopy in transplantation: from animal models to man
    N Beckmann
    Core Technologies Area, Novartis Pharma AG, CH 4002 Basel, Switzerland
    NMR Biomed 13:329-48. 2000
    ..Finally, a general appraisal is made on available imaging techniques for the non-invasive characterization of grafts in situ, highlighting the role of MR methods in the field of transplantation...
  9. ncbi request reprint High resolution magnetic resonance angiography non-invasively reveals mouse strain differences in the cerebrovascular anatomy in vivo
    N Beckmann
    Novartis Pharma Inc, Basel, Switzerland
    Magn Reson Med 44:252-8. 2000
    ..Magn Reson Med 44:252-258, 2000...
  10. ncbi request reprint Age-dependent cerebrovascular abnormalities and blood flow disturbances in APP23 mice modeling Alzheimer's disease
    Nicolau Beckmann
    Discovery Technologies Center, Novartis Institutes for BioMedical Research, CH 4002 Basel, Switzerland
    J Neurosci 23:8453-9. 2003
    ..The study also shows the power of MRA to identify changes of vascular function in genetically engineered mice. MRA as a noninvasive technique could be applied to test new therapeutic concepts in animal models of AD and in humans...
  11. ncbi request reprint Techniques: magnetic resonance imaging of the lung provides potential for non-invasive preclinical evaluation of drugs
    Nicolau Beckmann
    Discovery Technologies Center, Novartis Institutes for BioMedical Research, Lichtstrasse 35, WSJ 386 2 09, CH 4002 Basel, Switzerland
    Trends Pharmacol Sci 24:550-4. 2003
  12. ncbi request reprint Noninvasive detection of endotoxin-induced mucus hypersecretion in rat lung by MRI
    Nicolau Beckmann
    Central Technologies, Novartis Pharma, CH 4002 Basel, Switzerland
    Am J Physiol Lung Cell Mol Physiol 283:L22-30. 2002
    ..In particular, the prospect of noninvasively detecting a sustained mucus hypersecretory phenotype in the lung brings an important new perspective to models of chronic obstructive pulmonary diseases in animals...
  13. pmc In vivo pharmacological evaluation of compound 48/80-induced airways oedema by MRI
    H Karmouty-Quintana
    Global Imaging Group, Novartis Institutes for BioMedical Research, Basel, Switzerland
    Br J Pharmacol 154:1063-72. 2008
    ..We used MRI to follow the consequences of non-immunological mast cell activation induced by compound 48/80 in the rat lungs in vivo...
  14. ncbi request reprint Current awareness
    N Beckmann
    Core Technologies Area, Novartis Pharma AG, CH-4002 Basel, Switzerland
    NMR Biomed 14:217-22. 2001
    ..Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted...
  15. pmc Activation of the lung S1P(1) receptor reduces allergen-induced plasma leakage in mice
    F X Blé
    Global Imaging Group, Novartis Institutes for BioMedical Research, Basel, Switzerland
    Br J Pharmacol 158:1295-301. 2009
    ..However, the receptor responsible for this effect has not been defined...
  16. pmc Capsaicin-induced mucus secretion in rat airways assessed in vivo and non-invasively by magnetic resonance imaging
    H Karmouty-Quintana
    Discovery Technologies, Novartis Institutes for BioMedical Research, Basel, Switzerland
    Br J Pharmacol 150:1022-30. 2007
    ..The aim of this study was to assess non-invasively the acute effects (up to 60 min) of sensory nerve stimulation by capsaicin in the lung, using magnetic resonance imaging (MRI)...
  17. ncbi request reprint MRI and ultrasonographic detection of morphologic and hemodynamic changes in chronic renal allograft rejection in the rat
    L Gaschen
    Transplantation Research, Novartis Pharma Inc, Kohlenstrasse 35, WSJ 386 526, CH 4002 Basel, Switzerland
    J Magn Reson Imaging 13:232-41. 2001
    ..The purpose of this study is to describe the sonographic, MRI, and histopathologic findings in a rat model of chronic renal allograft rejection...
  18. ncbi request reprint In vivo magnetic resonance methods in pharmaceutical research: current status and perspectives
    M Rudin
    Core Technologies Area, Novartis Pharma Research, Basel, Switzerland
    NMR Biomed 12:69-97. 1999
    ..Successful applications in drug discovery exploit one or several of these aspects. In addition, the link between preclinical and clinical studies makes in vivo MR methods highly attractive methods for pharmaceutical research...
  19. ncbi request reprint Analysis of tracer transit in rat brain after carotid artery and femoral vein administrations using linear system theory
    M Rudin
    Core Technology Area, Novartis Pharma Ltd, Basel, Switzerland
    Magn Reson Imaging 15:551-8. 1997
    ..The results indicate that peripheral circulation has a significant influence on the MTT values and thus on the perfusion rates, which cannot be neglected...
  20. pmc ENaC-mediated effects assessed by MRI in a rat model of hypertonic saline-induced lung hydration
    F X Blé
    Global Imaging Group, Novartis Institutes for BioMedical Research, Basel, Switzerland
    Br J Pharmacol 160:1008-15. 2010
    ..We aimed to assess whether: (i) osmotically driven fluid flux into the rat lung could be quantified in vivo by magnetic resonance imaging (MRI); and (ii) the MRI signals could be modulated through the regulation of ENaC function...
  21. ncbi request reprint Magnetic resonance angiography of the rat cerebrovascular system without the use of contrast agents
    T Reese
    Core Technology, Novartis Pharma Ltd, Basel, Switzerland
    NMR Biomed 12:189-96. 1999
    ..Occlusion and reopening of the vessel could easily be verified by MRA. However, after reperfusion a slight reduction in blood flow was observed...
  22. ncbi request reprint In vivo mouse imaging and spectroscopy in drug discovery
    Nicolau Beckmann
    Discovery Technologies, Novartis Institutes for BioMedical Research, Lichtstrasse 35, CH 4002 Basel, Switzerland
    NMR Biomed 20:154-85. 2007
    ..In this paper we aim to illustrate how these techniques may be used to obtain meaningful information for the phenotyping of transgenic mice and for the analysis of compounds in murine models of disease...
  23. pmc Resolution of the oedema associated with allergic pulmonary inflammation in rats assessed noninvasively by magnetic resonance imaging
    Bruno Tigani
    Novartis Institutes for BioMedical Research, Central Technologies, Analytics and Imaging Sciences Unit, Lichtstr 35, WSJ 386 2 09 CH 4002 Basel, Switzerland
    Br J Pharmacol 140:239-46. 2003
    ..4. In conclusion, the effects of anti-inflammatory drugs on a component of allergic inflammation can be monitored by following with MRI the rate of resolution of the associated oedematous signals...
  24. ncbi request reprint Lung inflammation and vascular remodeling after repeated allergen challenge detected noninvasively by MRI
    Bruno Tigani
    Discovery Technologies Department, Novartis Institutes for BioMedical Research, Basel, Switzerland
    Am J Physiol Lung Cell Mol Physiol 292:L644-53. 2007
    ..As the contrast agent used in the DCE-MRI experiments is approved for clinical use, there is potential to translate the approach to patients...
  25. ncbi request reprint Pulmonary inflammation monitored noninvasively by MRI in freely breathing rats
    Bruno Tigani
    Central Technologies, Novartis Pharma AG, Lichtstrasse 35, CH 4002 Basel, Switzerland
    Biochem Biophys Res Commun 292:216-21. 2002
    ..Further, the prospect of noninvasively detecting a sustained mucus hypersecretory phenotype in the lung brings an important new perspective to models of chronic obstructive pulmonary diseases...
  26. doi request reprint Allergen-induced lung inflammation in actively sensitized mice assessed with MR imaging
    François Xavier Blé
    Respiratory Diseases Department, Novartis Institutes for BioMedical Research, Forum 1, Novartis Campus, WSJ 386 2 09, CH 4002 Basel, Switzerland
    Radiology 248:834-43. 2008
    ..To demonstrate the feasibility of using proton magnetic resonance (MR) imaging to noninvasively detect extravascular and luminal fluid in a murine model of allergen-induced airway inflammation...
  27. ncbi request reprint Macrophage infiltration detected at MR imaging in rat kidney allografts: early marker of chronic rejection?
    Nicolau Beckmann
    Departments of Discovery Technologies and Transplantation Research, Novartis Institutes for BioMedical Research, Lichtstrasse 35, WSJ 386 2 09, CH 4002 Basel, Switzerland
    Radiology 240:717-24. 2006
    ..To evaluate detection of iron-loaded macrophages at magnetic resonance (MR) imaging as a noninvasive means to monitor early signs of chronic allograft rejection in the life-supporting Fisher-to-Lewis rat kidney transplantation model...
  28. ncbi request reprint Identification with MRI of the pleura as a major site of the acute inflammatory effects induced by ovalbumin and endotoxin challenge in the airways of the rat
    Harry Karmouty Quintana
    Novartis Institutes for BioMedical Research, Discovery Technologies, Lichtstr 35, WSJ 386 2 09, CH 4002 Basel, Switzerland
    Am J Physiol Lung Cell Mol Physiol 291:L651-7. 2006
    ..Our data show that MRI is able to detect, non-invasively, inflammatory signals in both the lung and the pleura in spontaneously breathing animals, highlighting its potential to study the consequences of pulmonary insults on both sites...
  29. ncbi request reprint Evaluation of drug candidates: efficacy readouts during lead optimization
    Markus Rudin
    Institute for Biomedical Engineering, University of Zurich ETH Zurich, Switzerland
    Prog Drug Res 62:185-255. 2005
  30. ncbi request reprint Near-infrared fluorescence imaging and histology confirm anomalous edematous signal distribution detected in the rat lung by MRI after allergen challenge
    Bruno Tigani
    Novartis Institutes for BioMedical Research, Discovery Technologies, Basel, Switzerland
    J Magn Reson Imaging 20:967-74. 2004
    ..To address the issue concerning the predominant location, on the left anatomic side, of edematous signals detected by magnetic resonance imaging (MRI) in the lungs of actively sensitized rats following intratracheal (IT) allergen challenge...
  31. ncbi request reprint Proton MRI of lung parenchyma reflects allergen-induced airway remodeling and endotoxin-aroused hyporesponsiveness: a step toward ventilation studies in spontaneously breathing rats
    Nicolau Beckmann
    Discovery Technologies Center, Novartis Institutes for BioMedical Research, Basel, Switzerland
    Magn Reson Med 52:258-68. 2004
    ..Overall, these techniques provide invaluable information for profiling anti-inflammatory drugs in models of airway diseases...
  32. ncbi request reprint Magnetic resonance angiography and vascular corrosion casting as tools in biomedical research: application to transgenic mice modeling Alzheimer's disease
    Thomas Krucker
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA, USA
    Neurol Res 26:507-16. 2004
    ..Furthermore, being non-invasive, MRA can also be applied to studies in patients suffering from this disease...
  33. ncbi request reprint Two-dimensional electrophoresis protein profiling and identification in rat bronchoalveolar lavage fluid following allergen and endotoxin challenge
    Luca Signor
    Novartis Institutes for BioMedical Research, Central Technologies Analytical and Imaging Sciences Unit, CH 4002 Basel, Switzerland
    Proteomics 4:2101-10. 2004
    ..Furthermore, even if based on a limited number of animals, our results are of interest for the identification of lung protein markers and a better understanding of the mechanisms involved in the pathogenesis of lung diseases...
  34. ncbi request reprint Lung MRI for experimental drug research
    Nicolau Beckmann
    Discovery Technologies, Novartis Institutes for BioMedical Research, Lichtstr 35, WSJ 386 2 09, CH 4002 Basel, Switzerland
    Eur J Radiol 64:381-96. 2007
    ..The next subject concerns the use of MRI in pharmacological studies within the context of experimental lung research. A final discussion points towards advantages and limitations of MRI in this area...
  35. ncbi request reprint Bleomycin-induced lung injury assessed noninvasively and in spontaneously breathing rats by proton MRI
    Harry Karmouty-Quintana
    Discovery Technologies, Novartis Institutes for BioMedical Research, Basel, Switzerland
    J Magn Reson Imaging 26:941-9. 2007
    ..To apply proton magnetic resonance imaging (MRI) techniques to assess noninvasively and in spontaneously breathing rats, structural changes following a single intratracheal administration of bleomycin (BLM)...
  36. ncbi request reprint Proton MRI as a noninvasive tool to assess elastase-induced lung damage in spontaneously breathing rats
    Harry Karmouty Quintana
    Discovery Technologies, Novartis Institutes for BioMedical Research, Basel, Switzerland
    Magn Reson Med 56:1242-50. 2006
    ..The present approach complements other validated applications of proton MRI in experimental lung research as a method for assessing drugs in rat models of respiratory diseases...
  37. ncbi request reprint Retrospective cine 3He ventilation imaging under spontaneous breathing conditions: a non-invasive protocol for small-animal lung function imaging
    Vasile Stupar
    Universite Lyon 1, Laboratoire de RMN, UMR CNRS 5012, ESCPE, 43 Boulevard du 11 Novembre, 69622 Villeurbanne Cedex, France
    NMR Biomed 20:104-12. 2007
    ..The reproducibility and the non-invasiveness of this ventilation imaging protocol were evaluated by multiple acquisitions on the same animals...
  38. ncbi request reprint Magnetic resonance imaging in biomedical research: imaging of drugs and drug effects
    Markus Rudin
    Analytical and Imaging Sciences Unit, Novartis Institute for Biomedical Research, CH 4002 Basel, Switzerland
    Methods Enzymol 385:240-56. 2004
  39. ncbi request reprint Effects of a mitogen-activated protein kinase inhibitor on allergic airways inflammation in the rat studied by magnetic resonance imaging
    Bruno Tigani
    Discovery Technologies Center, Novartis Institutes for BioMedical Research, Lichstr 35, WSJ 386 2 09, CH 4002, Basel, Switzerland
    Eur J Pharmacol 482:319-24. 2003
    ..Collectively, our data suggest that the p38 MAP kinase inhibitor Compound 1 shows a different profile than glucocorticosteroids since its ability to resolve existing inflammation is limited...