Hanne Cecilie Winther-Larsen
Affiliation: University of Oslo
Brudal E, Lampe E, Reubsaet L, Roos N, Hegna I, Thrane I, et al
. Vaccination with outer membrane vesicles from Francisella noatunensis reduces development of francisellosis in a zebrafish model. Fish Shellfish Immunol. 2015;42:50-7 pubmed publisher
..Also granulomatous responses were reduced in F.n.n.-challenged zebrafish after OMV vaccination. Taken together, the data support the possible use of OMVs as vaccines against francisellosis in fish. ..
Tandberg J, Oliver C, Lagos L, Gaarder M, Yañez A, Ropstad E, et al
. Membrane vesicles from Piscirickettsia salmonis induce protective immunity and reduce development of salmonid rickettsial septicemia in an adult zebrafish model. Fish Shellfish Immunol. 2017;67:189-198 pubmed publisher
..1, tnf?, il1b, il10 and il6. The MVs induced the secretion of IgM upon immunization, indicating an immunogenic effect of the vesicles. Taken together, the data demonstrate a vaccine potential of MVs against P. salmonis. ..
Lampe E, Zingmark C, Tandberg J, Thrane I, Brudal E, Sjostedt A, et al
. Francisella noatunensis subspecies noatunensis clpB deletion mutant impairs development of francisellosis in a zebrafish model. Vaccine. 2017;35:7264-7272 pubmed publisher
..n.n. wt. Taken together, the results presented increases the knowledge on protective immune responses against F.n.n. ..
Lagos L, Tandberg J, Repnik U, Boysen P, Ropstad E, Varkey D, et al
. Characterization and Vaccine Potential of Membrane Vesicles Produced by Francisella noatunensis subsp. orientalis in an Adult Zebrafish Model. Clin Vaccine Immunol. 2017;24: pubmed publisher
..1, and ighm, was upregulated, thus confirming the immunogenic properties of F. noatunensis subsp. orientalis-derived MVs. ..