Lars T Westlye

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. doi request reprint Effects of APOE on brain white matter microstructure in healthy adults
    Lars T Westlye
    Department of Psychology, Center for the Study of Human Cognition, University of Oslo, Oslo, Norway
    Neurology 79:1961-9. 2012
  2. pmc Hippocampal volumes are important predictors for memory function in elderly women
    Martin A Ystad
    Department of Biomedicine, Neuroinformatics and Image Analysis Laboratory, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    BMC Med Imaging 9:17. 2009
  3. doi request reprint Linking an anxiety-related personality trait to brain white matter microstructure: diffusion tensor imaging and harm avoidance
    Lars T Westlye
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Oslo, Norway
    Arch Gen Psychiatry 68:369-77. 2011
  4. doi request reprint Associations between regional cortical thickness and attentional networks as measured by the attention network test
    Lars T Westlye
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Blindern, 0317 Oslo, Norway
    Cereb Cortex 21:345-56. 2011
  5. ncbi request reprint Differentiating maturational and aging-related changes of the cerebral cortex by use of thickness and signal intensity
    Lars T Westlye
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Oslo, Norway
    Neuroimage 52:172-85. 2010
  6. pmc Increased sensitivity to effects of normal aging and Alzheimer's disease on cortical thickness by adjustment for local variability in gray/white contrast: a multi-sample MRI study
    Lars T Westlye
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Oslo, Norway
    Neuroimage 47:1545-57. 2009
  7. doi request reprint Life-span changes of the human brain white matter: diffusion tensor imaging (DTI) and volumetry
    Lars T Westlye
    Department of Psychology, Center for the Study of Human Cognition, University of Oslo, Blindern, 0317 Oslo, Norway
    Cereb Cortex 20:2055-68. 2010
  8. doi request reprint Error-related negativity is mediated by fractional anisotropy in the posterior cingulate gyrus--a study combining diffusion tensor imaging and electrophysiology in healthy adults
    Lars T Westlye
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Oslo 0317, Norway
    Cereb Cortex 19:293-304. 2009
  9. doi request reprint The brain dynamics of intellectual development: waxing and waning white and gray matter
    Christian K Tamnes
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Oslo, Norway
    Neuropsychologia 49:3605-11. 2011
  10. pmc The relationship between diffusion tensor imaging and volumetry as measures of white matter properties
    Anders M Fjell
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Norway
    Neuroimage 42:1654-68. 2008

Detail Information

Publications45

  1. doi request reprint Effects of APOE on brain white matter microstructure in healthy adults
    Lars T Westlye
    Department of Psychology, Center for the Study of Human Cognition, University of Oslo, Oslo, Norway
    Neurology 79:1961-9. 2012
    ..The main objective was to investigate the association between APOE and diffusion tensor imaging-derived indices of WM microstructure...
  2. pmc Hippocampal volumes are important predictors for memory function in elderly women
    Martin A Ystad
    Department of Biomedicine, Neuroinformatics and Image Analysis Laboratory, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    BMC Med Imaging 9:17. 2009
    ..In the present study we utilize 3D MR imaging, genetic analysis and assessment of verbal memory function to investigate relationships between these factors in a sample of 170 healthy volunteers (age range 46-77 years)...
  3. doi request reprint Linking an anxiety-related personality trait to brain white matter microstructure: diffusion tensor imaging and harm avoidance
    Lars T Westlye
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Oslo, Norway
    Arch Gen Psychiatry 68:369-77. 2011
    ..Therefore, anxiety-related personality traits and associated increased risk of psychiatric disease might be rooted in structural variability in large-scale neuronal networks...
  4. doi request reprint Associations between regional cortical thickness and attentional networks as measured by the attention network test
    Lars T Westlye
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Blindern, 0317 Oslo, Norway
    Cereb Cortex 21:345-56. 2011
    ....
  5. ncbi request reprint Differentiating maturational and aging-related changes of the cerebral cortex by use of thickness and signal intensity
    Lars T Westlye
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Oslo, Norway
    Neuroimage 52:172-85. 2010
    ....
  6. pmc Increased sensitivity to effects of normal aging and Alzheimer's disease on cortical thickness by adjustment for local variability in gray/white contrast: a multi-sample MRI study
    Lars T Westlye
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Oslo, Norway
    Neuroimage 47:1545-57. 2009
    ..In sum, the findings indicate that adjusting for contrast can increase the sensitivity of MR morphometry to variables of interest...
  7. doi request reprint Life-span changes of the human brain white matter: diffusion tensor imaging (DTI) and volumetry
    Lars T Westlye
    Department of Psychology, Center for the Study of Human Cognition, University of Oslo, Blindern, 0317 Oslo, Norway
    Cereb Cortex 20:2055-68. 2010
    ..Tractwise and voxel-based analyses yielded regional differences in development and aging but did not provide ample evidence in support of a simple last-in-first-out hypothesis of life-span changes...
  8. doi request reprint Error-related negativity is mediated by fractional anisotropy in the posterior cingulate gyrus--a study combining diffusion tensor imaging and electrophysiology in healthy adults
    Lars T Westlye
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Oslo 0317, Norway
    Cereb Cortex 19:293-304. 2009
    ....
  9. doi request reprint The brain dynamics of intellectual development: waxing and waning white and gray matter
    Christian K Tamnes
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Oslo, Norway
    Neuropsychologia 49:3605-11. 2011
    ....
  10. pmc The relationship between diffusion tensor imaging and volumetry as measures of white matter properties
    Anders M Fjell
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Norway
    Neuroimage 42:1654-68. 2008
    ..Further, FA and WM volume are moderately to weakly related and to a large extent sensitive to different characteristics of WM integrity...
  11. pmc Critical ages in the life course of the adult brain: nonlinear subcortical aging
    Anders M Fjell
    Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
    Neurobiol Aging 34:2239-47. 2013
    ..91). The main conclusions are that most brain structures do not follow a simple path throughout adult life and that accelerated decline in high age is not the norm of healthy brain aging. ..
  12. ncbi request reprint Interactive effects of APOE and CHRNA4 on attention and white matter volume in healthy middle-aged and older adults
    Thomas Espeseth
    University of Oslo, Oslo, Norway
    Cogn Affect Behav Neurosci 6:31-43. 2006
    ....
  13. doi request reprint Memory training impacts short-term changes in aging white matter: a longitudinal diffusion tensor imaging study
    Andreas Engvig
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Oslo, Norway
    Hum Brain Mapp 33:2390-406. 2012
    ..The training effect on FA seemed to be driven by a relative decrease in radial diffusivity, which might indicate a role for myelin-related processes in WM plasticity...
  14. doi request reprint Social reward dependence and brain white matter microstructure
    Astrid Bjørnebekk
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Blindern, 0317 Oslo, Norway
    Cereb Cortex 22:2672-9. 2012
    ..In contrast, no effects were observed for NS. These findings support the theory that WM fiber tract properties modulate individual differences in social reward processing...
  15. doi request reprint Brain maturation in adolescence and young adulthood: regional age-related changes in cortical thickness and white matter volume and microstructure
    Christian K Tamnes
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, 0317 Oslo, Norway
    Cereb Cortex 20:534-48. 2010
    ..It is concluded that none of the measures are redundant and that the integration of the 3 will yield a more complete understanding of brain maturation...
  16. ncbi request reprint Consistent neuroanatomical age-related volume differences across multiple samples
    Kristine B Walhovd
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Norway
    Neurobiol Aging 32:916-32. 2011
    ..Healthy aging appears associated with more widespread and consistent age-related neuroanatomical volume differences than previously believed...
  17. doi request reprint Intracortical myelin links with performance variability across the human lifespan: results from T1- and T2-weighted MRI myelin mapping and diffusion tensor imaging
    Håkon Grydeland
    Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, 0317 Oslo, Norway
    J Neurosci 33:18618-30. 2013
    ....
  18. doi request reprint Becoming consistent: developmental reductions in intraindividual variability in reaction time are related to white matter integrity
    Christian K Tamnes
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, 0317 Oslo, Norway
    J Neurosci 32:972-82. 2012
    ....
  19. doi request reprint Reduced white matter integrity is related to cognitive instability
    Anders M Fjell
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, 0317 Oslo, Norway
    J Neurosci 31:18060-72. 2011
    ..We concluded that performance variability is a likely consequence of individual differences in WM integrity, and that it is a promising behavioral correlate of individual differences in WM microstructure...
  20. pmc Minute effects of sex on the aging brain: a multisample magnetic resonance imaging study of healthy aging and Alzheimer's disease
    Anders M Fjell
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, 0317 Oslo, Norway
    J Neurosci 29:8774-83. 2009
    ..Analyses of the AD sample showed no interactions between sex and age for any brain region. We conclude that sex has negligible effects on the age slope of brain volumes both in healthy participants and in AD...
  21. doi request reprint Neuroanatomical correlates of executive functions in children and adolescents: a magnetic resonance imaging (MRI) study of cortical thickness
    Christian K Tamnes
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, and Department of Radiology, Rikshospitalet, Oslo University Hospital, PO Box 1094 Blindern, 0317 Oslo, Norway
    Neuropsychologia 48:2496-508. 2010
    ..The results from the present study add to previous knowledge about the cortical correlates of executive functions by indicating an important role of posterior cerebral areas in executive development...
  22. ncbi request reprint Improved prediction of Alzheimer's disease with longitudinal white matter/gray matter contrast changes
    Håkon Grydeland
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Oslo, Norway
    Hum Brain Mapp 34:2775-85. 2013
    ..The findings suggest that signal intensity properties constitute a sensitive biomarker for cerebral degeneration in AD...
  23. ncbi request reprint Accelerated age-related cortical thinning in healthy carriers of apolipoprotein E epsilon 4
    Thomas Espeseth
    Department of Psychology, University of Oslo, P O Box 1094, Blindern, N 0317 Oslo, Norway
    Neurobiol Aging 29:329-40. 2008
    ....
  24. pmc High consistency of regional cortical thinning in aging across multiple samples
    Anders M Fjell
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Olso 0317, Norway
    Cereb Cortex 19:2001-12. 2009
    ..The inferior temporal lobe and anterior cingulate cortices were relatively less affected by age. The results are discussed in relation to leading theories of cognitive aging...
  25. doi request reprint Accelerating cortical thinning: unique to dementia or universal in aging?
    Anders M Fjell
    Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, 0317 Oslo, Norway
    Cereb Cortex 24:919-34. 2014
    ..The relationship between the entorhinal changes and changes in memory performance suggests that non-AD mechanisms in AD-prone areas may still be causative for cognitive reductions...
  26. doi request reprint Brain development and aging: overlapping and unique patterns of change
    Christian K Tamnes
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Oslo, Norway
    Neuroimage 68:63-74. 2013
    ..A key question in future research will be to disentangle the neurobiological underpinnings for the differences and the similarities between brain changes in development and aging...
  27. doi request reprint A multi-modal investigation of behavioral adjustment: post-error slowing is associated with white matter characteristics
    Anders M Fjell
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Pb 1084, 0317 Oslo, Norway
    Neuroimage 61:195-205. 2012
    ..It is concluded that individual differences in WM characteristics can partly explain why some people are better at adjusting their behavior in response to poor performance than others...
  28. doi request reprint Hippocampal subfield volumes correlate with memory training benefit in subjective memory impairment
    Andreas Engvig
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Norway
    Neuroimage 61:188-94. 2012
    ..Also, previous studies have tended to exclude patients with concomitant depressive symptoms and memory complaints. The present results, however, strengthen the rationale and potential for cognitive intervention in these patients...
  29. doi request reprint Apolipoprotein E ε4-related thickening of the cerebral cortex modulates selective attention
    Thomas Espeseth
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Oslo, Norway
    Neurobiol Aging 33:304-322.e1. 2012
    ..The results suggest that APOE ε4 modulates the structural integrity of critical nodes in brain attentional networks...
  30. doi request reprint When does brain aging accelerate? Dangers of quadratic fits in cross-sectional studies
    Anders M Fjell
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Pb 1094 Blindern, 0317 Oslo, Norway
    Neuroimage 50:1376-83. 2010
    ..g. the quadratic model. A nonparametric local smoothing technique (the smoothing spline) was found to be more robust to the effects of different starting ages. The results were replicated in an independent sample of 309 participants...
  31. doi request reprint Heterogeneity in subcortical brain development: A structural magnetic resonance imaging study of brain maturation from 8 to 30 years
    Ylva Ostby
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Norway
    J Neurosci 29:11772-82. 2009
    ..These results emphasize the importance of studying a wide range of structural variables in the same sample, for a broader understanding of brain developmental principles...
  32. pmc Cortical gray matter atrophy in healthy aging cannot be explained by undetected incipient cognitive disorders: a comment on Burgmans et al. (2009)
    Anders M Fjell
    Department of Psychology, University of Oslo, Norway, P B 1094 Blindern, 0317 Oslo, Norway
    Neuropsychology 24:258-63; discussion 264-266. 2010
    ..Longitudinally, 1-year atrophy was identified in all tested regions. It is likely that cortical brain atrophy is manifested in cognitively normal elderly without subclinical cognitive disorders...
  33. doi request reprint Neuronal correlates of the five factor model (FFM) of human personality: Multimodal imaging in a large healthy sample
    Astrid Bjørnebekk
    Centre for the Study of Human Cognition, Department of Psychology, University of Oslo, Norway, PO Box 1094 Blindern, 0317 Oslo, Norway
    Neuroimage 65:194-208. 2013
    ..The results provide novel evidence of the associations between brain structure and variations in human personality, and corroborate previous findings of a consistent neuroanatomical basis of negative emotionality...
  34. doi request reprint Intellectual abilities and white matter microstructure in development: a diffusion tensor imaging study
    Christian K Tamnes
    Department of Psychology, Center for the Study of Human Cognition, University of Oslo, Oslo, Norway
    Hum Brain Mapp 31:1609-25. 2010
    ..Longitudinal data are needed to validate these interpretations. The results provide insight into the neurobiological underpinnings of intellectual development...
  35. doi request reprint CSF biomarker pathology correlates with a medial temporo-parietal network affected by very mild to moderate Alzheimer's disease but not a fronto-striatal network affected by healthy aging
    Anders M Fjell
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Norway
    Neuroimage 49:1820-30. 2010
    ..It is concluded that the pattern of macrostructural brain changes in very mild to moderate AD can be clearly delineated from that of healthy aging...
  36. ncbi request reprint Smaller stress-sensitive hippocampal subfields in women with borderline personality disorder without posttraumatic stress disorder
    Erlend Bøen
    Department of Psychosomatic Medicine, Oslo University Hospital, Oslo Norwegian Research Network On Mood Disorders, Oslo and Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
    J Psychiatry Neurosci 39:127-34. 2014
    ....
  37. doi request reprint Bipolar II disorder is associated with thinning of prefrontal and temporal cortices involved in affect regulation
    Torbjørn Elvsåshagen
    Department of Psychosomatic Medicine, Oslo University Hospital, Oslo, Norway Institute of Clinical Medicine, University of Oslo, Oslo, Norway
    Bipolar Disord 15:855-64. 2013
    ..In the present study, we compared magnetic resonance imaging (MRI)-based indices of cortical thickness and surface area between individuals with BD-II and healthy controls...
  38. doi request reprint Everyday memory: self-perception and structural brain correlates in a healthy elderly population
    Astrid Bjørnebekk
    Department of Psychology, University of Oslo, Norway
    J Int Neuropsychol Soc 16:1115-26. 2010
    ....
  39. doi request reprint Network-specific effects of age and in-scanner subject motion: a resting-state fMRI study of 238 healthy adults
    Athanasia M Mowinckel
    Centre for the Study of Human Cognition, Department of Psychology, University of Oslo, Norway
    Neuroimage 63:1364-73. 2012
    ....
  40. doi request reprint Amnesia following herpes simplex encephalitis: diffusion-tensor imaging uncovers reduced integrity of normal-appearing white matter
    Håkon Grydeland
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, PO Box 1094, Blindern, 0317 Oslo, Norway
    Radiology 257:774-81. 2010
    ....
  41. ncbi request reprint Effects of memory training on cortical thickness in the elderly
    Andreas Engvig
    Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Neuroimage 52:1667-76. 2010
    ..The present study included short-term assessments, and follow-up studies are needed in order to assess whether such training indeed alters the long-term structural trajectories...
  42. ncbi request reprint Blood markers of fatty acids and vitamin D, cardiovascular measures, body mass index, and physical activity relate to longitudinal cortical thinning in normal aging
    Kristine B Walhovd
    Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway Department of Physical Medicine and Rehabilitation, Unit of Neuropsychology, Oslo University Hospital, Oslo, Norway Electronic address
    Neurobiol Aging 35:1055-64. 2014
    ..Eicosapentaenoic acid and blood pressure showed no effects. The observed effects show promise for potential factors to reduce cortical atrophy in normal aging. ..
  43. doi request reprint The structure of the cerebral cortex across adult life: age-related patterns of surface area, thickness, and gyrification
    Larson J Hogstrom
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Oslo 0317, Norway
    Cereb Cortex 23:2521-30. 2013
    ....
  44. doi request reprint Reduced brain cortical folding in schizophrenia revealed in two independent samples
    Ragnar Nesvåg
    Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway Division of Mental Health, Norwegian Institute of Public Health, Oslo, Norway
    Schizophr Res 152:333-8. 2014
    ..The finding of reduced degree of folding in large regions of the cerebral cortex across two independent samples indicates that reduced gyrification is an inherent feature of the brain pathology in schizophrenia...
  45. ncbi request reprint Evidence for reduced dentate gyrus and fimbria volume in bipolar II disorder
    Torbjørn Elvsåshagen
    Department of Neuropsychiatry and Psychosomatic Medicine, Oslo University Hospital, Oslo, Norway
    Bipolar Disord 15:167-76. 2013
    ....