P M Ueland

Summary

Affiliation: University of Bergen
Country: Norway

Publications

  1. ncbi The controversy over homocysteine and cardiovascular risk
    P M Ueland
    LOCUS for Homocysteine and Related Vitamins, Armauer Hansens Hus, University of Bergen, Norway
    Am J Clin Nutr 72:324-32. 2000
  2. doi Importance of chemical reduction in plasma and serum homocysteine analysis
    Per Magne Ueland
    Section for Pharmacology, Institute of Medicine, University of Bergen and Haukeland Hospital, Bergen, Norway
    Clin Chem 54:1085-6. 2008
  3. ncbi [Measurement of methylmalonic acid, homocysteine and methionine in cobalamin and folate deficiencies and homocysteinuria]
    Per Magne Ueland
    Farmakologisk seksjon, Institutt for indremedisin, Universitetet i Bergen, 5021 Bergen
    Tidsskr Nor Laegeforen 128:690-3. 2008
  4. ncbi Quantitative profiling of folate and one-carbon metabolism in large-scale epidemiological studies by mass spectrometry
    Per Magne Ueland
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, Bergen, Norway
    Clin Chem Lab Med 45:1737-45. 2007
  5. ncbi Betaine: a key modulator of one-carbon metabolism and homocysteine status
    Per Magne Ueland
    LOCUS for Homocysteine and Related Vitamins, Institute of Medicine, University of Bergen, Bergen, Norway
    Clin Chem Lab Med 43:1069-75. 2005
  6. ncbi Biological and clinical implications of the MTHFR C677T polymorphism
    P M Ueland
    LOCUS for Homocysteine and Related Vitamins, Armauer Hanssens hus, University of Bergen, 5021, Bergen, Norway
    Trends Pharmacol Sci 22:195-201. 2001
  7. ncbi Hyperhomocysteinemia and B-vitamin deficiencies in infants and children
    Per Magne Ueland
    LOCUS for Homocysteine and Related Vitamins, Armauer Hansens Hus, University of Bergen, Bergen, Norway
    Clin Chem Lab Med 41:1418-26. 2003
  8. ncbi The Hordaland Homocysteine Studies
    P M Ueland
    LOCUS for Homocysteine and Related Vitamins, Armauer Hansens Hus, University of Bergen, Norway
    Lipids 36:S33-9. 2001
  9. doi Choline and betaine in health and disease
    Per Magne Ueland
    Section for Pharmacology, Institute of Medicine, University of Bergen, Bergen, Norway
    J Inherit Metab Dis 34:3-15. 2011
  10. ncbi Lifestyle and cardiovascular disease risk factors as determinants of total cysteine in plasma: the Hordaland Homocysteine Study
    L El-Khairy
    Department of Public Health and Primary Health Care and the Department of Pharmacology, University of Bergen, Norway
    Am J Clin Nutr 70:1016-24. 1999

Collaborators

Detail Information

Publications92

  1. ncbi The controversy over homocysteine and cardiovascular risk
    P M Ueland
    LOCUS for Homocysteine and Related Vitamins, Armauer Hansens Hus, University of Bergen, Norway
    Am J Clin Nutr 72:324-32. 2000
    ..Thus, only placebo-controlled intervention studies with tHcy-lowering B vitamins and clinical endpoints can provide additional valid arguments for the debate over whether tHcy is a causal CVD risk factor...
  2. doi Importance of chemical reduction in plasma and serum homocysteine analysis
    Per Magne Ueland
    Section for Pharmacology, Institute of Medicine, University of Bergen and Haukeland Hospital, Bergen, Norway
    Clin Chem 54:1085-6. 2008
  3. ncbi [Measurement of methylmalonic acid, homocysteine and methionine in cobalamin and folate deficiencies and homocysteinuria]
    Per Magne Ueland
    Farmakologisk seksjon, Institutt for indremedisin, Universitetet i Bergen, 5021 Bergen
    Tidsskr Nor Laegeforen 128:690-3. 2008
    ..The biomarkers methylmalonic acid and homocysteine are therefore complementary, and the combination is often requested when conventional tests fail to provide an unambiguous diagnosis...
  4. ncbi Quantitative profiling of folate and one-carbon metabolism in large-scale epidemiological studies by mass spectrometry
    Per Magne Ueland
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, Bergen, Norway
    Clin Chem Lab Med 45:1737-45. 2007
    ..Metabolic profiling as part of epidemiological studies in this area should include intermediates involved in the transfer of one-carbon units, cofactors for the relevant enzymes and markers of inflammation, kidney function and smoking...
  5. ncbi Betaine: a key modulator of one-carbon metabolism and homocysteine status
    Per Magne Ueland
    LOCUS for Homocysteine and Related Vitamins, Institute of Medicine, University of Bergen, Bergen, Norway
    Clin Chem Lab Med 43:1069-75. 2005
    ..Betaine status should be investigated in pathologies related to altered metabolism of homocysteine and folate, including cardiovascular disease, cancer and neural tube defects...
  6. ncbi Biological and clinical implications of the MTHFR C677T polymorphism
    P M Ueland
    LOCUS for Homocysteine and Related Vitamins, Armauer Hanssens hus, University of Bergen, 5021, Bergen, Norway
    Trends Pharmacol Sci 22:195-201. 2001
    ....
  7. ncbi Hyperhomocysteinemia and B-vitamin deficiencies in infants and children
    Per Magne Ueland
    LOCUS for Homocysteine and Related Vitamins, Armauer Hansens Hus, University of Bergen, Bergen, Norway
    Clin Chem Lab Med 41:1418-26. 2003
    ..These data have raised the question whether cobalamin deficiency may be widespread and undetected in babies born to non-vegetarian women on a Westernized diet...
  8. ncbi The Hordaland Homocysteine Studies
    P M Ueland
    LOCUS for Homocysteine and Related Vitamins, Armauer Hansens Hus, University of Bergen, Norway
    Lipids 36:S33-9. 2001
    ..The Hordaland Homocysteine cohort will be used for future investigations of the stability of tHcy and vitamin status over time, and to investigate associations with mortality and morbidity including cancer incidence...
  9. doi Choline and betaine in health and disease
    Per Magne Ueland
    Section for Pharmacology, Institute of Medicine, University of Bergen, Bergen, Norway
    J Inherit Metab Dis 34:3-15. 2011
    ..Thus, choline and betaine showed opposite relations with key components of metabolic syndrome, suggesting a disruption of mitochondrial choline oxidation to betaine as part of the mitochondrial dysfunction in metabolic syndrome...
  10. ncbi Lifestyle and cardiovascular disease risk factors as determinants of total cysteine in plasma: the Hordaland Homocysteine Study
    L El-Khairy
    Department of Public Health and Primary Health Care and the Department of Pharmacology, University of Bergen, Norway
    Am J Clin Nutr 70:1016-24. 1999
    ..Cysteine is structurally and metabolically related to homocysteine, but data on its association with cardiovascular disease and cardiovascular disease risk factors are sparse...
  11. pmc A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study
    D Theofylaktopoulou
    Section for Pharmacology, University of Bergen, Norway
    Clin Exp Immunol 173:121-30. 2013
    ..These findings are relevant for the design and interpretation of studies investigating the role of plasma neopterin, KTR and kynurenines in chronic diseases...
  12. ncbi Biological and environmental determinants of plasma homocysteine
    J Schneede
    Department of Pharmacology, University of Bergen, Norway
    Semin Thromb Hemost 26:263-79. 2000
    ..The data represent the total number of combined homocysteine and methylmalonic acid determinations, requested by general practitioners in Norway during February 1998...
  13. ncbi Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine Study
    O Nygard
    Department of Public Health and Primary Health Care, University of Bergen, Norway
    Am J Clin Nutr 67:263-70. 1998
    ..These findings are relevant for establishing adequate reference ranges for tHcy and emphasize folate intake, smoking status, and coffee consumption as major acquired determinants of tHcy concentration in this general population...
  14. ncbi Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians
    H Refsum
    Department of Pharmacology and the Locus for Homocysteine and Related Vitamins, University of Bergen, Norway
    Am J Clin Nutr 74:233-41. 2001
    ..In India, most people adhere to a vegetarian diet, which may lead to cobalamin deficiency...
  15. ncbi Factor V Leiden, pregnancy complications and adverse outcomes: the Hordaland Homocysteine Study
    E Nurk
    Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway
    QJM 99:289-98. 2006
    ..The factor V Leiden (FVL) mutation is the most common cause of inherited thrombophilia in Caucasian populations, and women with this variant allele are at increased risk for pregnancy complications...
  16. ncbi Coffee consumption and plasma total homocysteine: The Hordaland Homocysteine Study
    O Nygard
    Department of Clinical Biology, University of Bergen, Norway
    Am J Clin Nutr 65:136-43. 1997
    ..The results of the present report should promote future studies on tHcy as a possible mediator of adverse clinical effects related to heavy coffee consumption...
  17. ncbi Plasma total homocysteine and cardiovascular and noncardiovascular mortality: the Hordaland Homocysteine Study
    S E Vollset
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, Bergen, Norway
    Am J Clin Nutr 74:130-6. 2001
    ..Few population-based studies have assessed relations between plasma or serum total homocysteine (tHcy) and all-cause mortality...
  18. ncbi Homocysteine and cardiovascular disease
    H Refsum
    Department of Pharmacology, University of Bergen, Norway
    Annu Rev Med 49:31-62. 1998
    ..Supplementation with B-vitamins, in particular with folic acid, is an efficient, safe, and inexpensive means to reduce an elevated tHcy level. Studies are now in progress to establish whether such therapy will reduce cardiovascular risk...
  19. ncbi Disruption of a regulatory system involving cobalamin distribution and function in a methionine-dependent human glioma cell line
    T Fiskerstrand
    Department of Pharmacology, University of Bergen, 5021 Bergen, Norway
    J Biol Chem 273:20180-4. 1998
    ..This regulatory network is most prominent in the methionine-dependent P60 cells harboring a disruption of the network in the proximity of cobalamin(III) reductase...
  20. ncbi Riboflavin as a determinant of plasma total homocysteine: effect modification by the methylenetetrahydrofolate reductase C677T polymorphism
    S Hustad
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, Armauer Hansens Hus, N 5021 Bergen, Norway
    Clin Chem 46:1065-71. 2000
    ..This motivates the investigation of the possible relationship between riboflavin status and tHcy...
  21. ncbi Analysis of single-strand conformation polymorphism by capillary electrophoresis with laser-induced fluorescence detection using short-chain polyacrylamide as sieving medium
    J Ren
    Department of Clinical Biology, University of Bergen, Norway
    Anal Biochem 245:79-84. 1997
    ..The technique is simple and rapid and is well suited to analysis of large numbers of clinical samples...
  22. doi Combined analyses and extended follow-up of two randomized controlled homocysteine-lowering B-vitamin trials
    M Ebbing
    Department of Heart Disease, Haukeland University Hospital, Bergen, Norway
    J Intern Med 268:367-82. 2010
    ....
  23. pmc Interferon (IFN)-γ-mediated inflammation and the kynurenine pathway in relation to bone mineral density: the Hordaland Health Study
    E M Apalset
    Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway Department of Rheumatology, Haukeland University Hospital, Bergen, Norway
    Clin Exp Immunol 176:452-60. 2014
    ..BMD was also associated with two kynurenines in both age groups. These results may support a role of cell-mediated inflammation in bone metabolism. ..
  24. doi Vitamin B6 status and interferon-γ-mediated immune activation in primary hyperparathyroidism
    M H E Christensen
    Institute of Medicine, University of Bergen, Bergen, Norway
    J Intern Med 272:583-91. 2012
    ..The aim of the study was to investigate systemic markers of IFN-γ-mediated immune activation, such as neopterin, the kynurenine-to-tryptophan ratio (KTR) and kynurenine pathway metabolites, as well as B6 vitamers in patients with PHPT...
  25. ncbi Plasma total cysteine as a risk factor for vascular disease: The European Concerted Action Project
    L El-Khairy
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, Bergen, Norway
    Circulation 103:2544-9. 2001
    ..We studied the relation between plasma total cysteine (tCys) levels and the risk of vascular disease in the coronary, cerebral, and peripheral vessels...
  26. ncbi Chemical mismatch cleavage combined with capillary electrophoresis: detection of mutations exon 8 of the cystathionine beta-synthase gene
    J Ren
    Department of Pharmacology, University of Bergen, Norway
    Clin Chem 44:2108-14. 1998
    ..Thus, CMC combined with CE-LIF is suitable for screening of known mutations, giving expected CMC products, but will also detect unknown mutations, the locations of which are indicated by the fragment sizes...
  27. ncbi Homocysteine and its relation to B-vitamins in Graves' disease before and after treatment: effect modification by smoking
    B G Nedrebø
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, Haukeland University Hospital, Bergen, Norway
    J Intern Med 254:504-12. 2003
    ..To investigate plasma total homocysteine levels and its relation to B-vitamins and smoking in Graves' disease before and after antithyroid therapy...
  28. ncbi Disposition of homocysteine in subjects heterozygous for homocystinuria due to cystathionine beta-synthase deficiency: relationship between genotype and phenotype
    A B Guttormsen
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, Armauer Hansens Hus, Bergen, Norway
    Am J Med Genet 100:204-13. 2001
    ..Abnormal tHcy response after methionine loading was the most sensitive test. Our data suggest that the urinary tHcy excretion rate is a simple, non-invasive approach for studying mild disturbances in Hcy metabolism...
  29. ncbi Applications of short-chain polydimethylacrylamide as sieving medium for the electrophoretic separation of DNA fragments and mutation analysis in uncoated capillaries
    J Ren
    Department of Pharmacology, University of Bergen, Armauer Hansens Hus, N 5021 Bergen, Norway
    Anal Biochem 276:188-94. 1999
    ..Our results demonstrate that CE in uncoated capillaries using PDMA as sieving medium is a simple, versatile, and reliable strategy for separation and mutation analysis of clinical DNA samples...
  30. ncbi Response of the methionine synthase system to short-term culture with homocysteine and nitrous oxide and its relation to methionine dependence
    T Fiskerstrand
    Department of Pharmacology, University of Bergen, Norway
    Int J Cancer 72:301-6. 1997
    ..The inability of P60 to furnish CH3Cbl to the enzyme may explain both the Met-dependent phenotype and the increased sensitivity of Hcy remethylation to N2O exposure in these cells...
  31. ncbi Determinants of cobalamin status in newborns
    A L Bjørke Monsen
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, Bergen, Norway
    Pediatrics 108:624-30. 2001
    ..We investigated the relation between cobalamin status in newborns and in their healthy mothers who consumed an omnivorous diet...
  32. ncbi Methylmalonic acid and homocysteine in plasma as indicators of functional cobalamin deficiency in infants on macrobiotic diets
    J Schneede
    Department of Pharmacology and Toxicology, University of Bergen, Haukeland Hospital, Norway
    Pediatr Res 36:194-201. 1994
    ..Furthermore, the finding of high methylmalonic acid and total homocysteine in plasma of most macrobiotic infants demonstrates a functional cobalamin deficiency in these subjects...
  33. ncbi Routine determination of serum methylmalonic acid and plasma total homocysteine in Norway
    J Schneede
    Department for Pharmacology, University of Bergen, Norway
    Scand J Clin Lab Invest 63:355-67. 2003
    ..To study the total number of combined analyses of methylmalonic acid (MMA) and total plasma homocysteine (tHcy) carried out during February 1998 at the Central Laboratory of Haukeland University Hospital...
  34. ncbi Homocysteine-lowering therapy does not affect inflammatory markers of atherosclerosis in patients with stable coronary artery disease
    Ø Bleie
    Department of Heart Disease, Haukeland University Hospital, Bergen, Norway
    J Intern Med 262:244-53. 2007
    ..We wanted to test the effect of homocysteine-lowering B-vitamin therapy, as used in the Western Norway B-vitamin Intervention Trial (WENBIT), on inflammatory markers associated with atherosclerosis...
  35. ncbi Plasma total homocysteine is influenced by prandial status in humans: the Hordaland Hhomocysteine Sstudy
    E Nurk
    Department of Public Health and Primary Health Care, University of Bergen, N 5021 Bergen, Norway
    J Nutr 131:1214-6. 2001
    ....
  36. ncbi Kinetic basis of hyperhomocysteinemia in patients with chronic renal failure
    A B Guttormsen
    Department of Pharmacology, University of Bergen, Norway
    Kidney Int 52:495-502. 1997
    ..High-dose folic acid reduces fasting tHcy by improving tissue Hcy remethylation without affecting the low renal clearance of tHcy...
  37. ncbi Total homocysteine and cardiovascular disease
    O Nygard
    Division for Medical Statistics, Department of Public Health, University of Bergen, Norway, Sweden
    J Intern Med 246:425-54. 1999
    ..This paper reviews the biochemical, clinical, epidemiological and experimental data underlying this conclusion and is critically questioning whether elevated tHcy is a causal factor...
  38. ncbi Hyperhomocysteinemia in terms of steady-state kinetics
    H Refsum
    Department of Pharmacology, University of Bergen, Norway
    Eur J Pediatr 157:S45-9. 1998
    ..In contrast, the hyperhomocysteinemia in renal failure is accounted for by a marked reduction in tHcy clearance, suggesting an important role of kidney in elimination of Hcy from plasma...
  39. ncbi Homocysteine and methylmalonic acid in diagnosis and risk assessment from infancy to adolescence
    Anne Lise Bjørke Monsen
    Department of Pediatrics, University of Bergen, Norway
    Am J Clin Nutr 78:7-21. 2003
    ..High MMA concentrations in newborns, occasionally denoted as benign methylmalonic aciduria, may reflect impaired cobalamin function...
  40. ncbi Automated assay for the determination of methylmalonic acid, total homocysteine, and related amino acids in human serum or plasma by means of methylchloroformate derivatization and gas chromatography-mass spectrometry
    Amrei Windelberg
    LOCUS for Homocysteine and Related Vitamins, and Section for Pharmacology, Institute of Medicine, University of Bergen, Norway
    Clin Chem 51:2103-9. 2005
    ....
  41. ncbi Recent data are not in conflict with homocysteine as a cardiovascular risk factor
    H Refsum
    Department of Pharmacology, University of Bergen, Norway
    Curr Opin Lipidol 9:533-9. 1998
    ..This observation is in accordance with the view that high total homocysteine itself may not be particularly deleterious, but provokes vascular occlusion under conditions predisposing to cardiovascular disease...
  42. ncbi Growth state dependent increase of glutathione by homocysteine and other thiols, and homocysteine formation in glutathione depleted mouse cell lines
    R Djurhuus
    Department of Pharmacology and Toxicology, University of Bergen, Norway
    Biochem Pharmacol 39:421-9. 1990
    ..1. cells was observed. The former demonstrated a decreasing export rate during exponential growth, while the latter showed an initial decrease and then a slight increase in homocysteine export rate...
  43. pmc Co-ordinate variations in methylmalonyl-CoA mutase and methionine synthase, and the cobalamin cofactors in human glioma cells during nitrous oxide exposure and the subsequent recovery phase
    B Riedel
    Department of Pharmacology, University of Bergen, Armauer Hansens Hus, N 5021 Bergen, Norway
    Biochem J 341:133-8. 1999
    ....
  44. ncbi Plasma total homocysteine levels during short-term iatrogenic hypothyroidism
    E A Lien
    Division of Pharmacology, University Hospital of Bergen, Norway
    J Clin Endocrinol Metab 85:1049-53. 2000
    ..The increase in both plasma tHcy and serum cholesterol may confer increased cardiovascular risk in hypothyroid patients...
  45. ncbi Evaluation of indicators of cobalamin deficiency defined as cobalamin-induced reduction in increased serum methylmalonic acid
    B J Bolann
    Laboratory of Clinical Biochemistry, Haukeland University Hospital, N 5021 Bergen, Norway
    Clin Chem 46:1744-50. 2000
    ..However, serum cobalamin and other commonly used tests have limited ability to diagnose a deficiency state...
  46. ncbi Smoking, folate and methylenetetrahydrofolate reductase status as interactive determinants of adenomatous and hyperplastic polyps of colorectum
    A Ulvik
    LOCUS for Homocysteine and Related Vitamins, Armauer Hansens Hus, University of Bergen, Bergen, Norway
    Am J Med Genet 101:246-54. 2001
    ..In conclusion, in smokers, high folate status may confer increased or decreased risk for HRAs, depending on the MTHFR genotype. These data demonstrate the strong gene-nutrition interaction involving the C677T MTHFR polymorphism...
  47. ncbi Quantification of riboflavin, flavin mononucleotide, and flavin adenine dinucleotide in human plasma by capillary electrophoresis and laser-induced fluorescence detection
    S Hustad
    Department of Pharmacology, University of Bergen, Armauer Hansens Hus, 5021 Bergen, Norway
    Clin Chem 45:862-8. 1999
    ..We have developed a capillary electrophoresis method for the determination of riboflavin and its two coenzyme forms in human plasma...
  48. ncbi Analysis of RNA by capillary electrophoresis
    J Skeidsvoll
    Department of Clinical Biology, University of Bergen, Norway
    Electrophoresis 17:1512-7. 1996
    ..This is the first systematic investigation of electrophoresis of higher molecular mass RNA in capillaries, and motivates further studies to transfer electrophoresis of RNA to the capillary format...
  49. ncbi Changes in basal and postmethionine load concentrations of total homocysteine and cystathionine after B vitamin intervention
    Øyvind Bleie
    Institute of Medicine, University of Bergen, Haukeland University Hospital, N 5021 Bergen, Norway
    Am J Clin Nutr 80:641-8. 2004
    ....
  50. doi Measurement of folate in fresh and archival serum samples as p-aminobenzoylglutamate equivalents
    Rita Hannisdal
    Section for Pharmacology, Institute of Medicine, University of Bergen, Bergen, Norway
    Clin Chem 54:665-72. 2008
    ..We therefore developed a serum folate assay that measures folate and putative degradation products as p-aminobenzoylglutamate (pABG) equivalents following oxidation and acid hydrolysis...
  51. pmc DNA cell cycle distribution and glutathione (GSH) content according to circadian stage in bone marrow of cancer patients
    R Smaaland
    Gade Institute, Department of Pathology, Haukeland Hospital, University of Bergen, Norway
    Br J Cancer 66:39-45. 1992
    ..Furthermore, GSH content in bone marrow may predict this tissue's sensitivity to cytotoxic agents...
  52. ncbi Divergent associations of plasma choline and betaine with components of metabolic syndrome in middle age and elderly men and women
    Svetlana V Konstantinova
    Department of Public Health and Primary Health Care, University of Bergen, Bergen 5020, Norway
    J Nutr 138:914-20. 2008
    ..Choline and betaine were associated in opposite directions with key components of metabolic syndrome, suggesting a disruption of mitochondrial choline dehydrogenase pathway...
  53. ncbi Plasma homocysteine, folate, and vitamin B 12 and the risk of hip fracture: the hordaland homocysteine study
    Clara Gram Gjesdal
    Department of Public Helath and Primary Health Care, University of Bergen, Bergen, Norway
    J Bone Miner Res 22:747-56. 2007
    ..High levels of homocysteine and low levels of folate predicted fracture, whereas vitamin B12 and genotypes were not related to fracture risk. High homocysteine may be a modifiable risk factor for hip fracture...
  54. ncbi The association of gastric cancer risk with plasma folate, cobalamin, and methylenetetrahydrofolate reductase polymorphisms in the European Prospective Investigation into Cancer and Nutrition
    Stein Emil Vollset
    LOCUS for Homocysteine and Related Vitamins, Institute of Medicine, University of Bergen, Bergen, Norway
    Cancer Epidemiol Biomarkers Prev 16:2416-24. 2007
    ..However, we observed increased gastric cancer risk at low cobalamin levels that was most likely due to compromised cobalamin status in atrophic gastritis preceding gastric cancer...
  55. doi Analytical recovery of folate and its degradation products in human serum stored at -25 degrees C for up to 29 years
    Rita Hannisdal
    Section for Pharmacology, Institute of Medicine, University of Bergen, Bergen 5021, Norway
    J Nutr 140:522-6. 2010
    ..The pABG assay appears to be the method of choice for the determination of folate status in archival serum samples...
  56. ncbi Modulation of the homocysteine-betaine relationship by methylenetetrahydrofolate reductase 677 C->t genotypes and B-vitamin status in a large-scale epidemiological study
    Pal I Holm
    Hormone Laboratory, Haukeland University Hospital, Section for Pharmacology, Institute of Medicine, Armauer Hanssens hus, University of Bergen, 5021 Bergen, Norway
    J Clin Endocrinol Metab 92:1535-41. 2007
    ....
  57. ncbi Cobalamin status and its biochemical markers methylmalonic acid and homocysteine in different age groups from 4 days to 19 years
    Anne Lise Bjørke Monsen
    Department of Pediatrics, University of Bergen, N 5021 Bergen, Norway
    Clin Chem 49:2067-75. 2003
    ..Recent data indicate that cobalamin and folate status, including the metabolic markers methylmalonic acid (MMA) and total homocysteine (tHcy), undergo marked changes during childhood, particularly during the first year...
  58. ncbi Hematological parameters and cobalamin status in infants born to smoking mothers
    Anne Lise Bjørke Monsen
    Department of Pediatrics, University of Bergen, Bergen, Norway
    Biol Neonate 85:249-55. 2004
    ..At 6 weeks, maternal smoking significantly predicted the methylmalonic acid and total homocysteine levels, suggesting an influence from smoking on the cobalamin function in these infants...
  59. ncbi Temperature and pH effects on single-strand conformation polymorphism analysis by capillary electrophoresis
    J Ren
    Department of Pharmacology, University of Bergen, Norway
    Hum Mutat 13:458-63. 1999
    ..0 and 6.4, and the CBS G797A mutation could not be detected at any pH value within the range 6.4--9.0. These data emphasize the importance of the pH of the separation matrix in detecting certain mutations by SSCP...
  60. pmc Distribution of tamoxifen and metabolites into brain tissue and brain metastases in breast cancer patients
    E A Lien
    Department of Pharmacology and Toxicology, University of Bergen, Norway
    Br J Cancer 63:641-5. 1991
    ....
  61. doi Coffee consumption and circulating B-vitamins in healthy middle-aged men and women
    Arve Ulvik
    LOCUS for Homocysteine and Related Vitamins, Department of Internal Medicine, Pharmacology Section, University of Bergen, Bergen, Norway
    Clin Chem 54:1489-96. 2008
    ..tHcy is determined by several B-vitamins. However, reports about the association between coffee intake and B-vitamin status are few...
  62. ncbi Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: a randomized controlled trial
    Marta Ebbing
    Department of Heart Disease, Haukeland University Hospital, Jonas Liesvei 65, 5021 Bergen, Norway
    JAMA 300:795-804. 2008
    ..Observational studies have reported associations between circulating total homocysteine concentration and risk of cardiovascular disease. Oral administration of folic acid and vitamin B(12) can lower plasma total homocysteine levels...
  63. ncbi Folate, vitamin B12, homocysteine, and the MTHFR 677C->T polymorphism in anxiety and depression: the Hordaland Homocysteine Study
    Ingvar Bjelland
    Department of Public Health and Primary Health Care, LOCUS for Homocysteine and Related Vitamins, University of Bergen, Norway
    Arch Gen Psychiatry 60:618-26. 2003
    ..This study examined the associations between folate, total homocysteine, vitamin B12, and the methylenetetrahydrofolate reductase 677C-->T polymorphism, and anxiety and depression in a large population-based study...
  64. ncbi Effects of oral contraceptives and hormone replacement therapy on markers of cobalamin status
    Bettina Riedel
    Laboratory of Clinical Biochemistry, Section of Clinical Pharmacology, Haukeland University Hospital, Bergen, Norway
    Clin Chem 51:778-81. 2005
  65. ncbi Plasma total homocysteine level and bone mineral density: the Hordaland Homocysteine Study
    Clara Gram Gjesdal
    Department of Public Health and Primary Health Care, Institute of Medicine, University of Bergen, and Department of Rheumatology, Haukeland University Hospital, Norway
    Arch Intern Med 166:88-94. 2006
    ..We examined the association of hip BMD with levels of plasma tHcy, folate, and vitamin B12 and the methylenetetrahydrofolate reductase (MTHFR) 677C-->T and 1298A-->C polymorphisms...
  66. ncbi Phenotypic expression of the methylenetetrahydrofolate reductase 677C-->T polymorphism and flavin cofactor availability in thyroid dysfunction
    Steinar Hustad
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, Bergen, Norway
    Am J Clin Nutr 80:1050-7. 2004
    ..Riboflavin status modifies the metabolic effect of the polymorphism, and thyroid hormones increase the synthesis of flavin cofactors...
  67. ncbi High-level multiplex genotyping of polymorphisms involved in folate or homocysteine metabolism by matrix-assisted laser desorption/ionization mass spectrometry
    Klaus Meyer
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, Bergen, Norway
    Clin Chem 50:391-402. 2004
    ..Future large epidemiologic studies of the genetic basis of hyperhomocysteinemia will require high-throughput assays for polymorphisms of genes related to folate and Hcy metabolism...
  68. ncbi Mid-trimester amniotic fluid methionine concentrations: a predictor of birth weight and length
    Anne Lise Bjørke Monsen
    Institute of Medicine, Section for Pharmacology, University of Bergen, N 5021 Bergen, Norway
    Metabolism 55:1186-91. 2006
    ..The most noticeable observation was that methionine in amniotic fluid during gestational weeks 13 to 17 strongly predicted final birth weight and length. Metabolism of methionine may be a critical factor affecting fetal growth...
  69. ncbi Dietary predictors of plasma total homocysteine in the Hordaland Homocysteine Study
    Svetlana V Konstantinova
    Section of Epidemiology and Medical Statistics, Department of Public Health and Primary Health Care, University of Bergen, Kalfarveien, 31, Bergen, Norway
    Br J Nutr 98:201-10. 2007
    ..In conclusion, food items rich in B-vitamins and with a low content of fat and sugar were related to lower tHcy levels. Eggs, chicken, non-processed meat, fish and milk were inversely associated with tHcy...
  70. pmc The methylenetetrahydrofolate reductase 677C-->T polymorphism as a modulator of a B vitamin network with major effects on homocysteine metabolism
    Steinar Hustad
    The Hormone Laboratory, Haukeland University Hospital, Bergen, Norway
    Am J Hum Genet 80:846-55. 2007
    ..Individuals with the TT genotype were particularly sensitive to the status of several B vitamins and might be candidates for personalized nutritional recommendations...
  71. doi MALDI-TOF MS genotyping of polymorphisms related to 1-carbon metabolism using common and mass-modified terminators
    Klaus Meyer
    Bevital A S, Armauer Hansens Hus, University of Bergen, Bergen, Norway
    Clin Chem 55:139-49. 2009
    ..We developed a genotyping method based on MALDI-TOF MS and compared assay performance for formats based on standard and mass-modified terminators...
  72. doi Liquid chromatography-tandem mass spectrometry analysis of folate and folate catabolites in human serum
    Rita Hannisdal
    LOCUS for Homocysteine and Related Vitamins and Section for Pharmacology, Institute of Medicine, University of Bergen, Bergen, Norway
    Clin Chem 55:1147-54. 2009
    ..The diversity of folate forms complicates the task of assaying endogenous folate. We developed and validated an assay that measures various forms of folate in addition to folate catabolites in human serum...
  73. doi Analytical recovery of folate degradation products formed in human serum and plasma at room temperature
    Rita Hannisdal
    Section for Pharmacology, Institute of Medicine, University of Bergen, Bergen 5021, Norway
    J Nutr 139:1415-8. 2009
    ..Moreover, results obtained using conventional folate assays may be biased by improper sample handling or if samples contained high concentrations of hmTHF...
  74. ncbi Determination of choline, betaine, and dimethylglycine in plasma by a high-throughput method based on normal-phase chromatography-tandem mass spectrometry
    Pal I Holm
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, N 5021 Bergen, Norway
    Clin Chem 49:286-94. 2003
    ..Lack of a convenient, high-throughput method for the determination of these compounds has prevented population-based studies of their possible associations with lifestyle, nutrition, and chronic diseases...
  75. doi Vitamins B2 and B6 and genetic polymorphisms related to one-carbon metabolism as risk factors for gastric adenocarcinoma in the European prospective investigation into cancer and nutrition
    Simone J P M Eussen
    LOCUS for Homocysteine and Related Vitamins, Department of Pharmacology, Institute of Medicine, University of Bergen, and Haukeland University Hospital, Bergen, Norway
    Cancer Epidemiol Biomarkers Prev 19:28-38. 2010
    ..In summary, results from this large European cohort study showed an inverse association between vitamin B2 and GC risk, which is borderline significant, and a significant inverse association between vitamin B6 and GC risk...
  76. doi Infant birth size is not associated with maternal intake and status of folate during the second trimester in Norwegian pregnant women
    Roy M Nilsen
    Department of Public Health and Primary Health Care, University of Bergen, Bergen 5020, Norway
    J Nutr 140:572-9. 2010
    ..3; 95% CI: 1.6, 3.3). This study of well-nourished Norwegian pregnant women suggests that dietary folate and plasma folate during the second trimester are not risk factors for infant birth size...
  77. pmc Plasma folate, related genetic variants, and colorectal cancer risk in EPIC
    Simone J P M Eussen
    LOCUS for Homocysteine and Related Vitamins, Institute of Medicine, Section for Pharmacology, Department of Internal Medicine, University of Bergen, and Haukeland University Hospital, 5021 Laboratory Building, 9th Floor, Bergen, Norway
    Cancer Epidemiol Biomarkers Prev 19:1328-40. 2010
    ..We investigate the associations between plasma folate, several relevant folate-related polymorphisms, and CRC risk within the large European Prospective Investigation into Cancer and Nutrition cohort...
  78. ncbi Large-scale population-based metabolic phenotyping of thirteen genetic polymorphisms related to one-carbon metabolism
    Ase Fredriksen
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, Bergen, Norway
    Hum Mutat 28:856-65. 2007
    ..2756A>G (tHcy), BHMT c.716G>A (DMG), CBS c.844_845ins68 (tHcy, betaine), CBS c.699C>T (tHcy, betaine, cystathionine) and TCN2 c.776C>G (MMA). No associations were observed for the other polymorphisms investigated...
  79. ncbi Biochemical signs of impaired cobalamin status during and after radiotherapy for rectal cancer
    Marianne Grønlie Guren
    Department of Oncology, Ullevaal University Hospital, Oslo, Norway
    Int J Radiat Oncol Biol Phys 60:807-13. 2004
    ..The aim of the study was to investigate whether pelvic radiotherapy for rectal cancer had a negative impact on cobalamin status...
  80. ncbi Plasma concentration of folate as a biomarker for the intake of fruit and vegetables: the Hordaland Homocysteine Study
    Asgeir Brevik
    Department of Nutrition, School of Medicine, University of Oslo, Oslo, Norway
    Am J Clin Nutr 81:434-9. 2005
    ..Nutritional biomarkers may be used to assess dietary exposure without the errors commonly associated with self-reported dietary data...
  81. doi Common metabolic profile in infants indicating impaired cobalamin status responds to cobalamin supplementation
    Anne Lise Bjørke-Monsen
    Department of Clinical Biochemistry, Haukeland University Hospital, N 5021 Bergen, Norway
    Pediatrics 122:83-91. 2008
    ..A metabolic profile consistent with impaired cobalamin status is prevalent in breastfed infants. We investigated whether this profile reflects immature organ systems or impaired cobalamin status...
  82. ncbi Novel and established markers of cobalamin deficiency: complementary or exclusive diagnostic strategies
    Jorn Schneede
    Department of Clinical Chemistry, Umea University, Umea, Sweden
    Semin Vasc Med 5:140-55. 2005
    ..This article provides an overview of recent developments and a reappraisal of novel and established diagnostic markers for cobalamin deficiency...
  83. doi Homocysteine and folate status in an era of folic acid fortification: balancing benefits, risks, and B-vitamins
    Per Magne Ueland
    Clin Chem 54:779-81. 2008
  84. ncbi Homocysteine and cardiovascular risk: considering the evidence in the context of study design, folate fortification, and statistical power
    Per Magne Ueland
    Clin Chem 53:807-9. 2007
  85. ncbi Holo-transcobalamin is an early marker of changes in cobalamin homeostasis. A randomized placebo-controlled study
    Ebba Nexo
    Department of Clinical Biochemistry, AKH, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Clin Chem 48:1768-71. 2002
    ..We examined the effect of oral vitamin B(12) treatment on fluctuations in plasma total cobalamin and its binding proteins transcobalamin (TC) and haptocorrin (HC)...
  86. ncbi Uracil in human DNA from subjects with normal and impaired folate status as determined by high-performance liquid chromatography-tandem mass spectrometry
    Jicun Ren
    College of Chemistry and Chemical Engineering, Shanghai Jiaotong University, People s Republic of China
    Anal Chem 74:295-9. 2002
    ..Our data show that the uracil levels in human DNA isolated from peripheral white blood cells did not differ between subjects with folate deficiency and subjects with normal red cell folate levels...
  87. ncbi Homocysteine, cysteine, and related metabolites in maternal and fetal plasma in preeclampsia
    Kristin Braekke
    Department of Pediatric Intensive Care, Ulleval University Hospital, 0407 Oslo, Norway
    Pediatr Res 62:319-24. 2007
    ..The clinical significance of elevated homocysteine and cysteine concentrations in maternal and fetal compartments in preeclampsia remain to be explored, both regarding fetal growth and development of disease later in life...
  88. ncbi Homocysteine and folate in pregnancy
    Per Magne Ueland
    Clin Chem 50:1293-5. 2004
  89. pmc Folate and one-carbon metabolism gene polymorphisms and their associations with oral facial clefts
    Abee L Boyles
    Epidemiology Branch, National Institute of Environmental Health Sciences NIH, Durham, North Carolina 27709, USA
    Am J Med Genet A 146:440-9. 2008
    ..No associations were found between any of the polymorphisms and CPO. Genetic variations in the nine metabolic genes examined here do not confer a substantial degree of risk for clefts...
  90. ncbi Folic acid for the prevention of colorectal adenomas: a randomized clinical trial
    Bernard F Cole
    Department of Community and Family Medicine, Dartmouth Medical School, Hanover, NH, USA
    JAMA 297:2351-9. 2007
    ..Laboratory and epidemiological data suggest that folic acid may have an antineoplastic effect in the large intestine...
  91. ncbi Homocysteine lowering and cardiovascular events after acute myocardial infarction
    Kaare Harald Bønaa
    Institute of Community Medicine, University of Tromsø, Tromsø, Norway
    N Engl J Med 354:1578-88. 2006
    ..Homocysteine is a risk factor for cardiovascular disease. We evaluated the efficacy of homocysteine-lowering treatment with B vitamins for secondary prevention in patients who had had an acute myocardial infarction...
  92. doi Long term biweekly 1 mg oral vitamin B12 ensures normal hematological parameters, but does not correct all other markers of vitamin B12 deficiency. A study in patients with inherited vitamin B12 deficiency
    Mustafa Vakur Bor
    Haematologica 93:1755-8. 2008