Frits Thorsen

Summary

Affiliation: University of Bergen
Country: Norway

Publications

  1. ncbi NG2 proteoglycan promotes angiogenesis-dependent tumor growth in CNS by sequestering angiostatin
    Martha Chekenya
    Department of Anatomy and Cell Biology, University of Bergen, N 5009 Bergen, Norway
    FASEB J 16:586-8. 2002
  2. ncbi Imaging of experimental rat gliomas using a clinical MR scanner
    Frits Thorsen
    Department of Anatomy and Cell Biology, University of Bergen, Bergen, Norway
    J Neurooncol 63:225-31. 2003
  3. pmc Multimodal imaging enables early detection and characterization of changes in tumor permeability of brain metastases
    Frits Thorsen
    Department of Biomedicine, University of Bergen, Bergen, Norway Electronic address
    J Control Release 172:812-22. 2013
  4. ncbi Adeno-associated virus (AAV) serotypes 2, 4 and 5 display similar transduction profiles and penetrate solid tumor tissue in models of human glioma
    Frits Thorsen
    Department of Biomedicine, Section of Anatomy and Cell Biology, University of Bergen, and Department of Oncology and Medical Physics, Haukeland University Hospital, Bergen, Norway
    J Gene Med 8:1131-40. 2006
  5. ncbi Human glioblastoma biopsy spheroids xenografted into the nude rat brain show growth inhibition after stereotactic radiosurgery
    Frits Thorsen
    Department of Oncology and Medical Physics, Haukeland University Hospital, Jonas Lies vei 65, 5021, Bergen, Norway
    J Neurooncol 82:1-10. 2007
  6. ncbi Gamma knife stereotactic radiosurgery of Nelson syndrome
    Einar Osland Vik-Mo
    Department of Neurosurgery, Haukeland University Hospital, 5053 Bergen, Norway
    Eur J Endocrinol 160:143-8. 2009
  7. ncbi Adeno-associated viral vectors penetrate human solid tumor tissue in vivo more effectively than adenoviral vectors
    Per Øyvind Enger
    Department of Anatomy and Cell Biology, University of Bergen, Bergen, Norway
    Hum Gene Ther 13:1115-25. 2002
  8. ncbi Oncolytic herpes simplex virus type-1 therapy in a highly infiltrative animal model of human glioblastoma
    Peter C Huszthy
    Department of Biomedicine, The Gade Institute, University of Bergen, Bergen, Norway
    Clin Cancer Res 14:1571-80. 2008
  9. ncbi Antitumor efficacy improved by local delivery of species-specific endostatin
    Peter C Huszthy
    Gene Therapy Program, Department of Oncology and Medical Physics, Haukeland University Hospital, Bergen, Norway
    J Neurosurg 104:118-28. 2006
  10. ncbi In vivo animal models for studying brain metastasis: value and limitations
    Inderjit Daphu
    Norlux Neuro Oncology Laboratory, Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5019, Bergen, Norway
    Clin Exp Metastasis 30:695-710. 2013

Collaborators

Detail Information

Publications25

  1. ncbi NG2 proteoglycan promotes angiogenesis-dependent tumor growth in CNS by sequestering angiostatin
    Martha Chekenya
    Department of Anatomy and Cell Biology, University of Bergen, N 5009 Bergen, Norway
    FASEB J 16:586-8. 2002
    ..These results indicate a unique role for NG2 in regulating the transition from small, poorly vascularized tumors to large, highly vascular gliomas in situ by sequestering angiostatin...
  2. ncbi Imaging of experimental rat gliomas using a clinical MR scanner
    Frits Thorsen
    Department of Anatomy and Cell Biology, University of Bergen, Bergen, Norway
    J Neurooncol 63:225-31. 2003
    ..The purpose of this study was thus to obtain high-resolution images of experimental gliomas in the rat brain, using a clinical 1.5 T MR scanner...
  3. pmc Multimodal imaging enables early detection and characterization of changes in tumor permeability of brain metastases
    Frits Thorsen
    Department of Biomedicine, University of Bergen, Bergen, Norway Electronic address
    J Control Release 172:812-22. 2013
    ..Different-sized MR and PET contrast agents demonstrated the gradual increase in leakiness of the blood tumor barrier during metastatic progression, which could guide clinicians in choosing tailored treatment strategies...
  4. ncbi Adeno-associated virus (AAV) serotypes 2, 4 and 5 display similar transduction profiles and penetrate solid tumor tissue in models of human glioma
    Frits Thorsen
    Department of Biomedicine, Section of Anatomy and Cell Biology, University of Bergen, and Department of Oncology and Medical Physics, Haukeland University Hospital, Bergen, Norway
    J Gene Med 8:1131-40. 2006
    ..In the present work, the transduction efficacy of AAV serotypes 4 and 5 were compared to AAV2, both in vitro and in intracranial GBM xenografts derived from patient biopsies implanted into nude rats...
  5. ncbi Human glioblastoma biopsy spheroids xenografted into the nude rat brain show growth inhibition after stereotactic radiosurgery
    Frits Thorsen
    Department of Oncology and Medical Physics, Haukeland University Hospital, Jonas Lies vei 65, 5021, Bergen, Norway
    J Neurooncol 82:1-10. 2007
    ..In this work, the growth and invasiveness of human glioblastoma spheroids xenografted into nude rat brains were assessed after radiosurgery. Temporary in vitro as well as long-term in vivo radiation effects were studied...
  6. ncbi Gamma knife stereotactic radiosurgery of Nelson syndrome
    Einar Osland Vik-Mo
    Department of Neurosurgery, Haukeland University Hospital, 5053 Bergen, Norway
    Eur J Endocrinol 160:143-8. 2009
    ..We have examined the effect of GKR on tumor growth and ACTH-hypersecretion, and characterized the adverse events of this treatment in patients with NS...
  7. ncbi Adeno-associated viral vectors penetrate human solid tumor tissue in vivo more effectively than adenoviral vectors
    Per Øyvind Enger
    Department of Anatomy and Cell Biology, University of Bergen, Bergen, Norway
    Hum Gene Ther 13:1115-25. 2002
    ..These results suggest that AAV may be suitable for therapeutic gene delivery to malignant tumors...
  8. ncbi Oncolytic herpes simplex virus type-1 therapy in a highly infiltrative animal model of human glioblastoma
    Peter C Huszthy
    Department of Biomedicine, The Gade Institute, University of Bergen, Bergen, Norway
    Clin Cancer Res 14:1571-80. 2008
    ....
  9. ncbi Antitumor efficacy improved by local delivery of species-specific endostatin
    Peter C Huszthy
    Gene Therapy Program, Department of Oncology and Medical Physics, Haukeland University Hospital, Bergen, Norway
    J Neurosurg 104:118-28. 2006
    ..This allowed a direct assessment of the biological efficacy of soluble endostatin in vivo...
  10. ncbi In vivo animal models for studying brain metastasis: value and limitations
    Inderjit Daphu
    Norlux Neuro Oncology Laboratory, Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5019, Bergen, Norway
    Clin Exp Metastasis 30:695-710. 2013
    ..By combining the knowledge obtained from animal models, new important information on the molecular mechanisms behind metastasis will be obtained, leading to the future development of new therapeutic strategies...
  11. pmc Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival
    Aurélie Poli
    Translational Cancer Research, Department of Biomedicine, University of Bergen, Norway
    Oncotarget 4:1527-46. 2013
    ....
  12. ncbi Automated tracking of nanoparticle-labeled melanoma cells improves the predictive power of a brain metastasis model
    Terje Sundstrøm
    Department of Biomedicine, University of Bergen, Bergen, Norway
    Cancer Res 73:2445-56. 2013
    ..686; survival, P = 0.547). In summary, we present here a highly reproducible animal model that can improve the predictive value of mechanistic and therapeutic studies of melanoma brain metastasis...
  13. ncbi γ knife surgery versus reoperation for recurrent glioblastoma multiforme
    Bente Sandvei Skeie
    Department of Surgical Sciences, Haukeland University Hospital, Bergen, Norway
    World Neurosurg 78:658-69. 2012
    ..To validate the efficacy and safety of GKS, we compared the survival and complication rates of GKS and reoperation for recurrent GBMs...
  14. ncbi CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells
    Jian Wang
    Department of Biomedicine, University of Bergen, Bergen, Norway
    Int J Cancer 122:761-8. 2008
    ..Thus, our findings do not suggest that CD133 expression is required for brain tumor initiation, but that it may be involved during brain tumor progression...
  15. ncbi Two distinct tumor phenotypes isolated from glioblastomas show different MRS characteristics
    Frits Thorsen
    Department of Biomedicine, University of Bergen, 5009 Bergen, Norway
    NMR Biomed 21:830-8. 2008
    ..More pronounced anaerobic metabolism was present in the LG stem-cell-like tumors, suggesting a more malignant phenotype...
  16. pmc In vivo models of primary brain tumors: pitfalls and perspectives
    Peter C Huszthy
    NorLux, Neuro Oncology Laboratory, Department of Biomedicine, University of Bergen, Bergen, Norway
    Neuro Oncol 14:979-93. 2012
    ....
  17. pmc In vitro treatment of melanoma brain metastasis by simultaneously targeting the MAPK and PI3K signaling pathways
    Inderjit Daphu
    Norlux Neuro Oncology Laboratory, Department of Biomedicine, University of Bergen, 5009 Bergen, Norway
    Int J Mol Sci 15:8773-94. 2014
    ..The presented results highlight the potential of combined treatment to overcome treatment resistance that may develop after vemurafenib treatment of melanomas. ..
  18. ncbi Dynamic contrast enhanced MRI detects early response to adoptive NK cellular immunotherapy targeting the NG2 proteoglycan in a rat model of glioblastoma
    Cecilie Brekke Rygh
    Department of Biomedicine, University of Bergen, Bergen, Norway Cardiovascular Research Group, Haukeland University Hospital, Bergen, Norway
    PLoS ONE 9:e108414. 2014
    ..2.27 treated tumours compared to the other groups. In conclusion, ve was the most reliable radiological parameter for detecting response to intralesional NK cellular therapy. ..
  19. ncbi Multimodal imaging of gliomas in the context of evolving cellular and molecular therapies
    Olivier Keunen
    Norlux Neuro Oncology Laboratory, Department of Oncology, Centre de Recherche Public de la Santé, Luxembourg, Luxembourg Translational Cancer Research, Department of Biomedicine, University of Bergen, Norway Electronic address
    Adv Drug Deliv Rev 76:98-115. 2014
    ....
  20. ncbi Gamma knife stereotactic radiosurgery for acromegaly
    Einar Osland Vik-Mo
    Department of Neurosurgery, Haukeland University Hospital, Bergen, Norway
    Eur J Endocrinol 157:255-63. 2007
    ..Gamma knife radiosurgery (GKR) is an adjuvant treatment for acromegaly if surgery fails to normalize GH hypersecretion...
  21. ncbi MRI of experimental gliomas
    Frits Thorsen
    Department of Biomedicine, University of Bergen, Bergen, Norway
    Methods Mol Biol 711:451-71. 2011
    ..Tumour development is followed by MR imaging and proton spectroscopy. In this chapter, operating procedures and the MR techniques are presented...
  22. ncbi Localised delivery of therapeutic agents to CNS malignancies: old and new approaches
    Tracy Ann Read
    Department of Anatomy and Cell Biology, University of Bergen, Norway
    Curr Pharm Biotechnol 3:257-73. 2002
    ....
  23. ncbi Reprogramming of cell junction modules during stepwise epithelial to mesenchymal transition and accumulation of malignant features in vitro in a prostate cell model
    Xi Song Ke
    The Gade Institute, University of Bergen, Bergen, Norway
    Exp Cell Res 317:234-47. 2011
    ..Reprogramming of cell junction modules is involved in both steps...
  24. ncbi Effects of dietary intervention on MRI activity, de- and remyelination in the cuprizone model for demyelination
    Øivind Torkildsen
    Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, N 5021 Bergen, Norway
    Exp Neurol 215:160-6. 2009
    ..This may be of importance related to the discrepant results in dietary intervention studies for demyelinating diseases...
  25. ncbi [Stereotactic radiosurgery of cerebral arteriovenous malformations]
    Paal Henning Pedersen
    Nevrokirurgisk avdeling, Haukeland Sykehus 5021 Bergen
    Tidsskr Nor Laegeforen 122:1277-80. 2002
    ..Different treatment modalities are being used for cerebral arteriovenous malformations...