Erik Thorsby

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. doi request reprint A short history of HLA
    E Thorsby
    Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway
    Tissue Antigens 74:101-16. 2009
  2. pmc The Polynesian gene pool: an early contribution by Amerindians to Easter Island
    Erik Thorsby
    Institute of Immunology, Oslo University Hospital, Rikshospitalet, and University of Oslo, Oslo, Norway
    Philos Trans R Soc Lond B Biol Sci 367:812-9. 2012
  3. doi request reprint On the future of HLA
    E Thorsby
    Institute of Immunology, Oslo University Hospital, Rikshospitalet and University of Oslo, Oslo, Norway
    Tissue Antigens 78:229-40. 2011
  4. doi request reprint Further evidence of an Amerindian contribution to the Polynesian gene pool on Easter Island
    E Thorsby
    Institute of Immunology, Rikshospitalet University Hospital and University of Oslo, Oslo, Norway
    Tissue Antigens 73:582-5. 2009
  5. ncbi request reprint [Transplantation medicine in Norway through 50 years]
    Erik Thorsby
    Immunologisk institutt, Rikshospitalet Radiumhospitalet og Universitetet i Oslo, 0027 Oslo
    Tidsskr Nor Laegeforen 126:3305-10. 2006
  6. ncbi request reprint HLA associated genetic predisposition to autoimmune diseases: Genes involved and possible mechanisms
    Erik Thorsby
    Institute of Immunology, Rikshospitalet University Hospital and University of Oslo, Rikshospitalet, Oslo, Norway
    Transpl Immunol 14:175-82. 2005
  7. ncbi request reprint Particular genetic variants of ligands for natural killer cell receptors may contribute to the HLA associated risk of primary sclerosing cholangitis
    Tom H Karlsen
    Medical Department, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
    J Hepatol 46:899-906. 2007
  8. doi request reprint Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis
    Aslaug R Lorentzen
    Department of Neurology, Faculty Division Ulleval, Oslo University Hospital, University of Oslo, Oslo, Norway
    Ann Neurol 65:658-66. 2009
  9. ncbi request reprint Cholangiocarcinoma in primary sclerosing cholangitis is associated with NKG2D polymorphisms
    Espen Melum
    Medical Department, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Hepatology 47:90-6. 2008
  10. ncbi request reprint Association analysis in type 1 diabetes of the PRSS16 gene encoding a thymus-specific serine protease
    Benedicte A Lie
    Institute of Immunology, Rikshospitalet Radiumhospitalet Medical Center, and Institute of Medical Genetics, University of Oslo, Norway
    Hum Immunol 68:592-8. 2007

Detail Information

Publications22

  1. doi request reprint A short history of HLA
    E Thorsby
    Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway
    Tissue Antigens 74:101-16. 2009
    ....
  2. pmc The Polynesian gene pool: an early contribution by Amerindians to Easter Island
    Erik Thorsby
    Institute of Immunology, Oslo University Hospital, Rikshospitalet, and University of Oslo, Oslo, Norway
    Philos Trans R Soc Lond B Biol Sci 367:812-9. 2012
    ....
  3. doi request reprint On the future of HLA
    E Thorsby
    Institute of Immunology, Oslo University Hospital, Rikshospitalet and University of Oslo, Oslo, Norway
    Tissue Antigens 78:229-40. 2011
    ..Together, this will leave the HLA field with many new challenges and opportunities, which in the future will require more focus on functional aspects of the immunogenetics of HLA...
  4. doi request reprint Further evidence of an Amerindian contribution to the Polynesian gene pool on Easter Island
    E Thorsby
    Institute of Immunology, Rikshospitalet University Hospital and University of Oslo, Oslo, Norway
    Tissue Antigens 73:582-5. 2009
    ..The new data support our previous evidence of an Amerindian contribution to the gene pool on Easter Island...
  5. ncbi request reprint [Transplantation medicine in Norway through 50 years]
    Erik Thorsby
    Immunologisk institutt, Rikshospitalet Radiumhospitalet og Universitetet i Oslo, 0027 Oslo
    Tidsskr Nor Laegeforen 126:3305-10. 2006
    ....
  6. ncbi request reprint HLA associated genetic predisposition to autoimmune diseases: Genes involved and possible mechanisms
    Erik Thorsby
    Institute of Immunology, Rikshospitalet University Hospital and University of Oslo, Rikshospitalet, Oslo, Norway
    Transpl Immunol 14:175-82. 2005
    ..g. HLA-B27 for ankylosing spondylitis) and others which may be more common for several diseases. This will be briefly reviewed in the following...
  7. ncbi request reprint Particular genetic variants of ligands for natural killer cell receptors may contribute to the HLA associated risk of primary sclerosing cholangitis
    Tom H Karlsen
    Medical Department, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
    J Hepatol 46:899-906. 2007
    ..We aimed to clarify to what extent such combinations influence susceptibility to primary sclerosing cholangitis (PSC)...
  8. doi request reprint Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis
    Aslaug R Lorentzen
    Department of Neurology, Faculty Division Ulleval, Oslo University Hospital, University of Oslo, Oslo, Norway
    Ann Neurol 65:658-66. 2009
    ..We investigated the HLA class I alleles defined by their KIR binding motifs and the KIR genes to evaluate whether these genes could influence MS susceptibility or severity, alone or in combination...
  9. ncbi request reprint Cholangiocarcinoma in primary sclerosing cholangitis is associated with NKG2D polymorphisms
    Espen Melum
    Medical Department, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Hepatology 47:90-6. 2008
    ..Patients who are homozygous for the nonrisk alleles are unlikely to develop CCA; this finding could be helpful in identifying PSC patients with a low CCA risk...
  10. ncbi request reprint Association analysis in type 1 diabetes of the PRSS16 gene encoding a thymus-specific serine protease
    Benedicte A Lie
    Institute of Immunology, Rikshospitalet Radiumhospitalet Medical Center, and Institute of Medical Genetics, University of Oslo, Norway
    Hum Immunol 68:592-8. 2007
    ..Our data suggest that it is unlikely that polymorphisms within the PRSS16 gene are involved in the predisposition to T1D. However, we cannot rule out that regulatory polymorphisms located some distance away from the gene may be involved...
  11. ncbi request reprint Genetic polymorphisms associated with inflammatory bowel disease do not confer risk for primary sclerosing cholangitis
    Tom H Karlsen
    Medical Department, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Am J Gastroenterol 102:115-21. 2007
    ..The pathogenetic link between PSC and IBD is unknown. We aimed to assess whether genetic risk factors in PSC can be identified on the basis of known IBD susceptibility genes and the shared PSC-IBD phenotype...
  12. pmc Lack of association between the chemokine receptor 5 polymorphism CCR5delta32 in rheumatoid arthritis and juvenile idiopathic arthritis
    Ewald Lindner
    Institute of Immunology, Rikshospitalet Radiumhospitalet Medical Center, 0027 Oslo, Norway
    BMC Med Genet 8:33. 2007
    ..In juvenile idiopathic arthritis (JIA), an association with CCR5 was recently reported. The purpose of this study was to investigate if the CCR5Delta32 polymorphism is associated with RA or JIA in Norwegian cohorts...
  13. ncbi request reprint Lack of association with the CD28/CTLA4/ICOS gene region among Norwegian multiple sclerosis patients
    Aslaug R Lorentzen
    Institute of Immunology, University of Oslo and Rikshospitalet University Hospital, 00207 Oslo, Norway
    J Neuroimmunol 166:197-201. 2005
    ..In conclusion, this study could not confirm association with the CD28/CTLA4/ICOS gene region...
  14. ncbi request reprint Polymorphisms in the cathepsin L2 (CTSL2) gene show association with type 1 diabetes and early-onset myasthenia gravis
    Marte K Viken
    Institute of Immunology, Faculty Division Rikshospitalet, University of Oslo, Oslo, Norway
    Hum Immunol 68:748-55. 2007
    ..No association was observed in rheumatoid arthritis or juvenile idiopathic arthritis. Our findings suggest that the CTSL2 gene is associated with T1D and with early-onset MG...
  15. ncbi request reprint A gene in the telomeric HLA complex distinct from HLA-A is involved in predisposition to juvenile idiopathic arthritis
    Anna Smerdel
    Institute of Immunology and Center for Rheumatic Diseases, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Arthritis Rheum 46:1614-9. 2002
    ..e., they cannot be explained by the known linkage disequilibrium between alleles at these loci). The purpose of this study was to look for additional JIA susceptibility genes in the HLA complex...
  16. ncbi request reprint Human serum-induced porcine endothelial cell E-selectin expression is associated with IgG3 and IgM anti-Gal antibodies
    Marit Saethre
    Institute of Immunology, University of Oslo, Norway
    Xenotransplantation 9:350-8. 2002
    ..In conclusion, the close correlation between anti-Gal antibodies of the potent complement activating IgG3 subclass and porcine EC activation, may imply that these antibodies play a role in EC activation characteristic of AVR...
  17. ncbi request reprint No evidence of type 1 diabetes susceptibility genes in the region centromeric of the HLA complex
    Stefan Johansson
    Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway
    Hum Immunol 64:951-9. 2003
    ..In conclusion, our data argue against the presence of any strong genetic susceptibility factors for T1D in the region centromeric of the HLA complex...
  18. ncbi request reprint Polymorphisms in the steroid and xenobiotic receptor gene influence survival in primary sclerosing cholangitis
    Tom H Karlsen
    Medical Department, Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway
    Gastroenterology 131:781-7. 2006
    ..Ursodeoxycholic acid and rifampicin are known ligands. We investigated whether functional polymorphisms of the SXR gene influence disease susceptibility or disease progression in patients with primary sclerosing cholangitis (PSC)...
  19. ncbi request reprint Several genes in the extended human MHC contribute to predisposition to autoimmune diseases
    Benedicte A Lie
    Institute of Immunology, Rikshospitalet University Hospital, University of Oslo, Norway
    Curr Opin Immunol 17:526-31. 2005
    ..As a result of recent systematic screening studies additional genes and regions in the MHC, including the extended MHC, are now known to contribute to the predisposition...
  20. ncbi request reprint Human complement-activating immunoglobulin (Ig)G3 antibodies are essential for porcine endothelial cell activation
    Marit Saethre
    Institute of Immunology, Rikshospitalet University Hospital, University of Oslo, Norway
    Xenotransplantation 13:215-23. 2006
    ..The present study was undertaken to investigate whether there is a causal relationship between human anti-porcine IgG3 Abs and porcine endothelial cell activation...
  21. ncbi request reprint Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with primary sclerosing cholangitis
    Christopher L Bowlus
    Division of Gastroenterology, University of California Davis Medical Center, 4150 V Street, PSSB3500, Sacramento, CA 95817, USA
    J Hepatol 45:704-10. 2006
    ..The aims of this study were to determine if MAdCAM-1 polymorphisms or the K469E polymorphism of ICAM-1 are associated with PSC in Scandinavia...
  22. ncbi request reprint Changing the priority for HLA matching in kidney transplantation
    Erik Thorsby
    N Engl J Med 350:2095-6; author reply 2095-6. 2004