Mathis K Stokke
Affiliation: University of Oslo
Stokke M, Hougen K, Sjaastad I, Louch W, Briston S, Enger U, et al
. Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes. Cardiovasc Res. 2010;86:63-71 pubmed publisher
..FF: 8 +/- 1 VES/h) (P < 0.05 for all results). Reduced SERCA2 abundance resulted in decreased amplitude and decay rate of Ca(2+) transients, reduced SR Ca(2+) content, and decreased propensity for Ca(2+) wave development. ..
Stokke M, Briston S, Jølle G, Manzoor I, Louch W, Øyehaug L, et al
. Ca(2+) wave probability is determined by the balance between SERCA2-dependent Ca(2+) reuptake and threshold SR Ca(2+) content. Cardiovasc Res. 2011;90:503-12 pubmed publisher
..We suggest that this is caused by a CaMKII-dependent shift in the balance between SERCA2-dependent Ca(2+) reuptake and threshold SR Ca(2+) content. ..
Stokke M, Tovsrud N, Louch W, Øyehaug L, Hougen K, Sejersted O, et al
. I(CaL) inhibition prevents arrhythmogenic Ca(2+) waves caused by abnormal Ca(2+) sensitivity of RyR or SR Ca(2+) accumulation. Cardiovasc Res. 2013;98:315-25 pubmed publisher
..In contrast, unstimulated early Ca(2+) release during the decay of the Ca(2+) transient is not prevented, and merits further study to understand the full antiarrhythmic potential of I(CaL) inhibition. ..