Harald Stenmark

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. ncbi request reprint A dual function for Deep orange in programmed autophagy in the Drosophila melanogaster fat body
    Karine Lindmo
    Department of Biochemistry, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Exp Cell Res 312:2018-27. 2006
  2. ncbi request reprint The phosphatidylinositol 3-phosphate-binding FYVE finger
    Harald Stenmark
    Department of Biochemistry, The Norwegian Radium Hospital, Oslo, Norway
    FEBS Lett 513:77-84. 2002
  3. pmc Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis
    Ioannis P Nezis
    Centre for Cancer Biomedicine, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    J Cell Biol 190:523-31. 2010
  4. pmc The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy
    Maria Filimonenko
    Centre for Cancer Biomedicine, University of Oslo, Department of Biochemistry, The Norwegian Radium Hospital, Oslo, Norway
    Mol Cell 38:265-79. 2010
  5. ncbi request reprint Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domain
    Thomas Slagsvold
    Department of Biochemistry, The Norwegian Radium Hospital, Montebello, Oslo
    J Biol Chem 280:19600-6. 2005
  6. pmc Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain
    Ioannis P Nezis
    Department of Biochemistry, Centre for Cancer Biomedicine, University of Oslo and Institute for Cancer Research, The Norwegian Radium Hospital, N 0310 Oslo, Norway
    J Cell Biol 180:1065-71. 2008
  7. ncbi request reprint Differential functions of Hrs and ESCRT proteins in endocytic membrane trafficking
    Camilla Raiborg
    Centre for Cancer Biomedicine, University of Oslo, and Department of Biochemistry, The Norwegian Radium Hospital, Rikshospitalet, Norway
    Exp Cell Res 314:801-13. 2008
  8. ncbi request reprint Flat clathrin coats on endosomes mediate degradative protein sorting by scaffolding Hrs in dynamic microdomains
    Camilla Raiborg
    Department of Biochemistry, Institute for Cancer Research, the Norwegian Radium Hospital and the University of Oslo, Montebello, N 0310 Oslo, Norway
    J Cell Sci 119:2414-24. 2006
  9. ncbi request reprint Multivesicular endosome biogenesis in the absence of ESCRTs
    Susanne Stuffers
    Department of Biochemistry, Institute for Cancer Research, The Norwegian Radiumhospital and Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, N 0310 Oslo, Norway
    Traffic 10:925-37. 2009
  10. doi request reprint Spatiotemporal control of Cindr at ring canals during incomplete cytokinesis in the Drosophila male germline
    Asmund H Eikenes
    Department of Biochemistry, Institute for Cancer Research, Oslo University Hospital, Montebello, Oslo, Norway
    Dev Biol 377:9-20. 2013

Collaborators

Detail Information

Publications67

  1. ncbi request reprint A dual function for Deep orange in programmed autophagy in the Drosophila melanogaster fat body
    Karine Lindmo
    Department of Biochemistry, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Exp Cell Res 312:2018-27. 2006
    ..These results indicate that Dor controls autophagy indirectly, via ecdysone signaling, as well as directly, via autolysosomal fusion...
  2. ncbi request reprint The phosphatidylinositol 3-phosphate-binding FYVE finger
    Harald Stenmark
    Department of Biochemistry, The Norwegian Radium Hospital, Oslo, Norway
    FEBS Lett 513:77-84. 2002
    ..Here we review recent work that sheds light on the targeting of FYVE finger proteins to PI3P-containing membranes, and how these proteins serve to regulate multiple cellular functions...
  3. pmc Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis
    Ioannis P Nezis
    Centre for Cancer Biomedicine, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    J Cell Biol 190:523-31. 2010
    ..Our results reveal autophagic degradation of an IAP as a novel mechanism of triggering cell death and thereby provide a mechanistic link between autophagy and cell death...
  4. pmc The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy
    Maria Filimonenko
    Centre for Cancer Biomedicine, University of Oslo, Department of Biochemistry, The Norwegian Radium Hospital, Oslo, Norway
    Mol Cell 38:265-79. 2010
    ..We propose that Alfy plays a key role in selective macroautophagy by bridging cargo to the molecular machinery that builds autophagosomes...
  5. ncbi request reprint Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domain
    Thomas Slagsvold
    Department of Biochemistry, The Norwegian Radium Hospital, Montebello, Oslo
    J Biol Chem 280:19600-6. 2005
    ..Furthermore, we show that Eap45 colocalizes with ubiquitinated proteins on late endosomes. These results are consistent with a role for Eap45 in endosomal sorting of ubiquitinated cargo...
  6. pmc Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain
    Ioannis P Nezis
    Department of Biochemistry, Centre for Cancer Biomedicine, University of Oslo and Institute for Cancer Research, The Norwegian Radium Hospital, N 0310 Oslo, Norway
    J Cell Biol 180:1065-71. 2008
    ..Our findings reveal a major role for Ref(2)P in the formation of ubiquitin-positive protein aggregates both under physiological conditions and when normal protein turnover is inhibited...
  7. ncbi request reprint Differential functions of Hrs and ESCRT proteins in endocytic membrane trafficking
    Camilla Raiborg
    Centre for Cancer Biomedicine, University of Oslo, and Department of Biochemistry, The Norwegian Radium Hospital, Rikshospitalet, Norway
    Exp Cell Res 314:801-13. 2008
    ....
  8. ncbi request reprint Flat clathrin coats on endosomes mediate degradative protein sorting by scaffolding Hrs in dynamic microdomains
    Camilla Raiborg
    Department of Biochemistry, Institute for Cancer Research, the Norwegian Radium Hospital and the University of Oslo, Montebello, N 0310 Oslo, Norway
    J Cell Sci 119:2414-24. 2006
    ..We conclude that clathrin is responsible for concentrating Hrs in endosomal microdomains specialised for recognition of ubiquitylated membrane proteins, thus enabling efficient sorting of cargo into the degradative pathway...
  9. ncbi request reprint Multivesicular endosome biogenesis in the absence of ESCRTs
    Susanne Stuffers
    Department of Biochemistry, Institute for Cancer Research, The Norwegian Radiumhospital and Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, N 0310 Oslo, Norway
    Traffic 10:925-37. 2009
    ..Our observations suggest that both ESCRT-dependent and ESCRT-independent mechanisms of MVE biogenesis exist in mammalian cells...
  10. doi request reprint Spatiotemporal control of Cindr at ring canals during incomplete cytokinesis in the Drosophila male germline
    Asmund H Eikenes
    Department of Biochemistry, Institute for Cancer Research, Oslo University Hospital, Montebello, Oslo, Norway
    Dev Biol 377:9-20. 2013
    ..Taken together, our analyses reveal a key step of incomplete cytokinesis at the endpoint of the mitotic germ cell divisions in D. melanogaster...
  11. pmc Disruption of Vps4 and JNK function in Drosophila causes tumour growth
    Lina M Rodahl
    Faculty of Medicine, Centre for Cancer Biomedicine, University of Oslo and Institute for Cancer Research, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, Oslo, Norway
    PLoS ONE 4:e4354. 2009
    ..We conclude that dvps4 is a tumour suppressor in Drosophila and that JNK is central to the cell-autonomous phenotypes of ESCRT-deficient cells...
  12. pmc The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor
    Kristi G Bache
    Department of Biochemistry, Institute for Cancer Research, Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Mol Biol Cell 17:2513-23. 2006
    ..Together, our results reveal functional differences between ESCRT-I and ESCRT-III in degradative protein trafficking and indicate that degradation of the EGFR is not required for termination of its signaling...
  13. ncbi request reprint Alix regulates cortical actin and the spatial distribution of endosomes
    Alicia Cabezas
    Department of Biochemistry, The Norwegian Radium Hospital, Montebello, Oslo
    J Cell Sci 118:2625-35. 2005
    ....
  14. ncbi request reprint The structure of an endosomal protein sorter
    Thomas Slagsvold
    Department of Biochemistry, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Dev Cell 7:457-8. 2004
    ..Two recent reports, one in Nature and one in this issue of Developmental Cell, reveal the crystal structure of the yeast form of ESCRT-II...
  15. doi request reprint The PtdIns3P-binding protein Phafin 2 mediates epidermal growth factor receptor degradation by promoting endosome fusion
    Nina Marie Pedersen
    Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, N 0310, Oslo, Norway
    Traffic 13:1547-63. 2012
    ..Our results suggest that Phafin2 controls receptor trafficking and fluid-phase transport through early endosomes by facilitating endosome fusion in concert with EEA1...
  16. pmc Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration
    Angela Oppelt
    Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway
    EMBO Rep 14:57-64. 2013
    ..Thus, the identified phosphoinositide loop defines a new role for PtdIns5P in cell migration...
  17. ncbi request reprint The PI 3-kinase regulator Vps15 is required for autophagic clearance of protein aggregates
    Karine Lindmo
    Centre for Cancer Biomedicine, University of Oslo, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Autophagy 4:500-6. 2008
    ..These results provide the first genetic evidence for a function of Vps15 in autophagy in multicellular organisms and suggest that the Vps15-containing PI 3-kinase complex may play an important role in clearance of protein aggregates...
  18. ncbi request reprint Cargo-dependent degradation of ESCRT-I as a feedback mechanism to modulate endosomal sorting
    Lene Malerød
    Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, Oslo, Norway
    Traffic 12:1211-26. 2011
    ....
  19. pmc A tumor-associated mutation of FYVE-CENT prevents its interaction with Beclin 1 and interferes with cytokinesis
    Antonia P Sagona
    Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway
    PLoS ONE 6:e17086. 2011
    ..These findings suggest a positive feedback loop for recruitment of FYVE-CENT and Beclin 1 to the intercellular bridge during cytokinesis, and reveal a novel potential tumor suppressor mechanism for Beclin 1...
  20. pmc Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors
    Tor Erik Rusten
    Department of Biochemistry, the Norwegian Radium Hospital and the University of Oslo, Montebello, N 0310 Oslo, Norway
    Mol Biol Cell 17:3989-4001. 2006
    ..This is consistent with the possibility that Fab1 functions at a late stage in endocytic receptor trafficking, at a point when signal termination has occurred...
  21. doi request reprint Phosphatidylinositol 3-phosphate, a lipid that regulates membrane dynamics, protein sorting and cell signalling
    Kay O Schink
    Faculty of Medicine, Centre for Cancer Biomedicine, University of Oslo, Montebello, Oslo, Norway Department of Biochemistry, Institute for Cancer Research, Oslo University Hospital, Montebello, Oslo, Norway
    Bioessays 35:900-12. 2013
    ..Here we discuss how Ptdins3P is generated on specific cellular membranes, how its localizations and functions can be studied, and how its effectors serve to control cellular functions...
  22. ncbi request reprint Endosomal and non-endosomal functions of ESCRT proteins
    Thomas Slagsvold
    Department of Biochemistry, the Norwegian Radium Hospital and the University of Oslo, Montebello, N 0310 Oslo, Norway
    Trends Cell Biol 16:317-26. 2006
    ..We also discuss evidence that some ESCRT subunits have evolved additional functions that are unrelated to membrane trafficking...
  23. ncbi request reprint Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101
    Edward Leithe
    Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo and Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, Norway
    J Cell Sci 122:3883-93. 2009
    ..Collectively, these data reveal a central role of early endosomes in sorting of ubiquitylated Cx43, and identify Hrs and Tsg101 as crucial regulators of trafficking of Cx43 to lysosomes...
  24. ncbi request reprint Cindr interacts with anillin to control cytokinesis in Drosophila melanogaster
    Kaisa Haglund
    Department of Biochemistry, Institute for Cancer Research, Oslo University Hospital, N 0310 Oslo, Norway
    Curr Biol 20:944-50. 2010
    ..We propose that Cindr and Anillin cooperate to promote intercellular bridge stability during incomplete cytokinesis in Drosophila melanogaster...
  25. pmc Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease
    Maria Filimonenko
    Centre for Cancer Biomedicine, University of Oslo and Department of Biochemistry, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    J Cell Biol 179:485-500. 2007
    ..Together, our data indicate that efficient autophagic degradation requires functional MVBs and provide a possible explanation to the observed neurodegenerative phenotype seen in patients with CHMP2B mutations...
  26. ncbi request reprint Cloning and subcellular localization of a human phosphatidylinositol 3-phosphate 5-kinase, PIKfyve/Fab1
    Alicia Cabezas
    Department of Biochemistry, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Gene 371:34-41. 2006
    ..We show that PIKfyve is distributed in microdomains that are distinct from those occupied by EEA1 and Hrs...
  27. doi request reprint ESCRT proteins in physiology and disease
    Susanne Stuffers
    Centre for Cancer Biomedicine, Faculty Division, The Norwegian Radium Hospital, University of Oslo, Norway
    Exp Cell Res 315:1619-26. 2009
    ..We also review the additional functions of ESCRT proteins in cytokinesis and discuss how these may be related to ESCRT-associated pathologies...
  28. pmc Time-resolved ultrastructural detection of phosphatidylinositol 3-phosphate
    Susanne Stuffers
    Dept of Biochemistry, Institute for Cancer Research, the Norwegian Radium Hospital and Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, Oslo, Norway
    J Histochem Cytochem 58:1025-32. 2010
    ..We conclude that the dimerizer-inducible probe is useful for the time-resolved detection of PtdIns(3)P at the ultrastructural level, but its effects on endosome morphology after EGF stimulation need to be taken into account...
  29. ncbi request reprint How a RING finger protein and a steroid hormone control autophagy
    Karine Lindmo
    Department of Biochemistry, the Norwegian Radium Hospital and the University of Oslo, Montebello, Oslo, Norway
    Autophagy 2:321-2. 2006
    ..In this Addendum we review these findings and provide some speculations about how Dor may control both ecdysone signalling and autolysosomal fusion...
  30. ncbi request reprint Monitoring phosphatidylinositol 3-phosphate in multivesicular endosome biogenesis
    Catherine Sem Wegner
    Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Methods Enzymol 534:3-23. 2014
    ..We are describing several methods to track these sorting events by both light and electron microscopy and combination of both methods. ..
  31. ncbi request reprint Cell death during Drosophila melanogaster early oogenesis is mediated through autophagy
    Ioannis P Nezis
    Centre for Cancer Biomedicine, University of Oslo and Institute for Cancer Research, Department of Biochemistry, Rikshospitalet Radiumhospitalet HF, Montebello, Oslo, Norway
    Autophagy 5:298-302. 2009
    ..This study provides new insights into the mechanisms that regulate cell death in vivo during development...
  32. ncbi request reprint A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic
    Sigrid B Thoresen
    Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, Oslo, Norway
    Exp Cell Res 316:3368-78. 2010
    ....
  33. pmc Autophagy as a trigger for cell death: autophagic degradation of inhibitor of apoptosis dBruce controls DNA fragmentation during late oogenesis in Drosophila
    Ioannis P Nezis
    Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway
    Autophagy 6:1214-5. 2010
    ..These studies demonstrate that autophagic degradation of an inhibitor: of apoptosis is a novel mechanism of triggering cell death...
  34. doi request reprint The ESCRT machinery mediates polarization of fibroblasts through regulation of myosin light chain
    Viola Hélène Lobert
    Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway
    J Cell Sci 125:29-36. 2012
    ..These results suggest that, through their role in regulating integrin trafficking, ESCRTs regulate phosphorylation of MRLC and, subsequently, Golgi orientation and cell spreading...
  35. ncbi request reprint Ultrastructural characterization of giant endosomes induced by GTPase-deficient Rab5
    Catherine Sem Wegner
    Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, Norway
    Histochem Cell Biol 133:41-55. 2010
    ..In addition, we observe defects in the sorting of the EGF receptor and the transferrin receptor through this compartment...
  36. ncbi request reprint Regulation of membrane traffic by phosphoinositide 3-kinases
    Karine Lindmo
    Department of Biochemistry, Norwegian Radium Hospital and University of Oslo, Montebello, N 0310 Oslo, Norway
    J Cell Sci 119:605-14. 2006
    ..By contrast, class III PI 3-kinases mainly mediate receptor-independent trafficking events, which mostly are related to endocytic membrane traffic, phagosome maturation and autophagy...
  37. pmc CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4
    Thomas Slagsvold
    Department of Biochemistry, the Norwegian Radium Hospital and the University of Oslo, Montebello, Oslo, Norway
    EMBO J 25:3738-49. 2006
    ..Taken together, these results reveal a critical function of CISK in specifically attenuating ubiquitin-dependent degradation of CXCR4, and provide a mechanistic link between the PI 3-kinase pathway and CXCR4 stability...
  38. ncbi request reprint Analyzing phosphoinositides and their interacting proteins
    Tor Erik Rusten
    Department of Biochemistry, the Norwegian Radium Hospital and the University of Oslo, Montebello, N 0310 Oslo, Norway
    Nat Methods 3:251-8. 2006
    ..Here we describe strategies and techniques for quantitative and qualitative measurement of PIs, for characterization of specific PI-binding proteins and for determination of PI kinase and phosphatase activities in vitro and in vivo...
  39. ncbi request reprint Cytokinesis and cancer
    Antonia P Sagona
    Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway
    FEBS Lett 584:2652-61. 2010
    ..In this minireview, we will discuss the possible links between cytokinesis and cancer, and highlight key mechanisms that connect these processes...
  40. ncbi request reprint A new side to ubiquitin
    Camilla Raiborg
    Department of Biochemistry, the Norwegian Radium Hospital and the University of Oslo, Montebello, N 0310 Oslo, Norway
    Trends Biochem Sci 31:541-4. 2006
    ..The discovery of an alternative interaction face of ubiquitin opens new avenues for understanding how this small protein regulates protein function...
  41. doi request reprint The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins
    Camilla Raiborg
    Centre for Cancer Biomedicine, Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    Nature 458:445-52. 2009
    ..The involvement of the ESCRT machinery in suppressing diseases such as cancer, neurodegeneration and infections underscores its importance to the cell...
  42. ncbi request reprint ESCRTs
    Lene Malerød
    Department of Biochemistry, Institute for Cancer Research, Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Curr Biol 17:R42-3. 2007
  43. pmc Self-eating from an ER-associated cup
    Anne Simonsen
    Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway
    J Cell Biol 182:621-2. 2008
    ..Griffiths, and N.T. Ktistakis. 2008. J. Cell Biol. 182:685-701) provides evidence that cup-shaped protrusions from the endoplasmic reticulum, named omegasomes, serve as platforms for autophagosome biogenesis in mammalian cells...
  44. ncbi request reprint Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes
    Anne Simonsen
    Department of Biochemistry, The Norwegian Radium Hospital, Montebello, Oslo 0310, Norway
    J Cell Sci 117:4239-51. 2004
    ..By electron microscopy, similar structures can be found within autophagosomes. We propose that Alfy might target cytosolic protein aggregates for autophagic degradation...
  45. doi request reprint Divide and ProsPer: the emerging role of PtdIns3P in cytokinesis
    Ioannis P Nezis
    Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, Oslo, Norway
    Trends Cell Biol 20:642-9. 2010
    ..Elucidating the role of PtdIns3P in cytokinesis might contribute to insight into mechanisms of tumour development and suppression...
  46. doi request reprint p62, an autophagy hero or culprit?
    Tor Erik Rusten
    Centre for Cancer Biomedicine, University of Oslo and Department of Biochemistry, The Norwegian Radium Hospital Montebello, N 0310, Oslo, Norway
    Nat Cell Biol 12:207-9. 2010
    ..Lack of autophagy leads to accumulation of p62, which is not good for liver cells, as it induces a cellular stress response that leads to disease...
  47. ncbi request reprint Aberrant receptor signaling and trafficking as mechanisms in oncogenesis
    Kaisa Haglund
    Centre for Cancer Biomedicine, University of Oslo, and Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Crit Rev Oncog 13:39-74. 2007
    ..In this review we will discuss these signaling pathways and how their dysfunction may contribute to oncogenesis. We will also highlight the important role of endocytic membrane trafficking in receptor signaling and tumor suppression...
  48. ncbi request reprint Rab GTPases as coordinators of vesicle traffic
    Harald Stenmark
    Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, University of Oslo, Montebello, N 0310 Oslo, Norway
    Nat Rev Mol Cell Biol 10:513-25. 2009
    ..Functional impairments of Rab pathways are associated with diseases, such as immunodeficiencies, cancer and neurological disorders...
  49. ncbi request reprint Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway
    Tor Erik Rusten
    Department of Biochemistry, The Norwegian Radium Hospital, Montebello, N 0310 Oslo
    Dev Cell 7:179-92. 2004
    ..Hence, these studies link hormonal induction of autophagy to the regulatory function of the PI3K signaling pathway in vivo...
  50. pmc Structure and functions of stable intercellular bridges formed by incomplete cytokinesis during development
    Kaisa Haglund
    Department of Biochemistry Institute for Cancer Research Oslo University Hospital Centre for Cancer Biomedicine Faculty of Medicine University of Oslo Montebello, Oslo, Norway
    Commun Integr Biol 4:1-9. 2011
    ....
  51. doi request reprint Photochemical internalization (PCI) of immunotoxins targeting CD133 is specific and highly potent at femtomolar levels in cells with cancer stem cell properties
    Monica Bostad
    Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    J Control Release 168:317-26. 2013
    ..The excellent high efficacy and selectivity of eliminating CD133-expressing cells by PCI warrant further pre-clinical evaluations of this novel therapeutic approach...
  52. doi request reprint Cell differentiation: midbody remnants - junk or fate factors?
    Kay O Schink
    Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Curr Biol 21:R958-60. 2011
    ..This structure has been regarded as a piece of cellular debris, but two recent papers suggest an unexpected function for the midbody remnant in promoting an undifferentiated cellular phenotype...
  53. pmc The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation
    Kristi G Bache
    Department of Biochemistry, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Mol Biol Cell 15:4337-46. 2004
    ..Together, these results indicate that HCRP1 is a subunit of mammalian ESCRT-I and that its function is essential for lysosomal sorting of EGF receptors...
  54. ncbi request reprint Cell biology. A helix for the final cut
    Camilla Raiborg
    Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, Oslo, Norway
    Science 331:1533-4. 2011
    ..The constriction of a protein helix and the action of a microtubule-severing enzyme trigger the final stage of separation during cell division...
  55. pmc Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1
    Harald W Platta
    Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, 0310 Oslo, Norway
    Biochem J 441:399-406. 2012
    ..Beclin 1 is thus the first tumour suppressor reported to be controlled by Lys11-linked polyubiquitination...
  56. pmc Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes
    Kristi G Bache
    Department of Biochemistry, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    J Cell Biol 162:435-42. 2003
    ..We conclude that Hrs mediates the initial recruitment of ESCRT-I to endosomes and, thereby, indirectly regulates multivesicular body formation...
  57. ncbi request reprint Phosphatidylinositol 3-phosphate is found in microdomains of early endosomes
    David J Gillooly
    Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Histochem Cell Biol 120:445-53. 2003
    ..These microdomains may be necessary for the assembly of distinct multimolecular complexes that specify organelle identity, membrane trafficking and receptor signalling...
  58. ncbi request reprint Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B
    Sebastian Hoepfner
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    Cell 121:437-50. 2005
    ..We propose that this mechanism could have important implications for signaling...
  59. ncbi request reprint Role of Rab5 in the recruitment of hVps34/p150 to the early endosome
    James T Murray
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA
    Traffic 3:416-27. 2002
    ..However, Rab5 does not appear to act by directly recruiting p150/hVps34 complexes from the cytosol to the endosomal membrane...
  60. ncbi request reprint Working out coupled monoubiquitination
    Kaisa Haglund
    Nat Cell Biol 8:1218-9. 2006
  61. pmc Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes
    Manu Sharma
    Hospital for Sick Children, Program in Cell and Lung Biology, 555 University Ave, Toronto, Ontario M5G 1X8, Canada
    J Cell Biol 164:923-33. 2004
    ....
  62. ncbi request reprint The biogenesis of multivesicular endosomes
    Jean Gruenberg
    Department of Biochemistry, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva 4, Switzerland
    Nat Rev Mol Cell Biol 5:317-23. 2004
  63. pmc Cell-cycle-dependent binding kinetics for the early endosomal tethering factor EEA1
    Trygve Bergeland
    Department of Molecular Biosciences, University of Oslo, PO Box 1041, Blindernveien 31, Oslo 0316, Norway
    EMBO Rep 9:171-8. 2008
    ..This might be a general mechanism to fine-tune and control tethering and fusion of early endosomes...
  64. ncbi request reprint Structural basis of ubiquitin recognition by mammalian Eap45 GLUE domain
    Satoshi Hirano
    Structural Biology Research Center, Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization KEK, Tsukuba, Ibaraki 305 0801, Japan
    Nat Struct Mol Biol 13:1031-2. 2006
    ..In the Eap45 GLUE-Ub complex structure, Ub binds far from the proposed PI-binding site of Eap45 GLUE, suggesting their independent binding...
  65. pmc The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport
    Anna C Rutherford
    The Henry Wellcome Integrated Signalling Laboratories, Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK
    J Cell Sci 119:3944-57. 2006
    ..It follows that the swollen endosomal phenotype observed in PIKfyve-suppressed cells results primarily from a reduction in retrograde membrane fission rather than a defect in multivesicular body biogenesis...
  66. ncbi request reprint Double-sided ubiquitin binding of Hrs-UIM in endosomal protein sorting
    Satoshi Hirano
    Structural Biology Research Center, Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization, Tsukuba, Ibaraki 305 0801, Japan
    Nat Struct Mol Biol 13:272-7. 2006
    ..Hrs-UIM belongs to a new subclass of double-sided UIMs, in contrast to its yeast homolog Vps27p, which has two tandem single-sided UIMs...
  67. ncbi request reprint Regulation of ubiquitin-binding proteins by monoubiquitination
    Daniela Hoeller
    Institute for Biochemistry II, Goethe University Medical School, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Nat Cell Biol 8:163-9. 2006
    ..We propose that monoubiquitination of ubiquitin-binding proteins inhibits their capacity to bind to and control the functions of ubiquitinated targets in vivo...