Research Topics
Genomes and GenesSpecies | Therese SørlieSummaryAffiliation: University of Oslo Country: Norway Publications
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Detail Information
Publications
Distinct molecular mechanisms underlying clinically relevant subtypes of breast cancer: gene expression analyses across three different platformsTherese Sørlie
Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, N 0310 Oslo, Norway
BMC Genomics 7:127. 2006..To further validate and more thoroughly characterize these two subtypes at the molecular level in tumors at an early stage, we report a gene expression profiling study using three different DNA microarray platforms...- Combining gene signatures improves prediction of breast cancer survivalXi Zhao
Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway
PLoS ONE 6:e17845. 2011..Gene sets from eleven previously published gene signatures are included in the study... 
Molecular diversity in ductal carcinoma in situ (DCIS) and early invasive breast cancerAslaug Aamodt Muggerud
Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, 0310 Oslo, Norway
Mol Oncol 4:357-68. 2010....- Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signalingVessela N Kristensen
Department of Genetics, Institute for Cancer Research, and Cancer Clinic, Oslo University Hospital Radiumhospitalet, 0310 Oslo, Norway
Proc Natl Acad Sci U S A 109:2802-7. 2012..In conclusion, by means of a pathway-based modeling methodology (PARADIGM) integrating different layers of molecular data from whole-tumor samples, we demonstrate that we can stratify immune signatures that predict patient survival... - Evaluation of MetriGenix custom 4D arrays applied for detection of breast cancer subtypesAslaug Aamodt Muggerud
Department of Genetics, Faculty Division, The Norwegian Radium Hospital, University of Oslo, N 0310 Oslo, Norway
BMC Cancer 6:59. 2006..A new MetriGenix 4D array proposed for diagnostic use was evaluated... - Ischemia caused by time to freezing induces systematic microRNA and mRNA responses in cancer tissueEldrid Borgan
Department of Genetics, Institute of Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway
Mol Oncol 5:564-76. 2011..The induced miRNAs may play both direct and indirect roles in biological responses. Caution should be taken when the miRNAs and mRNAs reported to be affected by ischemia time are included in a prognostic or predictive signature... 
Effects of anastrozole on the intratumoral gene expression in locally advanced breast cancerVessela Nedelcheva Kristensen
Department of Genetics, Institute for Cancer Research, Norwegian Radium Hospital, Montebello 0310, Oslo, Norway
J Steroid Biochem Mol Biol 95:105-11. 2005..Using significance analysis of microarrays (SAM), we identified 298 genes significantly differently expressed between the partial response and progressive disease groups...- Genomic architecture characterizes tumor progression paths and fate in breast cancer patientsHege G Russnes
Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, 0310 Oslo, Norway
Sci Transl Med 2:38ra47. 2010..This study emphasizes the relation among structural genomic alterations, molecular subtype, and clinical behavior and shows that objective score of genomic complexity (CAAI) is an independent prognostic marker in breast cancer... - Pathway based analysis of SNPs with relevance to 5-FU therapy: relation to intratumoral mRNA expression and survivalSilje H Nordgard
Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Montebello, Oslo, Norway
Int J Cancer 123:577-85. 2008..These data suggest that 3 copies of the TYMS 5'UTR repeat may give a treatment specific reduced survival in breast cancer patients, and that TP53 may have a direct, allele specific, role in 5-FU mediated response... - Merging transcriptomics and metabolomics--advances in breast cancer profilingEldrid Borgan
Department of Genetics, Institute for Cancer Research, Division of Surgery and Cancer, Oslo University Hospital Radiumhospitalet, Oslo, Norway
BMC Cancer 10:628. 2010..The aim of this study was to explore the potential of combining these two different types of information... - Molecular profiling and characterization of luminal-like and basal-like in vivo breast cancer xenograft modelsAnna Bergamaschi
Department of Genetics, Norwegian Radium Hospital, Oslo University Hospital, Montebello, N 0310 Oslo, Norway
Mol Oncol 3:469-82. 2009..These two new breast cancer xenografts represent useful preclinical tools for developing and testing of new therapies and improving our knowledge on breast cancer biology... - In silico ascription of gene expression differences to tumor and stromal cells in a model to study impact on breast cancer outcomeSimen Myhre
Department of Genetics, Institute for Cancer Research, Division of Surgery and Cancer, Oslo University Hospital Radiumhospitalet, Oslo, Norway
PLoS ONE 5:e14002. 2010..These findings were confirmed in gene expression data from the representative compartments from microdissected breast tissue. The method described was also found to be robust to different histopathological procedures... - Molecular classification of breast tumors: toward improved diagnostics and treatmentsTherese Sørlie
Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway
Methods Mol Biol 360:91-114. 2007..This chapter describes the molecular classification and characterization of breast tumors into distinct subtypes by using DNA microarrays and discusses the statistical relationships of the subgroups with clinical features of the disease... - Gene expression profiling of breast cancer in relation to estrogen receptor status and estrogen-metabolizing enzymes: clinical implicationsVessela N Kristensen
Department of Genetics, Institute of Cancer Research, Norwegian Radium Hospital, Montebello, Oslo, Norway
Clin Cancer Res 11:878s-83s. 2005..Using significance analysis of microarrays, we identified 298 genes significantly differently expressed between partial response and progressive disease groups... - Subtype-specific response to bevacizumab is reflected in the metabolome and transcriptome of breast cancer xenograftsEldrid Borgan
Department of Genetics, Institute for Cancer Research, Division for Cancer Medicine, Surgery and Transplantation, Oslo University Hospital, Norwegian Radium Hospital, P O Box 4953 Nydalen, 0424 Oslo, Norway
Mol Oncol 7:130-42. 2013..This study underlines the importance of characterizing biological differences between subtypes of breast cancer to identify personalized biomarkers for improved patient stratification and evaluation of response to therapy... - Mutation screening of the TP53 gene by temporal temperature gradient gel electrophoresisTherese Sørlie
Department of Genetics, The Norwegian Radium Hospital, Oslo, Norway
Methods Mol Biol 291:207-16. 2005..The result is a rapid and sensitive screening technique that is robust and easily set up in smaller laboratory environments... - Glycan gene expression signatures in normal and malignant breast tissue; possible role in diagnosis and progressionIvan O Potapenko
Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, 0310 Oslo, Norway
Mol Oncol 4:98-118. 2010.... - Frequent aberrant DNA methylation of ABCB1, FOXC1, PPP2R2B and PTEN in ductal carcinoma in situ and early invasive breast cancerAslaug Aa Muggerud
Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, Oslo, N 0310, Norway
Breast Cancer Res 12:R3. 2010.... - Molecular portraits of breast cancer: tumour subtypes as distinct disease entitiesTherese Sørlie
Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway
Eur J Cancer 40:2667-75. 2004..This Review describes advances in the characterisation of breast tumour phenotypes using DNA microarrays and the identification of five subtypes of breast cancer with significant clinical implications...