Therese Sørlie

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. pmc Distinct molecular mechanisms underlying clinically relevant subtypes of breast cancer: gene expression analyses across three different platforms
    Therese Sørlie
    Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, N 0310 Oslo, Norway
    BMC Genomics 7:127. 2006
  2. doi request reprint Influence of DNA copy number and mRNA levels on the expression of breast cancer related proteins
    Simen Myhre
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, N 0310 Oslo, Norway
    Mol Oncol 7:704-18. 2013
  3. pmc Combining gene signatures improves prediction of breast cancer survival
    Xi Zhao
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway
    PLoS ONE 6:e17845. 2011
  4. doi request reprint Molecular diversity in ductal carcinoma in situ (DCIS) and early invasive breast cancer
    Aslaug Aamodt Muggerud
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, 0310 Oslo, Norway
    Mol Oncol 4:357-68. 2010
  5. pmc Genetic variation in putative regulatory loci controlling gene expression in breast cancer
    Vessela N Kristensen
    Department of Genetics, Institute of Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Montebello, 0310 Oslo, Norway
    Proc Natl Acad Sci U S A 103:7735-40. 2006
  6. ncbi request reprint Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene-expression subtypes of breast cancer
    Anna Bergamaschi
    Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Genes Chromosomes Cancer 45:1033-40. 2006
  7. pmc Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling
    Vessela N Kristensen
    Department of Genetics, Institute for Cancer Research, and Cancer Clinic, Oslo University Hospital Radiumhospitalet, 0310 Oslo, Norway
    Proc Natl Acad Sci U S A 109:2802-7. 2012
  8. pmc Evaluation of MetriGenix custom 4D arrays applied for detection of breast cancer subtypes
    Aslaug Aamodt Muggerud
    Department of Genetics, Faculty Division, The Norwegian Radium Hospital, University of Oslo, N 0310 Oslo, Norway
    BMC Cancer 6:59. 2006
  9. doi request reprint Ischemia caused by time to freezing induces systematic microRNA and mRNA responses in cancer tissue
    Eldrid Borgan
    Department of Genetics, Institute of Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway
    Mol Oncol 5:564-76. 2011
  10. ncbi request reprint Effects of anastrozole on the intratumoral gene expression in locally advanced breast cancer
    Vessela Nedelcheva Kristensen
    Department of Genetics, Institute for Cancer Research, Norwegian Radium Hospital, Montebello 0310, Oslo, Norway
    J Steroid Biochem Mol Biol 95:105-11. 2005

Collaborators

Detail Information

Publications22

  1. pmc Distinct molecular mechanisms underlying clinically relevant subtypes of breast cancer: gene expression analyses across three different platforms
    Therese Sørlie
    Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, N 0310 Oslo, Norway
    BMC Genomics 7:127. 2006
    ..To further validate and more thoroughly characterize these two subtypes at the molecular level in tumors at an early stage, we report a gene expression profiling study using three different DNA microarray platforms...
  2. doi request reprint Influence of DNA copy number and mRNA levels on the expression of breast cancer related proteins
    Simen Myhre
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, N 0310 Oslo, Norway
    Mol Oncol 7:704-18. 2013
    ..Further stratification suggested subtype-specific regulation that was not evident across the entire sample set...
  3. pmc Combining gene signatures improves prediction of breast cancer survival
    Xi Zhao
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway
    PLoS ONE 6:e17845. 2011
    ..Gene sets from eleven previously published gene signatures are included in the study...
  4. doi request reprint Molecular diversity in ductal carcinoma in situ (DCIS) and early invasive breast cancer
    Aslaug Aamodt Muggerud
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, 0310 Oslo, Norway
    Mol Oncol 4:357-68. 2010
    ....
  5. pmc Genetic variation in putative regulatory loci controlling gene expression in breast cancer
    Vessela N Kristensen
    Department of Genetics, Institute of Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Montebello, 0310 Oslo, Norway
    Proc Natl Acad Sci U S A 103:7735-40. 2006
    ..It provides the statistical framework for further genotype expression correlation studies in cancer data sets...
  6. ncbi request reprint Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene-expression subtypes of breast cancer
    Anna Bergamaschi
    Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Genes Chromosomes Cancer 45:1033-40. 2006
    ..This article contains Supplementary Material available at http://www.interscience.wiley.com/jpages/1045-2257/suppmat..
  7. pmc Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling
    Vessela N Kristensen
    Department of Genetics, Institute for Cancer Research, and Cancer Clinic, Oslo University Hospital Radiumhospitalet, 0310 Oslo, Norway
    Proc Natl Acad Sci U S A 109:2802-7. 2012
    ..In conclusion, by means of a pathway-based modeling methodology (PARADIGM) integrating different layers of molecular data from whole-tumor samples, we demonstrate that we can stratify immune signatures that predict patient survival...
  8. pmc Evaluation of MetriGenix custom 4D arrays applied for detection of breast cancer subtypes
    Aslaug Aamodt Muggerud
    Department of Genetics, Faculty Division, The Norwegian Radium Hospital, University of Oslo, N 0310 Oslo, Norway
    BMC Cancer 6:59. 2006
    ..A new MetriGenix 4D array proposed for diagnostic use was evaluated...
  9. doi request reprint Ischemia caused by time to freezing induces systematic microRNA and mRNA responses in cancer tissue
    Eldrid Borgan
    Department of Genetics, Institute of Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway
    Mol Oncol 5:564-76. 2011
    ..The induced miRNAs may play both direct and indirect roles in biological responses. Caution should be taken when the miRNAs and mRNAs reported to be affected by ischemia time are included in a prognostic or predictive signature...
  10. ncbi request reprint Effects of anastrozole on the intratumoral gene expression in locally advanced breast cancer
    Vessela Nedelcheva Kristensen
    Department of Genetics, Institute for Cancer Research, Norwegian Radium Hospital, Montebello 0310, Oslo, Norway
    J Steroid Biochem Mol Biol 95:105-11. 2005
    ..Using significance analysis of microarrays (SAM), we identified 298 genes significantly differently expressed between the partial response and progressive disease groups...
  11. doi request reprint Genomic architecture characterizes tumor progression paths and fate in breast cancer patients
    Hege G Russnes
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, 0310 Oslo, Norway
    Sci Transl Med 2:38ra47. 2010
    ..This study emphasizes the relation among structural genomic alterations, molecular subtype, and clinical behavior and shows that objective score of genomic complexity (CAAI) is an independent prognostic marker in breast cancer...
  12. doi request reprint Pathway based analysis of SNPs with relevance to 5-FU therapy: relation to intratumoral mRNA expression and survival
    Silje H Nordgard
    Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Montebello, Oslo, Norway
    Int J Cancer 123:577-85. 2008
    ..These data suggest that 3 copies of the TYMS 5'UTR repeat may give a treatment specific reduced survival in breast cancer patients, and that TP53 may have a direct, allele specific, role in 5-FU mediated response...
  13. doi request reprint Subtype-specific response to bevacizumab is reflected in the metabolome and transcriptome of breast cancer xenografts
    Eldrid Borgan
    Department of Genetics, Institute for Cancer Research, Division for Cancer Medicine, Surgery and Transplantation, Oslo University Hospital, Norwegian Radium Hospital, P O Box 4953 Nydalen, 0424 Oslo, Norway
    Mol Oncol 7:130-42. 2013
    ..This study underlines the importance of characterizing biological differences between subtypes of breast cancer to identify personalized biomarkers for improved patient stratification and evaluation of response to therapy...
  14. ncbi request reprint Molecular classification of breast tumors: toward improved diagnostics and treatments
    Therese Sørlie
    Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    Methods Mol Biol 360:91-114. 2007
    ..This chapter describes the molecular classification and characterization of breast tumors into distinct subtypes by using DNA microarrays and discusses the statistical relationships of the subgroups with clinical features of the disease...
  15. pmc Merging transcriptomics and metabolomics--advances in breast cancer profiling
    Eldrid Borgan
    Department of Genetics, Institute for Cancer Research, Division of Surgery and Cancer, Oslo University Hospital Radiumhospitalet, Oslo, Norway
    BMC Cancer 10:628. 2010
    ..The aim of this study was to explore the potential of combining these two different types of information...
  16. pmc In silico ascription of gene expression differences to tumor and stromal cells in a model to study impact on breast cancer outcome
    Simen Myhre
    Department of Genetics, Institute for Cancer Research, Division of Surgery and Cancer, Oslo University Hospital Radiumhospitalet, Oslo, Norway
    PLoS ONE 5:e14002. 2010
    ..These findings were confirmed in gene expression data from the representative compartments from microdissected breast tissue. The method described was also found to be robust to different histopathological procedures...
  17. doi request reprint Molecular profiling and characterization of luminal-like and basal-like in vivo breast cancer xenograft models
    Anna Bergamaschi
    Department of Genetics, Norwegian Radium Hospital, Oslo University Hospital, Montebello, N 0310 Oslo, Norway
    Mol Oncol 3:469-82. 2009
    ..These two new breast cancer xenografts represent useful preclinical tools for developing and testing of new therapies and improving our knowledge on breast cancer biology...
  18. ncbi request reprint Gene expression profiling of breast cancer in relation to estrogen receptor status and estrogen-metabolizing enzymes: clinical implications
    Vessela N Kristensen
    Department of Genetics, Institute of Cancer Research, Norwegian Radium Hospital, Montebello, Oslo, Norway
    Clin Cancer Res 11:878s-83s. 2005
    ..Using significance analysis of microarrays, we identified 298 genes significantly differently expressed between partial response and progressive disease groups...
  19. doi request reprint Glycan gene expression signatures in normal and malignant breast tissue; possible role in diagnosis and progression
    Ivan O Potapenko
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, 0310 Oslo, Norway
    Mol Oncol 4:98-118. 2010
    ....
  20. pmc Frequent aberrant DNA methylation of ABCB1, FOXC1, PPP2R2B and PTEN in ductal carcinoma in situ and early invasive breast cancer
    Aslaug Aa Muggerud
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, Oslo, N 0310, Norway
    Breast Cancer Res 12:R3. 2010
    ....
  21. ncbi request reprint Mutation screening of the TP53 gene by temporal temperature gradient gel electrophoresis
    Therese Sørlie
    Department of Genetics, The Norwegian Radium Hospital, Oslo, Norway
    Methods Mol Biol 291:207-16. 2005
    ..The result is a rapid and sensitive screening technique that is robust and easily set up in smaller laboratory environments...
  22. ncbi request reprint Molecular portraits of breast cancer: tumour subtypes as distinct disease entities
    Therese Sørlie
    Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Eur J Cancer 40:2667-75. 2004
    ..This Review describes advances in the characterisation of breast tumour phenotypes using DNA microarrays and the identification of five subtypes of breast cancer with significant clinical implications...