Ludvig M Sollid

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. pmc Novel therapies for coeliac disease
    L M Sollid
    Centre for Immune Regulation, Institute of Immunology, University of Oslo and Oslo University Hospital, Oslo, Norway
    J Intern Med 269:604-13. 2011
  2. pmc Triggers and drivers of autoimmunity: lessons from coeliac disease
    Ludvig M Sollid
    Centre for Immune Regulation and the Department of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, N 0372 Oslo, Norway
    Nat Rev Immunol 13:294-302. 2013
  3. pmc Celiac disease and transglutaminase 2: a model for posttranslational modification of antigens and HLA association in the pathogenesis of autoimmune disorders
    Ludvig M Sollid
    Centre for Immune Regulation and Department of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, 0027 Oslo, Norway
    Curr Opin Immunol 23:732-8. 2011
  4. pmc Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules
    Ludvig M Sollid
    Centre for Immune Regulation and Department of Immunology, University of Oslo and Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Immunogenetics 64:455-60. 2012
  5. doi request reprint Diagnosis and treatment of celiac disease
    L M Sollid
    Centre for Immune Regulation, Institute of Immunology, University of Oslo and Rikshospitalet University Hospital, Oslo, Norway
    Mucosal Immunol 2:3-7. 2009
  6. ncbi request reprint Is celiac disease an autoimmune disorder?
    Ludvig M Sollid
    Institute of Immunology, University of Oslo and Rikshospitalet University Hospital, Rikshospitalet, N 0027 Oslo, Norway
    Curr Opin Immunol 17:595-600. 2005
  7. ncbi request reprint Celiac disease genetics: current concepts and practical applications
    Ludvig M Sollid
    Institute of Immunology, University of Oslo, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Clin Gastroenterol Hepatol 3:843-51. 2005
  8. ncbi request reprint Future therapeutic options for celiac disease
    Ludvig M Sollid
    University of Oslo and Rikshopitalet University Hospital, Norway
    Nat Clin Pract Gastroenterol Hepatol 2:140-7. 2005
  9. doi request reprint Direct cloning and tetramer staining to measure the frequency of intestinal gluten-reactive T cells in celiac disease
    Michael Bodd
    Department of Immunology, Centre for Immune Regulation, Oslo University Hospital Rikshospitalet, Oslo, Norway
    Eur J Immunol 43:2605-12. 2013
  10. ncbi request reprint Antigen presentation to celiac lesion-derived T cells of a 33-mer gliadin peptide naturally formed by gastrointestinal digestion
    Shuo Wang Qiao
    Institute of Immunology, Rikshospitalet University Hospital, University of Oslo, Oslo, Norway
    J Immunol 173:1757-62. 2004

Detail Information

Publications83

  1. pmc Novel therapies for coeliac disease
    L M Sollid
    Centre for Immune Regulation, Institute of Immunology, University of Oslo and Oslo University Hospital, Oslo, Norway
    J Intern Med 269:604-13. 2011
    ..We conclude that future development of novel therapies will be aided considerably by the identification of new, preferably noninvasive, surrogate markers for coeliac disease activity...
  2. pmc Triggers and drivers of autoimmunity: lessons from coeliac disease
    Ludvig M Sollid
    Centre for Immune Regulation and the Department of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, N 0372 Oslo, Norway
    Nat Rev Immunol 13:294-302. 2013
    ....
  3. pmc Celiac disease and transglutaminase 2: a model for posttranslational modification of antigens and HLA association in the pathogenesis of autoimmune disorders
    Ludvig M Sollid
    Centre for Immune Regulation and Department of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, 0027 Oslo, Norway
    Curr Opin Immunol 23:732-8. 2011
    ..This insight gives clues for understanding the involvement of PTMs in other autoimmune diseases...
  4. pmc Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules
    Ludvig M Sollid
    Centre for Immune Regulation and Department of Immunology, University of Oslo and Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Immunogenetics 64:455-60. 2012
    ..In this work, we give an overview of these epitopes and suggest a comprehensive, new nomenclature...
  5. doi request reprint Diagnosis and treatment of celiac disease
    L M Sollid
    Centre for Immune Regulation, Institute of Immunology, University of Oslo and Rikshospitalet University Hospital, Oslo, Norway
    Mucosal Immunol 2:3-7. 2009
    ..Here we discuss how the new insight in the pathogenesis has lead to development of new diagnostics and nourished research into novel treatments...
  6. ncbi request reprint Is celiac disease an autoimmune disorder?
    Ludvig M Sollid
    Institute of Immunology, University of Oslo and Rikshospitalet University Hospital, Rikshospitalet, N 0027 Oslo, Norway
    Curr Opin Immunol 17:595-600. 2005
    ..In light of this, the many autoimmune phenomena associated with celiac disease are thought-provoking, and they challenge us to rethink the boundaries between autoimmunity and immunopathology...
  7. ncbi request reprint Celiac disease genetics: current concepts and practical applications
    Ludvig M Sollid
    Institute of Immunology, University of Oslo, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Clin Gastroenterol Hepatol 3:843-51. 2005
    ....
  8. ncbi request reprint Future therapeutic options for celiac disease
    Ludvig M Sollid
    University of Oslo and Rikshopitalet University Hospital, Norway
    Nat Clin Pract Gastroenterol Hepatol 2:140-7. 2005
    ..Other possible treatments include cytokine therapy, and selective adhesion molecule inhibitors that interfere with inflammatory reactions, some of which are already showing promise in the clinic for other gastrointestinal diseases...
  9. doi request reprint Direct cloning and tetramer staining to measure the frequency of intestinal gluten-reactive T cells in celiac disease
    Michael Bodd
    Department of Immunology, Centre for Immune Regulation, Oslo University Hospital Rikshospitalet, Oslo, Norway
    Eur J Immunol 43:2605-12. 2013
    ..Tetramer staining of gluten-reactive T cells in biopsy material is a useful tool for future studies of such cells in CD and could also potentially serve as a diagnostic supplement in selected cases...
  10. ncbi request reprint Antigen presentation to celiac lesion-derived T cells of a 33-mer gliadin peptide naturally formed by gastrointestinal digestion
    Shuo Wang Qiao
    Institute of Immunology, Rikshospitalet University Hospital, University of Oslo, Oslo, Norway
    J Immunol 173:1757-62. 2004
    ..The 33-mer is thus a potent T cell stimulator that does not require further processing within APC for T cell presentation and that binds to DQ2 with a pH profile that promotes extracellular binding...
  11. pmc HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease
    Stig Tollefsen
    Institute of Immunology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    J Clin Invest 116:2226-36. 2006
    ..Peptides combining the DQ2 and DQ8 signatures could be presented by DQ2, DQ8, and trans-encoded DQ heterodimers. Our findings shed light on the basis for the HLA associations in celiac disease and type 1 diabetes...
  12. pmc The propensity for deamidation and transamidation of peptides by transglutaminase 2 is dependent on substrate affinity and reaction conditions
    Jorunn Stamnaes
    Centre for Immune Regulation, Institute of Immunology, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Biochim Biophys Acta 1784:1804-11. 2008
    ..This was observed also for gliadin peptides introducing a novel route for the generation of deamidated T cell epitopes in celiac disease...
  13. pmc Transglutaminase 2-specific autoantibodies in celiac disease target clustered, N-terminal epitopes not displayed on the surface of cells
    Rasmus Iversen
    Centre for Immune Regulation, University of Oslo and Oslo University Hospital, N 0372 Oslo, Norway
    J Immunol 190:5981-91. 2013
    ..The findings give insight into the mechanisms controlling the formation of anti-TG2 autoantibodies in celiac disease...
  14. doi request reprint High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions
    Roberto Di Niro
    Centre for Immune Regulation and Department of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway
    Nat Med 18:441-5. 2012
    ..This could result in preferential recruitment of plasma cells from naive IgD- and IgM-expressing B cells, thus possibly explaining why the antibody response to TG2 bears signs of a primary immune response despite the disease chronicity...
  15. pmc The preferred substrates for transglutaminase 2 in a complex wheat gluten digest are Peptide fragments harboring celiac disease T-cell epitopes
    Siri Dørum
    Centre for Immune Regulation, Institute of Immunology, University of Oslo, Oslo, Norway
    PLoS ONE 5:e14056. 2010
    ..In this study we aimed to identify the preferred peptide substrates of TG2 in a heterogeneous proteolytic digest of whole wheat gluten...
  16. doi request reprint Antigen presentation in celiac disease
    Shuo Wang Qiao
    Centre for Immune Regulation, Institute of Immunology, Rikshospitalet University Hospital and University of Oslo, Norway
    Curr Opin Immunol 21:111-7. 2009
    ..In comparison, DQ8 exhibits different binding characteristics, which may explain the lesser risk for disease in association with this molecule...
  17. ncbi request reprint Refining the rules of gliadin T cell epitope binding to the disease-associated DQ2 molecule in celiac disease: importance of proline spacing and glutamine deamidation
    Shuo Wang Qiao
    Institute of Immunology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
    J Immunol 175:254-61. 2005
    ..Contrary to previous findings, our data do not show selective presentation of DQ2.5 over DQ2.2 for gluten epitopes that carry proline residues at the P3 position...
  18. pmc Structural and functional studies of trans-encoded HLA-DQ2.3 (DQA1*03:01/DQB1*02:01) protein molecule
    Stig Tollefsen
    Centre for Immune Regulation and Department of Immunology, University of Oslo and Oslo University Hospital, Rikshospitalet, 0027 Oslo, Norway
    J Biol Chem 287:13611-9. 2012
    ..3 together with all other available DQ crystal structures and sequences led us to categorize DQA1 and DQB1 genes into two groups where any α-chain and β-chain belonging to the same group are expected to form a stable heterodimer...
  19. doi request reprint Analysis of the binding of gluten T-cell epitopes to various human leukocyte antigen class II molecules
    Elin Bergseng
    Centre for Immune Regulation and Institute of Immunology, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Hum Immunol 69:94-100. 2008
    ..The results demonstrate that the gluten T-cell epitopes mainly bind to the DQ2 molecule...
  20. ncbi request reprint A unique dendritic cell subset accumulates in the celiac lesion and efficiently activates gluten-reactive T cells
    Melinda Raki
    Institute of Immunology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Gastroenterology 131:428-38. 2006
    ..The aim of this study was to identify the antigen-presenting cells that are responsible for the activation of gluten-reactive T cells in the celiac lesion...
  21. doi request reprint Long-lived plasma cells from human small intestine biopsies secrete immunoglobulins for many weeks in vitro
    Luka Mesin
    Center for Immune Regulation, University of Oslo, Q3 N 0027 Oslo, Norway
    J Immunol 187:2867-74. 2011
    ..This study demonstrates that the human small intestine harbors a population of nonproliferating plasma cells that are instructed by the microenvironment for prolonged survival and Ab secretion...
  22. doi request reprint A quantitative analysis of transglutaminase 2-mediated deamidation of gluten peptides: implications for the T-cell response in celiac disease
    Siri Dørum
    Centre for Immune Regulation, Institute of Immunology, University of Oslo, and Rikshospitalet University Hospital, N 0027 Oslo, Norway
    J Proteome Res 8:1748-55. 2009
    ..Thus, the rate of deamidation by TG2 appears to be a factor of importance for the T-cell response to gluten in celiac disease...
  23. doi request reprint Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation
    Lars Egil Fallang
    Centre for Immune Regulation, Institute of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway
    Nat Immunol 10:1096-101. 2009
    ..2 (phenylalanine) cannot. Our findings suggest that the kinetic stability of complexes of peptide and major histocompatibility complex (MHC) is of importance for the association of HLA with disease...
  24. ncbi request reprint Tissue transglutaminase-mediated formation and cleavage of histamine-gliadin complexes: biological effects and implications for celiac disease
    Shuo Wang Qiao
    Institute of Immunology, Rikshospitalet, University of Oslo, Oslo, Norway
    J Immunol 174:1657-63. 2005
    ..Interestingly, TG2 is able to hydrolyze the peptide-histamine conjugates when the concentrations of substrates are lowered, thereby releasing deamidated gluten peptides that are stimulatory to T cells...
  25. doi request reprint Evidence that HLA-DQ9 confers risk to celiac disease by presence of DQ9-restricted gluten-specific T cells
    Michael Bodd
    Centre for Immune Regulation and Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway
    Hum Immunol 73:376-81. 2012
    ..The differential ability of DQ8 and DQ9 to harness a negatively charged anchor at P9 may result in fewer potential gluten epitopes in DQ9 patients. Our data further indicate that DQ9 is a susceptibility factor for celiac disease...
  26. pmc The molecular basis for oat intolerance in patients with celiac disease
    Helene Arentz-Hansen
    Institute of Immunology, Rikshospitalet University Hospital, University of Oslo, Oslo, Norway
    PLoS Med 1:e1. 2004
    ..This study aimed to investigate whether oat intolerance exists in celiac disease and to characterize the cells and processes underlying this intolerance...
  27. ncbi request reprint Main chain hydrogen bond interactions in the binding of proline-rich gluten peptides to the celiac disease-associated HLA-DQ2 molecule
    Elin Bergseng
    Institute of Immunology, University of Oslo, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    J Biol Chem 280:21791-6. 2005
    ..This is a unique feature of DQ2 and is likely a key parameter for preferential binding of proline-rich gluten peptides and development of celiac disease...
  28. doi request reprint Rapid generation of rotavirus-specific human monoclonal antibodies from small-intestinal mucosa
    Roberto Di Niro
    Center for Immune Regulation, Oslo University Hospital, Oslo, Norway
    J Immunol 185:5377-83. 2010
    ....
  29. ncbi request reprint FOXP3 polymorphisms in type 1 diabetes and coeliac disease
    Marit Bjørnvold
    Institute of Medical Genetics, Faculty Division Ulleval University Hospital, University of Oslo, Oslo, Norway
    J Autoimmun 27:140-4. 2006
    ..On the other hand, we were unable to reproduce our initial findings in the T1D case-control dataset (global p=0.6). Our results suggest that the tested FOXP3 markers do not have any major impact on susceptibility for these diseases...
  30. pmc Anti-PAD4 autoantibodies in rheumatoid arthritis: levels in serum over time and impact on PAD4 activity as measured with a small synthetic substrate
    Sylvie Pollmann
    Centre for Immune Regulation, Institute of Immunology, University of Oslo, Oslo University Hospital Rikshospitalet, 0027 Oslo, Norway
    Rheumatol Int 32:1271-6. 2012
    ..However, this finding may not exclude an effect of these autoantibodies on citrullination of protein substrates in RA...
  31. doi request reprint T-cell response to gluten in patients with HLA-DQ2.2 reveals requirement of peptide-MHC stability in celiac disease
    Michael Bodd
    Centre for Immune Regulation and Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway
    Gastroenterology 142:552-61. 2012
    ..2 without any other risk alleles. Epitopes commonly recognized by T cells of patients with HLA-DQ2.5 bind stably to DQ2.5 but unstably to DQ2.2. We investigated the response to gluten in patients with HLA-DQ2.2...
  32. ncbi request reprint Mapping of gluten T-cell epitopes in the bread wheat ancestors: implications for celiac disease
    Oyvind Molberg
    Institute of Immunology, Rikshospitalet, University of Oslo, Oslo, Norway
    Gastroenterology 128:393-401. 2005
    ....
  33. pmc Tetramer visualization of gut-homing gluten-specific T cells in the peripheral blood of celiac disease patients
    Melinda Raki
    Institute of Immunology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center, 0027 Oslo, Norway
    Proc Natl Acad Sci U S A 104:2831-6. 2007
    ..Most of the cells had a memory phenotype, but many other phenotypic markers showed a heterogeneous pattern. Tetramer staining of gluten-specific T cells has the potential to be used for diagnosis of celiac disease...
  34. ncbi request reprint A comprehensive screen for SNP associations on chromosome region 5q31-33 in Swedish/Norwegian celiac disease families
    Silja Svanstrøm Amundsen
    Institute of Immunology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Centre, Oslo, Norway
    Eur J Hum Genet 15:980-7. 2007
    ..Collective effects of multiple risk genes within the region, incomplete genetic coverage or effects related to copy number variation are possible explanations for our findings...
  35. doi request reprint Recombinant antibodies for delivery of antigen: a single loop between beta-strands in the constant region can accommodate long, complex and tandem T cell epitopes
    Gro Tunheim
    Center for Immune Regulation, Institute of Immunology, Medical Faculty, University of Oslo and Rikshospitalet University Hospital, Norway
    Int Immunol 20:295-306. 2008
    ..Thus, single loops in C regions of recombinant antibodies seem versatile and may be used for delivery of lengthy, complex and multiple T cell epitopes to human APCs...
  36. ncbi request reprint Complexes of two cohorts of CLIP peptides and HLA-DQ2 of the autoimmune DR3-DQ2 haplotype are poor substrates for HLA-DM
    Lars Egil Fallang
    Centre for Immune Regulation and Institute of Immunology, University of Oslo, Oslo, Norway
    J Immunol 181:5451-61. 2008
    ..We suggest that the unusual interaction of DQ2 with Ii and DM may provide a basis for the known disease associations of DQ2...
  37. ncbi request reprint Molecular characterization of covalent complexes between tissue transglutaminase and gliadin peptides
    Burkhard Fleckenstein
    Institute of Immunology, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    J Biol Chem 279:17607-16. 2004
    ..The results are relevant to the understanding of how antibodies to TG2 are formed in celiac disease...
  38. doi request reprint Mucosal cytokine response after short-term gluten challenge in celiac disease and non-celiac gluten sensitivity
    Margit Brottveit
    Department of Gastroenterology, Oslo University Hospital Ulleval, Oslo, Norway
    Am J Gastroenterol 108:842-50. 2013
    ..Non-celiac gluten sensitivity (NCGS) is another form of gluten intolerance where the immune response is less characterized. The aim of our study was to explore and compare the early mucosal immunological events in CD and NCGS...
  39. doi request reprint Posttranslational modification of gluten shapes TCR usage in celiac disease
    Shuo Wang Qiao
    Department of Immunology, Centre for Immune Regulation, University of Oslo, 0027 Oslo, Norway
    J Immunol 187:3064-71. 2011
    ..The findings have implications for understanding T cell responses to posttranslationally modified Ags...
  40. ncbi request reprint Coeliac disease: dissecting a complex inflammatory disorder
    Ludvig M Sollid
    Institute of Immunology, Rikshospitalet, University of Oslo, 0027 Oslo, Norway
    Nat Rev Immunol 2:647-55. 2002
    ..This dissection of the pathogenic mechanisms of coeliac disease has uncovered principles that are relevant to other chronic inflammatory diseases...
  41. doi request reprint Soluble HLA-DQ2 expressed in S2 cells copurifies with a high affinity insect cell derived protein
    Ulrike Jüse
    Centre for Immune Regulation, Institute of Immunology, University of Oslo, Oslo, Norway
    Immunogenetics 61:81-9. 2009
    ..Further mapping of this fragment of 54 residues identified a pentadecapeptide with high affinity for sDQ2 which may serve as a lead compound for the design of HLA-DQ2 blockers...
  42. ncbi request reprint Celiac disease as a model of gastrointestinal inflammation
    Ludvig M Sollid
    University of Oslo, Oslo, Norway
    J Pediatr Gastroenterol Nutr 40:S41-2. 2005
  43. pmc Isolation of Mycobacterium avium subspecies paratuberculosis reactive CD4 T cells from intestinal biopsies of Crohn's disease patients
    Ingrid Olsen
    Department of Animal Health, National Veterinary Institute, Oslo, Norway
    PLoS ONE 4:e5641. 2009
    ..The response is characterized by a strong Th1/Th17 response, but the relative importance of the various bacteria is not known...
  44. ncbi request reprint Intestinal T-cell responses to high-molecular-weight glutenins in celiac disease
    Øyvind Molberg
    Institute of Immunology, Rikshospitalet, University of Oslo, N 0027, Oslo, Norway
    Gastroenterology 125:337-44. 2003
    ....
  45. ncbi request reprint Coeliac disease patients carry conserved HLA-DR3-DQ2 haplotypes revealed by association of TNF alleles
    Andrew S Louka
    Institute of Immunology, University of Oslo, Rikshospitalet, 0027 Oslo, Norway
    Immunogenetics 55:339-43. 2003
    ..In conclusion, we confirmed in this study, the largest of its kind, that additional CD risk factors independent of DQ2 alleles do exist on the DR3 haplotype...
  46. ncbi request reprint Association analysis of MYO9B gene polymorphisms with celiac disease in a Swedish/Norwegian cohort
    Silja S Amundsen
    Institute of Immunology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
    Hum Immunol 67:341-5. 2006
    ..Alternatively, it might be due to variable linkage disequilibria in distinct populations in the tested SNPs and a causative mutation yet to be identified or to false positive findings (type I error) in the Dutch study...
  47. doi request reprint The adaptive immune response in celiac disease
    Shuo Wang Qiao
    Department of Immunology and Centre for Immune Regulation, University of Oslo, Oslo University Hospital Rikshospitalet, 0027, Oslo, Norway
    Semin Immunopathol 34:523-40. 2012
    ..Here we review recent developments in the understanding of the role of T cells, B cells, and antigen-presenting cells in the pathogenic immune response of this instructive disorder...
  48. doi request reprint Gluten T cell epitope targeting by TG3 and TG6; implications for dermatitis herpetiformis and gluten ataxia
    Jorunn Stamnaes
    Centre for Immune Regulation, Institute of Immunology, University of Oslo, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Amino Acids 39:1183-91. 2010
    ..Our findings lend credence to the notion that TG3 and TG6 are involved in the gluten-induced autoimmune responses of DH and GA...
  49. pmc Redox regulation of transglutaminase 2 activity
    Jorunn Stamnaes
    Centre for Immune Regulation, Institute of Immunology, University of Oslo, Oslo, Norway
    J Biol Chem 285:25402-9. 2010
    ..Our findings suggest that oxidation is likely to influence the amount of active TG2 present in the extracellular environment...
  50. ncbi request reprint Celiac lesion T cells recognize epitopes that cluster in regions of gliadins rich in proline residues
    Helene Arentz-Hansen
    Institute of Immunology and Department of Medicine, Rikshopitalet, University of Oslo, Oslo, Norway
    Gastroenterology 123:803-9. 2002
    ..Only a few gliadin T-cell epitopes have been identified by earlier work. The aim of this study was to perform a systematic characterization of DQ2-restricted T-cell epitopes in alpha- and gamma-gliadins...
  51. doi request reprint Design of new high-affinity peptide ligands for human leukocyte antigen-DQ2 using a positional scanning peptide library
    Ulrike Jüse
    Centre for Immune Regulation, Institute of Immunology, Oslo University Hospital Rikshospitalet, 0027 Oslo, Norway
    Hum Immunol 71:475-81. 2010
    ..Our approach represents a straightforward strategy for developing high-affinity binders to HLA class II molecules...
  52. doi request reprint Assessing high affinity binding to HLA-DQ2.5 by a novel peptide library based approach
    Ulrike Jüse
    Centre for Immune Regulation, Institute of Immunology, Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway
    Bioorg Med Chem 19:2470-7. 2011
    ..5 peptide binding motif. This novel method, limited by library complexity and sensitivity of mass spectrometry, allows the analysis of several thousand synthetic sequences concomitantly in a simple water soluble format...
  53. doi request reprint Pitfalls in determining the cytokine profile of human T cells
    Ingrid Olsen
    Centre for Immune Regulation and Department of Immunology, Oslo University Hospital Rikshospitalet, 0027 Oslo, Norway
    J Immunol Methods 390:106-12. 2013
    ....
  54. doi request reprint Primary sequence, together with other factors, influence peptide deimination by peptidylarginine deiminase-4
    Maria E Stensland
    Centre for Immune Regulation, Institute of Immunology, University of Oslo, Department of Rheumatology, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Biol Chem 390:99-107. 2009
    ..Finally, we observed that a methylated lysine residue flanking the targeted arginine influences PAD-4-mediated deimination, also suggesting that posttranslational modifications can affect substrate efficiency...
  55. ncbi request reprint Intraepithelial lymphocytes in celiac disease: license to kill revealed
    Ludvig M Sollid
    Institute of Immunology, Rikshospitalet, University of Oslo, N 0027, Norway
    Immunity 21:303-4. 2004
    ..In this issue of Immunity, two papers uncover mechanisms controlling the cytolytic potential of these cells and provide evidence that lymphocyte killing of enterocytes is an important part of the celiac disease pathogenesis...
  56. ncbi request reprint A gut feeling for joint inflammation - using coeliac disease to understand rheumatoid arthritis
    Øyvind Molberg
    Institute of Immunology and Department of Rheumatology, Rikshospitalet University Hospital, University of Oslo, N 0027 Oslo, Norway
    Trends Immunol 27:188-94. 2006
    ..The experiences from coeliac disease should therefore help identify disease-relevant T-cell epitopes in rheumatoid arthritis...
  57. ncbi request reprint A collaborative European search for non-DQA1*05-DQB1*02 celiac disease loci on HLA-DR3 haplotypes: analysis of transmission from homozygous parents
    Andrew S Louka
    Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway
    Hum Immunol 64:350-8. 2003
    ..This effect should be tested in large populations with significant representations of both B8-DR3 and non-B8 DR3 haplotypes...
  58. ncbi request reprint Mapping genes and pathways in autoimmune disease
    Anne Spurkland
    Institute of Basic Medical Sciences, University of Oslo, Rikshospitalet University Hospital, Oslo N 0317, Norway
    Trends Immunol 27:336-42. 2006
    ..The potential benefit of reducing the heterogeneity of clinically defined diseases by the careful phenotyping of patients, cells and lesions using advanced molecular biology and imaging techniques is highlighted...
  59. ncbi request reprint Specific modification of peptide-bound citrulline residues
    Anders Holm
    Institute of Immunology, University of Oslo, NO 0027 Oslo, Norway
    Anal Biochem 352:68-76. 2006
    ..The results presented should facilitate the development of tags that can be used for the enrichment and subsequent detection of citrulline-containing protein fragments by mass spectrometry...
  60. doi request reprint Biased usage and preferred pairing of α- and β-chains of TCRs specific for an immunodominant gluten epitope in coeliac disease
    Shuo Wang Qiao
    Centre for Immune Regulation and Department of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, 0372 Oslo, Norway
    Int Immunol 26:13-9. 2014
    ..This study extends previous reports on biased TCR usage in both HLA-DQ2.5- and DQ8-restricted gluten-specific TCRs and provides data for further studies on TRAV and TRBV pairing...
  61. ncbi request reprint Gliadin T cell epitope selection by tissue transglutaminase in celiac disease. Role of enzyme specificity and pH influence on the transamidation versus deamidation process
    Burkhard Fleckenstein
    Institute of Immunology, Rikshospitalet, University of Oslo, N 0027 Oslo, Norway
    J Biol Chem 277:34109-16. 2002
    ..This suggests that the deamidation of gluten peptides by TG2 more likely takes place in slightly acidic environments...
  62. ncbi request reprint A mouse C kappa-specific T cell clone indicates that DC-SIGN is an efficient target for antibody-mediated delivery of T cell epitopes for MHC class II presentation
    Karoline W Schjetne
    Institute of Immunology, University of Oslo, Rikshospitalet, 0027 Oslo, Norway
    Int Immunol 14:1423-30. 2002
    ..These results strongly argue that DC-SIGN-specific mAb are channeled into the MHC class II presentation pathway. Thus, DC-SIGN could be an efficient target for antibody-mediated delivery of T cell epitopes in vaccine development...
  63. pmc The intestinal B-cell response in celiac disease
    Luka Mesin
    Centre for Immune Regulation, Department of Immunology, Oslo University Hospital Rikshospitalet, University of Oslo Oslo, Norway
    Front Immunol 3:313. 2012
    ..Here we review the current knowledge of this B-cell response and how it is induced, and we discuss key questions to be addressed in future research...
  64. ncbi request reprint Structural basis for gluten intolerance in celiac sprue
    Lu Shan
    Department of Chemical Engineering, Stanford University, Stanford, CA 94305 5025, USA
    Science 297:2275-9. 2002
    ..The peptide could be detoxified in in vitro and in vivo assays by exposure to a bacterial prolyl endopeptidase, suggesting a strategy for oral peptidase supplement therapy for Celiac Sprue...
  65. ncbi request reprint Heterologous expression, purification, refolding, and structural-functional characterization of EP-B2, a self-activating barley cysteine endoprotease
    Michael T Bethune
    Department of Biochemistry, Stanford University, Stanford, California 94305, USA
    Chem Biol 13:637-47. 2006
    ..2 A resolution and provided atomic insights into the observed subsite specificity of the endoprotease. Our findings suggest that orally administered proEP-B2 may be especially well suited for treatment of celiac sprue...
  66. pmc Inhibition of HLA-DQ2-mediated antigen presentation by analogues of a high affinity 33-residue peptide from alpha2-gliadin
    Jiang Xia
    Departments of Chemistry, Chemical Engineering, and Biochemistry, Stanford University, Stanford, CA 94305 5025, USA
    J Am Chem Soc 128:1859-67. 2006
    ....
  67. ncbi request reprint Cross-dressing T cells go wild
    Ludvig M Sollid
    Nat Med 12:611-2. 2006
  68. ncbi request reprint Putative efficacy and dosage of prolyl endopeptidase for digesting and detoxifying gliadin peptides
    Chaitan Khosla
    Gastroenterology 129:1362-3; author reply 1363. 2005
  69. pmc Identification and analysis of multivalent proteolytically resistant peptides from gluten: implications for celiac sprue
    Lu Shan
    Department of Chemical Engineering, Stanford University, Stanford, CA 94305 5025, USA
    J Proteome Res 4:1732-41. 2005
    ....
  70. ncbi request reprint HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European Genetics Cluster on Celiac Disease
    Kati Karell
    Department of Tissue Typing, Finnish Red Cross Blood Transfusion Service, Helsinki, Finland
    Hum Immunol 64:469-77. 2003
    ..These results underline the primary importance of HLA-DQ alleles in susceptibility to celiac disease, and the extreme rarity of celiac patients carrying neither the DQ2 or DQ8 heterodimers nor one half of the DQ2 heterodimer alone...
  71. pmc Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease
    Jiang Xia
    Department of Chemistry, Stanford University, Stanford, CA 94305 5025, USA
    Bioorg Med Chem 15:6565-73. 2007
    ..One dimeric peptide analogue with an intermediate linker length was found to be especially effective at inhibiting DQ2 mediated antigen presentation. The implications of these findings for the treatment of celiac disease are discussed...
  72. pmc Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease
    Chu Young Kim
    Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 101:4175-9. 2004
    ..Finally, surface-exposed proline residues in the proteolytically resistant ligand were replaced with functionalized analogs, thereby providing a starting point for the design of orally active agents for blocking gluten-induced toxicity...
  73. doi request reprint Hunting for celiac disease genes
    Ludvig M Sollid
    Gastroenterology 134:869-71. 2008
  74. ncbi request reprint Meta and pooled analysis of European coeliac disease data
    Marie Claude Babron
    1INSERM U535, Villejuif, France
    Eur J Hum Genet 11:828-34. 2003
    ..This region was suggested by several individual studies, but did not reach statistical values high enough to be conclusive when data sets were analysed separately...
  75. ncbi request reprint [Disease mechanisms in coeliac disease]
    Ludvig M Sollid
    Immunologisk institutt, Rikshospitlet, Oslo
    Tidsskr Nor Laegeforen 123:3230-3. 2003
    ..In recent years we have gained new knowledge of the molecular basis of this disorder; this paper gives an overview of the current understanding of the pathogenesis of coeliac disease...
  76. pmc Dependence of antibody-mediated presentation of antigen on FcRn
    Shuo Wang Qiao
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:9337-42. 2008
    ....
  77. ncbi request reprint [Coeliac disease--new clinical findings and diagnostic tools]
    Knut E A Lundin
    Medisinsk avdeling, Rikshospitlet, Oslo
    Tidsskr Nor Laegeforen 123:3226-9. 2003
    ..Coeliac disease can also exist with a normal serology. The trend in many countries is to require less pronounced mucosal abnormalities than previously for the diagnosis...
  78. ncbi request reprint Prolyl endopeptidase-mediated destruction of T cell epitopes in whole gluten: chemical and immunological characterization
    Thomas Marti
    Celiac Sprue Research Foundation, 3181 Porter Dr, Palo Alto, CA 94304, USA
    J Pharmacol Exp Ther 312:19-26. 2005
    ....
  79. ncbi request reprint Mechanisms of disease: immunopathogenesis of celiac disease
    Bana Jabri
    Department of Pathology, Medicine and Pediatrics, University of Chicago, IL 60637, USA
    Nat Clin Pract Gastroenterol Hepatol 3:516-25. 2006
    ....
  80. ncbi request reprint Equilibrium and kinetic analysis of the unusual binding behavior of a highly immunogenic gluten peptide to HLA-DQ2
    Jiang Xia
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    Biochemistry 44:4442-9. 2005
    ....
  81. ncbi request reprint A role for bacteria in celiac disease?
    Ludvig M Sollid
    Am J Gastroenterol 99:905-6. 2004
    ..This editorial discusses this possibility in relation to the current understanding of the molecular basis of this disorder...
  82. ncbi request reprint Pathomechanisms in celiac disease
    Frits Koning
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, P O Box 9600, 2300 RC Leiden, The Netherlands
    Best Pract Res Clin Gastroenterol 19:373-87. 2005
    ..Together, these observations provide a unique explanation for the disease inducing capacity of gluten...
  83. pmc Comparative biochemical analysis of three bacterial prolyl endopeptidases: implications for coeliac sprue
    Lu Shan
    Department of Chemical Engineering, Stanford Unversity, Stanford, CA 94305, USA
    Biochem J 383:311-8. 2004
    ....